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公开(公告)号：US20140357665A1
公开(公告)日：2014-12-04
申请号：US14361348
申请日：2012-11-27
IPC分类号： C07D217/26
CPC分类号： A61K31/472 , C07D217/06 , C07D217/26
摘要： Compounds are disclosed that are useful for treating ophthalmic conditions caused by or related to production of toxic visual cycle products that accumulate in the eye, such as dry adult macular degeneration, as well as conditions caused by or related to the misfolding of mutant opsin proteins and/or the mis-localization of opsin proteins. Compositions of these compounds alone or in combination with other therapeutic agents are also described, along with therapeutic methods of using such compounds and/or compositions. Methods of synthesizing such agents are also disclosed.
摘要翻译： 公开的化合物可用于治疗由眼睛中累积的毒性视觉循环产物引起或与其相关的眼部疾病，例如干性成人黄斑变性，以及由突变视蛋白质蛋白质错误折叠引起或与之相关的病症，以及 /或视蛋白蛋白质的错位。 还描述了这些化合物单独或与其它治疗剂组合的组合物，以及使用这些化合物和/或组合物的治疗方法。 还公开了合成这些试剂的方法。
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公开(公告)号：US20170037024A1
公开(公告)日：2017-02-09
申请号：US15204429
申请日：2016-07-07
发明人： David S. Garvey
IPC分类号： C07D333/22 , C07C49/792 , C07C33/50 , C07C49/813 , C07C255/56 , C07D307/46 , C07D333/16 , C07C25/13 , C07C25/06 , C07C33/34 , C07D307/42
CPC分类号： C07D333/22 , A61K31/045 , A61K31/12 , A61K31/277 , C07C25/06 , C07C25/13 , C07C25/18 , C07C33/14 , C07C33/34 , C07C33/50 , C07C43/23 , C07C49/792 , C07C49/813 , C07C49/84 , C07C255/53 , C07C255/56 , C07C259/18 , C07C2601/14 , C07C2601/16 , C07D307/42 , C07D307/46 , C07D333/16
摘要： Compounds are disclosed that are useful for treating ophthalmic conditions caused by or related to production of toxic visual cycle products that accumulate in the eye, such as dry adult macular degeneration, as well as conditions caused by or related to the misfolding of mutant opsin proteins and/or the mis-localization of opsin proteins. Compositions of these compounds alone or in combination with other therapeutic agents are also described, along with therapeutic methods of using such compounds and/or compositions. Methods of synthesizing such agents are also disclosed.
摘要翻译： 公开的化合物可用于治疗由眼睛中累积的毒性视觉循环产物引起或与其相关的眼部疾病，例如干性成人黄斑变性，以及由突变视蛋白质蛋白质错误折叠引起或与之相关的病症，以及 /或视蛋白蛋白质的错位。 还描述了这些化合物单独或与其它治疗剂组合的组合物，以及使用这些化合物和/或组合物的治疗方法。 还公开了合成这些试剂的方法。
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公开(公告)号：US09457004B2
公开(公告)日：2016-10-04
申请号：US14825699
申请日：2015-08-13
发明人： David S. Garvey
IPC分类号： A61K31/277 , C07D333/16 , C07D333/22 , C07D307/42 , C07D307/46 , C07C33/14 , C07C33/34 , C07C33/50 , C07C43/23 , C07C255/53 , C07C255/56 , C07C259/18 , C07C25/18 , C07C25/06 , C07C25/13 , C07C49/792 , C07C49/813 , C07C49/84 , A61K31/045 , A61K31/12
CPC分类号： C07D333/22 , A61K31/045 , A61K31/12 , A61K31/277 , C07C25/06 , C07C25/13 , C07C25/18 , C07C33/14 , C07C33/34 , C07C33/50 , C07C43/23 , C07C49/792 , C07C49/813 , C07C49/84 , C07C255/53 , C07C255/56 , C07C259/18 , C07C2601/14 , C07C2601/16 , C07D307/42 , C07D307/46 , C07D333/16
摘要： Compounds are disclosed that are useful for treating ophthalmic conditions caused by or related to production of toxic visual cycle products that accumulate in the eye, such as dry adult macular degeneration, as well as conditions caused by or related to the misfolding of mutant opsin proteins and/or the mis-localization of opsin proteins. Compositions of these compounds alone or in combination with other therapeutic agents are also described, along with therapeutic methods of using such compounds and/or compositions. Methods of synthesizing such agents are also disclosed.
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公开(公告)号：US09757370B2
公开(公告)日：2017-09-12
申请号：US15134832
申请日：2016-04-21
IPC分类号： A61K31/472 , C07D217/06 , C07D217/26
CPC分类号： A61K31/472 , C07D217/06 , C07D217/26
摘要： Compounds are disclosed that are useful for treating ophthalmic conditions caused by or related to production of toxic visual cycle products that accumulate in the eye, such as dry adult macular degeneration, as well as conditions caused by or related to the misfolding of mutant opsin proteins and/or the mis-localization of opsin proteins. Compositions of these compounds alone or in combination with other therapeutic agents are also described, along with therapeutic methods of using such compounds and/or compositions. Methods of synthesizing such agents are also disclosed.
