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    Methods and devices for intradermal injection
    1.
    发明授权
    Methods and devices for intradermal injection 有权
    用于皮内注射的方法和装置

    公开(公告)号：US08556861B2

    公开(公告)日：2013-10-15

    申请号：US12597103

    申请日：2008-04-23

    Applicant: Izrail Tsals

    Inventor： Izrail Tsals

    IPC: A61M5/00

    CPC classification number: A61M5/46 ,  A61M5/3243 ,  A61M5/3271 ,  A61M5/3287 ,  A61M5/425 ,  A61M2005/3247

    Abstract: Devices and methods for intradermal (ID) administration of diagnostic and therapeutic agents, vaccines and other compounds into the dermal layer of the skin are disclosed. The devices and the methods simplify the ID injection process and increase the consistency of the placement of the needle tip in the dermal space close to the skin surface allowing for a shallow cannula placement in the dermis. Furthermore, the devices and methods broaden the number of sites suitable for ID injection and make the ID injection possible with limited training.

    Abstract translation: 公开了将皮肤（ID）给予皮肤真皮层中的诊断和治疗剂，疫苗和其它化合物的装置和方法。 装置和方法简化了ID注射过程，并且增加了针尖靠近皮肤表面的皮肤空间中的放置位置的一致性，从而允许在真皮中放置浅插管。 此外，设备和方法扩大了适用于ID注入的站点数量，并且可以通过有限的培训进行ID注入。

    Microbicidal compositions and methods and use
    2.
    发明申请
    Microbicidal compositions and methods and use 审中-公开
    杀菌组合物及方法及用途

    公开(公告)号：US20050037033A1

    公开(公告)日：2005-02-17

    申请号：US10850456

    申请日：2004-05-21

    Applicant: Florence Camus-Bablon ,  Lourens Zaneveld ,  Donald Waller

    Inventor： Florence Camus-Bablon ,  Lourens Zaneveld ,  Donald Waller

    IPC: A61F13/15 ,  A61F13/20 ,  A61K9/00 ,  A61K31/44

    CPC classification number: A61K9/0034 ,  A61F13/202 ,  A61F2013/8414

    Abstract: The present invention is directed to microbicidal compositions containing a microbicidal formulation or agent and methods of use thereof for preventing the transmission of or treating sexually transmitted infections and/or common vaginal infections, while minimizing disruptions to vaginal ecology and epithelium. In a preferred embodiment, the microbicidal formulation or agent is ciclopirox olamine. These compositions are preferably encapsulated in the form of a foam, cream, wash, gel, suppository, ovule, lotion, ointment, film, tablet, foaming tablet, tampon, vaginal spray, or aerosol. Preferably the concentration of microbicidal agent is approximately 0.01% to approximately 50% by weight, more preferably between approximately 0.1% to approximately 28%, and most preferably between approximately 0.5% and approximately 5%.

    Abstract translation: 本发明涉及含有杀微生物制剂或试剂的杀微生物组合物及其用于预防透皮或治疗性传播感染和/或常见阴道感染的方法，同时最小化对阴道生态学和上皮细胞的破坏。 在优选的实施方案中，杀微生物制剂或试剂是环吡咯胺。 这些组合物优选以泡沫，乳膏，洗涤剂，凝胶剂，栓剂，胚珠，洗剂，软膏，薄膜，片剂，发泡片剂，卫生棉条，阴道喷雾剂或气雾剂的形式包封。 优选地，杀微生物剂的浓度为约0.01％至约50％重​​量，更优选约0.1％至约28％，最优选约0.5％至约5％。

    Chemical temperature control
    4.
    发明授权
    Chemical temperature control 有权
    化学温度控制

    公开(公告)号：US08431387B2

    公开(公告)日：2013-04-30

    申请号：US12134965

    申请日：2008-06-06

    Applicant: Paul Donald LaBarre ,  Jay Lewis Gerlach ,  Bernhard Hans Weigl ,  Gonzalo Jose Domingo-Villegas

    Inventor： Paul Donald LaBarre ,  Jay Lewis Gerlach ,  Bernhard Hans Weigl ,  Gonzalo Jose Domingo-Villegas

    IPC: C12M3/00 ,  C12M1/34 ,  C12M1/00 ,  B06B1/00 ,  A61F7/00 ,  A61F7/08 ,  F24J1/00 ,  F24J3/00

    CPC classification number: C12Q1/686 ,  B01L3/5027 ,  B01L3/50273 ,  B01L7/00 ,  B01L7/525 ,  B01L2300/0663 ,  B01L2300/0816 ,  B01L2300/088 ,  B01L2300/1855 ,  B01L2300/1877 ,  B01L2400/0406 ,  B01L2400/0442 ,  B01L2400/0445 ,  B01L2400/0478 ,  B01L2400/0487

    Abstract: Exothermic and/or endothermic chemical reactions in combination with phase change materials can produce output temperature(s) within strict tolerances without requiring expensive and complicated external equipment to generate and maintain an output temperature. Similarly, an exothermic phase change material, which generates heat as a consequence of crystallizing a supercooled liquid, can generate heat at a constant temperature, without requiring expensive and complicated external equipment, as a consequence of the liquid form of the exothermic phase change material being in equilibrium with the solid form of the exothermic phase change material. Numerous biological and chemical processes and/or diagnostic devices require a constant temperature or temperatures for set periods of time. An example completely non-instrumented diagnostic platform based on nucleic acid amplification is described, which is particularly suited for use in developing countries that may not have access to expensive and complicated external equipment.

