公开(公告)号：US10964075B2

公开(公告)日：2021-03-30

申请号：US15294737

申请日：2016-10-16

Applicant: Spectrum Dynamics LLC

Inventor： Omer Ziv ,  Ran Ravhon ,  Eli Dichterman ,  Leonid Gluhovsky ,  Shlomo Ben-Haim ,  Benny Rousso

IPC: G06T11/00 ,  A61B6/03 ,  G01T1/161 ,  G01T1/24 ,  G06T7/62 ,  A61B5/055 ,  A61B5/00 ,  A61B6/00 ,  A61B8/13 ,  A61B8/08 ,  G01T1/164 ,  G06T7/00

Abstract: A method for reconstructing a radioactive emission image of an overall volume having first and second volumetric regions, each volumetric region having respectively independent dynamic characteristics. The method comprises the following steps: a) obtaining radioactive emissions from the overall volume, including the volumetric regions, b) reconstructing an initial radioactive emission image of the volumetric region according to the radioactive emissions, c) segmenting the initial radioactive emission image to delineate the first and second volumetric regions, and d) separately reconstructing the first and the second volumetric regions according to the respectively independent dynamic characteristics.

公开(公告)号：US09470801B2

公开(公告)日：2016-10-18

申请号：US12087150

申请日：2006-12-28

Applicant: Omer Ziv ,  Ran Ravhon ,  Eli Dichterman ,  Leonid Gluhovsky ,  Shlomo Ben-Haim ,  Benny Rousso

Inventor： Omer Ziv ,  Ran Ravhon ,  Eli Dichterman ,  Leonid Gluhovsky ,  Shlomo Ben-Haim ,  Benny Rousso

IPC: G01T1/164 ,  A61B5/055 ,  A61B5/00 ,  A61B6/03 ,  G06T11/00 ,  A61B6/00 ,  A61B8/08 ,  A61B8/00

CPC classification number: G01T1/1644 ,  A61B5/055 ,  A61B5/415 ,  A61B5/416 ,  A61B5/418 ,  A61B5/7285 ,  A61B6/037 ,  A61B6/503 ,  A61B6/541 ,  A61B8/0883 ,  A61B8/543 ,  G01T1/1663 ,  G06T11/005 ,  G06T11/006 ,  G06T11/008 ,  G06T2207/10104 ,  G06T2207/30048 ,  G06T2211/436

Abstract: A method for reconstructing a radioactive emission image of an overall volume having first and second volumetric regions, each volumetric region having respectively independent dynamic characteristics. The method comprises the following steps: a) obtaining radioactive emissions from the overall volume, including the volumetric regions, b) reconstructing an initial radioactive emission image of the volumetric region according to the radioactive emissions, c) segmenting the initial radioactive emission image to delineate the first and second volumetric regions, and d) separately reconstructing the first and the second volumetric regions according to the respectively independent dynamic characteristics.

Abstract translation: 一种用于重建具有第一和第二体积区域的总体积的放射性发射图像的方法，每个体积区域具有分别独立的动态特性。 该方法包括以下步骤：a）从总体积（包括体积区域）获得放射性发射，b）根据放射性发射重建体积区域的初始放射性发射图像，c）分割初始放射性发射图像以描绘 第一和第二体积区域，以及d）根据分别独立的动态特性分别重建第一和第二体积区域。

公开(公告)号：US08571881B2

公开(公告)日：2013-10-29

申请号：US11750057

申请日：2007-05-17

Applicant: Benny Rousso ,  Shlomo Ben-Haim ,  Haim Melman ,  Zohar Bronshtine ,  Yoel Zilberstien ,  Michael Nagler ,  Dalia Dickman ,  Einav Omer

Inventor： Benny Rousso ,  Shlomo Ben-Haim ,  Haim Melman ,  Zohar Bronshtine ,  Yoel Zilberstien ,  Michael Nagler ,  Dalia Dickman ,  Einav Omer

IPC: G06Q10/00

CPC classification number: A61B5/417 ,  A61B6/037 ,  A61M5/007 ,  A61M5/1452 ,  A61M5/1782 ,  A61M5/1785 ,  A61M5/31511 ,  A61M2205/3576 ,  A61M2205/6054 ,  A61M2205/6072 ,  B65B3/003 ,  G06F19/00 ,  G06F19/3468

Abstract: Apparatus is provided for use with at least one labeled radiopharmaceutical agent, the apparatus including a container (22) containing the at least one labeled radiopharmaceutical agent, and a portable computer-communicatable data carrier (120, 24) associated with the container (22), the data carrier (120, 24) containing imaging protocol information for use with the at least one labeled radiopharmaceutical agent. Other embodiments are also described.

