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公开(公告)号：US20060192100A1
公开(公告)日：2006-08-31
申请号：US11349551
申请日：2006-02-07
Applicant: Roman Zubarev , Alexander Misharin , Oleg Silivra , Frank Kjeldsen
Inventor： Roman Zubarev , Alexander Misharin , Oleg Silivra , Frank Kjeldsen
CPC classification number: H01J49/005 , G01N33/6848 , H01J49/02 , Y10S250/91 , Y10T436/17
Abstract: The invention relates to a method and apparatus for the fragmentation of large molecules, especially biopolymers. The invention consists in reacting analyte ions with excited or radical neutral particles, whereby, at least in the case of bombardment of analyte ions with helium atoms from an FAB generator, a new type of fragmentation occurs which strongly resembles fragmentation by electron capture (ECD). The reactions may be performed in magnetic ion traps (ion cyclotron resonance cells, ICR), in RF ion traps according to Wolfgang Paul, in RF ion guides, or in free beams of analyte ions or neutral particles.
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公开(公告)号：US07476853B2
公开(公告)日：2009-01-13
申请号：US11349551
申请日：2006-02-07
Applicant: Roman Zubarev , Alexander Misharin , Oleg Silivra , Frank Kjeldsen
Inventor： Roman Zubarev , Alexander Misharin , Oleg Silivra , Frank Kjeldsen
CPC classification number: H01J49/005 , G01N33/6848 , H01J49/02 , Y10S250/91 , Y10T436/17
Abstract: The invention relates to a method and apparatus for the fragmentation of large molecules, especially biopolymers. The invention consists in reacting analyte ions with excited or radical neutral particles, whereby, at least in the case of bombardment of analyte ions with helium atoms from an FAB generator, a new type of fragmentation occurs which strongly resembles fragmentation by electron capture (ECD). The reactions may be performed in magnetic ion traps (ion cyclotron resonance cells, ICR), in RF ion traps according to Wolfgang Paul, in RF ion guides, or in free beams of analyte ions or neutral particles.
Abstract translation: 本发明涉及一种用于大分子，特别是生物聚合物破碎的方法和装置。 本发明包括使分析物离子与激发或自由基中性颗粒反应，由此，至少在从FAB发生器轰击具有氦原子的分析物离子的情况下，发生类似于通过电子捕获（ECD）破碎的新型碎裂， 。 反应可以在磁离子阱（离子回旋共振池，ICR），RF离子阱中根据Wolfgang Paul，RF离子导向器或分析离子或中性粒子的自由光束进行。
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公开(公告)号：US06800851B1
公开(公告)日：2004-10-05
申请号：US10644648
申请日：2003-08-20
Applicant: Roman Zubarev , Frank Kjeldsen , Igor Ivonin , Oleg Silivra
Inventor： Roman Zubarev , Frank Kjeldsen , Igor Ivonin , Oleg Silivra
IPC: H01J3934
CPC classification number: H01J49/0054 , H01J49/063 , H01J49/4225
Abstract: The present invention relates to ion fragmentation techniques by electron-ion reactions in multipolar radiofrequency fields like those in quadrupole ion traps or in ion guides, and devices to perform ion fragmentation by such techniques. The fragmentation techniques are useful for tandem mass spectrometry. The invention consists of the application of a magnetic field essentially parallel to the axis of the radiofrequency field to confine the electrons in the direction perpendicular to the magnetic field.
Abstract translation: 本发明涉及通过多极射频场中的电子 - 离子反应的离子碎片化技术，如四极离子阱或离子导向器中的离子碎片化技术，以及通过这些技术进行离子碎裂的装置。 碎裂技术可用于串联质谱法。 本发明包括施加基本上平行于射频场的轴的磁场，以在垂直于磁场的方向上限制电子。
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