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    ANTIBODIES FOR ONCOGENIC STRAINS OF HPV AND METHODS OF THEIR USE
    6.
    发明申请
    ANTIBODIES FOR ONCOGENIC STRAINS OF HPV AND METHODS OF THEIR USE 有权
    HPV的致敏菌株的抗体及其使用方法

    公开(公告)号：US20150093742A1

    公开(公告)日：2015-04-02

    申请号：US14310138

    申请日：2014-06-20

    Applicant: Arbor Vita Corporation

    Inventor： Peter S. Lu ,  Jonathan David Garman ,  Michael P. Belmares ,  Chamorro Somoza Diaz-Sarmiento ,  Johannes Schweizer

    IPC: C07K16/08 ,  G01N33/569 ,  G01N33/574

    CPC classification number: C07K16/084 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/92 ,  G01N33/56983 ,  G01N33/57411 ,  G01N33/5748 ,  G01N2333/025

    Abstract: The subject invention provides antibodies, including polyclonal and monoclonal antibodies, that bind to E6 proteins from at least three oncogenic strains of HPV. In general, the antibodies bind to amino acids motifs that are conserved between the E6 proteins of different HPV strains, particularly HPV strains 16 and 18. The subject antibodies may be used to detect HPV E6 protein in a sample, and, accordingly, the antibodies find use in a variety of diagnostic applications, including methods of diagnosing cancer. Kits for performing the subject methods and containing the subject antibodies are also provided.

    Abstract translation: 本发明提供了结合来自至少三种致癌菌株的HPV的E6蛋白质的抗体，包括多克隆和单克隆抗体。 通常，抗体结合不同HPV株的E6蛋白之间保守的氨基酸基序，特别是HPV 16和18。本发明的抗体可用于检测样品中的HPV E6蛋白，因此，抗体 可用于各种诊断应用，包括诊断癌症的方法。 还提供了用于进行受试方法并含有目标抗体的试剂盒。

    Effective monitoring system for anthrax smallpox, or other pathogens
    7.
    发明申请
    Effective monitoring system for anthrax smallpox, or other pathogens 有权
    有效的监测系统为炭疽病或其他病原体

    公开(公告)号：US20030153021A1

    公开(公告)日：2003-08-14

    申请号：US10313354

    申请日：2002-12-06

    Applicant: Arbor Vita Corporation

    Inventor： Peter S. Lu ,  Thomas M. Sherlock ,  Joseph Byerly

    IPC: G01N033/554 ,  G01N033/569 ,  C12Q001/04 ,  C12M001/34

    CPC classification number: G01N33/56911 ,  C12M23/32 ,  C12M41/36 ,  C12Q1/04 ,  G01N2001/021 ,  G01N2001/028 ,  G01N2333/32 ,  Y02A50/451 ,  Y02A50/52 ,  Y10S435/808

    Abstract: A device and method for detecting anthrax or other pathogens are disclosed. Individual self-contained monitoring devices of a monitoring system can be portable or stationary (e.g. installed in air ducts or plumbing of buildings) and can be part of a network of devices. Monitoring devices may be used for the detection of a variety of airborne or surface pathogens, including but not limited to anthrax, smallpox, and Salmonella. Bioamplification-coupled proteomics assays provide rapid and reliable detection of pathogens, with self-checking capabilities reducing or eliminating false positives and false negatives. Sample preservation capability allows pathogen samples to be preserved after detection for further testing. The device of the invention can be remotely operated by minimally trained technicians or security personnel. The pathogen monitoring device of the invention provides a more compact, accurate, rapid, and cost-effective alternative to other anthrax detectors, and an effective weapon against bioterrorism.

    Abstract translation: 公开了一种用于检测炭疽病或其他病原体的装置和方法。 监控系统的各个独立的监控设备可以是便携式的或静态的（例如安装在空气管道或建筑物的管道中），并且可以是设备网络的一部分。 监测装置可用于检测各种空气传播或表面病原体，包括但不限于炭疽，天花和沙门氏菌。 生物扩增耦合蛋白质组学检测提供了快速可靠的病原体检测，具有自我检查功能，减少或消除假阳性和假阴性。 样品保存能力允许在检测后保留病原体样品进行进一步测试。 本发明的装置可由受过训练的技术人员或安全人员进行远程操作。 本发明的病原体监测装置为其他炭疽检测器提供了更紧凑，准确，快速和成本有效的替代方案，也是提供了抗生物恐怖主义的有效武器。

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