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公开(公告)号：US11951127B2
公开(公告)日：2024-04-09
申请号：US16625443
申请日：2018-06-22
申请人： THE WESTMEAD INSTITUTE FOR MEDICAL RESEARCH , THE UNIVERSITY OF SYDNEY , WESTERN SYDNEY LOCAL HEALTH DISTRICT , NEW SOUTH WALES HEALTH PATHOLOGY
CPC分类号： A61K35/17 , A61K39/0002 , A61K39/001153 , A61K39/12 , A61P31/10 , A61P31/12 , A61P35/00 , A61K2039/5158 , A61K2039/70
摘要： The present disclosure relates to compositions comprising isolated T cells, with activity against a fungal antigen, a viral antigen or a tumour antigen, wherein the composition comprises a defined number or defined ratio of T cells. Described herein are compositions comprising at least two populations of T cells, the compositions being suitable for treating various diseases and disorders.
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公开(公告)号：US11923927B2
公开(公告)日：2024-03-05
申请号：US17771298
申请日：2020-10-26
发明人： Alva Kosasih , Wibowo Hardjawana , Branka Vucetic
IPC分类号： H04L23/02 , H04B1/10 , H04B7/0452 , H04B7/08
CPC分类号： H04B7/0452 , H04B1/1027 , H04B7/0854 , H04B7/0857
摘要： A method for detecting transmitted data in a multiple-input multiple-output (MIMO) receiver, the method comprising: iteratively calculating symbol estimates by: obtaining input symbol estimates and input symbol variances; calculating error values for the input symbol estimates; refining the input symbol estimates to obtain refined symbol estimates, based on the error values, wherein the refined symbol estimates are used as input symbol estimates for the subsequent iteration of the above calculation, and wherein the refined symbol estimates are used as final symbol estimates when the difference between refined symbol estimates from one iteration to the next is below a threshold change.
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公开(公告)号：US20240008215A1
公开(公告)日：2024-01-04
申请号：US18250605
申请日：2021-10-27
发明人： Oliver Jay , John Eisenhuth , Glenda Anderson
CPC分类号： H05K7/20181 , H05K7/20145 , G01W1/02
摘要： An apparatus (200) for shielding a sensor, the sensor being configured to measure one or more meteorological parameters, the apparatus (200) including: a first shielding element (202) to be irradiated by sunlight, the first shielding element (202) having a hollow body (204) providing a longitudinal central axis (208), the body (204) at least partly surrounding a chamber (206) in which the sensor is to be located; a second shielding element (212) axially spaced from an upper portion of the body (204) to form an air opening between the first and second shielding elements (202, 212) to permit air to pass from the chamber (206) and across the body (204); the apparatus (200) further including an airflow generator (214) positioned within the chamber (206) and operatively associated with the first and second shielding elements (202, 212) to provide an airflow between the opening and the chamber (206).
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公开(公告)号：US20230259929A1
公开(公告)日：2023-08-17
申请号：US18007065
申请日：2021-07-30
发明人： Abubakar Sadiq Sani , Zhao Yang Dong , Ke Meng , Dong Yuan
CPC分类号： G06Q20/389 , G06Q20/4014 , G06Q20/3825 , G06Q20/3829 , G06Q20/308 , H04L9/3247 , H04L9/50 , H04L9/3066
摘要： Disclosed is a computer implemented method, system and computer readable medium for performing blockchain-based identity management for a supply chain of a computerised network. In one aspect, the method includes receiving, by a computerised device of a party, an identity issuing transaction initiated by a computerised component or service being in the supply chain, the identity issuing transaction being indicative of a name of the computerised component or service, an identity issuing request message, and a first random number obtained from a distributed database, wherein the identity issuing transaction is initiated by the computerised component or service in response to determining the party is an authoritative party recorded in the blockchain and permitted to issue an identity, invoking a first smart contract, and executing an identity issuance logic of the first smart contract.
