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公开(公告)号：US20020098151A1
公开(公告)日：2002-07-25
申请号：US10029712
申请日：2001-12-19
发明人： Ernest G. Schutt , David P. Evitts , Rene Alta Kinner , Charles David Anderson , Jeffry G. Weers
IPC分类号： A61K049/22
CPC分类号： A61K49/227 , A61K49/223 , G02B6/0006
摘要： A microbubble preparation formed of a plurality of microbubbles comprising a first gas and a second gas surrounded by a membrane such as a surfactant, wherein the first gas and the second gas are present in a molar ratio of from about 1:100 to about 1000:1, and wherein the first gas has a vapor pressure of at least about (760nullx) mm Hg at 37 C., where x is the vapor pressure of the second gas at 37 C., and wherein the vapor pressure of each of the first and second gases is greater than about 75 mm Hg at 37 C.; also disclosed are methods for preparing microbubble compositions, including compositions that rapidly shrink from a first average diameter to a second average diameter less than about 75% of the first average diameter and are stabilized at the second average diameter; kits for preparing microbubbles; and methods for using such microbubbles as ultrasound contrast agents
摘要翻译： 一种由多个微泡形成的微泡制品，包括第一气体和被诸如表面活性剂的膜包围的第二气体，其中第一气体和第二气体以约1:100至约1000:1的摩尔比存在。 1，并且其中第一气体在37℃下具有至少约（760-x）mm Hg的蒸汽压，其中x是第二气体在37℃的蒸汽压，并且其中每个 第一和第二气体在37℃下大于约75mm Hg。 还公开了制备微泡组合物的方法，包括从第一平均直径快速收缩至小于第一平均直径的约75％的第二平均直径的组合物，并且稳定在第二平均直径; 用于制备微泡的试剂盒 以及使用这种微泡作为超声造影剂的方法
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公开(公告)号：US20020051750A1
公开(公告)日：2002-05-02
申请号：US09863982
申请日：2001-05-21
发明人： Ernest G. Schutt , David P. Evitts , Rene Alta Kinner , Charles David Anderson , Jeffry G. Weers
IPC分类号： A61K049/22
CPC分类号： A61K49/227 , A61K49/223 , G02B6/0006
摘要： A microbubble preparation formed of a plurality of microbubbles comprising a first gas and a second gas surrounded by a membrane such as a surfactant, wherein the first gas and the second gas are present in a molar ratio of from about 1:100 to about 1000:1, and wherein the first gas has a vapor pressure of at least about (760nullx) mm Hg at 37null C., where x is the vapor pressure of the second gas at 37null C., and wherein the vapor pressure of each of the first and second gases is greater than about 75 mm Hg at 37null C.; also disclosed are methods for preparing microbubble compositions, including compositions that rapidly shrink from a first average diameter to a second average diameter less than about 75% of the first average diameter and are stabilized at the second average diameter; kits for preparing microbubbles; and methods for using such microbubbles as ultrasound contrast agents.
摘要翻译： 一种由多个微泡形成的微泡制品，包括第一气体和被诸如表面活性剂的膜包围的第二气体，其中第一气体和第二气体以约1:100至约1000:1的摩尔比存在。 1，并且其中所述第一气体在37℃下具有至少约（760-x）mm Hg的蒸汽压，其中x是所述第二气体在37℃的蒸气压，并且其中， 第一和第二气体中的每一种在37℃下大于约75mm Hg。 还公开了制备微泡组合物的方法，包括从第一平均直径快速收缩至小于第一平均直径的约75％的第二平均直径的组合物，并且稳定在第二平均直径; 用于制备微泡的试剂盒 以及使用这种微泡作为超声造影剂的方法。
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公开(公告)号：US6105572A
公开(公告)日：2000-08-22
申请号：US966340
申请日：1997-11-07
IPC分类号： A61M16/00
CPC分类号： A61M16/0054 , A61M2202/0476 , Y10S128/913
摘要： A liquid ventilator having a dual loop, single pump configuration is disclosed. The liquid ventilator preferably utilizes two three-way valves for routing liquid from a reservoir in a regeneration apparatus and to a patient's pulmonary system, and back to the reservoir again. A controller controls the configuration of the three-way valves and the pump speed of the motor to allow user control over the parameters of inspiration and expiration.
摘要翻译： 公开了一种具有双回路，单泵结构的液体通气机。 液体呼吸机优选地使用两个三通阀，用于从再生设备中的贮存器和患者的肺部系统路由液体，并再次返回储存器。 控制器控制三通阀的配置和电机的泵速，以允许用户控制吸气和呼气的参数。
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公开(公告)号：US6041777A
公开(公告)日：2000-03-28
申请号：US566023
申请日：1995-12-01
CPC分类号： A61M16/0054 , A61M16/0009 , A61M16/0081 , A61M16/22 , A61M2016/102 , A61M2016/1025 , A61M2202/0476 , Y10S128/913
摘要： Methods and apparatus are provided which allow for closed-circuit ventilation for the treatment or diagnosis of disorders. The closed-circuit ventilation apparatus of the present invention provide a closed-circuit respirator that isolates the gas flow path from the ventilator apparatus. This allows the prolonged administration of expensive materials such as fluorochemicals without excessive loss due to evaporation. As such the provided methods an apparatus are particularly applicable to liquid ventilation including partial liquid ventilation and total liquid ventilation.
