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    SPECTRAL DECONVOLUTION IN ION CYCLOTRON RESONANCE MASS SPECTROMETRY
    1.
    发明申请
    SPECTRAL DECONVOLUTION IN ION CYCLOTRON RESONANCE MASS SPECTROMETRY 有权
    离子循环共振质谱分析中的光谱分解

    公开(公告)号：US20110251801A1

    公开(公告)日：2011-10-13

    申请号：US12755977

    申请日：2010-04-07

    申请人： Alexander MISHARIN ,  Konstantin Novoselov ,  Vladimir M. Doroshenko

    发明人： Alexander MISHARIN ,  Konstantin Novoselov ,  Vladimir M. Doroshenko

    IPC分类号： G06F19/00 ,  H01J49/26

    CPC分类号： H01J49/0036 ,  H01J49/38

    摘要： A method and system for deconvolution of a frequency spectrum obtained in an ICR mass spectrometer based on a detection of ion oscillation overtones of the M-th order (where the integer M>1). A plurality of frequency peaks is collected within the frequency spectrum corresponding respectively to oscillations of different groups of ions, and associates at least one of the frequency peaks having a frequency f and a measured amplitude A with a particular group of the ions. The method and system identify whether the frequency peak is related to one of an overtone frequency, a subharmonic frequency, a higher harmonic frequency, or a side-shifted frequency of the oscillations of the different group of ions. The method and system derive calculated amplitudes of the overtone frequency peaks associated with the groups of ions by incorporating measured amplitudes of the frequency peaks related to the subharmonic frequency, the higher harmonic frequency, or the side-shifted frequency associated with the groups of ions into the calculated amplitudes of the overtone frequency peaks. The method and system generate a deconvoluted frequency spectrum including the overtone frequency peaks associated with the different groups of ions.

    摘要翻译： 基于对M阶离子振荡泛音（其中整数M> 1）的检测，在ICR质谱仪中获得的频谱的去卷积方法和系统。 在分别对应于不同离子组的振荡的频谱内收集多个频率峰值，并且将具有频率f和测量幅度A的频率峰值中的至少一个与特定的一组离子相关联。 该方法和系统识别频率峰值是否与不同离子组的振荡的泛音频率，次谐波频率，高次谐波频率或侧移频率之一相关。 该方法和系统通过将与次谐波频率，高次谐波频率或与离子组相关联的侧移频率相关的频率峰值的测量幅度并入到离子组相关的泛音频率峰值中来计算振幅 计算的泛音频率峰值的幅度。 该方法和系统产生包括与不同离子组相关的泛音频率峰值的解卷积频谱。

    Portable ion trap mass spectrometer with metal hydride container as source of hydrogen buffer gas
    3.
    发明授权
    Portable ion trap mass spectrometer with metal hydride container as source of hydrogen buffer gas 有权
    便携式离子阱质谱仪，金属氢化物容器作为氢气缓冲气体源

    公开(公告)号：US08476586B2

    公开(公告)日：2013-07-02

    申请号：US13168690

    申请日：2011-06-24

    申请人： Alexander Misharin ,  Vladimir M. Doroshenko

    发明人： Alexander Misharin ,  Vladimir M. Doroshenko

    IPC分类号： B01D59/44 ,  H01J49/00

    CPC分类号： H01J49/424 ,  H01J49/0013 ,  H01J49/0081 ,  H01J49/0481 ,  H01J49/422

    摘要： A mass spectrometry (MS) method which includes generating in a vicinity of the quadrupole ion trap hydrogen molecules, directing at least part of the hydrogen molecules into the quadrupole ion trap cell, applying AC and DC voltages to quadrupole ion trap cell electrodes to create a combined AC/DC trapping field, placing sample ions inside the quadrupole ion trap cell, cooling at least part of said ions using said hydrogen molecules as a buffer gas, changing the combined AC/DC trapping field to eject the ions from the quadrupole ion trap cell, and detecting the ejected ions.