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公开(公告)号：US20230248442A1
公开(公告)日：2023-08-10
申请号：US18014691
申请日：2021-07-08
申请人： UNIVERSITY OF SYDNEY
CPC分类号： A61B34/20 , A61N5/1037 , G06T7/11 , A61B2034/2046 , G06T2207/10076
摘要： Systems, methods, and apparatus are disclosed for cardiac structure tracking. An example method includes segmenting a diaphragm or respiratory surrogate, heart, and target. The method also includes performing a peak-exhale to peak-inhale registration and generating a respiratory motion model. The method further includes tracking the diaphragm using X-ray imaging and estimating a target position for an x-ray guided cardiac radioablation treatment. The example method provides directly, precisely controlled x-ray guided cardiac radioablation that accurately targets the substrates of cardiac ablation while minimizing doses to healthy tissue.
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公开(公告)号：US20230236285A1
公开(公告)日：2023-07-27
申请号：US17997602
申请日：2021-04-30
发明人： Ziqian Zhang , Yang Liu , Benjamin John Eggleton
IPC分类号： G01S7/03 , G01S7/35 , A61B5/0507
CPC分类号： G01S7/032 , A61B5/0507 , G01S7/352 , A61B5/0816
摘要： The present application relates to radio detection and ranging (radar) systems and, in particular, to a radar system having a photonics-based signal generator. Such a radar system comprises a stepped-frequency optical signal generator, an optical-to-electrical converter, and a transmitter. The stepped-frequency optical signal generator is configured for converting an optical signal into a stepped-frequency optical signal. The optical-to-electrical converter for converting the stepped-frequency optical signal into a stepped-frequency electrical signal. The transmitter for transmitting a microwave signal based on the stepped-frequency electrical signal.
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公开(公告)号：US20230002446A1
公开(公告)日：2023-01-05
申请号：US17616809
申请日：2020-06-05
摘要： The invention relates to anti-inflammatory peptides, to pharmaceutical compositions comprising same and to uses thereof for treatment of inflammation including, but not limited to inflammation associated with immune activation.
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公开(公告)号：US20220259265A1
公开(公告)日：2022-08-18
申请号：US17628061
申请日：2020-07-30
发明人： Robert Baxter
IPC分类号： C07K7/08 , A61K31/7048 , A61K31/502 , A61K31/4184 , A61P35/00
摘要： The invention generally relates to inhibitors of DNA double strand break (DSB) repair in cancer cells exposed to DNA-damaging chemotherapy drugs or radiotherapy. In particular, agents that inhibit binding between insulin-like growth factor binding protein-3 (IGFBP-3) and non-POU (pituitary-specific Pit-1, octamer-binding proteins Oct-1 and Oct-2, and neural Unc-86) domain-containing octamer-binding protein (NONO) and methods of using such agents to enhance chemosensitivity or radiosensitivity in cancer treatment are disclosed.
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公开(公告)号：US20220211860A1
公开(公告)日：2022-07-07
申请号：US17608463
申请日：2020-04-30
发明人： Pegah Varamini , Sepideh Khazeni
摘要： Provided herein are luteinizing hormone-releasing hormone (LHRH) peptide derivatives that target the LHRH receptor. LHRH peptide derivatives, LHRH peptide-drug conjugates (LHRH-PDCs) and methods of using the derivatives and/or conjugates thereof to treat a LHRH receptor expressing cancer are described.
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公开(公告)号：US20220177659A1
公开(公告)日：2022-06-09
申请号：US17600691
申请日：2020-03-31
IPC分类号： C08J5/18 , C08F2/38 , C08F257/02 , C08F2/20 , C08F293/00 , C08F212/08
摘要： The present invention relates to a method which uses non-core-shell polymer particles to form polymer film on a pre-formed solid substrate surface, said non-core-shell polymer particles comprising two covalently coupled polymer regions of different molecular composition, wherein (a) one of the two polymer regions is a crosslinked RAFT polymer region and the other polymer region is a film forming polymer region, (b) the crosslinked RAFT polymer region comprising particle aggregation prevention means selected from one or more of charged and steric stabilising functionality, and (c) the film forming polymer region comprising 0-3 wt. % of charged polymerised monomer residues relative to the total amount of polymerised monomer residues present in that region.
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