公开(公告)号：US20020098151A1

公开(公告)日：2002-07-25

申请号：US10029712

申请日：2001-12-19

申请人： Alliance Pharmaceutical Corp.

发明人： Ernest G. Schutt ,  David P. Evitts ,  Rene Alta Kinner ,  Charles David Anderson ,  Jeffry G. Weers

IPC分类号： A61K049/22

CPC分类号： A61K49/227 ,  A61K49/223 ,  G02B6/0006

摘要： A microbubble preparation formed of a plurality of microbubbles comprising a first gas and a second gas surrounded by a membrane such as a surfactant, wherein the first gas and the second gas are present in a molar ratio of from about 1:100 to about 1000:1, and wherein the first gas has a vapor pressure of at least about (760nullx) mm Hg at 37 C., where x is the vapor pressure of the second gas at 37 C., and wherein the vapor pressure of each of the first and second gases is greater than about 75 mm Hg at 37 C.; also disclosed are methods for preparing microbubble compositions, including compositions that rapidly shrink from a first average diameter to a second average diameter less than about 75% of the first average diameter and are stabilized at the second average diameter; kits for preparing microbubbles; and methods for using such microbubbles as ultrasound contrast agents

摘要翻译： 一种由多个微泡形成的微泡制品，包括第一气体和被诸如表面活性剂的膜包围的第二气体，其中第一气体和第二气体以约1:100至约1000:1的摩尔比存在。 1，并且其中第一气体在37℃下具有至少约（760-x）mm Hg的蒸汽压，其中x是第二气体在37℃的蒸汽压，并且其中每个 第一和第二气体在37℃下大于约75mm Hg。 还公开了制备微泡组合物的方法，包括从第一平均直径快速收缩至小于第一平均直径的约75％的第二平均直径的组合物，并且稳定在第二平均直径; 用于制备微泡的试剂盒 以及使用这种微泡作为超声造影剂的方法

公开(公告)号：US20020051750A1

公开(公告)日：2002-05-02

申请号：US09863982

申请日：2001-05-21

申请人： Alliance Pharmaceutical Corp.

发明人： Ernest G. Schutt ,  David P. Evitts ,  Rene Alta Kinner ,  Charles David Anderson ,  Jeffry G. Weers

IPC分类号： A61K049/22

CPC分类号： A61K49/227 ,  A61K49/223 ,  G02B6/0006

摘要： A microbubble preparation formed of a plurality of microbubbles comprising a first gas and a second gas surrounded by a membrane such as a surfactant, wherein the first gas and the second gas are present in a molar ratio of from about 1:100 to about 1000:1, and wherein the first gas has a vapor pressure of at least about (760nullx) mm Hg at 37null C., where x is the vapor pressure of the second gas at 37null C., and wherein the vapor pressure of each of the first and second gases is greater than about 75 mm Hg at 37null C.; also disclosed are methods for preparing microbubble compositions, including compositions that rapidly shrink from a first average diameter to a second average diameter less than about 75% of the first average diameter and are stabilized at the second average diameter; kits for preparing microbubbles; and methods for using such microbubbles as ultrasound contrast agents.

摘要翻译： 一种由多个微泡形成的微泡制品，包括第一气体和被诸如表面活性剂的膜包围的第二气体，其中第一气体和第二气体以约1:100至约1000:1的摩尔比存在。 1，并且其中所述第一气体在37℃下具有至少约（760-x）mm Hg的蒸汽压，其中x是所述第二气体在37℃的蒸气压，并且其中， 第一和第二气体中的每一种在37℃下大于约75mm Hg。 还公开了制备微泡组合物的方法，包括从第一平均直径快速收缩至小于第一平均直径的约75％的第二平均直径的组合物，并且稳定在第二平均直径; 用于制备微泡的试剂盒 以及使用这种微泡作为超声造影剂的方法。