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    NEBULISER OUTLET ASSEMBLY
    1.
    发明公开
    NEBULISER OUTLET ASSEMBLY 审中-公开

    公开(公告)号：US20240363322A1

    公开(公告)日：2024-10-31

    申请号：US18686595

    申请日：2022-08-31

    申请人： Micromass UK Limited

    发明人： Suloke Mathai ,  Ian David Trivett

    IPC分类号： H01J49/04 ,  G01N27/623 ,  H01J49/16

    CPC分类号： H01J49/045 ,  H01J49/167 ,  G01N27/623

    摘要： A nebuliser outlet assembly comprises an inlet end and an outlet end, and a first channel (24) arranged between the inlet end and the outlet end, wherein the first channel is configured to receive a capillary. The nebuliser outlet assembly comprises a first part (40) and one or more second parts (50), wherein the one or more second parts are removably attachable to the first part. The nebuliser outlet assembly is configured such that the first channel is formed from the first part and the one or more second parts when the one or more second parts are attached to the first part. The first part comprises an open-sided channel that corresponds to the first channel for at least some of its length. The nebuliser outlet assembly is configured such that when the one or more second parts are removed from the first part, said open-sided channel is exposed.

    ION ENTRY/EXIT DEVICE
    3.
    发明公开
    ION ENTRY/EXIT DEVICE 审中-公开

    公开(公告)号：US20240355606A1

    公开(公告)日：2024-10-24

    申请号：US18758956

    申请日：2024-06-28

    申请人： Micromass UK Limited

    发明人： Kevin Giles ,  David J. Langridge ,  Jason Lee Wildgoose

    IPC分类号： H01J49/06 ,  G01N27/622 ,  G01N27/623 ,  H01J49/00 ,  H01J49/42 ,  H01J49/40

    CPC分类号： H01J49/062 ,  G01N27/622 ,  G01N27/623 ,  H01J49/0031 ,  H01J49/061 ,  H01J49/422 ,  H01J49/408

    摘要： A method of introducing and ejecting ions from an ion entry/exit device 4 is disclosed. The ion entry/exit device 4 has at least two arrays of electrodes 20,22. The device is operated in a first mode wherein DC potentials are successively applied to successive electrodes of at least one of the electrode arrays 20,22 in a first direction such that a potential barrier moves along the at least one array in the first direction and drives ions into and/or out of the device in the first direction. The device is also operated in a second mode, wherein DC potentials are successively applied to successive electrodes of at least one of the electrode arrays 20,22 in a second, different direction such that a potential barrier moves along the array in the second direction and drives ions into and/or out of the device in the second direction. The device provides a single, relatively simple device for manipulating ions in multiple directions. For example, the device may be used to load ions into or eject ions from an ion mobility separator in a first direction, and may then be used to cause ions to move through the ion mobility separator in the second direction so as to cause the ions to separate.

    Ion entry/exit device
    5.
    发明授权
    Ion entry/exit device 有权

    公开(公告)号：US12051583B2

    公开(公告)日：2024-07-30

    申请号：US18053916

    申请日：2022-11-09

    申请人： Micromass UK Limited

    发明人： Kevin Giles ,  David J. Langridge ,  Jason Lee Wildgoose

    IPC分类号： H01J49/06 ,  G01N27/622 ,  G01N27/623 ,  H01J49/00 ,  H01J49/42 ,  H01J49/40

    CPC分类号： H01J49/062 ,  G01N27/622 ,  G01N27/623 ,  H01J49/0031 ,  H01J49/061 ,  H01J49/422 ,  H01J49/408

    摘要： A method of introducing and ejecting ions from an ion entry/exit device (4) is disclosed. The ion entry/exit device (4) has at least two arrays of electrodes (20,22). The device is operated in a first mode wherein DC potentials are successively applied to successive electrodes of at least one of the electrode arrays ((20,22) in a first direction such that a potential barrier moves along the at least one array in the first direction and drives ions into and/or out of the device in the first direction. The device is also operated in a second mode, wherein DC potentials are successively applied to successive electrodes of at least one of the electrode arrays (20,22) in a second, different direction such that a potential barrier moves along the array in the second direction and drives ions into and/or out of the device in the second direction. The device provides a single, relatively simple device for manipulating ions in multiple directions. For example, the device may be used to load ions into or eject ions from an ion mobility separator in a first direction, and may then be used to cause ions to move through the ion mobility separator in the second direction so as to cause the ions to separate.

    Self-calibration of high resolution mass spectrum
    9.
    发明授权
    Self-calibration of high resolution mass spectrum 有权

    公开(公告)号：US12020918B2

    公开(公告)日：2024-06-25

    申请号：US17435266

    申请日：2020-03-02

    申请人： Micromass UK Limited

    发明人： Boris Kozlov ,  Vasiliy Makarov ,  Keith Richardson

    IPC分类号： H01J49/00 ,  H01J49/40

    CPC分类号： H01J49/0009 ,  H01J49/0036 ,  H01J49/406

    摘要： A method of self-calibrating a mass spectrometer or mass spectral data is disclosed. At least some first observed mass to charge ratios are matched with or against a comprehensive reference set of possible or predicted elemental compositions having known precise mass to charge ratios. One or more calibration parameters of a calibration routine are then adjusted so as to optimise the match between one or more of the first observed mass to charge ratios and the corresponding known precise mass to charge ratios of one or more possible or predicted elemental compositions contained within the reference set.