    摘要翻译： 一种质谱（MS）方法，其包括在四极离子阱附近产生氢分子，将至少部分氢分子引入四极离子阱电池中，向四极离子阱电池电极施加AC和DC电压，以产生 组合的AC / DC捕获场，将样品离子放置在四极离子阱单元内，使用所述氢分子作为缓冲气体冷却至少部分所述离子，改变组合的AC / DC捕获场以从四极离子阱中排出离子 电池，并检测被排出的离子。

    Spectral deconvolution in ion cyclotron resonance mass spectrometry
    4.
    发明授权
    Spectral deconvolution in ion cyclotron resonance mass spectrometry 有权
    离子回旋共振质谱中的光谱去卷积

    公开(公告)号：US08825413B2

    公开(公告)日：2014-09-02

    申请号：US12755977

    申请日：2010-04-07

    申请人： Alexander Misharin ,  Konstantin Novoselov ,  Vladimir M. Doroshenko

    发明人： Alexander Misharin ,  Konstantin Novoselov ,  Vladimir M. Doroshenko

    IPC分类号： G01N31/00 ,  H01J49/38 ,  H01J49/00 ,  H03F1/26

    CPC分类号： H01J49/0036 ,  H01J49/38

    摘要： A method and system for deconvolution of a frequency spectrum obtained in an ICR mass spectrometer based on a detection of ion oscillation overtones of the M-th order (where the integer M>1). A plurality of frequency peaks is collected within the frequency spectrum corresponding respectively to oscillations of different groups of ions, and associates at least one of the frequency peaks having a frequency f and a measured amplitude A with a particular group of the ions. The method and system identify whether the frequency peak is related to one of an overtone frequency, a subharmonic frequency, a higher harmonic frequency, or a side-shifted frequency of the oscillations of the different group of ions. The method and system derive calculated amplitudes of the overtone frequency peaks associated with the groups of ions by incorporating measured amplitudes of the frequency peaks related to the subharmonic frequency, the higher harmonic frequency, or the side-shifted frequency associated with the groups of ions into the calculated amplitudes of the overtone frequency peaks. The method and system generate a deconvoluted frequency spectrum including the overtone frequency peaks associated with the different groups of ions.

    摘要翻译： 基于对M阶离子振荡泛音（其中整数M> 1）的检测，在ICR质谱仪中获得的频谱的去卷积方法和系统。 在分别对应于不同离子组的振荡的频谱内收集多个频率峰值，并且将具有频率f和测量幅度A的频率峰值中的至少一个与特定的一组离子相关联。 该方法和系统识别频率峰值是否与不同离子组的振荡的泛音频率，次谐波频率，高次谐波频率或侧移频率之一相关。 该方法和系统通过将与次谐波频率，高次谐波频率或与离子组相关联的侧移频率相关的频率峰值的测量幅度并入到离子组相关的泛音频率峰值中来计算振幅 计算的泛音频率峰值的幅度。 该方法和系统产生包括与不同离子组相关的泛音频率峰值的解卷积频谱。

    PORTABLE ION TRAP MASS SPECTROMETER WITH METAL HYDRIDE CONTAINER AS SOURCE OF HYDROGEN BUFFER GAS
    5.
    发明申请
    PORTABLE ION TRAP MASS SPECTROMETER WITH METAL HYDRIDE CONTAINER AS SOURCE OF HYDROGEN BUFFER GAS 有权
    具有金属氢化物容器的便携式离子质谱仪作为氢气缓冲气体源

