公开(公告)号：US20230380901A1

公开(公告)日：2023-11-30

申请号：US18450328

申请日：2023-08-15

申请人： Axon Therapies, Inc.

发明人： Dorin PANESCU ,  Andrew WU ,  Zoar Jacob ENGELMAN ,  Mark GELFAND ,  Mark S. LEUNG

IPC分类号： A61B18/14 ,  A61B18/02 ,  A61B18/12

CPC分类号： A61B18/1492 ,  A61B18/0218 ,  A61B2090/3966 ,  A61B18/1477 ,  A61B18/1206

摘要： Systems, devices, and methods for transvascular ablation of target tissue are disclosed herein. The devices and methods may, in some examples, be used for splanchnic nerve ablation to increase splanchnic venous blood capacitance to treat at least one of heart failure and hypertension. For example, the devices disclosed herein may be advanced endovascularly to a target vessel in the region of a thoracic splanchnic nerve (TSN), such as a greater splanchnic nerve (GSN) or a TSN nerve root. Also disclosed are method of treating heart failure, such as HFpEF, by endovascularly ablating a thoracic splanchnic nerve to increase venous capacitance and reduce pulmonary blood pressure.

公开(公告)号：US20230380896A1

公开(公告)日：2023-11-30

申请号：US18366522

申请日：2023-08-07

申请人： Axon Therapies, Inc.

发明人： Dorin PANESCU ,  Andrew WU ,  Zoar Jacob ENGELMAN ,  Mark GELFAND ,  Mark S. LEUNG

IPC分类号： A61B18/14 ,  A61B18/02 ,  A61B18/12

CPC分类号： A61B18/1492 ,  A61B18/0218 ,  A61B18/1206 ,  A61B18/1477 ,  A61B2090/3966

摘要： Systems, devices, and methods for transvascular ablation of target tissue are disclosed herein. The devices and methods may, in some examples, be used for splanchnic nerve ablation to increase splanchnic venous blood capacitance to treat at least one of heart failure and hypertension. For example, the devices disclosed herein may be advanced endovascularly to a target vessel in the region of a thoracic splanchnic nerve (TSN), such as a greater splanchnic nerve (GSN) or a TSN nerve root. Also disclosed are method of treating heart failure, such as HFpEF, by endovascularly ablating a thoracic splanchnic nerve to increase venous capacitance and reduce pulmonary blood pressure.

公开(公告)号：US20240156521A1

公开(公告)日：2024-05-16

申请号：US18332599

申请日：2023-06-09

申请人： Axon Therapies, Inc.

发明人： Dorin PANESCU ,  Andrew WU ,  Zoar Jacob ENGELMAN ,  Mark GELFAND ,  Mark S. LEUNG ,  Howard LEVIN

IPC分类号： A61B18/14

CPC分类号： A61B18/1492 ,  A61B2018/0022

摘要： Systems, devices, and methods for transvascular ablation of target tissue. The devices and methods may, in some examples, be used for splanchnic nerve ablation to increase splanchnic venous blood capacitance to treat at least one of heart failure and hypertension. For example, the devices disclosed herein may be advanced endovascularly to a target vessel in the region of a thoracic splanchnic nerve (TSN), such as a greater splanchnic nerve (GSN) or a TSN nerve root. Also disclosed are method of treating heart failure, such as HFpEF, by endovascularly ablating a thoracic splanchnic nerve to increase venous capacitance and reduce pulmonary blood pressure.

公开(公告)号：US20210128229A1

公开(公告)日：2021-05-06

申请号：US16963559

申请日：2019-01-28

申请人： AXON THERAPIES, INC.

发明人： Dorin PANESCU ,  Andrew WU ,  Zoar Jacob ENGELMAN ,  Mark GELFAND ,  Mark S. LEUNG

IPC分类号： A61B18/14 ,  A61B18/02 ,  A61B18/12

摘要： Systems, devices, and methods for transvascular ablation of target tissue are disclosed herein. The devices and methods may, in some examples, be used for splanchnic nerve ablation to increase splanchnic venous blood capacitance to treat at least one of heart failure and hypertension. For example, the devices disclosed herein may be advanced endovascularly to a target vessel in the region of a thoracic splanchnic nerve (TSN), such as a greater splanchnic nerve (GSN) or a TSN nerve root. Also disclosed are method of treating heart failure, such as HFpEF, by endovascularly ablating a thoracic splanchnic nerve to increase venous capacitance and reduce pulmonary blood pressure.