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1.发明授权公开(公告)号：US10766970B2
公开(公告)日：2020-09-08
申请号：US16311992
申请日：2017-06-30
Inventor： Mark E. Welker , Emmanuel C. Opara , Surya R. Banks , Amber N. Weissenfluh
IPC: C08B37/00 , A61K31/734 , A61K47/69
Abstract: Modified alginates are described herein along with hydrogels comprising the same. A modified alginate may be prepared by reacting alginate and an aromatic compound (e.g., an aromatic amine) and/or pH sensitive compound. The modified alginates, hydrogels, and/or methods described herein may be used to coat and/or encapsulate at least a portion of a bioactive substance, optionally for oral delivery in humans and other animals.
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公开(公告)号：US08501233B2
公开(公告)日：2013-08-06
申请号：US12530852
申请日：2008-03-13
Applicant: David Loren Carroll , John H. Stewart, IV , Nicole H. Levi
Inventor： David Loren Carroll , John H. Stewart, IV , Nicole H. Levi
CPC classification number: A61K41/0052 , A61K9/0092 , A61K9/14 , A61K9/51 , A61K47/6923 , A61N1/406 , A61N5/062 , B82Y5/00 , Y10S977/742 , Y10S977/743 , Y10S977/752 , Y10S977/906 , Y10S977/911
Abstract: The present invention relates to compositions and methods for treating cancer and, in particular, to composition and methods comprising nanostructures. In one embodiment, the present invention provides a composition comprising a mixture, the mixture comprising at least one nanoparticle and at least one chemotherapeutic.
Abstract translation: 本发明涉及用于治疗癌症的组合物和方法，特别涉及包含纳米结构的组合物和方法。 在一个实施方案中，本发明提供包含混合物的组合物，所述混合物包含至少一种纳米颗粒和至少一种化学治疗剂。
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3.发明申请METHODS AND COMPOSITIONS FOR PRINTING BIOLOGICALLY COMPATIBLE NANOTUBE COMPOSITES OF AUTOLOGOUS TISSUE 审中-公开印刷自动组织生物合成纳米复合材料的方法与组合物公开(公告)号：US20090117087A1
公开(公告)日：2009-05-07
申请号：US12250820
申请日：2008-10-14
Applicant: David Carroll , William Wagner , Nicole Levi , Louis Argenta , Michael Morykwas
Inventor： David Carroll , William Wagner , Nicole Levi , Louis Argenta , Michael Morykwas
IPC: A61K35/12
CPC classification number: A61L27/38 , C12N5/0629 , C12N5/0656 , C12N2501/115 , C12N2501/165 , C12N2501/17 , C12N2533/54 , C12N2533/74 , C12N2535/10
Abstract: A method of carrying out an autologous tissue implant in a subject in need thereof is carried out by: (a) forming an autologous tissue implant from autologous cells collected from a subject (e.g., by ink-jet printing, the autologous cells and the scaffold, separately or together), and then (b) implanting the autologous tissue implant in said subject.
Abstract translation: 在有需要的受试者中进行自体组织植入的方法通过以下方式进行：（a）从从受试者收集的自体细胞（例如通过喷墨印刷，自体细胞和支架）形成自体组织植入物 ，单独地或一起），然后（b）将自体组织植入物植入所述受试者。
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公开(公告)号：US11286231B2
公开(公告)日：2022-03-29
申请号：US16344452
申请日：2017-10-26
Inventor： Mark E. Welker , Aleksander Skardal , Amber N. Weissenfluh , Surya Banks
IPC: C07C215/50 , C07C211/27 , C07C235/46 , C07C251/24 , C08B37/08 , C08L89/06 , A61L15/28 , A61L15/42 , A61L27/22 , A61L27/24 , A61L27/52
Abstract: Described herein are compounds having a hydrogen-bonding group and optionally a functional group for binding (e.g., covalently binding) the compound to another compound (e.g., hyaluronic acid and/or gelatin). A compound of the present invention may have a structure represented by and/or comprising Formula I, Formula II, Formula III, Formula IV, Formula IV′, Formula V, Formula V′, Formula VI, Formula VII, and/or Formula VIII as described herein. Compositions including compounds of the present invention along with methods of preparing and using the same are also described herein.
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5.发明申请公开(公告)号：US20190375860A1
公开(公告)日：2019-12-12
申请号：US16311992
申请日：2017-06-30
Inventor： Mark E. WELKER , Emmanuel C. OPARA , Surya R. BANKS , Amber N. WEISSENENFLUH
Abstract: Modified alginates are described herein along with hydrogels comprising the same. A modified alginate may be prepared by reacting alginate and an aromatic compound (e.g., an aromatic amine) and/or pH sensitive compound. The modified alginates, hydrogels, and/or methods described herein may be used to coat and/or encapsulate at least a portion of a bioactive substance, optionally for oral delivery in humans and other animals.
