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公开(公告)号：US12078578B2
公开(公告)日：2024-09-03
申请号：US18211046
申请日：2023-06-16
发明人： Bela Suki , Jae Hun Kim , Joseph Hall , Ramaswamy Krishnan , Niccole Schaible
CPC分类号： G01N1/06 , G01N1/312 , G01N3/08 , G01N35/00009 , G01N2035/00019
摘要： Provided herein are systems for determining a stretch condition of a tissue and assessing the stiffness of the tissue. Also provided herein are methods for using the systems for measuring stiffness of a tissue, assessing the effect of an agent on a tissue, and identifying subjects having a disease or disorder associated with increased or decreased stiffness of a tissue.
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2.发明公开公开(公告)号：US20240288367A1
公开(公告)日：2024-08-29
申请号：US18574571
申请日：2022-07-01
发明人： Lev T. Perelman
CPC分类号： G01N21/51 , C12Q1/04 , G01N33/49 , G01N2021/4704 , G01N2201/0683
摘要： Methods for identifying bacterial species in biofluid samples (e.g., whole blood samples) are described. The methods rely on optical spectroscopy, and enable rapid detection and identification of bacteria directly from whole blood. Not only can LSS-based techniques detect and identify bacteria in biofluids such as whole blood, but that species-level identification can potentially be made based on a small number of bacterial cells, without the need for observing entire colonies or performing susceptibility testing. The methods may comprise illuminating the biofluid sample with input light, detecting scattered light produced by the biofluid sample in response to the illuminating, generating first data indicative of a measured scattering spectrum associated with the biofluid sample using the detected scattered light, and identifying whether at least one of the bacterial species is present in the biofluid sample using the first data.
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公开(公告)号：US20240287533A1
公开(公告)日：2024-08-29
申请号：US18570935
申请日：2022-06-29
发明人： Gerard C. L. WONG , Jaime DE ANDA , Wujing XIAN , Xinhua CHEN , Ciaran KELLY
IPC分类号： C12N15/82 , C07K14/415
CPC分类号： C12N15/8242 , C07K14/415
摘要： The present disclosure provides methods for modifying gluten polypeptides to produce gluten polypeptides with a reduced inflammatory potential, as well as modified plants and compositions comprising modified gluten polypeptides with a reduced inflammatory potential.
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公开(公告)号：US20240287142A1
公开(公告)日：2024-08-29
申请号：US18455151
申请日：2023-08-24
IPC分类号： C07K14/075 , A61K31/7088 , A61K35/761 , A61K39/235 , C07K14/54 , C12N15/861
CPC分类号： C07K14/075 , A61K31/7088 , A61K35/761 , A61K39/235 , C07K14/5425 , C12N15/861
摘要： Featured are recombinant adenoviruses and vectors thereof. In particular, the adenoviruses are simian (rhesus) adenoviruses having a low seroprevalence and high immunogenicity (when expressing, e.g., an antigenic polypeptide) relative to other adenoviruses and vectors thereof. Also featured are methods for producing the adenoviruses and methods of treatment of diseases by administering the adenoviral vector(s) to a subject (e.g., a human).
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公开(公告)号：US12061199B2
公开(公告)日：2024-08-13
申请号：US16541707
申请日：2019-08-15
IPC分类号： G01N15/1433 , G01N1/36 , G01N33/574 , G02B21/16 , G16H30/20 , G16H50/20 , G01N15/10
CPC分类号： G01N33/57415 , G01N1/36 , G01N15/1433 , G02B21/16 , G16H30/20 , G16H50/20 , G01N2015/1006
摘要： A method for diagnosing cancer in an expanded biological tissue sample of a patient comprising providing at least one sample image of the expanded biological tissue sample; providing a computer configured to analyze the sample; analyzing, with the computer, the sample detect and segment nuclei; calculating, with the computer, molecular characteristics of those nuclei; and determining, with the computer, a diagnosis of cancer of the sample by comparing the sample with a benign normal tissue reference.
