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公开(公告)号：US09855238B2
公开(公告)日：2018-01-02
申请号：US15383889
申请日：2016-12-19
申请人： Afimmune Limited
发明人： David Coughlan , John Climax
IPC分类号： A61K31/202 , A61K31/232
CPC分类号： A61K31/202 , A61K31/232
摘要： The present invention relates to the compositions comprising 15-HEPE and methods of treatment relating to same.
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公开(公告)号：US20170368184A1
公开(公告)日：2017-12-28
申请号：US15545197
申请日：2015-01-21
发明人： Hiromitsu ITO , Hirosato FUJII , Motoo YAMAGATA
IPC分类号： A61K47/44 , A61K47/24 , A61K31/232 , A61K47/26 , A61K9/107
摘要： A self-emulsifying composition contains: 70 to 90% by weight of at least one compound selected from the group consisting of ω3 polyunsaturated fatty acids and their pharmaceutically acceptable salts and esters; 0.5 to 6% by weight of water; 1 to 29% by weight of a polyoxyethylene sorbitan fatty acid ester as an emulsifier (optionally including a polyoxyl castor oil, and not including lecithin); and lecithin in an amount of 3 to 40 parts by weight in relation to 100 parts by weight of ω3 polyunsaturated fatty acids and the like. The self-emulsifying composition is excellent in self-emulsifying property, composition dispersibility, emulsion stability, and absorbability, is free from ethanol and polyhydric alcohols or only has such an alcohol added thereto at a reduced concentration, and is useful for foods and pharmaceuticals.
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公开(公告)号：US20170333381A9
公开(公告)日：2017-11-23
申请号：US15005181
申请日：2016-01-25
IPC分类号： A61K31/232 , A61K9/00 , A61K9/107 , A61K45/06
CPC分类号： A61K31/232 , A61K9/0019 , A61K9/1075 , A61K45/06 , A61K2300/00
摘要： The present invention relates to the use of an oil enriched in docosahexaenoic acid, which is conjugated to triglyceride, for manufacturing a pharmaceutical composition for the treatment of a tumorous disease, said oil being enriched in a concentration of up to 70% by weight in relation to the total weight of said pharmaceutical composition, and said docosahexaenoic acid being in a percentage of at least 50% in relation to the total fatty acids in said oil.
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公开(公告)号：US20170326094A1
公开(公告)日：2017-11-16
申请号：US15529058
申请日：2015-12-01
申请人： NESTEC S.A.
IPC分类号： A61K31/232 , G01N33/92 , A61K31/231 , G01N33/49 , A61K31/5575 , G01N33/00
CPC分类号： A61K31/232 , A61K31/23 , A61K31/231 , A61K31/5575 , G01N33/00 , G01N33/49 , G01N33/92 , G01N2800/42 , G01N2800/44 , G01N2800/7095
摘要： The present invention provides an oxygenated fatty acyl glycerol for use in treating and/or preventing an inflammatory disease a subject.
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公开(公告)号：US09801846B2
公开(公告)日：2017-10-31
申请号：US15114937
申请日：2015-01-28
CPC分类号： A61K31/232 , A61K9/0029 , A61K9/107 , A61K47/10 , A61K47/12 , A61K47/24
摘要： Described herein are compositions for parenteral administration that include an aqueous phase and 5 to 30%, by weight, of an oil phase, based on the total weight of the composition. The oil phase comprises the omega-3 fatty acid ethylesters eicosapentaenoic acid ethylester, docosahexaenoic acid ethylester, and mixtures thereof. The composition further comprises at least one anionic surfactant and at least one amphoteric surfactant, and less than 0.05% by weight of oleic acid, based on the total weight of the composition. Also described is a method for preparing such a composition as well as such compositions for use as a medicament, in particular for use in treating stroke, sepsis, Alzheimer's disease or cancer. Also featured are methods of treating these conditions by parenterally administering a composition to a patient in need thereof and methods of providing parenteral nutrition to such patients by administering to them a composition as described herein.
