- 专利标题： A FUSION PROTEON OF STROMAL CELL-DERIVED FACTOR-1 (SDF-1) AND INTERLEUKIN-2 (IL-2) AND APPLICATIONS THEREOF
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申请号： US18122768申请日： 2023-03-17
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公开(公告)号： US20230265150A1公开(公告)日： 2023-08-24
- 发明人: Shiow-Her CHIOU , Kuan-Chih CHOW , Jui-Hung SHIEN , Yi-Hsin FAN , Pei-Hua LIN , Pei-Shan WU
- 申请人： NATIONAL CHUNG HSING UNIVERSITY
- 申请人地址： TW TAICHUNG CITY
- 专利权人： NATIONAL CHUNG HSING UNIVERSITY
- 当前专利权人： NATIONAL CHUNG HSING UNIVERSITY
- 当前专利权人地址： TW TAICHUNG CITY
- 分案原申请号： US16415143 2019.05.17
- 主分类号： C07K14/55
- IPC分类号： C07K14/55 ; C07K14/525 ; C07K14/52 ; C07K14/54 ; C07K14/705 ; A61K39/39
摘要：
The present invention provides a fusion protein, comprising a chemokine polypeptide, which is a chemokine or a receptor binding domain thereof; and a cytokine polypeptide connected to said chemokine polypeptide, which is an interleukin, a TNF-superfamily cytokine or a receptor-binding domain thereof; wherein the chemokine polypeptide and the cytokine polypeptide have a common target cell, and the fusion protein has an improved chemokine activity as compared to the chemokine polypeptide, and an improved cytokine activity as compared to the cytokine polypeptide.
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