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    Sol-Gel Phase-Reversible Hydrogel Templates and Uses Thereof
    2.
    发明申请
    Sol-Gel Phase-Reversible Hydrogel Templates and Uses Thereof 审中-公开

    公开(公告)号：US20180221281A1

    公开(公告)日：2018-08-09

    申请号：US15872895

    申请日：2018-01-16

    申请人： AKINA, INC.

    发明人： Kinam Park ,  Ghanashyam S. Acharya ,  Haesun Park

    IPC分类号： A61K9/16 ,  A61K9/50 ,  A61K31/00

    CPC分类号： A61K9/1682 ,  A61K9/1647 ,  A61K9/5031 ,  A61K9/5089 ,  A61K31/00 ,  Y10S977/773 ,  Y10S977/887 ,  Y10S977/89 ,  Y10S977/906

    摘要： Discrete microstructures of predefined size and shape are prepared using sol-gel phase-reversible hydrogel templates. An aqueous solution of hydrogel-forming material is covered onto a microfabricated silicon wafer master template having predefined microfeatures, such as pillars. A hydrogel template is formed, usually by lowering the temperature, and the formed hydrogel template is peeled away from the silicon master template. The wells of predefined size and shape on the hydrogel template are filled with a solution or a paste of a water-insoluble polymer, and the solvent is removed to form solid structures. The formed microstructures are released from the hydrogel template by simply melting the hydrogel template in water. The microstructures are collected by centrifugation. The microstructures fabricated by this method exhibit pre-defined size and shape that exactly correspond to the microwells of the hydrogel template. The method of preparing microstructures based on hydrogel templates is simple and can easily produce large quantities of the microstructures.

    BIODEGRADABLE POLYMER FORMULATIONS FOR EXTENDED EFFICACY OF BOTULINUM TOXIN
    3.
    发明申请
    BIODEGRADABLE POLYMER FORMULATIONS FOR EXTENDED EFFICACY OF BOTULINUM TOXIN 有权

    公开(公告)号：US20210161826A1

    公开(公告)日：2021-06-03

    申请号：US17170614

    申请日：2021-02-08

    申请人： Akina, Inc.

    发明人： Kinam Park ,  Yeonhee Yun ,  Sarah Michelle Skidmore ,  Byung Kook Lee ,  John Solomon Garner

    IPC分类号： A61K9/50 ,  A61K47/36 ,  A61K47/34 ,  A61K9/00 ,  A61K9/16 ,  A61K9/14 ,  A61K9/51 ,  A61K38/48 ,  C01G9/04 ,  C08G63/08

    摘要： Methods for the formulation of biodegradable microparticles for delivery of protein drugs, such as botulinum toxin, have been developed. The methods include the steps of precipitating and washing proteins with organic solvent to remove water prior to dispersing in polymer-dissolved organic solvent to prevent exposure to water/solvent interfaces and maintain bioactivity of the protein drugs and fabrication of microparticles by either template or emulsion method. Biodegradable microparticles, formed of one or more biodegradable polymers having entrapped in the polymer one or more protein agents, such as botulinum toxin, are also provided. Precipitated botulinum toxin and botulinum toxin-loaded microparticles can also be formulated into thermogels or crosslinked hydrogels. The stability of the protein within these microparticles, as well as the controlled release of the entrapped agents, provides for sustained efficacy of the agents.

    Sol-Gel Phase-Reversible Hydrogel Templates and Uses Thereof
    6.
    发明申请
    Sol-Gel Phase-Reversible Hydrogel Templates and Uses Thereof 审中-公开
    溶胶凝胶相可逆水凝胶模板及其用途

    公开(公告)号：US20150150807A1

    公开(公告)日：2015-06-04

    申请号：US14617804

    申请日：2015-02-09

    申请人： AKINA, INC.

