公开(公告)号：US20240390467A1

公开(公告)日：2024-11-28

申请号：US18805305

申请日：2024-08-14

Applicant: Academisch Ziekenhuis Leiden

Inventor： Daniël Verhoef ,  Pieter H. Reitsma ,  Mettine H. A. Bos

IPC: A61K38/48 ,  C07K14/46 ,  C12N9/64

Abstract: Described are recombinant FXa polypeptides that can be used as antidotes to completely or partially reverse an anti-coagulant effect of a coagulation inhibitor in a subject, preferably a direct factor Xa inhibitor. Disclosed herein are recombinant factor Xa proteins and a method of completely or partially reversing an anti-coagulant effect of a coagulation inhibitor in a subject.

公开(公告)号：US20230391839A1

公开(公告)日：2023-12-07

申请号：US18322507

申请日：2023-05-23

Applicant: Universiteit Leiden ,  Academisch Ziekenhuis Leiden h.o.d.n. LUMC

Inventor： Harald Martijn Ijsbrand Kerkkamp ,  Michael Keith Richardson ,  Gilles Philippus van Wezel ,  Jan Wouter Drijfhout ,  Robert Alexander Cordfunke ,  Michella Manon Voet ,  Petrus Hendricus Nibbering

IPC: C07K14/46

CPC classification number: C07K14/46 ,  A61K38/00

Abstract: The disclosure concerns snake-derived peptides and the useful application of such peptides to inhibit bacterial, fungal, viral and parasitic infections. The disclosed peptides are also useful for the treatment of an inflammatory condition or cancers.

公开(公告)号：US20230203448A1

公开(公告)日：2023-06-29

申请号：US18009231

申请日：2021-06-07

Applicant: Erasmus University Medical Center Rotterdam ,  Academisch Ziekenhuis Leiden h.o.d.n. LUMC ,  Wageningen Universiteit

Inventor： Alessandro IULIANO ,  Wilhelmus Wenceslaus Matthias PIJNAPPEL ,  Antje Tjitske VAN DER PLOEG ,  Vittorio SAGGIOMO ,  Jessica Christine DE GREEF ,  Erik VAN DER WAL ,  Silvere Maria VAN DER MAAREL

IPC: C12N5/077 ,  C12M3/00 ,  C12M3/06 ,  C12M1/12

CPC classification number: C12N5/0658 ,  C12M21/08 ,  C12M23/16 ,  C12M25/14 ,  C12N2501/115 ,  C12N2501/727 ,  C12N2513/00 ,  B33Y10/00

Abstract: A method of manufacturing a microstructure comprises printing a positive mold structure, filling the positive mold structure with a second material to form an elastically deformable negative mold structure, filling the negative mold structure with a third material to form the microstructure, and releasing the microstructure from the negative mold structure. Advantageously, the negative mold structure can be stretched to facilitate the release of the microstructure. For example, the microstructure comprises a chamber with capped micropillars for the generation and/or analysis of muscle tissue.

公开(公告)号：US20230184758A1

公开(公告)日：2023-06-15

申请号：US18080342

申请日：2022-12-13

Applicant: ACADEMISCH ZIEKENHUIS LEIDEN (H.O.D.N. LUMC)

Inventor： Tamas PONGRACZ ,  Maaike BIEWENGA ,  Manfred WUHRER ,  Noortje DE HAAN ,  Bart VAN HOEK

IPC: G01N33/564 ,  G01N33/576

CPC classification number: G01N33/564 ,  G01N33/5767 ,  G01N2800/50 ,  G01N2440/38

Abstract: The present invention relates to methods for diagnosing and/or predicting the risk of developing autoimmune hepatitis (AIH) in a subject. The methods are based on the inventors' identification of a novel biomarker for AIH. The invention further comprises the use of said biomarker in the methods disclosed herein, and kits comprising agents for detecting said biomarker. The invention also relates to a method of treating AIH in a subject, wherein the subject has been diagnosed with AIH or determined to be at risk of developing AIH using the methods disclosed herein.

公开(公告)号：US20230151362A1

公开(公告)日：2023-05-18

申请号：US17814781

申请日：2022-07-25

Applicant: BioMarin Technologies B.V. ,  Academisch Ziekenhuis Leiden

Inventor： Josephus Johannes de Kimpe ,  Adriana Marie Rus ,  Gerard Johannes Platenburg ,  Judith Christina Theodora van Deutekom ,  Garrit-Jan Boudewijn van Ommen

IPC: C12N15/113 ,  A61K31/56 ,  A61K31/57 ,  A61K38/17 ,  A61K31/7088 ,  A61K45/06 ,  A61K31/573 ,  A61K31/58

CPC classification number: C12N15/113 ,  A61K31/56 ,  A61K31/57 ,  A61K31/58 ,  A61K31/573 ,  A61K31/7088 ,  A61K38/1719 ,  A61K45/06 ,  A61K48/00

Abstract: The invention relates to a method for inducing or promoting skipping of exon 45 of DMD pre-mRNA in a Duchenne Muscular Dystrophy patient, preferably in an isolated (muscle) cell, the method comprising providing said cell with an antisense molecule that binds to a continuous stretch of at least 21 nucleotides within said exon. The invention further relates to such antisense molecule used in said method.