    公开(公告)号：US20120326026A1

    公开(公告)日：2012-12-27

    申请号：US13168690

    申请日：2011-06-24

    申请人： Alexander MISHARIN ,  Vladimir M. Doroshenko

    发明人： Alexander MISHARIN ,  Vladimir M. Doroshenko

    IPC分类号： H01J49/34 ,  H01J49/26

    CPC分类号： H01J49/424 ,  H01J49/0013 ,  H01J49/0081 ,  H01J49/0481 ,  H01J49/422

    摘要： A mass spectrometry (MS) method which includes generating in a vicinity of the quadrupole ion trap hydrogen molecules, directing at least part of the hydrogen molecules into the quadrupole ion trap cell, applying AC and DC voltages to quadrupole ion trap cell electrodes to create a combined AC/DC trapping field, placing sample ions inside the quadrupole ion trap cell, cooling at least part of said ions using said hydrogen molecules as a buffer gas, changing the combined AC/DC trapping field to eject the ions from the quadrupole ion trap cell, and detecting the ejected ions

    摘要翻译： 一种质谱（MS）方法，其包括在四极离子阱附近产生氢分子，将至少部分氢分子引入四极离子阱电池中，向四极离子阱电池电极施加AC和DC电压，以产生 组合的AC / DC捕获场，将样品离子放置在四极离子阱单元内，使用所述氢分子作为缓冲气体冷却至少部分所述离子，改变组合的AC / DC捕获场以从四极离子阱中排出离子 电池，并检测被排出的离子

    Measuring cell for ion cyclotron resonance mass spectrometer
    6.
    发明授权
    Measuring cell for ion cyclotron resonance mass spectrometer 有权
    用于离子回旋共振质谱仪的测量池

    公开(公告)号：US07655903B2

    公开(公告)日：2010-02-02

    申请号：US11737300

    申请日：2007-04-19

    申请人： Roman Zubarev ,  Alexander Misharin

    发明人： Roman Zubarev ,  Alexander Misharin

    IPC分类号： H01J49/36

    CPC分类号： H01J49/38

    摘要： An ion cyclotron resonance cell has at least one trapping electrode comprised of electrically isolated sections that are used for the detection of an induced ion image signal. Such an arrangement increases the sensitivity of image signal detection without a significant increase in the amplitude of parasitic harmonics. When a multielectrode detection arrangement is used, the resolving power of an analyzer incorporating such a cyclotron resonance cell multiplies without a corresponding sensitivity loss.

    摘要翻译： 离子回旋共振池具有至少一个由用于检测诱导离子图像信号的电隔离部分组成的俘获电极。 这种布置增加了图像信号检测的灵敏度，而不会明显增加寄生谐波的幅度。 当使用多电极检测装置时，包含这种回旋共振元件的分析仪的分辨率倍增而没有相应的灵敏度损失。

    Methods and systems for obtaining physiologic information
    7.
    发明授权
    Methods and systems for obtaining physiologic information 有权

    公开(公告)号：US10925496B2

    公开(公告)日：2021-02-23

    申请号：US15650850

    申请日：2017-07-15

    申请人： Alexander Misharin

    发明人： Alexander Misharin

    IPC分类号： A61B5/024 ,  A61B5/00 ,  G06T7/00 ,  A61B5/08 ,  G06T7/246

    摘要： The present invention discloses methods suitable for obtaining information related to at least one physiologic parameter of a person belonging to the group comprising respiration rate, heart rate, respiration rate variability, heart rate variability, temporal characteristics of at least a part of a heartbeat, and temporal characteristics of at least a part of a respiration cycle in a non-contact fashion. The present invention also discloses systems suitable for obtaining information related to at least one physiologic parameter of a person belonging to said group of physiologic parameters in a non-contact fashion.