    发明人： Kinam Park ,  Ghanashyam Acharya ,  Haesun Park

    IPC分类号： A61K9/16

    CPC分类号： A61K9/1682 ,  A61K9/1647 ,  A61K9/5031 ,  A61K9/5089 ,  A61K31/00 ,  Y10S977/773 ,  Y10S977/887 ,  Y10S977/89 ,  Y10S977/906

    摘要： Discrete microstructures of predefined size and shape are prepared using sol-gel phase-reversible hydrogel templates. An aqueous solution of hydrogel-forming material is covered onto a microfabricated silicon wafer master template having predefined microfeatures, such as pillars. A hydrogel template is formed, usually by lowering the temperature, and the formed hydrogel template is peeled away from the silicon master template. The wells of predefined size and shape on the hydrogel template are filled with a solution or a paste of a water-insoluble polymer, and the solvent is removed to form solid structures. The formed microstructures are released from the hydrogel template by simply melting the hydrogel template in water. The microstructures are collected by centrifugation. The microstructures fabricated by this method exhibit pre-defined size and shape that exactly correspond to the microwells of the hydrogel template. The method of preparing microstructures based on hydrogel templates is simple and can easily produce large quantities of the microstructures.

    摘要翻译： 使用溶胶 - 凝胶相可逆水凝胶模板制备预定尺寸和形状的离散微结构。 将水凝胶形成材料的水溶液覆盖在具有预定义的微特征（例如柱）的微制造硅晶片主模板上。 通常通过降低温度形成水凝胶模板，并将形成的水凝胶模板从硅主模板剥离。 在水凝胶模板上预定尺寸和形状的孔填充有水不溶性聚合物的溶液或糊剂，并除去溶剂以形成固体结构。 通过在水中简单地熔化水凝胶模板，将形成的微结构从水凝胶模板中释放出来。 通过离心收集微结构。 通过该方法制造的微结构显示出与水凝胶模板的微孔完全对应的预定义的尺寸和形状。 基于水凝胶模板制备微结构的方法简单，容易产生大量微结构。

    SYNTHESIS OF ENVIRONMENTALLY DEGRADABLE ALKYL POLYESTERS
    7.
    发明申请
    SYNTHESIS OF ENVIRONMENTALLY DEGRADABLE ALKYL POLYESTERS 有权

    公开(公告)号：US20210403639A1

    公开(公告)日：2021-12-30

    申请号：US17304496

    申请日：2021-06-22

    申请人： Akina, Inc

    发明人： John Solomon Garner ,  Kinam Park

    IPC分类号： C08G63/12 ,  C08G63/08 ,  C08G63/82 ,  C08L67/04

    摘要： A solid crosslinked polyester composition is disclosed wherein the crosslinked polyester is environmentally degradable in less than about 180 days. The crosslinked polyester is the polyesterification reaction product between one or more multi-hydroxylic alcohols, one or more hydroxy acids, and one or more multi-carboxylic acid compounds. Alternately, the crosslinked polyester is the polyesterification reaction product between one or more multi-hydroxylic alcohols, one or more hydroxy acids, one or more multi-carboxylic acid compounds, and a cyclic ester.

    Sol-gel phase-reversible hydrogel templates and uses thereof
    10.
    发明授权
    Sol-gel phase-reversible hydrogel templates and uses thereof 有权

    公开(公告)号：US10478398B2

    公开(公告)日：2019-11-19

    申请号：US15872895

    申请日：2018-01-16

    申请人： AKINA, INC.

    发明人： Kinam Park ,  Ghanashyam S. Acharya ,  Haesun Park

    IPC分类号： A61K9/16 ,  A61K9/50 ,  A61K31/00

    摘要： Discrete microstructures of predefined size and shape are prepared using sol-gel phase-reversible hydrogel templates. An aqueous solution of hydrogel-forming material is covered onto a microfabricated silicon wafer master template having predefined microfeatures, such as pillars. A hydrogel template is formed, usually by lowering the temperature, and the formed hydrogel template is peeled away from the silicon master template. The wells of predefined size and shape on the hydrogel template are filled with a solution or a paste of a water-insoluble polymer, and the solvent is removed to form solid structures. The formed microstructures are released from the hydrogel template by simply melting the hydrogel template in water. The microstructures are collected by centrifugation. The microstructures fabricated by this method exhibit pre-defined size and shape that exactly correspond to the microwells of the hydrogel template. The method of preparing microstructures based on hydrogel templates is simple and can easily produce large quantities of the microstructures.