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    Allergenic proteins of natural rubber latex, their production and use in assays
    81.
    发明授权
    Allergenic proteins of natural rubber latex, their production and use in assays 失效
    天然橡胶胶乳的过敏蛋白，其生产和用于测定

    公开(公告)号：US06759517B1

    公开(公告)日：2004-07-06

    申请号：US08529152

    申请日：1995-09-15

    申请人： Mary Jane Cardosa ,  Hamid Sharifah ,  Shirley Samuel-Verghese ,  Elumalai Sunderasan ,  Hoong Yeet Yeang ,  Hamzah Samsidar

    发明人： Mary Jane Cardosa ,  Hamid Sharifah ,  Shirley Samuel-Verghese ,  Elumalai Sunderasan ,  Hoong Yeet Yeang ,  Hamzah Samsidar

    IPC分类号： C07K1700

    CPC分类号： C08C3/02 ,  A61K38/00 ,  A61K39/35 ,  C07K14/415 ,  C07K16/16 ,  C08C1/04 ,  Y10S530/868

    摘要： This invention relates to allergenic proteins of natural rubber latex in substantially purified form, their production and their use, together with monoclonal antibodies developed against those allergenic proteins, in assays for the qualitative and quantitative determination of the levels of the allergenic proteins in natural rubber latex or in products made from latex. Assays for identifying and/or quantitating antibodies in blood or blood products that mediate the occurrence of an allergic reaction induced by natural rubber latex are also provided, together with in vivo and in vitro diagnostic tests for detecting hypersensitivity to natural rubber latex and which involve use of the aforesaid allergenic proteins. The invention also provides for the use of the aforesaid allergens as de-sensitizing agents in the treatment of latex protein allergy. There is still further provided a method for removing allergenic proteins from latex products.

    摘要翻译： 本发明涉及基本纯化形式的天然橡胶胶乳的过敏原蛋白，其生产及其用途，以及针对这些过敏原蛋白的单克隆抗体，用于定性和定量测定天然橡胶胶乳中过敏原蛋白水平的测定 或由乳胶制成的产品。 还提供用于鉴定和/或定量介导由天然橡胶胶乳引起的过敏反应发生的血液或血液制品中的抗体的测定，以及用于检测对天然橡胶胶乳的超敏反应的体内和体外诊断测试，其涉及使用 的上述变应原蛋白。 本发明还提供了上述变应原作为去敏化剂在治疗胶乳蛋白过敏中的用途。 还提供了从乳胶产品中除去过敏原蛋白的方法。

    Method of cleaning or purifying elastomers and elastomeric articles which are intended for medical or pharmaceutical use
    82.
    发明授权
    Method of cleaning or purifying elastomers and elastomeric articles which are intended for medical or pharmaceutical use 失效
    用于医疗或药物用途的清洁或净化弹性体和弹性制品的方法

    公开(公告)号：US06241828B1

    公开(公告)日：2001-06-05

    申请号：US09155268

    申请日：1998-09-25

    申请人： Paul Barnes

    发明人： Paul Barnes

    IPC分类号： B08B304

    CPC分类号： B01D11/0203 ,  C08C3/02 ,  C08J7/02 ,  C08J2321/00 ,  Y02P20/544

    摘要： A method is disclosed for removing impurities from an elastomer intended for medical or pharmaceutical use, which includes a step of performing a first solvent extraction process on the elastomer by contacting the elastomer with a first extracting solvent in a non-supercritical state to substantially remove impurities from the elastomer, thereby leaving a residue of said first extracting solvent in the elastomer. The elastomer is there after subjected to a second solvent extraction process, by contacting the elastomer with a second extracting solvent, which is a supercritical fluid or a mixture of super critical fluids, in order to remove substantially reduce the concentration of the residue of the first extracting solvent remaining in the elastomer after the first solvent extraction process.

    摘要翻译： 公开了一种用于从用于医疗或药物用途的弹性体中除去杂质的方法，其包括通过使弹性体与非超临界状态的第一提取溶剂接触来对弹性体进行第一溶剂萃取过程以基本上除去杂质 从弹性体中除去弹性体中的所述第一提取溶剂的残留物。 通过使弹性体与作为超临界流体或超临界流体的混合物的第二提取溶剂接触来进行第二溶剂萃取过程之后，弹性体就在那里，以便基本上降低第一溶剂的残余物的浓度 在第一溶剂萃取过程之后萃取残留在弹性体中的溶剂。

    Process for curing liquid chloroprene polymer containing xanthate active terminal groups using polyfunctional amines
    84.
    发明授权
    Process for curing liquid chloroprene polymer containing xanthate active terminal groups using polyfunctional amines 失效
    使用多官能胺固化含有黄原酸酯活性端基的液态氯丁二烯聚合物的方法

    公开(公告)号：US4054731A

    公开(公告)日：1977-10-18

    申请号：US596783

    申请日：1975-07-17

    申请人： Kiyonobu Marubashi ,  Hideji Oshima ,  Yasuaki Sakano

    发明人： Kiyonobu Marubashi ,  Hideji Oshima ,  Yasuaki Sakano

    IPC分类号： C08C3/02 ,  C08F36/16 ,  C08F36/18 ,  C08K5/17 ,  C08F2/00 ,  C08F4/00 ,  C08F14/02 ,  C08F34/00

    CPC分类号： C08F36/16 ,  C08C3/02 ,  C08F36/18 ,  C08K5/17

    摘要： A process for preparing a chloroprene-based liquid polymer having active terminal groups substantially at the terminals thereof comprising polymerizing chloroprene alone or in combination with one or more monomers copolymerizable with chloroprene in (1) an organic solvent having a boiling point of about 160.degree. C or less at atmospheric pressure and selected from the group consisting of aromatic hydrocarbons, aliphatic halogenated hydrocarbons and cyclic ethers, or (2) in carbon disulfide, which is present in an amount of about 20 to 200 parts by weight per 100 parts by weight of the total monomer, in the presence of a xanthogen disulfide compound represented by the formula: ##STR1## wherein R can contain from 1 to 12 carbon atoms and is an alkyl group, an aryl group, an aralkyl group or a cycloaliphatic group, which is present in an amount substantially equal to a ratio of about 2.5 to 20 parts by weight of diethyl xanthogen disulfide per 100 parts by weight of the total monomer. The chloroprene-based liquid polymer is purified by contacting the polymer or the polymer containing solution with an alcohol represented by the formula:R.sub.1 OHwherein R.sub.1 is an alkyl group containing 1 to 5 carbon atoms, to remove any unreacted xanthogen disulfide compound.

    摘要翻译： 一种制备基本上在其末端具有活性末端基的氯丁二烯基液体聚合物的方法，包括在（1）沸点为约160℃的有机溶剂中单独聚合氯丁二烯或与可与氯丁二烯共聚的一种或多种单体组合 或更低，并且选自芳族烃，脂族卤代烃和环醚，或（2）在二硫化碳中，其存在量为每100重量份的约20至200重量份 所述总单体在由下式表示的黄原二硫化物存在下进行：其中R可含有1至12个碳原子，并且为烷基，芳基，芳烷基或脂环族基团，其为 存在的量基本上等于每100重量份总单体约2.5至20重量份的二乙基黄原二硫化物的比例。 通过使聚合物或含聚合物的溶液与由下式表示的醇接触来纯化氯丁二烯类液体聚合物：

    Island
    90.
    发明授权
    Island 失效

    公开(公告)号：US1406654A

    公开(公告)日：1922-02-14

    申请号：US1406654D

    IPC分类号： C08C3/02

    CPC分类号： C08C3/02