公开(公告)号：US11864826B2

公开(公告)日：2024-01-09

申请号：US17171447

申请日：2021-02-09

申请人： Axon Therapies, Inc.

发明人： Howard Levin ,  Mark Gelfand

IPC分类号： A61B18/14 ,  A61N1/00 ,  A61N1/36 ,  A61B18/00 ,  A61B90/00

CPC分类号： A61B18/1492 ,  A61N1/00 ,  A61N1/36017 ,  A61B2018/00214 ,  A61B2018/00404 ,  A61B2018/00434 ,  A61B2018/00791 ,  A61B2018/00863 ,  A61B2018/00875 ,  A61B2090/064

摘要： A method for treating a heart failure patient by ablating a nerve of the splanchnic sympathetic nervous system to increase venous capacitance and reduce pulmonary blood pressure. A method including: inserting a catheter into a vein adjacent the nerve, applying stimulation energy and observing hemodynamic effects, applying ablation energy and observing hemodynamic effects, applying simulation energy after the ablation and observing hemodynamic effects.

公开(公告)号：US11806073B2

公开(公告)日：2023-11-07

申请号：US17451991

申请日：2021-10-22

申请人： Axon Therapies, Inc.

发明人： Anisha Bapna ,  Zoar Jacob Engelman ,  Howard Levin ,  Pajhand Iranitalab ,  Casey Andrew Miller ,  Thomas Ryan McGrath ,  Manuel Arzadon Javier, Jr.

IPC分类号： A61B18/14 ,  A61B34/20 ,  A61B90/00 ,  A61B18/00 ,  A61B6/12 ,  A61B6/00

CPC分类号： A61B18/1492 ,  A61B6/12 ,  A61B6/4441 ,  A61B6/481 ,  A61B6/504 ,  A61B34/20 ,  A61B90/39 ,  A61B2018/00404 ,  A61B2018/00577 ,  A61B2034/2065 ,  A61B2090/3966

摘要： Systems, devices, and methods for transvascular ablation of target tissue. The devices and methods may, in some examples, be used for splanchnic nerve ablation to increase splanchnic venous blood capacitance to treat at least one of heart failure and hypertension. For example, the devices disclosed herein may be advanced endovascularly to a target vessel in the region of a thoracic splanchnic nerve (TSN), such as a greater splanchnic nerve (GSN) or a TSN nerve root. Also disclosed are methods of treating heart failure, such as HFpEF, by endovascularly ablating a thoracic splanchnic nerve to increase venous capacitance and reduce pulmonary blood pressure.

公开(公告)号：US20200179045A1

公开(公告)日：2020-06-11

申请号：US16318447

申请日：2017-07-31

申请人： AXON THERAPIES, INC.

发明人： Howard LEVIN ,  Mark GELFAND ,  Zoar Jacob ENGELMAN ,  Dorin PANESCU ,  Mark S. LEUNG

IPC分类号： A61B18/14

摘要： Apparatuses and methods for treating a heart failure patient by ablating a nerve of the thoracic splanchnic sympathetic nervous system to increase venous capacitance and reduce pulmonary blood pressure. A method comprising: inserting a catheter into a vein adjacent the nerve, applying stimulation energy and observing hemodynamic effects, applying ablation energy and observing hemodynamic effects, applying stimulation energy after the ablation and observing hemodynamic effects and monitoring for presence of the lung in the ablation zone. An alternative method comprising: inserting a catheter into a vein adjacent the nerve, detecting that lung tissue is a safe distance from an ablation zone, and delivering ablation energy to the target nerve when lung tissue is a safe distance from the ablation zone.

公开(公告)号：US10561461B2

公开(公告)日：2020-02-18

申请号：US16222823

申请日：2018-12-17

申请人： Axon Therapies, Inc.

发明人： Dorin Panescu ,  Andrew Wu ,  Zoar Jacob Engelman ,  Mark Gelfand ,  Mark S. Leung ,  Howard Levin

IPC分类号： A61B18/14 ,  A61B18/00 ,  A61M25/10

摘要： Systems, devices, and methods for transvascular ablation of target tissue. The devices and methods may, in some examples, be used for splanchnic nerve ablation to increase splanchnic venous blood capacitance to treat at least one of heart failure and hypertension. For example, the devices disclosed herein may be advanced endovascularly to a target vessel in the region of a thoracic splanchnic nerve (TSN), such as a greater splanchnic nerve (GSN) or a TSN nerve root. Also disclosed are methods of treating heart failure, such as HFpEF, by endovascularly ablating a thoracic splanchnic nerve to increase venous capacitance and reduce pulmonary blood pressure.

公开(公告)号：US20240024682A1

公开(公告)日：2024-01-25

申请号：US18171972

申请日：2023-02-21

申请人： Axon Therapies, Inc.

发明人： Mark GELFAND ,  Tamara Colette BAYNHAM ,  Howard LEVIN

IPC分类号： A61N1/36 ,  A61N1/05 ,  A61B5/00 ,  A61N1/362 ,  A61B5/11 ,  A61B5/021 ,  A61B5/029 ,  G16H20/30 ,  G16H40/63 ,  A61B5/02 ,  G16H20/40 ,  A61B5/388

CPC分类号： A61N1/36114 ,  A61N1/0556 ,  A61B5/4848 ,  A61N1/3627 ,  A61N1/36135 ,  A61B5/686 ,  A61B5/1123 ,  A61B5/021 ,  A61B5/029 ,  A61B5/4806 ,  A61B5/1118 ,  A61B5/4836 ,  G16H20/30 ,  G16H40/63 ,  A61B5/02007 ,  A61B5/1116 ,  G16H20/40 ,  A61B5/388 ,  A61B2562/0219 ,  A61B5/024

摘要： Disclosed herein is a device, and method for treating heart failure by electrically modulating a splanchnic nerve with an implantable device.

