公开(公告)号：US20100280224A1

公开(公告)日：2010-11-04

申请号：US12676178

申请日：2008-09-03

Applicant: Jens Beator ,  Angelika Lüking ,  Axel Kowald ,  Helmut Meyer

Inventor： Jens Beator ,  Angelika Lüking ,  Axel Kowald ,  Helmut Meyer

IPC: C07K14/435 ,  C07H21/04

CPC classification number: G01N33/564 ,  G01N2800/285

Abstract: The present invention relates to new marker sequences for multiple sclerosis and the diagnostic use thereof together with a method for screening of potential active substances for multiple sclerosis by means of these marker sequences. Furthermore, the invention relates to a diagnostic device containing such marker sequences for multiple sclerosis, in particular a protein biochip and the use thereof.

Abstract translation: 本发明涉及用于多发性硬化的新标志物序列及其诊断用途以及通过这些标记序列筛选多发性硬化的潜在活性物质的方法。 此外，本发明涉及含有这种用于多发性硬化的标志物序列，特别是蛋白质生物芯片的诊断装置及其用途。

公开(公告)号：US20100261881A1

公开(公告)日：2010-10-14

申请号：US12676223

申请日：2008-09-03

Applicant: Jens Beator ,  Angelika Lüking ,  Axel Kowald ,  Helmut E. Meyer

Inventor： Jens Beator ,  Angelika Lüking ,  Axel Kowald ,  Helmut E. Meyer

IPC: C07K14/00 ,  C07H21/04

CPC classification number: C12Q1/6883 ,  C12Q2600/158 ,  G01N33/564 ,  G01N2800/102 ,  G01N2800/50

Abstract: The present invention relates to new marker sequences for rheumatoid arthritis and the diagnostic use thereof together with a method for screening of potential active substances for rheumatoid arthritis by means of these marker sequences. Furthermore, the invention relates to a diagnostic device containing such marker sequences for rheumatoid arthritis, in particular a protein biochip and the use thereof.

Abstract translation: 本发明涉及用于类风湿性关节炎的新标记序列及其诊断用途以及通过这些标记序列筛选类风湿性关节炎的潜在活性物质的方法。 此外，本发明涉及含有类风湿性关节炎特别是蛋白质生物芯片的标记序列的诊断装置及其用途。

公开(公告)号：US20110184375A1

公开(公告)日：2011-07-28

申请号：US12809831

申请日：2008-12-22

Applicant: Heike Göhler ,  Helmut E. Meyer ,  Katrin Marcus ,  Axel Kowald ,  Florian Tribl ,  Manfred Gerlach ,  Peter Riederer ,  Angelika Lüking ,  Christian Scheer ,  Jens Beator

Inventor： Heike Göhler ,  Helmut E. Meyer ,  Katrin Marcus ,  Axel Kowald ,  Florian Tribl ,  Manfred Gerlach ,  Peter Riederer ,  Angelika Lüking ,  Christian Scheer ,  Jens Beator

IPC: A61M1/36 ,  C40B30/00 ,  C40B40/08 ,  C40B40/10 ,  C07H21/00 ,  C07K14/00 ,  C40B30/04

CPC classification number: C12Q1/6883 ,  C12Q2600/158 ,  G01N33/6896 ,  G01N2500/02 ,  G01N2800/2835 ,  G01N2800/56

Abstract: The present invention relates to new marker sequences for neurodegenerative diseases and the diagnostic use thereof together with a method for screening of potential active substances for neurodegenerative diseases by means of these marker sequences. Furthermore, the invention relates to a diagnostic device containing such marker sequences for neurodegenerative diseases, in particular a protein biochip and the use thereof.

Abstract translation: 本发明涉及用于神经变性疾病的新标记序列及其诊断用途以及通过这些标记序列筛选神经变性疾病的潜在活性物质的方法。 此外，本发明涉及含有神经变性疾病的标记序列，特别是蛋白质生物芯片的诊断装置及其用途。

公开(公告)号：US20100331201A1

公开(公告)日：2010-12-30

申请号：US12304060

申请日：2007-06-11

Applicant: Stefan Müllner ,  Angelika Lüking ,  Verena Trappe

Inventor： Stefan Müllner ,  Angelika Lüking ,  Verena Trappe

IPC: C40B30/04 ,  C40B40/10 ,  G01N33/53

CPC classification number: G01N33/6845 ,  C07K1/1077 ,  C07K17/02 ,  G01N33/6878

Abstract: The present invention relates to a system of protein binders containing at least one protein binder presented in at least one native form and at least one non-native form and its use including a method for discrimination and/or differential screening of suitable protein binders in native and non-native form.

Abstract translation: 本发明涉及含有至少一种以至少一种天然形式和至少一种非天然形式存在的至少一种蛋白质粘合剂的蛋白质粘合剂的系统，其用途包括鉴定和/或鉴别和/或差异筛选天然的蛋白质结合剂的方法 和非本地形式。

公开(公告)号：US20090246203A1

公开(公告)日：2009-10-01

申请号：US12162240

申请日：2007-01-24

Applicant: Angelika Lüking ,  Christian Scheer ,  Verena Gruss Trappe ,  Claudia Gutjahr ,  Kirsten Schulte

Inventor： Angelika Lüking ,  Christian Scheer ,  Verena Gruss Trappe ,  Claudia Gutjahr ,  Kirsten Schulte

IPC: A61K39/395 ,  C40B30/04 ,  A61P37/06

CPC classification number: C07K14/4713 ,  A61M1/3679 ,  G01N33/564

Abstract: The invention relates to a novel method for immunoadsorption therapy of human autoimmune diseases by means of immobilized or fixed autoantigens.

Abstract translation: 本发明涉及一种通过固定或固定的自身抗原免疫吸附治疗人类自身免疫性疾病的新方法。