公开(公告)号：US12215317B2

公开(公告)日：2025-02-04

申请号：US18143533

申请日：2023-05-04

Applicant: Helix Nanotechnologies Inc.

Inventor： Nikhil Dhar ,  Kyle Backman ,  Dario de Jesus Davila Pasillas ,  Justin Sean Huang ,  Nikolai Eroshenko

IPC: C12N15/11 ,  C07H13/04 ,  C07H19/10 ,  C07H19/16 ,  C07H19/20

Abstract: Disclosed herein is a modified ribonucleotide comprising a nucleoside comprising 2′-O-acetylated ribose, and polyribonucleotides comprising the same. Also provided herein are compositions comprising a polyribonucleotide of the present disclosure and methods of making and using the same.

公开(公告)号：US12181480B2

公开(公告)日：2024-12-31

申请号：US17111403

申请日：2020-12-03

Applicant: Adimab, LLC

Inventor： Piotr Bobrowicz ,  Amber D. Hanna ,  Jerry M. Thomas

IPC: C40B30/04 ,  C12N15/10 ,  G01N33/68

Abstract: The present invention relates, inter alia, to polyspecificity reagents, methods of making the same, and methods of using the same in, inter alia, the selection, screening, enrichment, and identification of non-polyspecific, and thus developable, polypeptides.

公开(公告)号：US12156858B2

公开(公告)日：2024-12-03

申请号：US17834839

申请日：2022-06-07

Applicant: InTrance Medical Systems Inc.

Inventor： Roger Bolsöy

IPC: A61K31/198 ,  A61K9/00 ,  A61K9/06 ,  A61K9/16 ,  A61K31/165 ,  A61K31/277 ,  A61K45/06 ,  A61K47/38

Abstract: A pharmaceutical gel composition for intra-intestinal administration comprises (i) a dopamine replacement agent, (ii) a dopamine decarboxylase inhibitor (DDI), and (iii) a COMT inhibitor.

公开(公告)号：US12151494B2

公开(公告)日：2024-11-26

申请号：US18387643

申请日：2023-11-07

Applicant: X Display Company Technology Limited

Inventor： Tanya Yvette Moore ,  David Gomez ,  Christopher Andrew Bower ,  Matthew Alexander Meitl ,  Salvatore Bonafede

IPC: B41K3/04 ,  B41F16/00 ,  G03F7/00

Abstract: A micro-transfer structure comprises a stamp comprising a rigid support, only a single contiguous bulk layer disposed on the rigid support, and posts disposed on the bulk layer. Components are adhered to (e.g., disposed in contact with) some but not all of the posts. The posts can be substantially identical and disposed in a regular array on the bulk layer. Each component is adhered to (e.g., in contact with) two or more posts. Components can be disposed on a source wafer entirely over sacrificial portions of a sacrificial layer on or in the source wafer and attached to anchors disposed between sacrificial portions with a tether.

公开(公告)号：US12133966B2

公开(公告)日：2024-11-05

申请号：US18374816

申请日：2023-09-29

Applicant: Regina E. Herzlinger

Inventor： Regina E. Herzlinger

IPC: A61M5/142

Abstract: Presented herein are methods, systems, and apparatus for administering an antibody treatment via an infusion device, e.g., a rapid infusion device, e.g., for the treatment of a disease or condition that requires one or more infusions of monoclonal and/or polyclonal antibodies.

公开(公告)号：US12133899B2

公开(公告)日：2024-11-05

申请号：US17988742

申请日：2022-11-16

Applicant: BioNTech SE

Inventor： Ugur Sahin ,  Alptekin Güler ,  Andreas Kuhn ,  Alexander Muik ,  Annette Vogel ,  Kerstin Walzer ,  Sonja Witzel ,  Stephanie Hein ,  Özlem Türeci

IPC: A61K48/00 ,  A61K9/00 ,  A61K9/127 ,  A61K9/51 ,  A61K31/7088 ,  A61K31/7105 ,  A61K31/711 ,  A61K31/7115 ,  A61K31/712 ,  A61K39/00 ,  A61K39/12 ,  A61K39/215 ,  A61P31/14 ,  A61P35/00 ,  B82Y5/00 ,  C12N7/00 ,  C12N15/11 ,  C12N15/67 ,  C12N15/88 ,  C12P19/34 ,  A61K38/00

Abstract: This disclosure relates to the field of RNA to prevent or treat coronavirus infection. In particular, the present disclosure relates to methods and agents for vaccination against coronavirus infection and inducing effective coronavirus antigen-specific immune responses such as antibody and/or T cell responses. Specifically, in one embodiment, the present disclosure relates to methods comprising administering to a subject RNA encoding a peptide or protein comprising an epitope of SARS-CoV-2 spike protein (S protein) for inducing an immune response against coronavirus S protein, in particular S protein of SARS-CoV-2, in the subject, i.e., vaccine RNA encoding vaccine antigen.

公开(公告)号：US12128100B2

公开(公告)日：2024-10-29

申请号：US17293431

申请日：2019-11-13

Applicant: Variation Biotechnologies Inc.

