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公开(公告)号:US12234297B2
公开(公告)日:2025-02-25
申请号:US18792921
申请日:2024-08-02
Applicant: Phylaxis Bioscience, LLC , Inhibrx Biosciences, Inc.
Inventor: Bryan R. Becklund , Kyle S. Jones , Andrew M. Eckles , Brendan P. Eckelman , Tony Dung-Ling Yao
IPC: C07K16/42
Abstract: Provided herein are IgE-binding VHH domains, polypeptides, and proteins, and methods of using such IgE-binding polypeptides and proteins to modulate the biological activity of IgE.
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公开(公告)号:US12230491B2
公开(公告)日:2025-02-18
申请号:US18489510
申请日:2023-10-18
Applicant: Micromass UK Limited
Inventor: Ian David Trivett , Anthony Hesse , Mark Walford , Daniel J. Kenny , David Gordon , Stanislaw Koziol , Steve D. Trudeau , Alastair M. Booth , Stephen Ayrton
Abstract: A nebuliser outlet comprises an inlet end and an outlet end, a first channel and one or more second channels arranged between the inlet end and the outlet end. The first channel is configured to receive a capillary, and the one or more second channels are configured to pass gas to the outlet end. The nebuliser outlet is a single integrated component.
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公开(公告)号:US12227514B2
公开(公告)日:2025-02-18
申请号:US17052128
申请日:2019-04-30
Applicant: TIANJIN HEMAY PHARMACEUTICAL CO., LTD.
Inventor: Donglei Zhang , Liyu Wang , Yukun Chang
IPC: C07D495/04
Abstract: Disclosed is crystal form I of compound (S)—N-[5-[1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl]-4,6-dioxo-5,6-dihydro-4H-thieno[3,4-c]pyrrole-1-yl]acetamide.
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公开(公告)号:US12220122B2
公开(公告)日:2025-02-11
申请号:US18487601
申请日:2023-10-16
Applicant: Anika Therapeutics, Inc.
Inventor: Bart Bracy
Abstract: A multicomponent suture comprising first and second substantially elongate suture portions with respective first and second cross-sectional profiles, and further including respective first and second materials, one of said materials being bioabsorbable and a second of said materials being non-bioabsorbable.
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公开(公告)号:US12213939B2
公开(公告)日:2025-02-04
申请号:US18077002
申请日:2022-12-07
Applicant: RhinoSystems, Inc.
Inventor: Martin R. Hoke , Paul R. Metcalfe
Abstract: Systems and methods for nasal irrigation are provided in which a nasal irrigation device includes a source of saline solution, an effluent receptacle, a nasal interface, a vacuum source, a fluid passageway to communicate the source of saline solution with the effluent receptacle through the nasal interface and a nasal cavity of a user, and a switch and valve assembly for selectively controlling the vacuum source and flow of the saline solution through the fluid passageway. The source of saline solution is disposed relative to the device to provide gravitational inducement of the saline solution to the nasal interface in engagement to the device user's nostrils. A combination of the gravitational inducement and a relative vacuum from the effluent receptacle generates a fluid flow for irrigating, cleansing and massaging the nasal cavity and ostia of the user. The entire device is assembled as a hand-held device for convenient lifting and disposal against the user's nostrils.
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公开(公告)号:US12204451B2
公开(公告)日:2025-01-21
申请号:US18454707
申请日:2023-08-23
Applicant: Dynavisor, Inc.
Inventor: Sreekumar Nair
IPC: G06F12/0811 , G06F9/4401 , G06F9/455 , G06F12/0815 , G06F12/0897 , G06F16/174
Abstract: A system and method for providing storage virtualization (SV) is disclosed. According to one embodiment, a system includes a storage device having a tier 1 cache and a Tier 2 storage, an operating system and a file system having a Tier 0 memory cache that stores application data. The Tier 0 memory cache synchronizes the application data with the tier 1 cache and the Tier 2 storage.
