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公开(公告)号:US20230392184A1
公开(公告)日:2023-12-07
申请号:US18446048
申请日:2023-08-08
申请人: PHAST CORP.
发明人: Kwangmin SON , Roman STOCKER
CPC分类号: C12Q1/04 , G02B21/0084 , G02B21/365 , C40B30/06 , C40B40/02 , G01N33/9446 , G16C10/00
摘要: Among other things, motility of at least one individual microorganism or a change in motility of at least one individual microorganism or both is or are characterized. The characterized motility or change in motility is used to detect the presence or count of the at least one individual microorganism, or determine the identity of a species or strain of the at least one individual microorganism, or determine a susceptibility of the at least one individual microorganism to one or more antibiotics or other antimicrobials.
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公开(公告)号:US11837333B1
公开(公告)日:2023-12-05
申请号:US18085336
申请日:2022-12-20
摘要: Methods include generating a hypothetical formulation library of chemical formulations, including generating hypothetical formulations by one or more of: (a) directed combinatorics including: selecting starter formulations from historical data; performing substitution of one or more formulation components in at least one component class; and assigning concentration ratios within ranges established by the historical data; and (2) constrained randomization including: preparing template formulations including one or more component classes based on historical data; performing randomized substitution of formulation components in each of the component classes of the template formulations; randomly assign concentration ratios to the formulation components within ranges established by one or more constraints to produce hypothetical formulations; create descriptors for the hypothetical formulations; compare descriptor outputs from the hypothetical formulations with the range of descriptor outputs from the historical data; and remove duplicate and outlier formulations; and collecting the hypothetical formulations into the hypothetical formulation library.
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公开(公告)号:US11833267B2
公开(公告)日:2023-12-05
申请号:US16813720
申请日:2020-03-09
申请人: Nexus Spine, LLC
发明人: Peter Halverson , David T. Hawkes
IPC分类号: A61L27/56 , G16C20/30 , B33Y50/00 , G06T19/20 , B33Y80/00 , A61L27/06 , G16C20/10 , A61L27/36 , B22F10/38 , B22F10/20
CPC分类号: A61L27/06 , A61L27/365 , A61L27/56 , B22F10/38 , B33Y50/00 , G06T19/20 , G16C20/10 , G16C20/30 , A61L2420/02 , A61L2430/02 , B22F10/20 , B33Y80/00 , G06T2219/2021
摘要: A porous implant design method includes defining a design volume for a porous implant, a load to be borne by the design volume, and an objective function solution characteristic related to the design volume. Next, the load is divided into a plurality of sub-loads and an optimization procedure is performed: until all sub-loads have been applied, one of the plurality of sub-loads is applied to the material in the design volume, material from the design volume is removed such that remaining material within the design volume is capable of bearing one of the plurality of sub-loads while satisfying the objection function solution characteristic; the remaining material defines a void space without material, the void space is set as a new design volume for any remaining sub-loads, the new design volume is set as being full of material. Then, the remaining material from each cycle of the optimization is combined.
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84.
公开(公告)号:US20230386617A1
公开(公告)日:2023-11-30
申请号:US18234113
申请日:2023-08-15
发明人: Reiko HAGAWA , Hiromasa TAMAKI , Mayu MORIWAKI
IPC分类号: G16C60/00 , G06F16/904
CPC分类号: G16C60/00 , G06F16/904
摘要: A generation process display device that is a generation process output device includes: a first information obtainer that obtains first information about a target material; a deriver that derives, for each of one or more types of generation processes, a generation parameter based on a database regarding materials, where the generation parameter indicates a degree that the generation process is required for generating the target material specified by the first information; and an outputter that outputs one or more generation parameters that have been derived.
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85.
公开(公告)号:US20230368871A1
公开(公告)日:2023-11-16
申请号:US18091141
申请日:2022-12-29
发明人: Giovanni Cincilla , Simone Masoni , Jascha Blobel
IPC分类号: G16C20/50 , G16C20/30 , G16C20/80 , G06F3/04845
CPC分类号: G16C20/50 , G16C20/30 , G16C20/80 , G06F3/04845
摘要: The invention relates to a method, a computer program a system, a video game system and a video game for designing a molecule for medical applications by optimization of an associated drug score (101) of the molecule, comprising the steps of: a) providing a computer-readable representation of a selected molecule (100) and a drug score (101) associated to the selected molecule (100), b) determining (201) a first moiety (110) of the selected molecule (100) and a second moiety (120) of the selected molecule (100), wherein the selected molecule (100) consists of the first moiety (110) and second moiety (120), c) determining (202) a first moiety pharmacophore (130), wherein the first moiety (110) of the selected molecule (100) fits to the first moiety pharmacophore (130), d) providing (203) a graphical user interface (150), e) displaying (204) a graphical representation of a selected part (131) of the first moiety pharmacophore (130) on the graphical user interface (150), f) determining a starting point (160) on the graphical user interface (150) in relation to the graphical representation of the selected part (131) of the first moiety pharmacophore (130), g) from the starting point (160), arranging or rearranging graphical representations of molecular building blocks (170) on the graphical user interface (150), wherein the graphical representations of the molecular building blocks (170) are interconnected and form a graphical representation of a modified first moiety of a molecule (180), h) assigning (207) the graphical representation of the modified first moiety of the molecule (180) to a modified first moiety (111) of the selected molecule (100), i) determining (208) a modified molecule (190) consisting of the modified first moiety (111) and the second moiety (120) of the selected molecule (100), j) estimating (209) the associated drug score (101) for the modified molecule (190), k) disclosing (210) the associated drug score (101) of the modified molecule (190).