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Patent Agency Ranking
公开(公告)号：US20100185121A1
公开(公告)日：2010-07-22
申请号：US12443249
申请日：2007-09-28
Applicant: David L. Carroll , Faith M. Coldren , Nicole H. Levi , Lawrence X. Webb , William D. Wagner , Thomas L. Smith , Brian Werner , J. Baxter Mcguirt , Manoj Namboothiry
Inventor： David L. Carroll , Faith M. Coldren , Nicole H. Levi , Lawrence X. Webb , William D. Wagner , Thomas L. Smith , Brian Werner , J. Baxter Mcguirt , Manoj Namboothiry
IPC: A61B5/103
CPC classification number: G01L11/02 , A61B5/03 , A61B5/445 , A61B2562/0247
Abstract: The present invention provides a method of sensing pressure in a region of interest by providing a plurality of metallic particles operatively associated with one another in the region of interest (for example, wherein the metallic particles sustain a plasmon upon excitation), and with the metallic particles configured or positioned in relationship to one another so that a physical property of the particles (for example, the energy of the plasmon) varies in response to pressure; measuring the physical property of the metallic particles that varies in response to pressure; and then determining the pressure in the region of interest from the detected physical property (e.g., resistance, energy of the plasmon). Compositions, articles and formulations for carrying out the method in industrial and biomedical applications are also described.
Abstract translation: 本发明提供了一种通过在感兴趣的区域（例如，其中金属颗粒在激发时维持等离子体激元）可操作地相关联的多个金属颗粒，并且与金属 相互关联地配置或定位的颗粒，使得颗粒的物理性质（例如，等离子体激元的能量）响应于压力而变化; 测量响应于压力变化的金属颗粒的物理性质; 然后从检测到的物理性质（例如，电阻，等离子体激元的能量）确定感兴趣区域中的压力。 还描述了用于在工业和生物医学应用中进行该方法的组合物，制品和制剂。
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7.发明公开公开(公告)号：US20240261443A1
公开(公告)日：2024-08-08
申请号：US18603721
申请日：2024-03-13
Applicant: Wake Forest University Health Sciences
Inventor： Kiran K. Solingapuram Sai
IPC: A61K51/04
CPC classification number: A61K51/0427
Abstract: Provided herein are compounds and compositions useful for imaging, detecting, and/or diagnosing oxidative stress and/or a ROS modulated illness by detection of gamma radiation emitted by the compound, as well as intermediate compounds and methods useful to make the compounds and/or compositions, and methods of use thereof.
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公开(公告)号：US11993785B2
公开(公告)日：2024-05-28
申请号：US16533300
申请日：2019-08-06
Applicant: Wake Forest University Health Sciences
Inventor： Aleksander Skardal , Casey Cuvan Clark
CPC classification number: C12N5/0062 , B33Y10/00 , B33Y70/00 , B33Y80/00 , C12M21/08 , C12N5/0697 , C12N13/00 , G01N33/5088 , C12N2513/00
Abstract: Provided are methods of preparing organoids and compositions for use in such methods. In some embodiments, a method of depositing a plurality of the cells into a reservoir are provided, the method comprising depositing a gelatin composition into a reservoir; adding a composition comprising a plurality of cells into the gelatin composition, wherein the composition is added into the gelatin composition at a position below the surface of the gelatin composition and at least a portion of the composition and/or plurality of cells are suspended in the gelatin composition; curing at least a portion of the composition comprising the plurality of cells in the gelatin composition; and removing at least a portion of the gelatin composition in the reservoir, thereby depositing the plurality of cells in the reservoir.
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公开(公告)号：US20240165380A1
公开(公告)日：2024-05-23
申请号：US18454673
申请日：2023-08-23
Inventor： Timothy WILLIAMS , Daniel FONG , Michael Austin JOHNSON , Lucas NEFF
CPC classification number: A61M25/10188 , A61M5/1723 , A61M2005/1726 , A61M2025/0002 , A61M2025/1052 , A61M2202/0415 , A61M2202/0427 , A61M2202/0429
Abstract: A method for automatically controlling an expandable member in a blood vessel of a subject may comprise obtaining, using a controller, proximal sensor data from a proximal pressure sensor and distal sensor data from a distal pressure sensor, comparing the obtained proximal sensor data to a proximal pressure threshold value, adjusting, using the controller, a volume of the expandable member based on the distal sensor data in response to determining that the proximal sensor data is above or at the proximal pressure threshold value, and adjusting, using the controller, the volume of the expandable member based on the proximal sensor data in response to determining that the proximal sensor data is below the proximal pressure threshold value.
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公开(公告)号：US11976101B2
公开(公告)日：2024-05-07
申请号：US17465145
申请日：2021-09-02
Applicant: Wake Forest University Health Sciences
Inventor： Waldemar Debinski , Hetal Pandya , Denise Gibo
IPC: C07K14/54 , A61K47/64 , C07K14/005 , C07K14/195 , C07K14/21 , C07K14/34 , C07K19/00 , G01N33/50 , G01N33/532 , G01N33/68 , A61K38/00
CPC classification number: C07K14/5437 , A61K47/642 , C07K14/005 , C07K14/195 , C07K14/21 , C07K14/34 , C07K19/00 , G01N33/5008 , G01N33/5091 , G01N33/532 , G01N33/6869 , A61K38/00 , C07K2319/01 , C07K2319/09 , C07K2319/74 , G01N2333/025 , G01N2333/195 , G01N2333/5437
Abstract: A compound comprising, in combination: a cell surface binding ligand or internalizing factor, such as an IL-13Rα2 binding ligand; at least one effector molecule (e.g., one, two, three or more effector molecules); optionally but preferably, a cytosol localization element covalently coupled between said binding ligand and said at least one effector molecule; and a subcellular compartment localization signal element covalently coupled between said binding ligand and said at least one effector molecule (and preferably with said cytosol localization element between said binding ligand and said subcellular compartment localization signal element). Methods of using such compounds and formulations containing the same are also described.
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