公开(公告)号：US20240247024A1

公开(公告)日：2024-07-25

申请号：US18553278

申请日：2022-03-30

Applicant: UNIVERSITEIT LEIDEN

Inventor： Nathaniel I. Martin ,  Yonghzi Gao ,  Matthijs Van Haren ,  Ned Buijs ,  Richard Bramwell Parsons ,  Monica Emanuelli ,  Davide Sartini

IPC: C07H19/173 ,  A61K31/7076 ,  A61P35/00

CPC classification number: C07H19/173 ,  A61K31/7076 ,  A61P35/00

Abstract: This invention relates to compounds that are useful as inhibitors, in particular as inhibitors of Nicotinamide N-methyltransferase (NNMT), and formulations composing such compounds. The compounds and formulations may be used as a medicament, for example in the treatment of cancer, metabolic disease, or neurodegenerative disease. The compounds may be of formula (I).

公开(公告)号：US20230174584A1

公开(公告)日：2023-06-08

申请号：US17761376

申请日：2020-09-24

Applicant: UNIVERSITEIT LEIDEN

Inventor： Nathaniel I. Martin ,  Emma Van Groesen ,  Kamaleddin H.M.E. Tehrani ,  Nicola Wade

IPC: C07K9/00 ,  A61P31/04

CPC classification number: C07K9/008 ,  A61P31/04 ,  A61K38/00

Abstract: Provided herein are lipidated glycopeptide compounds of formula (I); or a pharmaceutically acceptable salt, stereoisomer, solvate, or prodrug thereof. R1 is a lipid, R2 is —H or a lipid, and R3 and R4 are as defined herein. These compounds have antibiotic activity. Also provided are formulations comprising such compounds; as well as such compounds or formulations for use as a medicament. The compounds and formulations may also be used in the treatment of bacterial infection.