公开(公告)号：US20240247024A1

公开(公告)日：2024-07-25

申请号：US18553278

申请日：2022-03-30

申请人： UNIVERSITEIT LEIDEN

发明人： Nathaniel I. Martin ,  Yonghzi Gao ,  Matthijs Van Haren ,  Ned Buijs ,  Richard Bramwell Parsons ,  Monica Emanuelli ,  Davide Sartini

IPC分类号： C07H19/173 ,  A61K31/7076 ,  A61P35/00

CPC分类号： C07H19/173 ,  A61K31/7076 ,  A61P35/00

摘要： This invention relates to compounds that are useful as inhibitors, in particular as inhibitors of Nicotinamide N-methyltransferase (NNMT), and formulations composing such compounds. The compounds and formulations may be used as a medicament, for example in the treatment of cancer, metabolic disease, or neurodegenerative disease. The compounds may be of formula (I).

公开(公告)号：US20230393090A1

公开(公告)日：2023-12-07

申请号：US18032011

申请日：2021-10-13

申请人： UNIVERSITEIT LEIDEN

发明人： Gerard Jacob Pieter van WESTEN ,  Hans Michiel de BRUIJN ,  Gregory Fabrice SCHNEIDER ,  Xuhan LIU ,  Erik Pieter van GEEST ,  Sylvestre Antoíne BONNET

IPC分类号： G01N27/414 ,  G01N33/00

CPC分类号： G01N27/4141 ,  G01N27/04 ,  G01N33/0034

摘要： There is provided a gas sensing apparatus (30) for sensing one or more analytes in a gas or gas mixture. The gas sensing apparatus (30) comprises: a plurality of sensors (32), each sensor (32) including a polymer layer (42), each polymer layer (42) made of a respective different type of chemically non-selective or semi-selective polymer; and a measurement device (38) configured to measure a change in parameter of each sensor (32) responsive to interaction of an analyte with the respective polymer layer (42).

公开(公告)号：US20230174584A1

公开(公告)日：2023-06-08

申请号：US17761376

申请日：2020-09-24

申请人： UNIVERSITEIT LEIDEN

发明人： Nathaniel I. Martin ,  Emma Van Groesen ,  Kamaleddin H.M.E. Tehrani ,  Nicola Wade

IPC分类号： C07K9/00 ,  A61P31/04

CPC分类号： C07K9/008 ,  A61P31/04 ,  A61K38/00

摘要： Provided herein are lipidated glycopeptide compounds of formula (I); or a pharmaceutically acceptable salt, stereoisomer, solvate, or prodrug thereof. R1 is a lipid, R2 is —H or a lipid, and R3 and R4 are as defined herein. These compounds have antibiotic activity. Also provided are formulations comprising such compounds; as well as such compounds or formulations for use as a medicament. The compounds and formulations may also be used in the treatment of bacterial infection.

公开(公告)号：US11525140B2

公开(公告)日：2022-12-13

申请号：US16087199

申请日：2017-03-23

申请人： Universiteit Leiden ,  Academisch Ziekenhuis Leiden h.o.d.n. LUMC

发明人： Marcel Tijsterman ,  Maartje Van Kregten ,  Paul Hooykaas

IPC分类号： C12N15/82

摘要： The present disclosure provides methods for transfecting plants and for expressing RNA or polypeptide molecules in plants. In particular, plants having reduced POLQ expression and/or activity are transfected in order to reduce random integration events. The disclosure further provides transfected plants and plant progeny produced by the methods disclosed herein.

公开(公告)号：US20220230757A1

公开(公告)日：2022-07-21

申请号：US17612866

申请日：2020-05-22

申请人： UNIVERSITEIT LEIDEN

发明人： Arko GHOSH

IPC分类号： G16H50/30 ,  A61B5/00

摘要： A method of monitoring a user's neuronal activity (10) includes recording a user's behavioural output with a portable electronic device, such as a mobile cellphone. The user's behavioural output (14) is compared (18) with predefined behavioural outputs associated with known event-related neuronal activations (20). The user's event-related neuronal activation (22) is determined based upon the comparison so as to provide an indication of the user's neuronal activity.

公开(公告)号：US20220064231A1

公开(公告)日：2022-03-03

申请号：US17276452

申请日：2019-09-17

申请人： Universiteit Leiden ,  Academisch Ziekenhuis Leiden h.o.d.n. LUMC

发明人： Harald Martijn Ijsbrand Kerkkamp ,  Michael Keith Richardson ,  Gilles Philippus van Wezel ,  Jan Wouter Drijfhout ,  Robert Alexander Cordfunke ,  Michella Manon Voet ,  Petrus Hendricus Nibbering

IPC分类号： C07K14/46

摘要： The disclosure concerns snake-derived peptides and the useful application of such peptides to inhibit bacterial, fungal, viral and parasitic infections. The disclosed peptides are also useful for the treatment of an inflammatory condition or cancers.

公开(公告)号：US20190071686A1

公开(公告)日：2019-03-07

申请号：US16107593

申请日：2018-08-21

申请人： VIB VZW ,  Universiteit Gent ,  Universiteit Leiden

发明人： Alain Goossens ,  Jan Mertens ,  Alex Van Moerkercke ,  Jacob Pollier ,  Johan Memelink

IPC分类号： C12N15/82 ,  C07K14/415

摘要： This disclosure relates to the field of secondary metabolite production in plants. More specifically, the disclosure relates to chimeric genes and their use in the regulation of biosynthesis and/or production of secondary metabolites in plants and plant-derived cell cultures.