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公开(公告)号：US20170037018A1
公开(公告)日：2017-02-09
申请号：US15204577
申请日：2016-07-07
发明人： David S. Garvey , Gregory J. LaRosa , Jeremy R. Greenwood , Mark L. Brewer , Tan Quach , Jamie B. Cöté , Judd Berman
IPC分类号： C07D295/215 , C07D295/185 , C07D295/205 , C07D295/26 , C07D207/12 , C07D241/04 , C07B59/00 , C07D211/38 , C07D241/08 , C07D205/04 , C07C275/14 , C07C233/10 , C07D207/14
CPC分类号： C07D295/215 , C07B59/002 , C07B2200/05 , C07C233/10 , C07C275/14 , C07C2601/16 , C07D205/04 , C07D207/12 , C07D207/14 , C07D211/38 , C07D241/04 , C07D241/08 , C07D243/08 , C07D295/182 , C07D295/185 , C07D295/194 , C07D295/205 , C07D295/26 , C07D491/10 , C07D493/08
摘要： Compounds and compositions of said compounds along with methods of use of compounds are disclosed for treating ophthalmic conditions related to mislocalization of opsin proteins, the misfolding of mutant opsin proteins and the production of toxic visual cycle products that accumulate in the eye. Compounds and compositions useful in the these methods, either alone or in combination with other therapeutic agents, are also described.
摘要翻译： 公开了所述化合物的化合物和组合物以及化合物的使用方法，用于治疗与视蛋白蛋白质错位定位相关的眼科疾病，突变视蛋白蛋白质的错误折叠和积聚在眼睛中的毒性视觉循环产物的产生。 还描述了用于这些方法的化合物和组合物，单独或与其它治疗剂组合。
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公开(公告)号：US20140256782A1
公开(公告)日：2014-09-11
申请号：US14352178
申请日：2012-10-19
申请人： David S. Garvey , Gregory J. Larosa , Jeremy R. Greenwood , Leah L. Frye , Tan Quach , Jamie B. Cote , Judd Berman
发明人： David S. Garvey , Gregory J. Larosa , Jeremy R. Greenwood , Leah L. Frye , Tan Quach , Jamie B. Cote , Judd Berman
IPC分类号： C07C49/443 , C07C233/58 , C07C69/75 , C07C35/32 , C07D307/83 , C07D209/34
CPC分类号： C07D307/83 , C07C35/32 , C07C49/443 , C07C49/553 , C07C69/75 , C07C233/58 , C07C251/44 , C07C2102/24 , C07D209/34 , C07D209/46
摘要： Compounds are disclosed that are useful for treating ophthalmic conditions caused by or related to production of toxic is visual cycle products that accumulate in the eye, such as dry adult macular degeneration, as well as conditions caused by or related to the misfolding of mutant opsin proteins and/or the mis-localization of opsin proteins. Compositions of these compounds alone or in combination with other therapeutic agents are also described, along with therapeutic methods of using such compounds and/or compositions. Methods of synthesizing such agents are also disclosed.
摘要翻译： 公开的化合物可用于治疗由生产有毒的视觉循环产物引起的或与生物相关的眼部疾病，其是积聚在眼睛中的视觉循环产物，例如干性成年黄斑变性，以及由突变视蛋白质蛋白质错误折叠引起或与之相关的病症 和/或视蛋白蛋白质的错误定位。 还描述了这些化合物单独或与其它治疗剂组合的组合物，以及使用这些化合物和/或组合物的治疗方法。 还公开了合成这些试剂的方法。
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公开(公告)号：US20140135374A1
公开(公告)日：2014-05-15
申请号：US14126177
申请日：2012-06-13
申请人： David S. Garvey
发明人： David S. Garvey
IPC分类号： C07C255/56 , C07C49/792 , C07C25/13 , C07C25/06 , C07D333/16 , C07C255/53 , C07D307/46 , C07D333/22 , C07C33/34 , C07D307/42
CPC分类号： C07D333/22 , A61K31/045 , A61K31/12 , A61K31/277 , C07C25/06 , C07C25/13 , C07C25/18 , C07C33/14 , C07C33/34 , C07C33/50 , C07C43/23 , C07C49/792 , C07C49/813 , C07C49/84 , C07C255/53 , C07C255/56 , C07C259/18 , C07C2601/14 , C07C2601/16 , C07D307/42 , C07D307/46 , C07D333/16
摘要： Compounds are disclosed that are useful for treating ophthalmic conditions caused by or related to production of toxic visual cycle products that accumulate in the eye, such as dry adult macular degeneration, as well as conditions caused by or related to the misfolding of mutant opsin proteins and/or the mis-localization of opsin proteins. Compositions of these compounds alone or in combination with other therapeutic agents are also described, along with therapeutic methods of using such compounds and/or compositions. Methods of synthesizing such agents are also disclosed.