Abstract translation: 提供了与至少一种标记的放射性药剂一起使用的装置，该装置包括容纳至少一个标记的放射性药剂的容器（22）和与容器（22）相关联的便携式计算机可通信数据载体（120,24） ，所述数据载体（120,24）包含与所述至少一种标记的放射性药剂一起使用的成像协议信息。 还描述了其它实施例。

公开(公告)号：US08280124B2

公开(公告)日：2012-10-02

申请号：US11628074

申请日：2005-06-01

Applicant: Eli Dichterman ,  Ran Ravhon ,  Michael Nagler

Inventor： Eli Dichterman ,  Ran Ravhon ,  Michael Nagler

IPC: G06K9/00

CPC classification number: G01T1/1644 ,  A61B6/4258

Abstract: A method is described for identifying an optimal, or preferred set of views for radioactive-emission measurements of a body structure, based on modeling the body structure, in terms of its geometry and radioactive emission distribution, obtaining different sets of views of the model, and scoring the different sets of views, with a scoring function, using information theoretic measures, for example, for uniformity, reliability and separability in reconstruction.The preferred set of views may then be applied in imaging the in-vivo body structure, that has been modeled.

Abstract translation: 描述了一种方法，用于基于对其身体结构的几何形状和放射性排放分布的建模来获得身体结构的放射性发射测量的最佳或优选视图集，以获得模型的不同视图集， 并利用评分函数对不同的观点进行评分，使用信息理论测量，例如重建中的均匀性，可靠性和可分离性。 然后可以将优选的一组视图应用于已经被建模的体内体结构的成像。

公开(公告)号：US08036731B2

公开(公告)日：2011-10-11

申请号：US10616301

申请日：2003-07-10

Applicant: Yoav Kimchy ,  Roni Amrami ,  Yona Bouskila ,  Udi Antebi ,  Nick Sidorenko ,  Gal Ben-David ,  Yoel Zilberstein

Inventor： Yoav Kimchy ,  Roni Amrami ,  Yona Bouskila ,  Udi Antebi ,  Nick Sidorenko ,  Gal Ben-David ,  Yoel Zilberstein

IPC: A61B6/00

CPC classification number: A61B1/041 ,  A61B5/06 ,  A61B5/062 ,  A61B5/067 ,  A61B5/073 ,  A61B5/415 ,  A61B6/425 ,  A61B6/4258 ,  A61B6/4423 ,  A61B6/5235 ,  A61B8/00 ,  A61B8/0833 ,  A61B8/4444 ,  A61B8/4472 ,  A61B8/5238 ,  A61B2090/378 ,  A61N7/02

Abstract: An ingestible device, adapted to travel in the gastrointestinal tract and perform a diagnostic image of tissue therein, is provided. The diagnostic image may comprise diagnostic information as a function of time, or diagnostic information as a function of distance traveled within the gastrointestinal tract. An imaging method by depth calculations is provided, based on the attenuation of photons of different energies, which are emitted from the same source, coupled with position monitoring.

Abstract translation: 提供适于在胃肠道中行进并执行其中的组织的诊断图像的可摄取装置。 诊断图像可以包括作为时间的函数的诊断信息，或者诊断信息作为在胃肠道内行进的距离的函数。 基于从相同源发射的不同能量的光子的衰减，结合位置监测，提供了通过深度计算的成像方法。

公开(公告)号：US07968851B2

公开(公告)日：2011-06-28

申请号：US12728383

申请日：2010-03-22

Applicant: Benny Rousso ,  Omer Ziv ,  Michael Nagler ,  Shlomo Ben-Haim

Inventor： Benny Rousso ,  Omer Ziv ,  Michael Nagler ,  Shlomo Ben-Haim

IPC: H01L27/146

CPC classification number: G06T11/006 ,  A61B5/055 ,  A61B5/7289 ,  A61B6/032 ,  A61B6/037 ,  A61B6/503 ,  A61B6/5288 ,  A61B8/13 ,  A61B8/5284 ,  G01T1/161 ,  G01T1/1644 ,  G01T1/243 ,  G01T1/247 ,  G01T1/249 ,  G06T7/0012 ,  G06T7/62 ,  G06T2207/10088 ,  G06T2207/10108 ,  G06T2207/10116 ,  G06T2207/10132 ,  G06T2207/10136 ,  G06T2207/30048

Abstract: A method of reconstruction of a radioactive emission image. The method comprises providing a first system of voxels for a region of interest, obtaining radioactive-emission data from the region of interest, performing a first reconstruction, based on the radioactive-emission data and the first system of voxels, to obtain a first image, correcting the first system of voxels, by aligning voxel boundaries with object boundaries, based on the first image; thus obtaining a second system of voxels, and performing a second reconstruction, based on the radioactive-emission data and the second system of voxels, thus obtaining a second image.

