公开(公告)号：US20240247024A1

公开(公告)日：2024-07-25

申请号：US18553278

申请日：2022-03-30

Applicant: UNIVERSITEIT LEIDEN

Inventor： Nathaniel I. Martin ,  Yonghzi Gao ,  Matthijs Van Haren ,  Ned Buijs ,  Richard Bramwell Parsons ,  Monica Emanuelli ,  Davide Sartini

IPC: C07H19/173 ,  A61K31/7076 ,  A61P35/00

CPC classification number: C07H19/173 ,  A61K31/7076 ,  A61P35/00

Abstract: This invention relates to compounds that are useful as inhibitors, in particular as inhibitors of Nicotinamide N-methyltransferase (NNMT), and formulations composing such compounds. The compounds and formulations may be used as a medicament, for example in the treatment of cancer, metabolic disease, or neurodegenerative disease. The compounds may be of formula (I).