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公开(公告)号：US20240252520A1
公开(公告)日：2024-08-01
申请号：US18408546
申请日：2024-01-09
发明人： Aristidis Veves , George Theocharidis , Zhuqing Li , Ioannis Vlachos , David J. Mooney , Sangmin Lee
IPC分类号： A61K31/662 , A61K9/06 , A61K9/70 , A61K31/27 , A61K31/445 , A61K31/473 , A61K31/55 , A61K47/02 , A61K47/36 , A61L26/00 , A61P17/02
CPC分类号： A61K31/662 , A61K9/06 , A61K9/7023 , A61K31/27 , A61K31/445 , A61K31/473 , A61K31/55 , A61K47/02 , A61K47/36 , A61L26/0023 , A61L26/0066 , A61L26/008 , A61P17/02 , A61L2300/102 , A61L2300/216 , A61L2300/258 , A61L2300/622
摘要： In certain aspects, the disclosure relates to devices and methods for treating wounds wherein an acetylcholinesterase inhibitor is delivered to a wound to promote wound healing. In further aspects, metrifonate can be delivered to the wound by time release from a wound dressing. In further aspects a sequence of wound dressings can be applied to the wound to treat different phases of wound healing.
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公开(公告)号：US20240252033A1
公开(公告)日：2024-08-01
申请号：US18629665
申请日：2024-04-08
发明人： Jatinder S. Gill
IPC分类号： A61B1/313 , A61B1/00 , A61B1/005 , A61B1/04 , A61B1/06 , A61B1/32 , A61B17/32 , A61B90/00 , A61B90/30
CPC分类号： A61B1/3135 , A61B1/00094 , A61B1/009 , A61B1/043 , A61B1/0684 , A61B1/32 , A61B17/320016 , A61B90/04 , A61B90/30 , A61B90/36 , A61B2017/320069 , A61B2017/32007 , A61B2217/005
摘要： The present invention relates to a flexible surgical system for endoscopic spinal decompression and methods thereof. Various methods of accessing the epidural space with this instrument are described. The system design enables placement of the device through several approaches. It is then advanced under direct visualization or fluoroscopic (X-Ray), for example, into areas of the spine including lumbar (low back), thoracic (mid and upper back) and cervical (neck). The pathologies encroaching upon the spinal space can then be visualized wherein the epidural membrane can optionally be displaced to further aid in visualization. The membrane can be used to protect regions of tissue adjacent the site to tissue removal.
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公开(公告)号：US20240238473A1
公开(公告)日：2024-07-18
申请号：US18408498
申请日：2024-01-09
发明人： Aristidis Veves , George Theocharidis , Zhuqing Li , Ioannis Vlachos , David Mooney , Sangmin Lee
CPC分类号： A61L15/32 , A61K47/6929 , A61L15/28 , C07K14/473 , C07K14/55 , C12Q1/6811 , A61K38/00
摘要： In certain aspects, the disclosure relates to a recombinant nucleic acid molecule (e.g. RNA molecule) encoding one or more polypeptides selected from the group consisting of chitinase-3-like protein 1 (CHI3L1), a fibroblast growth factor (FGF), interleukin-2 ORF7 (IL-2 ORF7), interleukin-2 (IL-2), an interleukin-17 (IL-17) protein, and an IL-17 receptor, wherein the recombinant RNA molecule comprises at least one chemical modification. Cells, pharmaceutical compositions and wound dressings comprising one or more of the recombinant nucleic acid molecules are also disclosed. Methods of promoting wound healing in a subject are further disclosed.
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公开(公告)号：US20240230641A1
公开(公告)日：2024-07-11
申请号：US18550008
申请日：2022-03-11
发明人： George C. Tsokos , Rhea Bhargava
IPC分类号： G01N33/564 , C12Q1/6851 , C12Q1/6883 , A61B10/00
CPC分类号： G01N33/564 , C12Q1/6851 , C12Q1/6883 , A61B10/007 , C12Q2600/158 , G01N2333/54 , G01N2333/912 , G01N2800/104 , G01N2800/347
摘要： Provided herein are methods of identifying and/or diagnosing an active lupus nephritis (LN) flare in a subject, the method comprising obtaining a sample from the subject; isolating cells from the urine sample; and determining a level of expression of calcium/calmodulin dependent protein kinase IV (CaMK4), IL-23, IL-17 receptor, and/or arginase 1, wherein an increased level of expression of CaMK4, IL-23, and/or IL-17 receptor as compared to a control or a decreased level of expression of arginase 1 as compared to a control indicates an active lupus nephritis (LN) flare in the subject.
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公开(公告)号：US20240156909A1
公开(公告)日：2024-05-16
申请号：US18417063
申请日：2024-01-19
CPC分类号： A61K38/1793 , A61K45/06 , A61P35/00 , C07K16/2803 , C07K16/2818 , A61K2039/505
摘要： The present invention relates to compositions comprising resolvins and their use in methods of treating cancer.
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