公开(公告)号：US20240060901A1

公开(公告)日：2024-02-22

申请号：US18496942

申请日：2023-10-30

申请人： National Chung Hsing University ,  PROTRUSTECH CO., LTD

发明人： Chien-Chung Chang ,  Chun-Ta Huang

IPC分类号： G01N21/65 ,  G01N21/64 ,  B22F1/054

CPC分类号： G01N21/658 ,  G01N21/648 ,  B22F1/0547

摘要： A signal enhancement structure configured to enhance a signal of a specimen is provided. The signal enhancement structure includes a plurality of nanowires stacked in a first direction, a second direction, and a third direction. The nanowires are extended along at least two directions. A particle of the specimen is on the nanowires or in a gap among the nanowires. A manufacturing method of a signal enhancement structure and a measuring method with signal enhancement are also provided.

公开(公告)号：US20230265150A1

公开(公告)日：2023-08-24

申请号：US18122768

申请日：2023-03-17

申请人： NATIONAL CHUNG HSING UNIVERSITY

发明人： Shiow-Her CHIOU ,  Kuan-Chih CHOW ,  Jui-Hung SHIEN ,  Yi-Hsin FAN ,  Pei-Hua LIN ,  Pei-Shan WU

IPC分类号： C07K14/55 ,  C07K14/525 ,  C07K14/52 ,  C07K14/54 ,  C07K14/705 ,  A61K39/39

CPC分类号： C07K14/55 ,  C07K14/525 ,  C07K14/52 ,  C07K14/521 ,  C07K14/522 ,  C07K14/5421 ,  C07K14/70575 ,  A61K39/39 ,  C07K2319/00 ,  A61K2039/55533

摘要： The present invention provides a fusion protein, comprising a chemokine polypeptide, which is a chemokine or a receptor binding domain thereof; and a cytokine polypeptide connected to said chemokine polypeptide, which is an interleukin, a TNF-superfamily cytokine or a receptor-binding domain thereof; wherein the chemokine polypeptide and the cytokine polypeptide have a common target cell, and the fusion protein has an improved chemokine activity as compared to the chemokine polypeptide, and an improved cytokine activity as compared to the cytokine polypeptide.

公开(公告)号：US20220346395A1

公开(公告)日：2022-11-03

申请号：US17535829

申请日：2021-11-26

申请人： National Chung Hsing University

发明人： Chuan-Mu CHEN ,  Hsiao-Ling CHEN

IPC分类号： A23C9/127 ,  A23C9/13 ,  A61P25/24

摘要： The invention discloses that a kefir peptide with an amino acid sequence of SEQ ID No: 2 or a fermentation product comprising the kefir peptide has an antidepressant activity, which means that by administering an effective amount of the kefir peptide or a composition comprising an effective amount of the kefir peptide to an individual with depressive behaviors is capable of effectively improving or alleviating the individual's depressive behaviors. Since the kefir peptide disclosed in the invention is not a chemical compound, the kefir peptide will not have side effects on the human body even taking it on a long-term basis.

公开(公告)号：US20220070406A1

公开(公告)日：2022-03-03

申请号：US17007941

申请日：2020-08-31

申请人： NATIONAL CHUNG HSING UNIVERSITY

发明人： Chun-Nien Liu ,  Tien-Tsorng Shih

IPC分类号： H04N5/74 ,  H04N3/14

摘要： A solid-state optical phase scanning array component is provided, including: a plurality of optical units, each of the optical units including a high dielectric constant layer, and a first electrode and a second electrode located on two sides of the high dielectric constant layer, the refractive index of each high dielectric constant layer being changeable as the power supply condition supplied to first and second electrodes is changed; and a lens unit, being disposed to face toward a light-exiting side of the plurality of optical units, and including a light-incident face and a light-exiting face, being configured to guide light beam incident from the light incident surface to the plurality of optical units to change the path of the light beam, and then the light beam emitting out from the light exiting surface.

公开(公告)号：US11094853B2

公开(公告)日：2021-08-17

申请号：US16857685

申请日：2020-04-24

申请人： NATIONAL CHUNG-HSING UNIVERSITY

发明人： Dong-Sing Wuu ,  Ray-Hua Horng ,  Po-Wei Chen

IPC分类号： H01L33/48 ,  H01L23/00 ,  H01L27/15

摘要： A passive micro light-emitting diode matrix device with uniform luminance includes a micro light-emitting diode matrix including a plurality of micro light-emitting matrices, each of which includes a first layer, a plurality of light-emitting layers disposed on the first layer, a plurality of second layers disposed on the light-emitting layers, respectively, a plurality of first inner electrode layers disposed on the second layers, respectively, and a second inner electrode layer which is disposed on the first layer, and which includes a first portion and a second portion having a plurality of through holes to accommodate said light-emitting layers, respectively.

公开(公告)号：US20200070254A1

公开(公告)日：2020-03-05

申请号：US16536051

申请日：2019-08-08

申请人： NATIONAL CHUNG HSING UNIVERSITY

发明人： JENQ-SHYONG CHEN ,  CHUAN-WU KO ,  HAO-TANG WANG

IPC分类号： B23B33/00 ,  B06B1/02 ,  B06B1/06 ,  B23Q5/10

摘要： A high frequency vibration spindle system with non-contact power transmission and a method for manufacturing a restraining part used therein are disclosed. The high frequency vibration spindle system comprises: a spindle; a toolholder; an electric power transmission device including a first induction module and a second induction module, wherein the second induction module is disposed at the spindle or the toolholder, and the second induction module is adapted to receive an electric power from the first induction module in a non-contact electromagnetic induction manner; a transducer adapted to be controlled to vibrate the tool and being disposed at the toolholder and electrically connected with the second induction module to receive the electric power; and a restraining part located between the first induction module and the second induction module. By the design of the restraining part, the structural strength and stability of the second induction module can be improved, and the maximum rotational speed of the high frequency vibration spindle system can be increased.