摘要翻译： 提供了允许闭路通气用于疾病的治疗或诊断的方法和装置。 本发明的闭路通风装置提供了一种闭路呼吸器，其将气体流路与呼吸机装置隔离。 这允许长时间地管理诸如含氟化合物的昂贵材料，而不会由于蒸发而导致过多的损失。 所提供的方法是一种装置特别适用于包括局部液体通气和总液体通气在内的液体通气。
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公开(公告)号：US5965258A
公开(公告)日：1999-10-12
申请号：US214411
申请日：1994-03-16
CPC分类号： B01J13/02 , A61K9/1274 , Y10S428/903 , Y10S977/70 , Y10T428/2913 , Y10T428/2924 , Y10T428/2925 , Y10T428/2975
摘要： Microstructures formed from fluorinated amphiphiles and mixed fluorinated and non-fluorinated amphiphiles and having the geometry of tubules, helixes and fibers and methods for preparing them. Tubular forms are capable of encapsulating or incorporating bioactive agents or other useful substances for controlled release in vivo.
摘要翻译： 由氟化两亲物和混合氟化和非氟化两亲物形成的微结构，并具有小管，螺旋和纤维的几何形状以及用于制备它们的方法。 管状形式能够在体内包封或掺入生物活性剂或其它有用物质用于控制释放。
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6.发明授权
公开(公告)号：US5853003A
公开(公告)日：1998-12-29
申请号：US910981
申请日：1997-08-07
IPC分类号： A61K9/08 , A61K9/107 , A61K31/02 , A61K31/025 , A61K31/035 , A61K31/08 , A61K31/135 , A61K31/34 , A61K31/341 , A61K31/47 , A61K31/472 , A61K45/00 , A61K45/06 , A61P11/00 , A61P11/10 , A61P31/04 , A61P43/00 , C07D207/10 , C07D217/22 , C07D307/18 , A61M15/00
CPC分类号： A61K31/135 , A61K31/02 , A61K31/025 , A61K31/035 , A61K31/08 , A61K45/06 , A61M2202/0476 , Y10S128/913
摘要： The present invention includes a method for treating a patient in need of facilitated oxygen delivery through the lungs, additional lung surfactant, removal of material from inside the lung, or inflation of collapsed portions of the lung, comprising the step of introducing into the lung of the patient an effective therapeutic amount of a fluorocarbon liquid, the amount not exceeding the functional residual capacity of the lung of the patient upon exhalation taking into account any positive and expiratory pressure applied to the patient's lung. The method may also comprise the additional step of providing an oxygen-containing breathing gas to the patient while the fluorocarbon liquid is in the lung.
摘要翻译： 本发明包括一种用于治疗需要通过肺的促进氧输送的患者的方法，另外的肺表面活性剂，从肺内部去除材料或肺部的塌陷部分的膨胀，包括将引入肺的步骤 患者有效治疗量的氟碳液体，其量不超过在呼气时患者的肺的功能残留能力，同时考虑到施用于患者肺部的任何正压和呼气压力。 该方法还可以包括在氟碳液体在肺中时向患者提供含氧呼吸气体的附加步骤。
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公开(公告)号：US5733526A
公开(公告)日：1998-03-31
申请号：US572859
申请日：1995-12-14
CPC分类号： A61K9/0026 , A61K9/113 , Y10S514/937 , Y10S977/786 , Y10S977/795 , Y10S977/902 , Y10S977/904 , Y10S977/905 , Y10S977/915 , Y10S977/926 , Y10S977/927 , Y10S977/962
摘要： Novel hydrocarbon oil/fluorochemical preparations and methods for their use are provided. The preparations, which preferably comprise a fluorophilic dispersing agent, may be in the form of hydrocarbon oil-in-fluorochemical dispersions or in the form of a multiple emulsion comprising a polar liquid continuous phase and are particularly useful for administering bioactive agents. In particular the preparations of the present invention may be used to control the bioavailability and improve the efficacy of lipophilic bioactive agents having limited solubility in an aqueous physiological environment.
