公开(公告)号：US06833348B1

公开(公告)日：2004-12-21

申请号：US09403861

申请日：2000-02-11

Applicant: Carlo Riccardi

Inventor： Carlo Riccardi

IPC: C07K1700

CPC classification number: C07K14/4703 ,  A61K38/00 ,  A61K48/00 ,  C07K14/4705

Abstract: A DNA sequence encoding a glucocorticoid-induced leucine-zipper family related protein (GILR), isoforms, fragments or analogs thereof said GILR, isoforms, fragments or analogs thereof capable of inhibiting apoptosis and stimulating lymphocyte activity, GILR proteins, isoforms, analogs, fragments and derivatives thereof encoded by the aforesaid DNA sequence, their preparation and uses.

Abstract translation: 编码糖皮质激素诱导的亮氨酸 - 拉链家族相关蛋白（GILR），同种型，其片段或类似物的DNA序列说明能够抑制凋亡和刺激淋巴细胞活性的GILR，同工型，其片段或类似物，GILR蛋白，同种型，类似物，片段 及其衍生物，其制备和用途。

公开(公告)号：US06800735B2

公开(公告)日：2004-10-05

申请号：US09832659

申请日：2001-04-11

Applicant: Adrian Whitty ,  Laura Runkel ,  Margot Brickelmaier ,  Paula Hochman

Inventor： Adrian Whitty ,  Laura Runkel ,  Margot Brickelmaier ,  Paula Hochman

IPC: C07K1700

CPC classification number: C07K14/565 ,  A61K38/00 ,  C07K2319/00 ,  C07K2319/30

Abstract: A fusion polypeptide is described having the amino acid sequence X-Y-Z, or portion thereof, comprising the amino acid sequence of a glycosylated interferon-beta (X); Y is an optional linker moiety; and Z is a polypeptide comprising at least a portion of a polypeptide other than glycosylated interferon-beta. It is preferred that X is human interferon-beta-1a. Mutants of interferon-beta-1a are also described.

Abstract translation: 描述了融合多肽，其具有包含糖基化干扰素-β（X）的氨基酸序列的氨基酸序列X-Y-Z或其部分。 Y是任选的接头部分; Z是包含至少一部分除糖基化干扰素-β以外的多肽的多肽。 优选X是人干扰素-β-1a。 还描述了干扰素-β-1a的突变体。

公开(公告)号：US06797809B2

公开(公告)日：2004-09-28

申请号：US10637323

申请日：2003-08-08

Applicant: David Y. Chien ,  Phillip Arcangel ,  Laura Tandeske ,  Carlos George-Nascimento ,  Doris Coit ,  Angelica Medina-Selby

Inventor： David Y. Chien ,  Phillip Arcangel ,  Laura Tandeske ,  Carlos George-Nascimento ,  Doris Coit ,  Angelica Medina-Selby

IPC: C07K1700

CPC classification number: C07K14/005 ,  C07K2319/00 ,  C12N2770/24222 ,  G01N33/5767 ,  G01N2333/18 ,  G01N2469/10 ,  G01N2469/20

Abstract: HCV immunoassays comprising an NS3/4a conformational epitope and a multiple epitope fusion antigen are provided, as well as immunoassay solid supports for use with the immunoassays.

Abstract translation: 提供包含NS3 / 4a构象表位和多表位融合抗原的HCV免疫测定，以及用于免疫测定的免疫测定固体支持物。

公开(公告)号：US06630576B2

公开(公告)日：2003-10-07

申请号：US09938936

申请日：2001-08-24

Applicant: Waldemar Debinski

Inventor： Waldemar Debinski

IPC: C07K1700

CPC classification number: C07K14/21 ,  A61K38/00 ,  A61K47/62 ,  C07K14/5437 ,  C07K2319/00

Abstract: This invention provides mutant hIL13 molecules include those made by substituting one or more of the amino acid residues that occur in the alpha-helix regions of native hIL13 with various other amino acid residues. Multiply mutated forms of hIL13 conjugated to cytotoxins are used to preferentially target diseased cells over non-diseased cells.