公开(公告)号：US10543510B2

公开(公告)日：2020-01-28

申请号：US15613048

申请日：2017-06-02

申请人： NATIONAL CHUNG HSING UNIVERSITY

发明人： Wei-Ping Dow ,  Wei-Yang Zeng ,  Yi-Yung Chen

IPC分类号： B05D7/22 ,  H01L21/02 ,  H01L29/16 ,  H01L29/66 ,  B05D7/24 ,  C09D5/24 ,  C09D7/61 ,  C08G73/02 ,  H05K3/42 ,  C09D1/00 ,  C09D179/02 ,  B05D7/00 ,  C08K3/04

摘要： Non-conductive substrates, especially the sidewalls of micro/nano holes thereof are chemically modified (i.e., chemically grafted) by reduced graphene oxide (rGO). The rGO possesses excellent electrical conductivity and therefore the modified substrates become conductive, so that it can be directly electroplated. These rGO-grafted holes can pass thermal shock reliability test after electroplating. The rGO grafting process possesses many advantages, such as a short process time, no complex agent (i.e., no chelator), no toxic agents (i.e., formaldehyde for electroless Cu deposition). It is employed in an aqueous solution instead of an organic solvent, and therefore is environmentally friendly and beneficial for industrial production.

公开(公告)号：US10517893B2

公开(公告)日：2019-12-31

申请号：US15686184

申请日：2017-08-25

申请人： CHANGHUA CHRISTIAN MEDICAL FOUNDATION CHANGHUA CHRISTIAN HOSPITAL ,  National Chung Hsing University

发明人： Jun-Yen Uan ,  Hung-Ming Wu

IPC分类号： A61K33/26 ,  A61K33/08

摘要： The present invention provides a pharmaceutical composition for treating a patient suffering from or predisposed to hyperphosphatemia, which contains Mg—Fe—Cl HCln. In one embodiment, the Mg—Fe—Cl HCln is shown in formula (I). The phosphorus uptaking capacity of the pharmaceutical composition is greater than 100 ppm/(g/L). The present invention further provides a method for treating a patient suffering from or predisposed to hyperphosphatemia by using said pharmaceutical composition. The present invention further provides a method of manufacturing the pharmaceutical composition.

公开(公告)号：US10000766B2

公开(公告)日：2018-06-19

申请号：US14802614

申请日：2015-07-17

申请人： NATIONAL CHUNG HSING UNIVERSITY

发明人： Shyi-Dong Yeh ,  Ching-Fu Yang ,  Kuan-Chun Chen ,  Ya-Ling Huang

IPC分类号： C12N15/82

CPC分类号： C12N15/8283 ,  C12N15/8218

摘要： Provided is a strategy for generating transgenic plants with concurrent resistance to DNA and RNA viruses at one construction, so as to develop an RNA-directed DNA methylation (RdDM) transgenic system using a hairpin construct of Ageratum yellow vein virus (AYVV) promoter region residing in an intron to resist DNA virus infection by RdDM. Furthermore, the hairpin construct of the AYVV promoter region coupled with an untranslatable nucleocapsid protein (NP) fragment of Melon yellow sport virus (MYSV) is created to induce post-transcriptional gene silencing (PTGS) against MYSV. A method for providing transgenic plants conferring concurrent resistance to both AYVV and MYSV for control of DNA and RNA virus at the same time, and underlying RdDM and PTGS mechanisms, respectively, is also provided.

公开(公告)号：US09142719B2

公开(公告)日：2015-09-22

申请号：US13242414

申请日：2011-09-23

申请人： Dong-Sing Wuu ,  Ray-Hua Horng ,  Wei-Ting Lin

发明人： Dong-Sing Wuu ,  Ray-Hua Horng ,  Wei-Ting Lin

IPC分类号： H01L21/02 ,  H01L33/20 ,  H01L33/00

CPC分类号： H01L33/20 ,  H01L21/0242 ,  H01L21/0243 ,  H01L21/02458 ,  H01L21/0254 ,  H01L33/007

摘要： A patterned substrate for epitaxially forming a light-emitting diode includes: a top surface; a plurality of spaced apart recesses, each of which is indented downwardly from the top surface and each of which is defined by a recess-defining wall, the recess-defining wall having a bottom wall face, and a surrounding wall face that extends from the bottom wall face to the top surface; and a plurality of protrusions, each of which protrudes upwardly from the bottom wall face of the recess-defining wall of a respective one of the recesses. A light-emitting diode having the patterned substrate is also disclosed.

摘要翻译： 用于外延形成发光二极管的图案化衬底包括：顶表面; 多个间隔开的凹部，每个凹槽从顶表面向下凹入，每个凹槽由凹口限定壁限​​定，凹口限定壁具有底壁面和围绕壁面延伸的周围壁面 底壁面向上表面; 以及多个突起，每个突起从相应的一个凹部的凹陷限定壁的底壁面向上突出。 还公开了具有图案化衬底的发光二极管。