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公开(公告)号：US20230302254A1
公开(公告)日：2023-09-28
申请号：US18018565
申请日：2021-07-27
发明人： Tom DAGAN , Yuval ZIPORY , Osnat HARBATER , Eran MILLER
CPC分类号： A61M25/0052 , A61M25/0108 , A61B2017/1205
摘要： An embolization microcatheter for embolization of peripheral arteries including an elongated tubular member comprising a distal end having a length of 150-500 mm and an outer diameter of less than 0.8 mm, wherein the elongated tubular member comprises a multiplicity sections, each having a length of 5 mm -150 mm, wherein a wall of each of the multiplicity of sections comprises a braid, a polymer formed around the braid and an inner liner coating an inner surface thereof; wherein the polymer of the multiplicity sections differ; and a distal tip having a length of 1 mm - 3 mm and extending between a proximal end of a first radiopaque marker of the elongated tubular member and a distal end opening of the elongated tubular member; the wall of the distal tip is devoid of braid.
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公开(公告)号：US20210393917A1
公开(公告)日：2021-12-23
申请号：US17464993
申请日：2021-09-02
发明人： Michael, Gabriel TAL , Eran MILLER
摘要： An embolization microcatheter having an elongated microcatheter body configured for passing therein a suspension of particles suspended in a suspension fluid; and a microcatheter head connected to a distal end of said microcatheter body and comprising a proximal head section and a distal head section, wherein the proximal head section includes a proximal wall forming a proximal section lumen, the proximal wall having a plurality of through-holes, wherein the distal head section includes a distal wall forming a distal section lumen, and a suspension delivery opening at a distal end of the distal end section; wherein the distal section is devoid of through-holes, and wherein each of the plurality of through-holes are shaped and/or sized to allow passage therethrough of the suspension fluid while blocking passage of the particles suspended therein.
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公开(公告)号：US10456235B2
公开(公告)日：2019-10-29
申请号：US15554850
申请日：2016-03-02
发明人： Michael Gabriel Tal , Eran Miller
IPC分类号： A61F2/01 , A61B17/12 , A61M25/00 , A61K9/00 , A61K9/16 , A61K31/704 , A61L24/00 , A61L24/02 , A61M5/00
摘要： Injectable embolization particulates (e.g., particles, microstructures, beads) employed in embolization procedures, for facilitating blood vessel occlusion. Exemplary embolization particulates for occluding a blood vessel include a plurality of embolization beads, each bead having a plurality of outwardly protruding portions, wherein, upon a first one and a second one of the beads accumulating against a boundary of the blood vessel, protruding portions of the first bead are configured to intermesh with protruding portions of the second bead, so as to occlude the blood vessel. Also disclosed are compositions of embolization particulates including a plurality of shaped embolization beads, and methods for embolizing or occluding a blood vessel using embolization particulates or compositions thereof. Embolization particulates have particular shapes for facilitating blood vessel occlusion while preventing or diminishing back flow (reflux) of embolic material, and may be coated or impregnated with therapeutic agents or radioactive isotopes, for increasing desirable therapeutic effects.
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公开(公告)号：US20180049747A1
公开(公告)日：2018-02-22
申请号：US15554825
申请日：2016-03-02
发明人： Michael Gabriel TAL , Eran MILLER
IPC分类号： A61B17/12
CPC分类号： A61F2/013 , A61B17/12109 , A61B17/12181 , A61B17/12186 , A61B2017/1205 , A61F2002/011 , A61F2002/016 , A61K9/0019 , A61K9/1676 , A61K31/704 , A61L24/0015 , A61L24/02 , A61L2300/23 , A61L2300/416 , A61L2430/36 , A61M5/007 , A61M25/0021 , A61M25/007 , A61M25/0074 , A61M2025/0042
摘要： Microcatheters and methods for modifying and delivering suspended particles to target bodily parts (e.g., of the cardiovascular system). Embolization microcatheters and uses thereof in performing local embolization procedures, involving modifying flow characteristics (momentum) of suspensions during delivery. Applicable for delivering embolization material in a small blood vessel towards a target bodily part, and for performing local embolizations in small blood vessels feeding (possibly, cancerous) target bodily parts, thereby forming emboli therein, while preventing or minimizing non-target embolization. Exemplary catheter includes: tubular wall with proximal and distal wall ends, and lumen extending therebetween, opened and configured to allow passage of suspension to distal outlet; distal outlet is shaped or/and sized to allow passage of both suspension fluid and particles; proximal outlet is configured to allow passage of suspension fluid without particles and to block passage of particles, during delivery of suspension.
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公开(公告)号：US11471646B2
公开(公告)日：2022-10-18
申请号：US16634344
申请日：2018-08-08
发明人： Michael Gabriel Tal , Eran Miller
IPC分类号： A61M25/00 , A61L29/04 , A61M25/01 , B29C61/02 , B29C63/00 , B29C63/18 , B29K675/00 , B29L31/00
摘要： A microcatheter comprising an inner layer, a strike layer and an outer layer and a braided skeleton located between the inner layer and the outer layer, wherein the inner layer is made of Polytetrafluoroethylene (PTFE) and has a thickness of 0.0015 inch or less, wherein the strike layer includes a polyether block amide and has a thickness of 0.001 inch or less, and wherein a distal portion of said outer layer is made of polycarbonate-based thermoplastic polyurethane having a shore of 90A or below.