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公开(公告)号:US12203461B2
公开(公告)日:2025-01-21
申请号:US18438252
申请日:2024-02-09
Applicant: BlueDesal Inc.
Inventor: Joseph B. Tate
IPC: F04B35/00 , C02F103/08
Abstract: A wave driven variable leverage pump for water desalination is disclosed. According to one embodiment, a variable leverage pump comprises a platform and a paddle comprising at least one lever arm extending therefrom. The at least one lever arm is pivotally coupled with the platform. The pump further comprises a pump having a first end pivotally coupled with the platform, and a second end pivotally coupled with the paddle. A pivot point of the at least one lever arm is located above a pivot point of the pump relative to the platform.
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公开(公告)号:US12201539B2
公开(公告)日:2025-01-21
申请号:US18058479
申请日:2022-11-23
Applicant: Otto Bock Healthcare LP
Inventor: Richard J. Casler, Jr. , Hugh M. Herr
IPC: A61F2/70 , A61F2/60 , A61F2/66 , A61F2/72 , A61F5/01 , A61H1/02 , A61H3/00 , B25J9/00 , G01L5/00 , G01P21/00 , H02K7/06 , A61F2/50 , A61F2/68 , A61F2/76 , H02K7/116
Abstract: Hybrid terrain-adaptive lower-extremity apparatus and methods that perform in a variety of different situations by detecting the terrain that is being traversed, and adapting to the detected terrain. In some embodiments, the ability to control the apparatus for each of these situations builds upon five basic capabilities: (1) determining the activity being performed; (2) dynamically controlling the characteristics of the apparatus based on the activity that is being performed; (3) dynamically driving the apparatus based on the activity that is being performed; (4) determining terrain texture irregularities (e.g., how sticky is the terrain, how slippery is the terrain, is the terrain coarse or smooth, does the terrain have any obstructions, such as rocks) and (5) a mechanical design of the apparatus that can respond to the dynamic control and dynamic drive.
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公开(公告)号:US12198930B2
公开(公告)日:2025-01-14
申请号:US17630674
申请日:2021-11-12
Inventor: Libin Zhang , Yayi Wei , Zhen Song , Yajuan Su , Jianfang He , Le Ma
IPC: H01L29/40 , H01L21/027 , H01L21/311 , H01L21/768
Abstract: A method for manufacturing a semiconductor device. A photolithographic coating, including a first film, a photolithographic film, and a second film, is formed on the to-be-connected structure. Refractive indexes of the first film and the second film are smaller than 1, so that the photolithographic coating forms an optical structure with a high reflection coefficient. The photolithographic coating is exposed to a light having a target wavelength through a mask. The to-be-connected structure is reflected in the photolithographic coating, and hence serves as another mask and is imaged to the photolithographic film. A pattern of the mask is simultaneously imaged to the photolithographic film. That is, both the to-be-connected structure and the pattern of the mask are imaged to a target region of the photolithographic film, and the target region corresponds to the to-be-connected structure.
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公开(公告)号:US12188112B2
公开(公告)日:2025-01-07
申请号:US18083261
申请日:2022-12-16
Applicant: Carpenter Technology Corporation
Inventor: Stephane Alexis Jacques Forsik , Mario Epler , Alojz Kajinic , Gaurav Lalwani , Logan Smith
IPC: C22C38/58 , C21D6/00 , C22C38/00 , C22C38/02 , C22C38/42 , C22C38/44 , C22C38/52 , C23C8/08 , C23C8/22 , C23C8/26 , C23C8/32
Abstract: A method for fabricating an article includes forming a billet consisting essentially of a stainless steel composition of manganese 2.00 wt. %-24.00 wt. % chromium 19.00 wt. %-30 wt. % molybdenum 0.50 wt. %-4.0 wt. % nitrogen 0.25 wt. %-1.10 wt. % carbon ≤1 wt. % phosphorus ≤0.03 wt. % sulfur ≤1 wt. % nickel
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