公开(公告)号：US11504185B2

公开(公告)日：2022-11-22

申请号：US17304007

申请日：2021-06-11

申请人： Axon Therapies, Inc.

发明人： Pajhand Iranitalab ,  Casey Andrew Miller ,  Thomas Ryan McGrath ,  Manuel Arzadon Javier ,  Anisha Bapna ,  Zoar Jacob Engelman ,  Howard Levin ,  Nicholas C. VanDillen ,  Anne Marie Ahonen

IPC分类号： A61B18/14 ,  A61B18/00 ,  A61M25/00 ,  A61M25/01 ,  A61N7/00

摘要： Systems, devices, and methods for transvascular ablation of target tissue. The devices and methods may, in some examples, be used for splanchnic nerve ablation to increase splanchnic venous blood capacitance to treat at least one of heart failure and hypertension. For example, the devices disclosed herein may be advanced endovascularly to a target vessel in the region of a thoracic splanchnic nerve (TSN), such as a greater splanchnic nerve (GSN) or a TSN nerve root. Also disclosed are methods of treating heart failure, such as HFpEF, by endovascularly ablating a thoracic splanchnic nerve to increase venous capacitance and reduce pulmonary blood pressure.

公开(公告)号：US11806073B2

公开(公告)日：2023-11-07

申请号：US17451991

申请日：2021-10-22

申请人： Axon Therapies, Inc.

发明人： Anisha Bapna ,  Zoar Jacob Engelman ,  Howard Levin ,  Pajhand Iranitalab ,  Casey Andrew Miller ,  Thomas Ryan McGrath ,  Manuel Arzadon Javier, Jr.

IPC分类号： A61B18/14 ,  A61B34/20 ,  A61B90/00 ,  A61B18/00 ,  A61B6/12 ,  A61B6/00

CPC分类号： A61B18/1492 ,  A61B6/12 ,  A61B6/4441 ,  A61B6/481 ,  A61B6/504 ,  A61B34/20 ,  A61B90/39 ,  A61B2018/00404 ,  A61B2018/00577 ,  A61B2034/2065 ,  A61B2090/3966

摘要： Systems, devices, and methods for transvascular ablation of target tissue. The devices and methods may, in some examples, be used for splanchnic nerve ablation to increase splanchnic venous blood capacitance to treat at least one of heart failure and hypertension. For example, the devices disclosed herein may be advanced endovascularly to a target vessel in the region of a thoracic splanchnic nerve (TSN), such as a greater splanchnic nerve (GSN) or a TSN nerve root. Also disclosed are methods of treating heart failure, such as HFpEF, by endovascularly ablating a thoracic splanchnic nerve to increase venous capacitance and reduce pulmonary blood pressure.