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公开(公告)号：US20170137398A1
公开(公告)日：2017-05-18
申请号：US15332034
申请日：2016-10-24
发明人： David S. Garvey , Gregory J. Larosa , Jeremy R. Greenwood , Leah L. Frye , Tan Quach , Jamie B. Cote , Judd Berman
IPC分类号： C07D307/83 , C07C35/32 , C07D209/46 , C07C251/44 , C07C49/553 , C07D209/34
CPC分类号： C07D307/83 , C07C35/32 , C07C49/443 , C07C49/553 , C07C69/75 , C07C233/58 , C07C251/44 , C07C2602/24 , C07D209/34 , C07D209/46
摘要： Compounds are disclosed that are useful for treating ophthalmic conditions caused by or related to production of toxic visual cycle products that accumulate in the eye, such as dry adult macular degeneration, as well as conditions caused by or related to the misfolding of mutant opsin proteins and/or the mis-localization of opsin proteins. Compositions of these compounds alone or in combination with other therapeutic agents are also described, along with therapeutic methods of using such compounds and/or compositions. Methods of synthesizing such agents are also disclosed.
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公开(公告)号：US09562022B2
公开(公告)日：2017-02-07
申请号：US12802898
申请日：2010-06-16
申请人： David S. Garvey , Gregory J. LaRosa , Jeremy R. Greenwood , Mark L. Brewer , Tan Quach , Jamie B. Côté , Judd Berman
发明人： David S. Garvey , Gregory J. LaRosa , Jeremy R. Greenwood , Mark L. Brewer , Tan Quach , Jamie B. Côté , Judd Berman
IPC分类号： C07D279/00 , C07D295/00 , C07D243/08 , C07D207/12 , C07D207/14 , C07D295/182 , C07D295/185 , C07D295/194 , C07D491/10 , C07D493/08
CPC分类号： C07D295/215 , C07B59/002 , C07B2200/05 , C07C233/10 , C07C275/14 , C07C2601/16 , C07D205/04 , C07D207/12 , C07D207/14 , C07D211/38 , C07D241/04 , C07D241/08 , C07D243/08 , C07D295/182 , C07D295/185 , C07D295/194 , C07D295/205 , C07D295/26 , C07D491/10 , C07D493/08
摘要： Compounds and compositions of said compounds along with methods of use of compounds are disclosed for treating ophthalmic conditions related to mislocalization of opsin proteins, the misfolding of mutant opsin proteins and the production of toxic visual cycle products that accumulate in the eye. Compounds and compositions useful in the these methods, either alone or in combination with other therapeutic agents, are also described.
摘要翻译： 公开了所述化合物的化合物和组合物以及化合物的使用方法，用于治疗与视蛋白蛋白质错位定位相关的眼科疾病，突变视蛋白蛋白质的错误折叠和积聚在眼睛中的毒性视觉循环产物的产生。 还描述了用于这些方法的化合物和组合物，单独或与其它治疗剂组合。
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公开(公告)号：US09499464B2
公开(公告)日：2016-11-22
申请号：US14352178
申请日：2012-10-19
发明人： David S. Garvey , Gregory J. Larosa , Jeremy R. Greenwood , Leah L. Frye , Tan Quach , Jamie B. Cote , Judd Berman
IPC分类号： C07D209/34 , C07D307/83 , C07C49/443 , C07C49/553 , C07C35/32 , C07C69/75 , C07C233/58
CPC分类号： C07D307/83 , C07C35/32 , C07C49/443 , C07C49/553 , C07C69/75 , C07C233/58 , C07C251/44 , C07C2102/24 , C07D209/34 , C07D209/46
摘要： Compounds are disclosed that are useful for treating ophthalmic conditions caused by or related to production of toxic is visual cycle products that accumulate in the eye, such as dry adult macular degeneration, as well as conditions caused by or related to the misfolding of mutant opsin proteins and/or the mis-localization of opsin proteins. Compositions of these compounds alone or in combination with other therapeutic agents are also described, along with therapeutic methods of using such compounds and/or compositions. Methods of synthesizing such agents are also disclosed.
摘要翻译： 公开的化合物可用于治疗由生产有毒的视觉循环产物引起的或与生物相关的眼部疾病，其是积聚在眼睛中的视觉循环产物，例如干性成年黄斑变性，以及由突变视蛋白质蛋白质错误折叠引起或与之相关的病症 和/或视蛋白蛋白质的错误定位。 还描述了这些化合物单独或与其它治疗剂组合的组合物，以及使用这些化合物和/或组合物的治疗方法。 还公开了合成这些试剂的方法。
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