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公开(公告)号:US20230360741A1
公开(公告)日:2023-11-09
申请号:US18222302
申请日:2023-07-14
CPC分类号: G16C20/40 , G06F9/4881 , G06F9/54 , G06F11/0715
摘要: In a method of molecular scaffold hopping an interface of a scheduler computer sends instructions, prepared by the scheduler computer, to a job runner computer to perform a plurality of separate computational tasks. Each of the separate computational tasks includes calculating one or more chemical properties for a query molecule or molecules in a library of molecules. One or more of the plurality of separate computational tasks performed on the job runner computer are preemptible computing instances. Status indicators sent from the job runner computer are received by the interface for each of the plurality of separate computational tasks. The indicators are one of: incomplete, completed, or failed computing instances. The interface resends the instructions to the job runner computer that correspond to the separate computational tasks having the failed computing instance indicator to increase fault-tolerance against the separate computational tasks not attaining the completed computing instance indicator.
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公开(公告)号:US11810646B2
公开(公告)日:2023-11-07
申请号:US16789993
申请日:2020-02-13
发明人: Chunbo Lou , Tae Seok Moon , Virgil Rhodius , Brynne Stanton , Alvin Tasmir , Karsten Temme , Chris Voigt
IPC分类号: C12N5/00 , G16B20/30 , G16B20/00 , G16B30/00 , G16B35/00 , G16C20/60 , C12N15/63 , G16B35/10 , G16B30/20 , C12N15/70 , C12N15/79 , G16B20/50
CPC分类号: G16B20/30 , C12N15/63 , C12N15/635 , C12N15/70 , C12N15/79 , G16B20/00 , G16B30/00 , G16B30/20 , G16B35/00 , G16B35/10 , G16C20/60 , G16B20/50
摘要: Methods for design of genetic circuits are provided.
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公开(公告)号:US11806784B2
公开(公告)日:2023-11-07
申请号:US17320443
申请日:2021-05-14
发明人: Steven M. Storck , Joseph J. Sopcisak , Christopher M. Peitsch , Salahudin M. Nimer , Zachary R. Ulbig
摘要: A rapid material development process for a powder bed fusion additive manufacturing (PBF AM) process generally utilizes a computational fluid dynamics (CFD) simulation to facilitate selection of a simulated parameter set, which can then be used in a design of experiments (DOE) to generate an orthogonal parameter space to predict an ideal parameter set. The orthogonal parameter space defined by the DOE can then be used to generate a multitude of reduced volume build samples using PBF AM with varying laser or electron beam parameters and/or feedstock chemistries. The reduced volume build samples are mechanically characterized using high throughput techniques and analyzed to provide an optimal parameter set for a 3D article or a validation sample, which provides an increased understanding of the parameters and their independent and confounding effects on defects and microstructure. Additionally, machine learning techniques can be used to optimize for future parameter selection by modeling the relationship between input processing parameters and outputs of material characterization.
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89.
公开(公告)号:US20230349886A1
公开(公告)日:2023-11-02
申请号:US17715796
申请日:2022-04-07
发明人: Sergei NOSKOV , Soren WACKER , Henry DUFF , Jiqing GUO
IPC分类号: G01N33/50 , G06N20/00 , G16B15/00 , G16B35/00 , G16B40/00 , G16C20/60 , G01N33/68 , G16B20/00 , G16C20/30 , G06N20/20 , G16H50/00 , G16B15/30 , G16B40/20 , G16B35/20 , G06N5/01 , G06N7/01
CPC分类号: G01N33/5014 , G01N33/6872 , G06N5/01 , G06N7/01 , G06N20/00 , G06N20/20 , G16B15/00 , G16B15/30 , G16B20/00 , G16B35/00 , G16B35/20 , G16B40/00 , G16B40/20 , G16C20/30 , G16C20/60 , G16H50/00 , G16C20/70
摘要: Systems and methods are provided for predicting cardiotoxicity of molecular parameters of a compound. A computer can provide as input to a machine learning algorithm the molecular parameters of the compound. The molecular parameters can include at least structural information about the compound. The machine learning algorithm can have been trained using respective molecular parameters of compounds known to have cardiotoxicity and of compounds known not to have cardiotoxicity. The computer can receive as output from the machine learning algorithm a representation of the predicted cardiotoxicity of each molecular parameter of at least a subset of the molecular parameters of the compound.
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公开(公告)号:US20230347260A1
公开(公告)日:2023-11-02
申请号:US18007126
申请日:2021-07-16
申请人: AMGEN INC.
摘要: A method of selecting raw materials for use in a column chromatography purification process in which, for each of one or more candidate resins, a respective set of resin attribute values is received, including at least one analytical measurement of the candidate resin. The method also includes, for each candidate resin, predicting a respective value of a performance indicator for the column chromatography purification process by applying the respective set of resin attribute values, and possibly other parameter values (e.g., harvest filtrate and/or purification process parameters) as inputs to a multivariate statistical model. The method further includes selecting a resin of the one or more candidate resins based at least in part on the predicted respective value(s) of the performance indicator, and performing the column chromatography purification process using the selected resin as a stationary phase.
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