公开(公告)号：US20230380901A1

公开(公告)日：2023-11-30

申请号：US18450328

申请日：2023-08-15

申请人： Axon Therapies, Inc.

发明人： Dorin PANESCU ,  Andrew WU ,  Zoar Jacob ENGELMAN ,  Mark GELFAND ,  Mark S. LEUNG

IPC分类号： A61B18/14 ,  A61B18/02 ,  A61B18/12

CPC分类号： A61B18/1492 ,  A61B18/0218 ,  A61B2090/3966 ,  A61B18/1477 ,  A61B18/1206

摘要： Systems, devices, and methods for transvascular ablation of target tissue are disclosed herein. The devices and methods may, in some examples, be used for splanchnic nerve ablation to increase splanchnic venous blood capacitance to treat at least one of heart failure and hypertension. For example, the devices disclosed herein may be advanced endovascularly to a target vessel in the region of a thoracic splanchnic nerve (TSN), such as a greater splanchnic nerve (GSN) or a TSN nerve root. Also disclosed are method of treating heart failure, such as HFpEF, by endovascularly ablating a thoracic splanchnic nerve to increase venous capacitance and reduce pulmonary blood pressure.

公开(公告)号：US11801092B2

公开(公告)日：2023-10-31

申请号：US17452305

申请日：2021-10-26

申请人： Axon Therapies, Inc.

发明人： Howard Levin ,  Mark Gelfand ,  Zoar Jacob Engelman ,  Dorin Panescu ,  Mark S. Leung

IPC分类号： A61B18/14 ,  A61B18/00 ,  A61N1/36

CPC分类号： A61B18/1492 ,  A61B2018/00285 ,  A61B2018/00434 ,  A61B2018/00577 ,  A61B2018/00648 ,  A61B2018/00702 ,  A61B2018/00791 ,  A61B2018/00875 ,  A61B2018/1467 ,  A61N1/36017

摘要： Apparatuses and methods for treating a heart failure patient by ablating a nerve of the thoracic splanchnic sympathetic nervous system to increase venous capacitance and reduce pulmonary blood pressure. A method comprising: inserting a catheter into a vein adjacent the nerve, applying stimulation energy and observing hemodynamic effects, applying ablation energy and observing hemodynamic effects, applying simulation energy after the ablation and observing hemodynamic effects and monitoring for presence of the lung in the ablation zone. An alternative method comprising: inserting a catheter into a vein adjacent the nerve, detecting that lung tissue is a safe distance from an ablation zone, and delivering ablation energy to the target nerve when lung tissue is a safe distance from the ablation zone.

公开(公告)号：US20190350650A1

公开(公告)日：2019-11-21

申请号：US16510503

申请日：2019-07-12

申请人： Axon Therapies, Inc.

发明人： Howard LEVIN ,  Mark GELFAND

IPC分类号： A61B18/14 ,  A61N1/00 ,  A61N1/36

摘要： A method for treating a heart failure patient by ablating a nerve of the splanchnic sympathetic nervous system to increase venous capacitance and reduce pulmonary blood pressure. A method including: inserting a catheter into a vein adjacent the nerve, applying stimulation energy and observing hemodynamic effects, applying ablation energy and observing hemodynamic effects, applying simulation energy after the ablation and observing hemodynamic effects.

公开(公告)号：US20240293176A1

公开(公告)日：2024-09-05

申请号：US18568206

申请日：2022-06-06

申请人： Axon Therapies, Inc.

发明人： Manuel Arzadon JAVIER, JR. ,  Pajhand IRANITALAB

IPC分类号： A61B18/14 ,  A61B18/00

CPC分类号： A61B18/1492 ,  A61B2018/00029 ,  A61B2018/00077 ,  A61B2018/00238 ,  A61B2018/00434 ,  A61B2018/00577 ,  A61B2018/00773 ,  A61B2018/00791 ,  A61B2018/1435 ,  A61B2218/002

摘要： Systems, devices, and methods for transvascular ablation of target tissue. The devices and methods may, in some examples, be used for splanchnic nerve ablation to increase splanchnic venous blood capacitance to treat at least one of heart failure and hypertension. For example, the devices disclosed herein may be advanced endovascularly to a target vessel in the region of a thoracic splanchnic nerve (TSN), such as a greater splanchnic nerve (GSN) or a TSN nerve root. Also disclosed are methods of treating heart failure, such as HFpEF, by endovascularly ablating a thoracic splanchnic nerve to increase venous capacitance and reduce pulmonary blood pressure.

公开(公告)号：US20230380896A1

公开(公告)日：2023-11-30

申请号：US18366522

申请日：2023-08-07

申请人： Axon Therapies, Inc.

发明人： Dorin PANESCU ,  Andrew WU ,  Zoar Jacob ENGELMAN ,  Mark GELFAND ,  Mark S. LEUNG

IPC分类号： A61B18/14 ,  A61B18/02 ,  A61B18/12

CPC分类号： A61B18/1492 ,  A61B18/0218 ,  A61B18/1206 ,  A61B18/1477 ,  A61B2090/3966

摘要： Systems, devices, and methods for transvascular ablation of target tissue are disclosed herein. The devices and methods may, in some examples, be used for splanchnic nerve ablation to increase splanchnic venous blood capacitance to treat at least one of heart failure and hypertension. For example, the devices disclosed herein may be advanced endovascularly to a target vessel in the region of a thoracic splanchnic nerve (TSN), such as a greater splanchnic nerve (GSN) or a TSN nerve root. Also disclosed are method of treating heart failure, such as HFpEF, by endovascularly ablating a thoracic splanchnic nerve to increase venous capacitance and reduce pulmonary blood pressure.