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公开(公告)号：US20170296507A1
公开(公告)日：2017-10-19
申请号：US15581558
申请日：2017-04-28
发明人： Bruce Bistrian , Frederic Destaillats , Cristina Cruz-Hernandez , Fabiola Dionisi , Isabelle Masserey-Elmelegy , Manuel Oliveira , Julie Celine Moulin
IPC分类号： A61K31/357 , A23L33/12 , A23K20/158 , A61K31/232 , A23L2/52
CPC分类号： A61K31/357 , A23K20/158 , A23L2/52 , A23L33/115 , A23L33/12 , A23V2002/00 , A61K31/202 , A61K31/232 , A23V2200/324 , A23V2250/187
摘要： The present invention relates generally to the field of lipids and in particular aims at improving lipid absorption, for example under conditions of lipid maldigestion or malabsorption. One embodiment of the present invention relates to a composition comprising a sn-2 monoacylglycerol derivative, wherein the sn-1 and sn-3 positions are blocked by protective groups. The acyl group may be a fatty acid, for example one with anti-inflammatory properties.
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87.发明申请公开(公告)号：US20170273928A1
公开(公告)日：2017-09-28
申请号：US15619860
申请日：2017-06-12
IPC分类号： A61K31/22 , A61K31/351 , A61K31/40 , A61K31/232 , A61K31/366 , A61K31/202 , A61K31/225
摘要： Disclosed is a composition which is useful for preventing the occurrence of a cardiovascular event, particularly a composition which is expected to show a prophylactic effect on a cardiovascular event occurring in a hypercholesterolemia patient despite providing the patient with a treatment with HMG-CoA RI or a cardiovascular event occurring in a multiple risk patient.
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88.发明申请公开(公告)号：US20170246136A1
公开(公告)日：2017-08-31
申请号：US15514261
申请日：2015-09-24
申请人： OliVentures, Inc
IPC分类号： A61K31/232 , A61K9/48 , A61K31/202 , A61K47/44 , A61K31/12 , A61K47/24 , A61K47/02 , A61K9/00 , A61K31/05
CPC分类号： A61K31/232 , A23L33/105 , A23L33/12 , A23V2002/00 , A61K9/4875 , A61K31/05 , A61K31/12 , A61K31/202 , A61K35/60 , A61K45/06 , A61K2300/00 , A23V2200/308 , A23V2250/1868 , A23V2250/187 , A23V2250/21 , A23V2250/2112 , A23V2250/2131 , A23V2200/30 , A23V2250/1592 , A23V2250/1634 , A23V2250/1842 , A23V2250/1846 , A23V2250/194
摘要： The present invention relates to cancer therapy by administering a specific dietary compensation. Especially the invention relates to a pharmaceutical, medical food or dietary supplement composition comprising the combination of the following three active ingredients: hydroxytyrosol, fish oil EPA/DHA and curcumin. The pharmaceutical composition is useful in the treatment or prevention of cancer, especially breast cancer.
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公开(公告)号：US09693986B2
公开(公告)日：2017-07-04
申请号：US15427238
申请日：2017-02-08
发明人： Paresh Soni
IPC分类号： A61K31/232 , A61K31/397 , A61K45/06
CPC分类号： A61K31/232 , A61K31/397 , A61K45/06 , A61K2300/00
摘要： In various embodiments, the present invention provides methods of reducing the risk of a cardiovascular event in a subject on statin therapy and, in particular, a method of reducing the risk of a cardiovascular event in a subject on statin therapy having a fasting baseline triglyceride level of about 135 mg/dL to about 500 mg/dL, and administering to the subject a pharmaceutical composition comprising about 1 g to about 4 g of eicosapentaenoic acid ethyl ester or a derivative thereof.
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公开(公告)号：US09693985B2
公开(公告)日：2017-07-04
申请号：US15422634
申请日：2017-02-02
发明人： Paresh Soni
IPC分类号： A61K31/232 , A61K31/397 , A61K45/06
CPC分类号： A61K31/232 , A61K31/397 , A61K45/06 , A61K2300/00
摘要： In various embodiments, the present invention provides methods of reducing the risk of a cardiovascular event in a subject on statin therapy and, in particular, a method of reducing the risk of a cardiovascular event in a subject on statin therapy having a fasting baseline triglyceride level of about 135 mg/dL to about 500 mg/dL, and administering to the subject a pharmaceutical composition comprising about 1 g to about 4 g of eicosapentaenoic acid ethyl ester or a derivative thereof.
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