公开(公告)号：US20230035037A1

公开(公告)日：2023-02-02

申请号：US17780398

申请日：2020-11-25

Applicant: Academisch Ziekenhuis Leiden (h.o.d.n. LUMC)

Inventor： Thorbald VAN HALL ,  Sjoerd Henricus VAN DER BURG ,  Koen MARJIT

IPC: C07K14/47 ,  C12N15/63 ,  A61K39/00

Abstract: Novel nucleic acid sequences, vectors, cells, binding agents, peptides and pharmaceutical compositions are provided that are useful as a medicament, for example in the prevention or treatment of cancer or viral infections associated with impaired HLA class I antigen presentation. Corresponding methods and uses are also provided.

公开(公告)号：US11459358B2

公开(公告)日：2022-10-04

申请号：US16461313

申请日：2017-11-15

Applicant: BioMarin Technologies B.V. ,  Academisch Ziekenhuis Leiden

Inventor： Peter Christian De Visser ,  Adriana Marie Aartsma-Rus ,  Silvana Maria Gerarda Jirka ,  Peter Abraham Christiaan 'T Hoen ,  Maria Begoña Aguilera Diez

IPC: C07K7/64 ,  A61K47/64 ,  A61K47/54 ,  A61P9/00 ,  A61K49/00 ,  C12N15/113

Abstract: The invention provides conjugates, comprising an organ or tissue targeting moiety linked to a biologically active moiety or linked to a diagnostic moiety. Such a biologically active or diagnostic moiety can be, for example, an oligonucleotide, small interfering RNA, a gene, a virus, a protein, a drug, a small organic molecule, a pharmaceutical, or a detectable agent.

公开(公告)号：US20220281921A1

公开(公告)日：2022-09-08

申请号：US17625483

申请日：2020-07-07

Applicant: ACADEMISCH ZIEKENHUIS LEIDEN (H.O.D.N. LUMC)

Inventor： Rob Cornelis HOEBEN ,  Selas BOTS ,  Vera KEMP

IPC: C07K14/005 ,  C12N7/00 ,  A61P35/00

Abstract: Novel nucleic acid sequences, vectors and adenoviral genomes are provided herein. Corresponding novel adenoviruses and genotypes and compositions are also provided. The novel nucleic acid sequences, vectors, genomes, adenoviruses, genotypes and compositions are useful in therapy. The novel nucleic acid sequences, vectors, genomes, adenoviruses, genotypes and compositions are particularly useful in treating or preventing cancer.

公开(公告)号：US20220265162A1

公开(公告)日：2022-08-25

申请号：US17634619

申请日：2020-08-21

Applicant: Advanced Bionics AG ,  Academisch Ziekenhuis Leiden

Inventor： Johannes H.M. Frijns ,  Jeroen J. Briaire ,  Patrick J. Boyle ,  Volkmar Hamacher ,  Leonid M. Litvak

IPC: A61B5/06 ,  A61B5/00 ,  A61N1/08 ,  A61N1/04 ,  A61N1/05

Abstract: An illustrative insertion management system may be configured to monitor, during a lead insertion procedure in which an electrode lead having a plurality of electrodes is inserted into a cochlea of a recipient of a cochlear implant, impedance values for a subset of electrodes included in the plurality of electrodes, the subset of electrodes being less than a total number of the plurality of electrodes; detect, during the lead insertion procedure and based on the monitoring, an anomaly in the impedance values; and generate, during the lead insertion procedure and based on the anomaly, translocation log data indicating that a translocation event in which the electrode lead translocates from a first scala of the cochlea to a second scala of the cochlea is about to occur or has occurred during the lead insertion procedure.

公开(公告)号：US11352389B2

公开(公告)日：2022-06-07

申请号：US16627230

申请日：2018-06-28

Applicant: ACADEMISCH ZIEKENHUIS LEIDEN (H.O.D.N. LEIDS UNIVERSITAIR MEDISCH CENTRUM)

Inventor： Marieke Griffioen ,  J. H. Frederik Falkenburg

IPC: C07K7/06 ,  A61P35/02 ,  A61K35/17 ,  A61K35/761 ,  C07K14/47 ,  C07K14/725 ,  C12N15/86 ,  A61K39/00

Abstract: Novel nucleic acid sequences, vectors, modified cells, peptides and pharmaceutical compositions are provided that are useful in the treatment of human subjects having a ΔNPM1 positive haematological malignancy. Corresponding methods and uses are also provided.