    Ion cyclotron resonance mass spectrometer system and a method of operating the same
    9.
    发明授权
    Ion cyclotron resonance mass spectrometer system and a method of operating the same 失效
    离子回旋共振质谱仪系统及其操作方法

    公开(公告)号：US08304715B2

    公开(公告)日：2012-11-06

    申请号：US12756015

    申请日：2010-04-07

    申请人： Alexander Misharin ,  Roman Zubarev

    发明人： Alexander Misharin ,  Roman Zubarev

    IPC分类号： H01J49/00 ,  B01D59/44

    CPC分类号： H01J49/38

    摘要： A measuring cell of an ICR mass spectrometer and a method of operating a measuring cell of the ICR mass spectrometer. The method and system trap ions in a first compartment of the ICR measuring cell by generating an electric potential well in the direction of the magnetic field with a minimum of the electric potential well located inside the first compartment. The method and system excite cyclotron motion of the ions trapped in the first compartment. The method and system transfer at least a part of the excited ions from the first compartment to a second compartment of the ICR measuring cell by displacement of a position of the minimum of the electric potential well from the first compartment to the second compartment. The ions are transferred by displacing the position of the minimum of the electric potential well from the first compartment to the second compartment preferably over a period of time equal to or longer than a characteristic period of ion oscillations along the direction of the magnetic field in the electric potential well. The method and system detect ion cyclotron motion of at least a part of the ions in the second compartment.

    摘要翻译： ICR质谱仪的测量单元和操作ICR质谱仪的测量单元的方法。 该方法和系统通过在第一隔室内位于最小的电位下在磁场的方向上产生电位而在ICR测量池的第一隔室中捕获离子。 该方法和系统激发捕获在第一隔室中的离子的回旋加速器运动。 该方法和系统通过将最小电势井的位置从第一隔室移位到第二隔室，将激发的离子的至少一部分从第一隔室转移到ICR测量池的第二隔室。 通过将电位阱的最小值的位置从第一隔室移动到第二隔室，优选地在等于或长于沿着沿着磁场方向的离子振荡的特征周期的时间段 电势很好 该方法和系统检测第二隔室中至少一部分离子的离子回旋加速器运动。

    Ion cyclotron resonance mass spectrometer system and a method of operating the same
    10.
    发明申请
    Ion cyclotron resonance mass spectrometer system and a method of operating the same 失效
    离子回旋共振质谱仪系统及其操作方法

    公开(公告)号：US20110248159A1

    公开(公告)日：2011-10-13

    申请号：US12756015

    申请日：2010-04-07

    申请人： Alexander MISHARIN ,  Roman Zubarev

    发明人： Alexander MISHARIN ,  Roman Zubarev

    IPC分类号： H01J49/34 ,  H01J49/02

    CPC分类号： H01J49/38

    摘要： A measuring cell of an ICR mass spectrometer and a method of operating a measuring cell of the ICR mass spectrometer. The method and system trap ions in a first compartment of the ICR measuring cell by generating an electric potential well in the direction of the magnetic field with a minimum of the electric potential well located inside the first compartment. The method and system excite cyclotron motion of the ions trapped in the first compartment. The method and system transfer at least a part of the excited ions from the first compartment to a second compartment of the ICR measuring cell by displacement of a position of the minimum of the electric potential well from the first compartment to the second compartment. The ions are transferred by displacing the position of the minimum of the electric potential well from the first compartment to the second compartment preferably over a period of time equal to or longer than a characteristic period of ion oscillations along the direction of the magnetic field in the electric potential well. The method and system detect ion cyclotron motion of at least a part of the ions in the second compartment.

    摘要翻译： ICR质谱仪的测量单元和操作ICR质谱仪的测量单元的方法。 该方法和系统通过在第一隔室内位于最小的电位下在磁场的方向上产生电位而在ICR测量池的第一隔室中捕获离子。 该方法和系统激发捕获在第一隔室中的离子的回旋加速器运动。 该方法和系统通过将最小电势井的位置从第一隔室移位到第二隔室，将激发的离子的至少一部分从第一隔室转移到ICR测量池的第二隔室。 通过将电位阱的最小值的位置从第一隔室移动到第二隔室，优选地在等于或长于沿着沿着磁场方向的离子振荡的特征周期的时间段 电势很好 该方法和系统检测第二隔室中至少一部分离子的离子回旋加速器运动。