公开(公告)号：US06569994B1

公开(公告)日：2003-05-27

申请号：US09105254

申请日：1998-06-26

Applicant: Ying-Fei Wei ,  Steven M. Ruben ,  Aziz Sancar ,  Shiao-Wen D. Hsu ,  Aleksey G. Kazantsev

Inventor： Ying-Fei Wei ,  Steven M. Ruben ,  Aziz Sancar ,  Shiao-Wen D. Hsu ,  Aleksey G. Kazantsev

IPC: C07K1700

CPC classification number: C07K14/705 ,  C07K2319/00 ,  C12N2799/026

Abstract: The present invention relates to a novel member of the blue-fight photoreceptor family of receptors. In particular, isolated nucleic acid molecules are provided encoding the human hCRY2 receptor. hCRY2 polypeptides are also provided as are vectors, host cells, antibodies, and recombinant methods for producing the same.

Abstract translation: 本发明涉及蓝色受感染家族的新型成员。 特别地，提供编码人hCRY2受体的分离的核酸分子。 还提供hCRY2多肽，载体，宿主细胞，抗体和用于制备它们的重组方法。

公开(公告)号：US06448377B1

公开(公告)日：2002-09-10

申请号：US09672239

申请日：2000-09-27

Applicant: Brian Kobilka ,  Tae Weon Lee

Inventor： Brian Kobilka ,  Tae Weon Lee

IPC: C07K1700

CPC classification number: G01N33/68 ,  G01N2333/726 ,  G01N2500/00

Abstract: The present invention provides modified G protein &agr;-subunits which are characterized by constitutive localization to the plasma membrane; enhanced binding to one or more of the normal receptor binding partners for that &agr;-subunit; and efficient binding to and activation of G protein binding partners. The distribution of these modified &agr;-subunits, which are “tethered” to the plasma membrane, allows the regulation of receptor-G protein coupling, and thus G-protein signaling, in various biological systems.

Abstract translation: 本发明提供修饰的G蛋白α亚基，其特征在于质膜定位到质膜; 增强与该α-亚基的一个或多个正常受体结合配偶体的结合; 并有效结合和激活G蛋白结合配偶体。 这些经修饰的α亚基的“拴系”到质膜中的分布允许在各种生物系统中调节受体-G蛋白偶联，从而调节G蛋白信号传导。

公开(公告)号：US06433144B1

公开(公告)日：2002-08-13

申请号：US09229039

申请日：1999-01-12

Applicant: Joseph P. Morris ,  Duy Nguyen ,  James Kappelman ,  Michael D. Potter ,  Mead M. McCabe ,  Reza Ziai ,  Stephen Feldman ,  Hipolito Hartman

Inventor： Joseph P. Morris ,  Duy Nguyen ,  James Kappelman ,  Michael D. Potter ,  Mead M. McCabe ,  Reza Ziai ,  Stephen Feldman ,  Hipolito Hartman

IPC: C07K1700

CPC classification number: C07K14/56 ,  A61K38/00

Abstract: This invention relates to methods for isolating highly purified mixtures of natural Type I interferon from white blood cells. The invention also relates to highly-purified mixtures of Type I interferon which resemble natural Type I interferon in that the highly purified mixtures of natural Type I interferon includes at least 9 subtypes, i.e., alpha-1, alpha-2, alpha-5, alpha-7, alpha-8, alpha-10, alpha-14, alpha-21 and omega, giving rise to at least 16, and possibly 20 or more molecular species, including alpha-1a, alpha-1new, alpha-2a, alpha-2b, alpha-2c, alpha-5, alpha-5LG, alpha-7, alpha-8a, alpha-8c, alpha-10a, alpha-14a, alphal4-b, alpha 14-c, alpha-14LG, alpha-21a, alpha-21b, alpha-21c, omega and omega LG.