    Abstract translation: 与相变材料相结合的放热和/或吸热化学反应可以在严格的公差范围内产生输出温度，而不需要昂贵和复杂的外部设备来产生和保持输出温度。 类似地，作为结晶过冷液体的结果产生热量的放热相变材料可以在恒定温度下产生热量，而不需要昂贵且复杂的外部设备，因为放热相变材料的液体形式是 与固体形式的放热相变材料平衡。 许多生物和化学过程和/或诊断装置需要恒定的温度或温度来设定一段时间。 描述了基于核酸扩增的完全非仪器化诊断平台的示例，其特别适用于可能无法访问昂贵且复杂的外部设备的发展中国家。

    Alignment of a Needle in an Intradermal Injection Device
    6.
    发明申请
    Alignment of a Needle in an Intradermal Injection Device 审中-公开
    针头在皮内注射装置中的对准

    公开(公告)号：US20110224609A1

    公开(公告)日：2011-09-15

    申请号：US13057006

    申请日：2009-12-07

    Applicant: Izrail Tsals ,  Darrell Harvey

    Inventor： Izrail Tsals ,  Darrell Harvey

    IPC: A61M5/46

    CPC classification number: A61M5/3287 ,  A61M5/3216 ,  A61M5/425 ,  A61M5/46

    Abstract: An adapter device (100, 200) for use in combination with a syringe (20) to form an assembly (10) for delivering an intradermal injection. The adapter device comprises a body (110, 210) which is connectable to the syringe. A second primary skin contacting surface (232) is positioned at a distal end (126, 226) of the body. At least one support element (140, 150, 240) is connected to the body. With the assembly in an assembled condition, the at least one support element supports a needle cannula (24) connected to the syringe. The needle cannula is supported by the at least one support element intermediate a base (26) and a tip (28) of the needle cannula. At least a terminal portion of the needle cannula extends axially in a direction substantially parallel to at least a planar portion of the second primary skin contacting surface.

    Abstract translation: 一种用于与注射器（20）组合使用以形成用于输送皮内注射的组件（10）的适配器装置（100,200）。 适配器装置包括可连接到注射器的本体（110,210）。 第二主要皮肤接触表面（232）位于身体的远端（126,226）。 至少一个支撑元件（140,150,240）连接到主体。 在组装在组装状态下，至少一个支撑元件支撑连接到注射器的针插管（24）。 所述针管由所述针插管的基部（26）和尖端（28）中间的所述至少一个支撑元件支撑。 针套管的至少一个末端部分沿与第二主要皮肤接触表面的至少平面部分基本平行的方向轴向延伸。

    Single use disposable syringe
    7.
    发明授权
    Single use disposable syringe 失效
    单次使用一次性注射器

    公开(公告)号：US5000737A

    公开(公告)日：1991-03-19

    申请号：US559394

    申请日：1990-07-26

    Applicant: Michael J. Free ,  Terence R. Ellard

    Inventor： Michael J. Free ,  Terence R. Ellard

    IPC: A61M5/50

    CPC classification number: A61M5/5013 ,  A61M2005/5006 ,  A61M2005/5033

    Abstract: A single use syringe including a mechanical means permitting a single withdrawal of the plunger to load the cylinder an a single advance of the plunger to inject the material, thereafter incapacitating the mechanism. The mechanical means may well be retrofit to existing syringes.

    Abstract translation: 一次性注射器，其包括机械装置，允许单个抽出柱塞以将柱塞装载到柱塞的单个前进部以注入材料，然后使该机构丧失能力。 机械装置可能会改进现有的注射器。

    Chemical Temperature Control
    8.
    发明申请
    Chemical Temperature Control 审中-公开
    化学温度控制

    公开(公告)号：US20140154786A1

    公开(公告)日：2014-06-05

    申请号：US13874060

    申请日：2013-04-30

    Applicant: Program For Appropriate Technology In Health

    Inventor： Paul Donald Labarre ,  Jay Lewis Gerlach ,  Bernhard Hans Weigl ,  Gonzalo Jose Domingo-Villegas

    IPC: C12Q1/68

    CPC classification number: C12Q1/686 ,  B01L3/5027 ,  B01L3/50273 ,  B01L7/00 ,  B01L7/525 ,  B01L2300/0663 ,  B01L2300/0816 ,  B01L2300/088 ,  B01L2300/1855 ,  B01L2300/1877 ,  B01L2400/0406 ,  B01L2400/0442 ,  B01L2400/0445 ,  B01L2400/0478 ,  B01L2400/0487

    Abstract: Exothermic and/or endothermic chemical reactions in combination with phase change materials can produce output temperature(s) within strict tolerances without requiring expensive and complicated external equipment to generate and maintain an output temperature. Similarly, an exothermic phase change material, which generates heat as a consequence of crystallizing a supercooled liquid, can generate heat at a constant temperature, without requiring expensive and complicated external equipment, as a consequence of the liquid form of the exothermic phase change material being in equilibrium with the solid form of the exothermic phase change material. Numerous biological and chemical processes and/or diagnostic devices require a constant temperature or temperatures for set periods of time. An example completely non-instrumented diagnostic platform based on nucleic acid amplification is described, which is particularly suited for use in developing countries that may not have access to expensive and complicated external equipment.

    Abstract translation: 与相变材料相结合的放热和/或吸热化学反应可以在严格的公差范围内产生输出温度，而不需要昂贵和复杂的外部设备来产生和保持输出温度。 类似地，作为结晶过冷液体的结果产生热量的放热相变材料可以在恒定温度下产生热量，而不需要昂贵且复杂的外部设备，因为放热相变材料的液体形式是 与固体形式的放热相变材料平衡。 许多生物和化学过程和/或诊断装置需要恒定的温度或温度来设定一段时间。 描述了基于核酸扩增的完全非仪器化诊断平台的示例，其特别适用于可能无法访问昂贵且复杂的外部设备的发展中国家。

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