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公开(公告)号：US20180028194A1
公开(公告)日：2018-02-01
申请号：US15554850
申请日：2016-03-02
发明人： Michael Gabriel TAL , Eran MILLER
CPC分类号： A61F2/013 , A61B17/12109 , A61B17/12181 , A61B17/12186 , A61B2017/1205 , A61F2002/011 , A61F2002/016 , A61K9/0019 , A61K9/1676 , A61K31/704 , A61L24/0015 , A61L24/02 , A61L2300/23 , A61L2300/416 , A61L2430/36 , A61M5/007 , A61M25/0021 , A61M25/007 , A61M25/0074 , A61M2025/0042
摘要： Injectable embolization particulates (e.g., particles, microstructures, beads) employed in embolization procedures, for facilitating blood vessel occlusion. Exemplary embolization particulates for occluding a blood vessel include a plurality of embolization beads, each bead having a plurality of outwardly protruding portions, wherein, upon a first one and a second one of the beads accumulating against a boundary of the blood vessel, protruding portions of the first bead are configured to intermesh with protruding portions of the second bead, so as to occlude the blood vessel. Also disclosed are compositions of embolization particulates including a plurality of shaped embolization beads, and methods for embolizing or occluding a blood vessel using embolization particulates or compositions thereof. Embolization particulates have particular shapes for facilitating blood vessel occlusion while preventing or diminishing back flow (reflux) of embolic material, and may be coated or impregnated with therapeutic agents or radioactive isotopes, for increasing desirable therapeutic effects.
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公开(公告)号：US12102776B2
公开(公告)日：2024-10-01
申请号：US17464993
申请日：2021-09-02
发明人： Michael Gabriel Tal , Eran Miller
CPC分类号： A61M25/007 , A61B17/12022 , A61B17/12186 , A61M25/0045 , A61M25/005 , A61M25/0051 , A61M25/0074 , A61M25/008 , A61B2017/1205 , A61M25/0013 , A61M2025/0042 , A61M2025/0059
摘要： An embolization microcatheter having an elongated microcatheter body configured for passing therein a suspension of particles suspended in a suspension fluid; and a microcatheter head connected to a distal end of said microcatheter body and comprising a proximal head section and a distal head section, wherein the proximal head section includes a proximal wall forming a proximal section lumen, the proximal wall having a plurality of through-holes, wherein the distal head section includes a distal wall forming a distal section lumen, and a suspension delivery opening at a distal end of the distal end section; wherein the distal section is devoid of through-holes, and wherein each of the plurality of through-holes are shaped and/or sized to allow passage therethrough of the suspension fluid while blocking passage of the particles suspended therein.
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公开(公告)号：US11931042B2
公开(公告)日：2024-03-19
申请号：US17243996
申请日：2021-04-29
发明人： Michael Gabriel Tal , Eran Miller
IPC分类号： A61B17/12 , A61K9/00 , A61K9/16 , A61K31/704 , A61L24/00 , A61L24/02 , A61M5/00 , A61M25/00 , A61F2/01
CPC分类号： A61B17/12181 , A61B17/12109 , A61B17/12186 , A61K9/0019 , A61K9/1676 , A61K31/704 , A61L24/0015 , A61L24/02 , A61M25/0074 , A61B2017/1205 , A61F2/011 , A61F2002/016 , A61L2300/23 , A61L2300/416 , A61L2430/36 , A61M5/007 , A61M25/0021 , A61M2025/0042 , A61M25/007
摘要： Devices, methods and kits for preventing or reducing non-target microparticles deposition and embolization, in conjunction with delivering microparticles (e.g., embolization material) via a blood vessel to a target bodily part. Applicable for entrapping infiltrated microparticles within heart right atrium. Entrapping device includes: filter; and filter collapsing mechanism sized for positioning in catheter lumen of a filter delivering catheter, and having proximal end actuatable from outside of subject. Filter configured for positioning within heart right atrium, for self-expanding and covering right atrium inlet opening, and configured, when expanded, to collect embolic material delivered to target organ and infiltrated into outflow vessel thereof draining to right atrium. Filter collapsing mechanism configured for collapsing, and being manipulated to form a pocket in filter, to entrap collected embolic material therein, and drawing filter with collected embolic material in pocket, into catheter lumen of filter delivering catheter.
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公开(公告)号：US20230047163A1
公开(公告)日：2023-02-16
申请号：US17966778
申请日：2022-10-15
发明人： Michael Gabriel TAL , Eran MILLER
摘要： A microcatheter comprising an inner layer, a strike layer and an outer layer and a braided skeleton located between the inner layer and the outer layer, wherein the inner layer is made of Polytetrafluoroethylene (PTFE) and has a thickness of 0.0015 inch or less, wherein the strike layer includes a polyether block amide and has a thickness of 0.001 inch or less, and wherein a distal portion of said outer layer is made of polycarbonate-based thermoplastic polyurethane having a shore of 90A or below.
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公开(公告)号：US11129960B2
公开(公告)日：2021-09-28
申请号：US16099166
申请日：2017-05-03
发明人： Michael Gabriel Tal , Eran Miller
摘要： An embolization microcatheter having an elongated microcatheter body configured for passing therein a suspension of particles suspended in a suspension fluid; and a microcatheter head connected to a distal end of said microcatheter body and comprising a proximal head section and a distal head section, wherein the proximal head section includes a proximal wall forming a proximal section lumen, the proximal wall having a plurality of through-holes, wherein the distal head section includes a distal wall forming a distal section lumen, and a suspension delivery opening at a distal end of the distal end section; wherein the distal section is devoid of through-holes, and wherein each of the plurality of through-holes are shaped and/or sized to allow passage therethrough of the suspension fluid while blocking passage of the particles suspended therein.
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