Abstract translation: 本发明涉及从白细胞中分离出高度纯化的天然I型干扰素混合物的方法。 本发明还涉及类似于天然I型干扰素的I型干扰素的高度纯化的混合物，因为天然I型干扰素的高度纯化的混合物包括至少9种亚型，即α-1，α-2，α-5， α-7，α-8，α-10，α-14，α-21和ω，产生至少16种，并且可能有20种或更多种分子物质，包括α-1a，α-1新，α-2a， α-2b，α-2c，α-5，α-5LG，α-7，α-8a，α-8c，α-10a，α-14a，alphal4-b，α14-c，α-14LG， -21a，α-21b，α-21c，ω和ωLG。

公开(公告)号：US06737510B1

公开(公告)日：2004-05-18

申请号：US09548373

申请日：2000-04-12

Applicant: Mark E. Gurney ,  Michael J. Bienkowski ,  Robert L. Heinrikson ,  Luis A. Parodi ,  Riqiang Yan

Inventor： Mark E. Gurney ,  Michael J. Bienkowski ,  Robert L. Heinrikson ,  Luis A. Parodi ,  Riqiang Yan

IPC: C07K1700

CPC classification number: C12N9/6478 ,  C07K14/4711 ,  C07K2319/00 ,  C12N2799/026 ,  C12Q1/37 ,  G01N2333/96472

Abstract: The present invention provides the enzyme and enzymatic procedures for cleaving the &bgr; secretase cleavage site of the APP protein and associated nucleic acids, peptides, vectors, cells and cell isolates and assays. The invention further provides a modified APP protein and associated nucleic acids, peptides, vectors, cells, and cell isolates, and assays that are particularly useful for identifying candidate therapeutics for treatment or prevention of Alzheimer's disease.

Abstract translation: 本发明提供用于切割APP蛋白和相关核酸，肽，载体，细胞和细胞分离物和测定的β分泌酶切割位点的酶和酶程序。 本发明还提供了修饰的APP蛋白和相关核酸，肽，载体，细胞和细胞分离物以及特别可用于鉴定用于治疗或预防阿尔茨海默病的候选治疗剂的测定。

公开(公告)号：US06689867B1

公开(公告)日：2004-02-10

申请号：US09684327

申请日：2000-10-10

Applicant: Lo Wei-Yu ,  Hsieh Shie-Liang

Inventor： Lo Wei-Yu ,  Hsieh Shie-Liang

IPC: C07K1700

CPC classification number: C07K14/47

Abstract: The invention provides the nucleic acid and amino acid sequences of a novel human tumor-associated antigen, planenta derived apoptotic factor (PDAF), and the use of these sequences in the treatment of disorders associated with immune and cell proliferation.

Abstract translation: 本发明提供新的人肿瘤相关抗原，平均衍生的凋亡因子（PDAF）的核酸和氨基酸序列，以及这些序列用于治疗与免疫和细胞增殖相关的病症的用途。

公开(公告)号：US06559290B1

公开(公告)日：2003-05-06

申请号：US08819630

申请日：1997-03-17

Applicant: Masaru Nakatani ,  Shigeo Furuyoshi ,  Satoshi Takata

Inventor： Masaru Nakatani ,  Shigeo Furuyoshi ,  Satoshi Takata

IPC: C07K1700

CPC classification number: B01D15/00 ,  C07K14/521

Abstract: An adsorbent for removing a chemokine except interleukin-8 in body fluid, which comprises a solid material having an anionic functional group, a method for efficiently removing a chemokine except interleukin-8 in body fluid, which comprises by bringing the above adsorbent into contact with body fluid containing the chemokine and an adsorber for removing a chemokine except for interleukin-8 using the above adsorbent.

Abstract translation: 一种用于除去体液中除白介素-8之外的趋化因子的吸附剂，其包含具有阴离子官能团的固体材料，用于有效除去体液中白细胞介素-8的趋化因子的方法，其包括通过使上述吸附剂与 含有趋化因子的体液和除了使用上述吸附剂的白细胞介素-8以外的趋化因子的吸附器。