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公开(公告)号：US07241879B2
公开(公告)日：2007-07-10
申请号：US10899715
申请日：2004-07-26
Applicant: David Y. Chien , Phillip Arcangel , Laura Tandeske , Carlos George-Nascimento , Doris Coit , Angelica Medina-Selby
Inventor： David Y. Chien , Phillip Arcangel , Laura Tandeske , Carlos George-Nascimento , Doris Coit , Angelica Medina-Selby
IPC: C07H21/04
CPC classification number: C07K14/005 , C07K2319/00 , C12N2770/24222 , G01N33/5767 , G01N2333/18 , G01N2469/10 , G01N2469/20
Abstract: HCV immunoassays comprising an NS3/4a conformational epitope and a multiple epitope fusion antigen are provided, as well as immunoassay solid supports for use with the immunoassays.
Abstract translation: 提供包含NS3 / 4a构象表位和多表位融合抗原的HCV免疫测定，以及用于免疫测定的免疫测定固体支持物。
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公开(公告)号：US07785782B2
公开(公告)日：2010-08-31
申请号：US10733767
申请日：2003-12-12
Applicant: David Y. Chien , Bruce H. Phelps , Yiu-Lan Fong
Inventor： David Y. Chien , Bruce H. Phelps , Yiu-Lan Fong
IPC: C12Q1/68
CPC classification number: B01L3/5027 , A61B5/14557 , B01L7/52 , B01L2200/027 , B01L2200/10 , B01L2300/0636 , B01L2300/0825 , B01L2300/0877 , B01L2300/0887 , G01N33/5302
Abstract: A device for in-line blood screening and testing using biochips is disclosed. The screening methods include nucleic acid amplification techniques and antibody/antigen assays to detect target molecules and agents indicative of infectious diseases or metabolic diseases.
Abstract translation: 公开了一种使用生物芯片在线血液筛选和测试的装置。 筛选方法包括核酸扩增技术和用于检测指示感染性疾病或代谢疾病的靶分子和试剂的抗体/抗原测定。
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3.发明授权Polynucleotides encoding a multiple epitope fusion antigen for use in an HCV antigen/antibody combination assay 有权编码用于HCV抗原/抗体组合测定中的多表位融合抗原的多核苷酸公开(公告)号：US07319144B2
公开(公告)日：2008-01-15
申请号：US10643853
申请日：2003-08-19
Applicant: David Y. Chien , Phillip Arcangel , Laura Tandeske , Carlos George-Nascimento , Doris Coit , Angelica Medina-Selby
Inventor： David Y. Chien , Phillip Arcangel , Laura Tandeske , Carlos George-Nascimento , Doris Coit , Angelica Medina-Selby
CPC classification number: C07K14/005 , C07K2319/00 , C12N2770/24222 , G01N33/5767 , G01N2333/18 , G01N2469/10 , G01N2469/20
Abstract: The invention relates to a method of detecting HCV infection in a biological sample, the method comprising providing an immunoassay solid support, comprising an HCV anti-core antibody, an antigen comprising an HCV NS3/4a epitope, and an HCV multiple epitope fusion antigen, that can detect both HCV antigens and antibodies present in a sample. The invention also includes polynucleotides encoding multiple epitope fusion antigens for use in the assay, recombinant vectors and host cells comprising such polynucleotides, and methods of producing the multiple epitope fusion antigens.
Abstract translation: 本发明涉及检测生物样品中HCV感染的方法，所述方法包括提供包含HCV抗核心抗体，包含HCV NS3 / 4a表位的抗原和HCV多表位融合抗原的免疫测定固体支持物， 其可以检测样品中存在的HCV抗原和抗体。 本发明还包括编码用于测定的多种表位融合抗原的多核苷酸，包含此类多核苷酸的重组载体和宿主细胞，以及产生多表位融合抗原的方法。
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公开(公告)号：US06924122B2
公开(公告)日：2005-08-02
申请号：US10225390
申请日：2002-08-20
Applicant: David Y. Chien , Mark J. Selby , Kevin Shoemaker , Robert L. Warne
Inventor： David Y. Chien , Mark J. Selby , Kevin Shoemaker , Robert L. Warne
CPC classification number: C07K14/005 , C12N2770/24222 , C12Q1/025 , C12Q1/37 , G01N2333/18 , G01N2500/00
Abstract: A polypeptide containing an anchor region, a protease recognition site, and a detectable signal region can be produced recombinantly and directly attached to a solid support. The polypeptide is useful for screening protease regulators, especially protease inhibitors.