Inventor： David Evander Anderson ,  Tanvir Ahmed

IPC: A61K39/00 ,  A61K38/21 ,  A61K39/12 ,  A61K39/29 ,  A61K45/06 ,  A61P31/20 ,  A61P37/04 ,  A61P43/00

CPC classification number: A61K39/292 ,  A61K45/06 ,  A61P31/20 ,  A61P37/04 ,  A61K2039/545 ,  A61K2039/55505 ,  A61K2039/57

Abstract: The present disclosure provides compositions and methods useful for inducing a The cell response in a subject suffering from Hepatitis B. As described herein, the compositions of the disclosure comprise HBsAg having S, Pre-S1 and Pre-S2 proteins and an aluminum phosphate adjuvant. In a preferred embodiment, the immunogenic composition comprises at least 20 μg/ml of HBsAg antigen and the amount of non-adsorbed antigen is at least 30%.

公开(公告)号：US12123004B2

公开(公告)日：2024-10-22

申请号：US17260984

申请日：2019-07-18

Applicant: Modular Genetics, Inc.

Inventor： Kevin A. Jarrell ,  Michelle Pynn

IPC: C12N15/52 ,  C12N1/20 ,  C12N9/02 ,  C12N9/10 ,  C12N9/90 ,  C12P13/14 ,  C12R1/125

CPC classification number: C12N15/52 ,  C12N1/20 ,  C12N9/0071 ,  C12N9/1007 ,  C12N9/90 ,  C12P13/14 ,  C12R2001/125 ,  C12Y502/01004

Abstract: Engineered polypeptides or engineered microbial cells useful in synthesizing acyl amino acids are provided. In some embodiments, engineered polypeptides or engineered microbial cells are useful in synthesizing acyl amino acids with one or more hydroxyl and/or methyl groups at one or more positions of the fatty acid portion of the acyl amino acid (e.g., at ω-1, ω-2, and/or ω-3 positions of the fatty acid portion of the acyl amino acid). Also provided are methods of making acyl amino acids using engineered polypeptides and/or engineered microbial cells.

公开(公告)号：US12112678B2

公开(公告)日：2024-10-08

申请号：US17822962

申请日：2022-08-29

Applicant: X Display Company Technology Limited

Inventor： Imre Knausz ,  Ronald S. Cok

IPC: G09G3/20 ,  G09G3/3233 ,  G09G3/32 ,  G09G3/36

CPC classification number: G09G3/2018 ,  G09G3/3233 ,  G09G3/32 ,  G09G3/36 ,  G09G2310/08 ,  G09G2330/02

Abstract: A hybrid pulse-width-modulation pixel includes a light controller responsive to a variable power signal specifying different powers and a pixel controller. The pixel controller is operable receive a pixel luminance signal comprising multiple bits specifying a desired light-controller luminance, generate the variable power signal in response to the pixel luminance signal, and drive the light controller to emit light at different luminances in response to the variable power signal for different time periods. The pixel controller is operable to provide the variable power signal at a constant first power for a first time period and provide the variable power signal at a constant second power different from the constant first power for a second time period.

公开(公告)号：US12080690B2

公开(公告)日：2024-09-03

申请号：US18507597

申请日：2023-11-13

Applicant: X Display Company Technology Limited

Inventor： Christopher Bower ,  Matthew Meitl ,  David Gomez ,  Salvatore Bonafede ,  David Kneeburg ,  Alin Fecioru ,  Carl Prevatte

IPC: H01L25/075 ,  F21V9/08 ,  G02B26/04 ,  G02F1/167 ,  G09G3/22 ,  G09G3/32 ,  H01L23/482 ,  H01L23/538 ,  H01L25/16 ,  H01L27/15 ,  H01L33/36 ,  H01L33/38 ,  H01L33/48 ,  H01L33/50 ,  H01L33/58 ,  H01L33/60 ,  H01L33/62 ,  H05K1/03 ,  H05K1/09 ,  H05K1/18 ,  H05K5/00 ,  F21Y105/10 ,  F21Y113/13 ,  F21Y115/10 ,  H01L33/20 ,  H01L33/40

CPC classification number: H01L25/0753 ,  F21V9/08 ,  G02B26/04 ,  G02F1/167 ,  G09G3/22 ,  G09G3/32 ,  H01L23/4821 ,  H01L23/5381 ,  H01L25/167 ,  H01L27/156 ,  H01L33/36 ,  H01L33/38 ,  H01L33/385 ,  H01L33/48 ,  H01L33/50 ,  H01L33/502 ,  H01L33/508 ,  H01L33/58 ,  H01L33/60 ,  H01L33/62 ,  H05K1/0306 ,  H05K1/09 ,  H05K1/181 ,  H05K1/182 ,  H05K5/0017 ,  F21Y2105/10 ,  F21Y2113/13 ,  F21Y2115/10 ,  G09G2300/0452 ,  G09G2300/0842 ,  G09G2310/0264 ,  H01L33/20 ,  H01L33/405 ,  H01L2224/18 ,  H01L2224/73267 ,  H01L2224/92244 ,  H05K2201/0329 ,  H05K2201/10106 ,  H05K2201/10128 ,  H05K2201/10166

Abstract: The disclosed technology provides micro-assembled micro-LED displays and lighting elements using arrays of micro-LEDs that are too small (e.g., micro-LEDs with a width or diameter of 10 μm to 50 μm), numerous, or fragile to assemble by conventional means. The disclosed technology provides for micro-LED displays and lighting elements assembled using micro-transfer printing technology. The micro-LEDs can be prepared on a native substrate and printed to a display substrate (e.g., plastic, metal, glass, or other materials), thereby obviating the manufacture of the micro-LEDs on the display substrate. In certain embodiments, the display substrate is transparent and/or flexible.