Abstract translation: 一种重建放射性发射图像的方法。 该方法包括提供用于感兴趣区域的体素的第一系统，从感兴趣区域获得放射性发射数据，基于放射性发射数据和第一体素体素执行第一重建，以获得第一图像 基于第一个图像，通过将体素边界与对象边界对齐来校正体素的第一系统; 从而获得体素的第二系统，并且基于放射性发射数据和第二体素体系执行第二重建，从而获得第二图像。

公开(公告)号：US07838838B2

公开(公告)日：2010-11-23

申请号：US12561751

申请日：2009-09-17

Applicant: Benny Rousso ,  Shlomo Ben-Haim ,  Haim Melman ,  Michael Nagler ,  Yoel Zilberstien ,  Sajed Haj-Yahya

Inventor： Benny Rousso ,  Shlomo Ben-Haim ,  Haim Melman ,  Michael Nagler ,  Yoel Zilberstien ,  Sajed Haj-Yahya

IPC: G01T1/00

CPC classification number: G01T1/1648

Abstract: An imaging system is provided for radioimaging a region of interest (ROI) of a subject. The system includes a housing, a support structure, which is movably coupled to the housing, and at least one motor assembly, coupled to the housing and the support structure, and configured to move the support structure with respect to the housing. The system also includes at least two detector assemblies, fixed to the support structure, and comprising respective radiation detectors and angular orientators. A control unit drives the motor assembly to position the support structure in a plurality of positions with respect to the housing, and, while the support structure is positioned in each of the plurality of positions, drives the orientators to orient the respective detectors in a plurality of rotational orientations with respect to the ROI, and to detect radiation from the ROI at the rotational orientations. Other embodiments are also described.

Abstract translation: 提供了一种用于对受试者的感兴趣区域（ROI）进行放射成像的成像系统。 该系统包括壳体，可移动地联接到壳体的支撑结构，以及联接到壳体和支撑结构并且被配置为使支撑结构相对于壳体移动的至少一个马达组件。 该系统还包括固定到支撑结构的至少两个检测器组件，并且包括相应的辐射检测器和角定向器。 控制单元驱动马达组件以将支撑结构定位在相对于壳体的多个位置中，并且当支撑结构位于多个位置中的每一个位置时，驱动取向器以将各个检测器定向成多个 相对于ROI的旋转取向，并且以旋转取向检测来自ROI的辐射。 还描述了其它实施例。

公开(公告)号：US07826889B2

公开(公告)日：2010-11-02

申请号：US09727464

申请日：2000-12-04

Applicant: Gal Ben David ,  Yoel Zilberstien ,  Yoav Kimchy ,  Roni Amrani

Inventor： Gal Ben David ,  Yoel Zilberstien ,  Yoav Kimchy ,  Roni Amrani

IPC: A61B6/00

CPC classification number: A61B6/4258 ,  A61B34/20 ,  A61B90/361 ,  A61B90/39 ,  A61B2017/00079 ,  A61B2034/105 ,  A61B2034/2051 ,  A61B2034/2055 ,  A61B2090/378 ,  A61B2090/392

Abstract: a system for calculating a position of a radioactivity emitting source in a system-of-coordinates, the system comprising (a) a radioactive emission detector; (b) a position tracking system being connected to and/or communicating with the radioactive emission detector; and (c) a data processor being designed and configured for receiving data inputs from the position tracking system and from the radioactive emission detector and for calculating the position of the radioactivity emitting source in the system-of-coordinates.

