公开(公告)号：US20030103992A1

公开(公告)日：2003-06-05

申请号：US09978244

申请日：2001-10-15

Applicant: ARBOR VITA CORPORATION

Inventor： Peter S. Lu ,  Jonathan David Garman ,  Albert F. Candia III

IPC: C07H021/04 ,  A61K039/00 ,  C12N009/64 ,  C12P021/02 ,  C12N005/06

CPC classification number: C07K16/28 ,  A01K2217/075 ,  A61K38/00 ,  A61K39/00 ,  A61K48/00 ,  C07K14/705 ,  C07K2319/00 ,  C12N2310/315

Abstract: The present invention relates to cell surface molecules, designated cadherin-like asymmetry proteins (nullCLASPsnull). In particular, it relates to CLASP polynucleotides, polypeptides, fusion proteins, and antibodies. The invention also relates to methods of modulating an immune response by interfering with CLASP function.

Abstract translation: 本发明涉及称为钙粘蛋白样不对称蛋白（“CLASP”）的细胞表面分子。 特别地，其涉及CLASP多核苷酸，多肽，融合蛋白和抗体。 本发明还涉及通过干扰CLASP功能来调节免疫应答的方法。