公开(公告)号：US20030103992A1

公开(公告)日：2003-06-05

申请号：US09978244

申请日：2001-10-15

Applicant: ARBOR VITA CORPORATION

Inventor： Peter S. Lu ,  Jonathan David Garman ,  Albert F. Candia III

IPC: C07H021/04 ,  A61K039/00 ,  C12N009/64 ,  C12P021/02 ,  C12N005/06

CPC classification number: C07K16/28 ,  A01K2217/075 ,  A61K38/00 ,  A61K39/00 ,  A61K48/00 ,  C07K14/705 ,  C07K2319/00 ,  C12N2310/315

Abstract: The present invention relates to cell surface molecules, designated cadherin-like asymmetry proteins (nullCLASPsnull). In particular, it relates to CLASP polynucleotides, polypeptides, fusion proteins, and antibodies. The invention also relates to methods of modulating an immune response by interfering with CLASP function.

Abstract translation: 本发明涉及称为钙粘蛋白样不对称蛋白（“CLASP”）的细胞表面分子。 特别地，其涉及CLASP多核苷酸，多肽，融合蛋白和抗体。 本发明还涉及通过干扰CLASP功能来调节免疫应答的方法。

公开(公告)号：US20030153021A1

公开(公告)日：2003-08-14

申请号：US10313354

申请日：2002-12-06

Applicant: Arbor Vita Corporation

Inventor： Peter S. Lu ,  Thomas M. Sherlock ,  Joseph Byerly

IPC: G01N033/554 ,  G01N033/569 ,  C12Q001/04 ,  C12M001/34

CPC classification number: G01N33/56911 ,  C12M23/32 ,  C12M41/36 ,  C12Q1/04 ,  G01N2001/021 ,  G01N2001/028 ,  G01N2333/32 ,  Y02A50/451 ,  Y02A50/52 ,  Y10S435/808

Abstract: A device and method for detecting anthrax or other pathogens are disclosed. Individual self-contained monitoring devices of a monitoring system can be portable or stationary (e.g. installed in air ducts or plumbing of buildings) and can be part of a network of devices. Monitoring devices may be used for the detection of a variety of airborne or surface pathogens, including but not limited to anthrax, smallpox, and Salmonella. Bioamplification-coupled proteomics assays provide rapid and reliable detection of pathogens, with self-checking capabilities reducing or eliminating false positives and false negatives. Sample preservation capability allows pathogen samples to be preserved after detection for further testing. The device of the invention can be remotely operated by minimally trained technicians or security personnel. The pathogen monitoring device of the invention provides a more compact, accurate, rapid, and cost-effective alternative to other anthrax detectors, and an effective weapon against bioterrorism.

Abstract translation: 公开了一种用于检测炭疽病或其他病原体的装置和方法。 监控系统的各个独立的监控设备可以是便携式的或静态的（例如安装在空气管道或建筑物的管道中），并且可以是设备网络的一部分。 监测装置可用于检测各种空气传播或表面病原体，包括但不限于炭疽，天花和沙门氏菌。 生物扩增耦合蛋白质组学检测提供了快速可靠的病原体检测，具有自我检查功能，减少或消除假阳性和假阴性。 样品保存能力允许在检测后保留病原体样品进行进一步测试。 本发明的装置可由受过训练的技术人员或安全人员进行远程操作。 本发明的病原体监测装置为其他炭疽检测器提供了更紧凑，准确，快速和成本有效的替代方案，也是提供了抗生物恐怖主义的有效武器。