公开(公告)号：US20230270890A1

公开(公告)日：2023-08-31

申请号：US18073624

申请日：2022-12-02

申请人： BIOACTS CORPORATION

发明人： JIN WOO PARK ,  SU JUNG JANG ,  EUNAE JEONG ,  JIHYUN LEE ,  KIWON KIM ,  EUNSEO YU ,  NURI CHOI ,  GYEONG RIM SHIN

IPC分类号： A61K49/00

CPC分类号： A61K49/0032

摘要： Provided is a fluorescent compound for labeling a biomaterial having the following Chemical Formula 1:




In Chemical Formula 1 above,



X1 and X2 are the same as or different from each other, and each independently selected from H, —SO3− and SO3H,
R1 and R2 are the same as each other or each independently selected from C1-7 alkyl, C8-18 alkyl, —(CH2)mSO3−, —(CH2)mSO3H, and










R3 and R4 are the same as or different from each other and each independently selected from C1-7 alkyl, —(CH2)mCOOZ and










R3 and R4 are simultaneously not any one selected from —(CH2)mCOOZ and

公开(公告)号：US11519017B2

公开(公告)日：2022-12-06

申请号：US16345700

申请日：2018-12-21

申请人： Bioacts Corporation

发明人： Jin Woo Park ,  Jae-Ho Choi ,  Bongkyu Lee ,  Hyoung Su Kim ,  Kiwon Kim ,  Jae-Sung Lee ,  Hyo Sung Jeon ,  Sora Yun

IPC分类号： C12Q1/14 ,  C09B29/02 ,  C09B29/30 ,  C09B29/46 ,  C12Q1/6844 ,  G01N33/84

摘要： Provided is a diagnostic kit for determining infection with Methicillin-Resistant Staphylococcus aureus (MRSA) in a specimen, and a method for determining the infection with MRSA using the diagnostic kit is performed by visually observing a color change after LAMP reaction, and the color change is caused by a change in a magnesium concentration and confirmed using a specific dye compound which sensitively reacts with magnesium ions. The amplification of the MRSA DNA is performed using the loop-mediated isothermal amplification (LAMP), so that the diagnostic kit has advantages of being conveniently used anytime and anywhere and quickly diagnosing.

公开(公告)号：US20210355521A1

公开(公告)日：2021-11-18

申请号：US16345700

申请日：2018-12-21

申请人： Bioacts Corporation

发明人： Jin Woo PARK ,  Jae-Ho CHOI ,  Bongkyu LEE ,  Hyoung Su KIM ,  Kiwon KIM ,  Jae-Sung LEE ,  Hyo Sung JEON ,  Sora YUN

IPC分类号： C12Q1/14 ,  C09B29/30 ,  C09B29/46 ,  C09B29/02 ,  C12Q1/6844 ,  G01N33/84

摘要： Provided is a diagnostic kit for determining infection with Methicillin-Resistant Staphylococcus aureus (MRSA) in a specimen, and a method for determining the infection with MRSA using the diagnostic kit is performed by visually observing a color change after LAMP reaction, and the color change is caused by a change in a magnesium concentration and confirmed using a specific dye compound which sensitively reacts with magnesium ions. The amplification of the MRSA DNA is performed using the loop-mediated isothermal amplification (LAMP), so that the diagnostic kit has advantages of being conveniently used anytime and anywhere and quickly diagnosing.

公开(公告)号：US20240058820A1

公开(公告)日：2024-02-22

申请号：US17892055

申请日：2022-08-20

申请人： Bioacts Corporation

发明人： Jin Woo PARK ,  Bong Kyun KIM ,  So Young KIM

IPC分类号： B01L7/00 ,  C12Q1/689

CPC分类号： B01L7/52 ,  C12Q1/689 ,  B01L2200/147 ,  B01L2300/042 ,  B01L2300/1805 ,  B01L2300/1883

摘要： Provided is a portable isothermal amplification device for amplifying a nucleic acid using an isothermal amplification method, the device comprising: a tube insertion part into which a PCR tube is to be inserted, which is provided in an upper portion of the portable isothermal amplification device; a cover for covering the tube insertion part; a storage space for accommodating a heating device and a storage space cover for blocking the storage space from an outside, which is provided in a lower portion of the portable isothermal amplification device; and a heat insulator for blocking heat from the outside and a heat-sensing sticker capable of measuring a temperature of heat generated by the heating device, which is provided inside the storage space.

公开(公告)号：US11835457B2

公开(公告)日：2023-12-05

申请号：US17151680

申请日：2021-01-19

申请人： Bioacts Corporation

发明人： Jin Woo Park ,  Kiwon Kim ,  HyungJun Yoon ,  Eunae Jeong ,  Hyejin Jin ,  Yoeseph Cho

IPC分类号： G01N21/64 ,  C09K11/06

CPC分类号： G01N21/6428 ,  C09K11/06 ,  C09K2211/1018 ,  G01N2021/6439

摘要： Disclosed is a fluorescent composition for whole blood analysis capable of predicting the diagnosis, treatment and prognosis of diseases through blood analysis. In the case of using the fluorescent composition of exemplary embodiments of the present invention for whole blood analysis, the shape of a target material such as red blood cells and white blood cells may be maintained as it is and non-target biomaterials and the like may be dissolved to increase the sensitivity and affinity to the target and improve the staining efficiency of the blood cell nucleic acids, thereby increasing the fluorescent efficiency. Therefore, more accurate blood cell analysis is possible than conventional techniques, and through this, it is possible to accurately predict not only the diagnosis of the disease, but also the treatment method and prognosis.