摘要翻译： 提供新型烃油/含氟化合物制剂及其使用方法。 优选包含嗜氟分散剂的制剂可以是烃油中的含氟化合物分散体的形式或者包含极性液体连续相的多重乳液的形式，并且特别可用于施用生物活性剂。 特别地，本发明的制剂可用于控制生物利用度并改善在水性生理环境中溶解度有限的亲脂性生物活性剂的功效。
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8.发明授权
公开(公告)号：US5667809A
公开(公告)日：1997-09-16
申请号：US482176
申请日：1995-06-07
CPC分类号： A61K9/0026 , Y10S514/937
摘要： A method for preparing a pharmaceutical microdispersion exhibiting enhanced bioavailability, including the steps of providing a thermodynamically stable pharmaceutical composition comprising at least one lipophilic pharmaceutical agent incorporated in a physiologically acceptable liquid carrier, the liquid carrier comprising one or more lipophilic solvents such as fluorochemicals and preferably at least one nonfluorinated co-solvent, and combining the stable pharmaceutical composition with an amount of at least one miscible diluent sufficient to initiate phase separation of the lipophilic pharmaceutical agent from the pharmaceutical composition wherein a microdispersion of the pharmaceutical composition is formed. Also disclosed are microdisperse pharmaceutical compositions and kits for forming such compositions.
摘要翻译： 一种制备显示增强的生物利用度的药物微分散体的方法，包括以下步骤：提供包含至少一种引入生理学上可接受的液体载体的亲脂性药剂的热力学稳定的药物组合物，所述液体载体包含一种或多种亲脂性溶剂如含氟化合物， 至少一种非氟化共溶剂，并将稳定的药物组合物与一定量的至少一种可混溶的稀释剂组合，所述至少一种可混溶的稀释剂足以引发亲脂性药剂与药物组合物的相分离，其中形成药物组合物的微分散体。 还公开了用于形成这种组合物的微分散药物组合物和试剂盒。
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公开(公告)号：US5626833A
公开(公告)日：1997-05-06
申请号：US480853
申请日：1995-06-07
CPC分类号： A61K49/227 , A61K49/223 , G02B6/0006
摘要： A microbubble preparation formed of a plurality of microbubbles comprising a first gas and a second gas surrounded by a membrane such as a surfactant, wherein the first gas and the second gas are present in a molar ratio of from about 1:100 to about 1000:1, and wherein the first gas has a vapor pressure of at least about (760-x) mm Hg at 37.degree. C., where x is the vapor pressure of the second gas at 37.degree. C., and wherein the vapor pressure of each of the first and second gases is greater than about 75 mm Hg at 37.degree. C.; also disclosed are methods for preparing microbubble compositions, including compositions that rapidly shrink from a first average diameter to a second average diameter less than about 75% of the first average diameter and are stabilized at the second average diameter; methods and kits for preparing microbubbles; and methods for using such microbubbles as contrast agents.
摘要翻译： 一种由多个微泡形成的微泡制品，包括第一气体和被诸如表面活性剂的膜包围的第二气体，其中第一气体和第二气体以约1:100至约1000:1的摩尔比存在。 1，并且其中第一气体在37℃具有至少约（760-x）mm Hg的蒸汽压，其中x是第二气体在37℃的蒸汽压，并且其中蒸气压 第一和第二气体中的每一种在37℃下大于约75mm Hg。 还公开了制备微泡组合物的方法，包括从第一平均直径快速收缩至小于第一平均直径的约75％的第二平均直径的组合物，并且稳定在第二平均直径; 制备微泡的方法和试剂盒; 以及使用这种微泡作为造影剂的方法。
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10.发明授权
公开(公告)号：US5573757A
公开(公告)日：1996-11-12
申请号：US316731
申请日：1994-10-03
申请人： Jean G. Riess , Marie-Pierre Krafft
发明人： Jean G. Riess , Marie-Pierre Krafft
IPC分类号： A61K8/02 , A61K8/70 , A61K9/00 , A61K9/06 , A61K9/107 , A61K31/02 , A61K31/025 , A61K47/06 , A61Q19/00 , C09K3/00 , A61K31/74
CPC分类号： A61K31/025 , A61K31/02 , A61K8/042 , A61K8/70 , A61K9/0026 , A61K9/06 , A61Q19/00 , A61Q17/04 , Y10S514/832
摘要： Compositions for topical application in gel form comprising a fluorocarbon or perfluorocarbon compound or mixtures thereof at a concentration of at least about 75% v/v, a minor quantity of a surface active agent and an aqueous phase.The compositions provide a storage-stable high concentration fluorocarbon gel that is prepared without the use of thickeners or additional stabilizing agents. The gels are useful in formulations for pharmaceutical, cosmetic purposes and for other products as well.
摘要翻译： 用于以凝胶形式局部施用的组合物，其包含浓度为至少约75％v / v，少量表面活性剂和水相的碳氟化合物或全氟化碳化合物或其混合物。 该组合物提供储存稳定的高浓度碳氟化合物凝胶，其不使用增稠剂或其它稳定剂制备。 凝胶在制剂，化妆品用途和其他产品的制剂中是有用的。
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