Abstract translation: 用于计算坐标系中的放射性发射源的位置的系统，所述系统包括（a）放射性发射检测器; （b）与放射性发射检测器连接和/或与其通信的位置跟踪系统; 和（c）数据处理器被设计和配置用于从位置跟踪系统和放射性发射检测器接收数据输入，并用于计算放射性发射源在坐标系中的位置。

公开(公告)号：US20090304582A1

公开(公告)日：2009-12-10

申请号：US11989223

申请日：2006-07-19

Applicant: Benny Rousso ,  Dalia Dickman ,  Yael Nir ,  Michael Nagler ,  Zohar Bronshtine ,  Shankar Vallabhajosula ,  Shlomo Ben-Haim ,  Simona Ben-Haim

Inventor： Benny Rousso ,  Dalia Dickman ,  Yael Nir ,  Michael Nagler ,  Zohar Bronshtine ,  Shankar Vallabhajosula ,  Shlomo Ben-Haim ,  Simona Ben-Haim

IPC: A61K51/02 ,  A61K51/04

CPC classification number: A61B5/02755 ,  A61B5/06 ,  A61B5/4064 ,  A61B5/4076 ,  A61B5/4088 ,  A61B5/411 ,  A61B5/415 ,  A61B5/417 ,  A61B5/418 ,  A61B5/4519 ,  A61B6/037 ,  A61B6/4057 ,  A61B6/4258 ,  A61B6/4291 ,  A61B6/4488 ,  A61B6/501 ,  A61B6/502 ,  A61B6/503 ,  A61B6/504 ,  A61B6/507 ,  A61B6/5247 ,  A61B6/583 ,  A61B8/0891 ,  A61B8/4416 ,  A61K51/02 ,  A61K51/04 ,  A61K51/0402 ,  A61K51/0476 ,  A61K51/0478 ,  A61K51/048 ,  A61K51/0489 ,  A61K51/0491 ,  A61K51/1203

Abstract: Protocols for radioimaging an event or disorder are provided. An exemplary protocol comprises a method of radioimaging a myocardial perfusion, the method comprising in sequence: (a) administering to a subject about 3 mCi Tl201 thallous chloride; (b) allowing said subject to rest; (c) radioimaging a heart of said subject; (d) subjecting said subject to a physical stress; (e) administering to said subject at a peak of said physical stress about 20-30 mCi Tc99m sestamibi; and (f) radioimaging said heart of said subject, thereby radioimaging a myocardial perfusion.

Abstract translation: 提供用于放射成像事件或障碍的协议。 示例性方案包括放射成像心肌灌注的方法，该方法依次包括：（a）向受试者施用约3mCi Tl201硫酸氯化物; （b）允许所述受试者休息; （c）对所述受试者的心脏进行放射成像; （d）使所述受试者受到身体压力; （e）在所述身体应激的峰值处施用约20-30mCi Tc99m sestamibi的所述受试者; 和（f）对所述受试者的所述心脏进行放射成像，从而放射成像心肌灌注。

公开(公告)号：US07601966B2

公开(公告)日：2009-10-13

申请号：US11769826

申请日：2007-06-28

Applicant: Shlomo Ben-Haim ,  Haim Melman ,  Michael Nagler ,  Benny Rousso ,  Yoel Zilberstien ,  Sajed Haj-Yahya

Inventor： Shlomo Ben-Haim ,  Haim Melman ,  Michael Nagler ,  Benny Rousso ,  Yoel Zilberstien ,  Sajed Haj-Yahya

IPC: G01T1/00

CPC classification number: G01T1/1648

Abstract: An imaging system is provided for radioimaging a region of interest (ROI) of a subject. The system includes a housing, a support structure, which is movably coupled to the housing, and at least one motor assembly, coupled to the housing and the support structure, and configured to move the support structure with respect to the housing. The system also includes at least two detector assemblies, fixed to the support structure, and comprising respective radiation detectors and angular orientators. A control unit drives the motor assembly to position the support structure in a plurality of positions with respect to the housing, and, while the support structure is positioned in each of the plurality of positions, drives the orientators to orient the respective detectors in a plurality of rotational orientations with respect to the ROI, and to detect radiation from the ROI at the rotational orientations. Other embodiments are also described.

Abstract translation: 提供了一种用于对受试者的感兴趣区域（ROI）进行放射成像的成像系统。 该系统包括壳体，可移动地联接到壳体的支撑结构，以及联接到壳体和支撑结构并且被配置为使支撑结构相对于壳体移动的至少一个马达组件。 该系统还包括固定到支撑结构的至少两个检测器组件，并且包括相应的辐射检测器和角定向器。 控制单元驱动马达组件以将支撑结构定位在相对于壳体的多个位置中，并且当支撑结构位于多个位置中的每一个位置时，驱动取向器以将各个检测器定向成多个 相对于ROI的旋转取向，并且以旋转取向检测来自ROI的辐射。 还描述了其它实施例。