公开(公告)号：US20230273192A1

公开(公告)日：2023-08-31

申请号：US18073631

申请日：2022-12-02

申请人： BIOACTS CORPORATION

发明人： JIN WOO PARK ,  KIWON KIM ,  SU JUNG JANG ,  NURI CHOI ,  GYEONG RIM SHIN

IPC分类号： G01N33/533 ,  C07D405/14 ,  C07D405/12 ,  C07D491/153

CPC分类号： G01N33/533 ,  C07D405/12 ,  C07D405/14 ,  C07D491/153

摘要： Provided is a fluorescent compound for detecting a biomaterial having the following Chemical Formula 1:





In Chemical Formula 1 above,

R1 and R5 are the same as or different from each other, and each independently selected from H, —SO3- and SO3H,
R2 and R6 are the same as each other or each independently selected from hydrogen or methyl
R4 and R8 are the same as or different from each other, and each independently selected from H, —SO3- and (CH2)SO3H,
R3 and R4 can form alkylene chain with arbituary-substituted 3 carbons combined with the nitrogen atom attached with R3,
R7 and R8 can form alkylene chain with arbituary-substituted 3 carbons combined with the nitrogen atom attached with R7,
when R8 and R8 do not form alkylene chain, R6, R7 and R8 are hydrogen at the same time and the nitrogen atom attached with R6 and R7 at the same time forms double bond with the carbon of mother molecule and has positive charge.

公开(公告)号：US12061203B2

公开(公告)日：2024-08-13

申请号：US17536035

申请日：2021-11-28

申请人： Bioacts Corporation

发明人： Jin Woo Park ,  Kiwon Kim ,  Gyeong Rim Shin ,  Eunseo Yu

IPC分类号： C09B23/06 ,  C09B23/08 ,  C09B23/10 ,  G01N33/58

CPC分类号： G01N33/582 ,  C09B23/06 ,  C09B23/083 ,  C09B23/107

摘要： A fluorescent compound in accordance with exemplary embodiments of the present invention has high stability under a water-soluble condition to be easily stored for a long time and improve pH stability and can be more efficiently used for labeling and dyeing of a target material by introducing the triazine substituted with a hydroxyl group as a linker to improve the fluorescent intensity even at a low concentration as compared with the conventional structure. Further, the fluorescent compound is excellent in optical stability and exhibits stable fluorescence in long-term dyeing, and is excellent in fluorescence intensity while being not accumulated in the body, and thus, can be easily dyed and imaged in vivo even in the use of a small amount as compared with the conventional dyes to be economically used.

公开(公告)号：US20240201177A1

公开(公告)日：2024-06-20

申请号：US18073644

申请日：2022-12-02

申请人： BIOACTS CORPORATION

发明人： JIN WOO PARK ,  KIWON KIM ,  SU JUNG JANG ,  MINA KIM

IPC分类号： G01N33/533 ,  C07D403/14

CPC分类号： G01N33/533 ,  C07D403/14

摘要： Provided is a fluorescent compound for labeling a biomaterial having the following Chemical Formula 1:




In Chemical Formula 1 above,



n is an integer of 1 to 6,
X1 and X2 are the same as or different from each other, and each independently selected from H, —SO3− and —SO3H,
R1 and R2 are the same as each other or each independently selected from C1-7 alkyl, substituted or unsubstituted C8-20 alkyl, —(CH2)m1SO3−, —(CH2)m2SO3H, and










m1 is an integer of 1 to 7,
m2 is an integer of 1 to 7,
p1 is an integer of 1 to 10,
q1 is an integer of 0 to 10,
r1 is an integer of 1 to 10, and

Y1 is selected from H, —OH, halogen and











o1 is an integer of 1 to 10.

公开(公告)号：US11667961B2

公开(公告)日：2023-06-06

申请号：US17128012

申请日：2020-12-19

申请人： Bioacts Corporation

发明人： Jin Woo Park ,  Ho Young Si ,  Eunae Jeong ,  Hyung Jun Yoon ,  Su Jung Jang

IPC分类号： C12Q1/68 ,  C09B23/06 ,  C12Q1/6848 ,  C12Q1/686 ,  G01N33/58

CPC分类号： C12Q1/6848 ,  C09B23/06 ,  C12Q1/686 ,  G01N33/582

摘要： The novel intercalating fluorescent compounds of exemplary embodiments of the present invention for analyzing nucleic acids, etc. have excellent intercalating efficiency with nucleic acids such as DNA and RNA of biomaterials, and may not only continuously maintain fluorescence properties and efficiency, but also have excellent effects even in terms of storage stability such as temperature and moisture, etc. and biosafety. In addition, the fluorescent compounds have various advantages capable of being dissolved in distilled water, which is a solvent harmless to the human body, and being applied to a wide range of analysis without being limited to the analysis of specific cells and living tissues.

公开(公告)号：US20210198729A1

公开(公告)日：2021-07-01

申请号：US17128012

申请日：2020-12-19

申请人： Bioacts Corporation

发明人： Jin Woo PARK ,  Ho Young SI ,  Eunae JEONG ,  Hyung Jun YOON ,  Su Jung JANG

IPC分类号： C12Q1/6848 ,  C09B23/06 ,  C12Q1/686 ,  G01N33/58

摘要： The novel intercalating fluorescent compounds of exemplary embodiments of the present invention for analyzing nucleic acids, etc. have excellent intercalating efficiency with nucleic acids such as DNA and RNA of biomaterials, and may not only continuously maintain fluorescence properties and efficiency, but also have excellent effects even in terms of storage stability such as temperature and moisture, etc. and biosafety. In addition, the fluorescent compounds have various advantages capable of being dissolved in distilled water, which is a solvent harmless to the human body, and being applied to a wide range of analysis without being limited to the analysis of specific cells and living tissues.