公开(公告)号：US20180179653A1

公开(公告)日：2018-06-28

申请号：US15613613

申请日：2017-06-05

申请人： UNIVERSITEIT LEIDEN

发明人： Alexei YANSON ,  Marcus KOPER ,  Paramaconi RODRIGUEZ ,  Nuria GARCIA-ARAEZ

IPC分类号： C25D1/00 ,  C25C5/02 ,  C25C5/00 ,  B01J23/40 ,  B01J23/46 ,  C09D11/52 ,  C02F1/72 ,  B82Y40/00 ,  B82Y30/00 ,  B23K35/26 ,  B23K35/02 ,  B01J37/34 ,  B01J35/00 ,  B01J23/89 ,  B01D53/94

CPC分类号： C25D1/006 ,  B01D53/94 ,  B01J23/40 ,  B01J23/462 ,  B01J23/464 ,  B01J23/468 ,  B01J23/89 ,  B01J35/00 ,  B01J35/0013 ,  B01J35/006 ,  B01J37/348 ,  B22F2998/00 ,  B23K35/025 ,  B23K35/262 ,  B82Y30/00 ,  B82Y40/00 ,  C02F1/725 ,  C09D11/52 ,  C25C5/00 ,  C25C5/02 ,  Y02W10/37 ,  B22F1/0018

摘要： The invention is directed to a process to prepare metal nanoparticles or metal oxide nanoparticles by applying a cathodic potential as an alternating current (ac) voltage to a solid starting metal object which solid metal object is in contact with a liquid electrolyte comprising a stabilising cation. The invention is also directed to the use of the nanoparticles as a catalyst.

公开(公告)号：US20170009249A1

公开(公告)日：2017-01-12

申请号：US15119681

申请日：2015-02-18

申请人： VIB VZW ,  Universiteit Gent ,  Universiteit Leiden

发明人： Alain GOOSSENS ,  Jan MERTENS ,  Alex van MOERKERCKE ,  Jacob POLLIER ,  Johan MEMELINK

IPC分类号： C12N15/82 ,  C07K14/415

CPC分类号： C12N15/8243 ,  C07K14/415

摘要： This disclosure relates to the field of secondary metabolite production in plants. More specifically, the disclosure relates to chimeric genes and their use in the regulation of biosynthesis and/or production of secondary metabolites in plants and plant-derived cell cultures.

摘要翻译： 本公开涉及植物中次生代谢产物的生产领域。 更具体地，本公开涉及嵌合基因及其在调节植物和植物来源的细胞培养物中次生代谢物的生物合成和/或生产中的用途。

公开(公告)号：US09174215B2

公开(公告)日：2015-11-03

申请号：US13147070

申请日：2010-01-29

申请人： Paul Vulto ,  Gerald Urban ,  Susann Podszun

发明人： Paul Vulto ,  Gerald Urban ,  Susann Podszun

IPC分类号： F15C1/08 ,  B01L3/00

CPC分类号： B01L3/502707 ,  B01L3/502723 ,  B01L3/502738 ,  B01L3/502746 ,  B01L3/502784 ,  B01L2200/0621 ,  B01L2200/0642 ,  B01L2300/0816 ,  B01L2300/0851 ,  B01L2300/087 ,  B01L2300/0874 ,  B01L2300/089 ,  B01L2300/161 ,  B01L2400/0406 ,  B01L2400/0605 ,  B01L2400/0688 ,  B01L2400/082 ,  B01L2400/086 ,  B01L2400/088 ,  Y10T137/8593

摘要： The present invention relates to phaseguide patterns for use in fluid systems such as channels, chambers, and flow through cells. In order to effectively control filling and/or emptying of fluidic chambers and channels, techniques for a controlled overflowing of phaseguides are proposed. In addition, techniques of confined liquid patterning in a larger fluidic structure, including approaches for patterning overflow structures and the specific shape of phaseguides, are provided. The invention also proposes techniques to effectively rotate the advancement of a liquid/air meniscus over a certain angle. In particular, a phaseguide pattern for guiding a flow of a liquid contained within a compartment is provided, wherein an overflow of the phaseguide by a moving liquid phase is controlled by a local change in capillary force along the phaseguide, wherein said overflow by the liquid over the phaseguide is provoked at the position of the local change in capillary force.

摘要翻译： 本发明涉及用于流体系统（例如通道，室和流通池）中的相位导图。 为了有效地控制流体室和通道的填充和/或排空，提出了用于受控溢流的相位导引的技术。 此外，还提供了在更大的流体结构中的限制液体图案化技术，包括图案化溢出结构的方法和相位导体的具体形状。 本发明还提出了在一定角度上有效地旋转液体/空气弯液面的推进的技术。 特别地，提供了用于引导容纳在隔间内的液体的流动的相位指示图案，其中通过移动液相的相位导向器的溢流通过沿着相位导管的毛细管力的局部变化来控制，其中所述液体溢出 在该位置上引发了相位导致毛细血管力变化的位置。