Abstract translation: 包含锚定区，蛋白酶识别位点和可检测信号区的多肽可以重组并直接连接到固体支持物上。 该多肽可用于筛选蛋白酶调节剂，特别是蛋白酶抑制剂。
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公开(公告)号：US06537745B2
公开(公告)日：2003-03-25
申请号：US09775962
申请日：2001-02-02
Applicant: David Y. Chien , Phillip Arcangel , Stephen Tirell , Wanda Zeigler
Inventor： David Y. Chien , Phillip Arcangel , Stephen Tirell , Wanda Zeigler
IPC: C12Q170
CPC classification number: G01N33/5767 , G01N33/5306 , G01N33/54306 , G01N33/6854 , G01N2469/20 , Y10T436/108331 , Y10T436/2525
Abstract: The present invention is directed to an antigen diluent or buffer for antigens, in particular HCV recombinant antigens, comprising a reducing agent. The antigen diluent or buffer serves as a stabilizing buffer for the antigens. The present invention is also directed to antigen diluents or buffers for use in an automated immunoassay.
Abstract translation: 本发明涉及用于抗原的抗原稀释剂或缓冲剂，特别是包含还原剂的HCV重组抗原。 抗原稀释液或缓冲液用作抗原的稳定缓冲液。 本发明还涉及用于自动化免疫测定中的抗原稀释剂或缓冲液。
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Patent Agency Ranking
公开(公告)号：US07439040B2
公开(公告)日：2008-10-21
申请号：US11193615
申请日：2005-08-01
Applicant: David Y. Chien , Mark J. Selby , Kevin Shoemaker , Robert L. Warne
Inventor： David Y. Chien , Mark J. Selby , Kevin Shoemaker , Robert L. Warne
CPC classification number: C07K14/005 , C12N2770/24222 , C12Q1/025 , C12Q1/37 , G01N2333/18 , G01N2500/00
Abstract: A polypeptide containing an anchor region, a protease recognition site, and a detectable signal region can be produced recombinantly and directly attached to a solid support. The polypeptide is useful for screening protease regulators, especially protease inhibitors.
Abstract translation: 包含锚定区，蛋白酶识别位点和可检测信号区的多肽可以重组并直接连接到固体支持物上。 该多肽可用于筛选蛋白酶调节剂，特别是蛋白酶抑制剂。
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公开(公告)号：US07108967B2
公开(公告)日：2006-09-19
申请号：US10820922
申请日：2004-04-07
Applicant: David Y. Chien , Phillip M. Arcangel
Inventor： David Y. Chien , Phillip M. Arcangel
CPC classification number: G01N33/5767 , C07K16/109 , G01N2333/18
Abstract: Immunoassays for detecting hepatitis C virus protein and immune complexes between hepatitis C virus protein and antibodies in biological samples, methods of screening blood products for hepatitis C virus, and kits employed therefor are provided.
Abstract translation: 提供用于检测丙型肝炎病毒蛋白质和丙型肝炎病毒蛋白与生物样品中抗体之间的免疫复合物的免疫测定，筛选丙型肝炎病毒血液制品的方法，以及用于其的试剂盒。
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8.发明授权公开(公告)号：US06797809B2
公开(公告)日：2004-09-28
申请号：US10637323
申请日：2003-08-08
Applicant: David Y. Chien , Phillip Arcangel , Laura Tandeske , Carlos George-Nascimento , Doris Coit , Angelica Medina-Selby
Inventor： David Y. Chien , Phillip Arcangel , Laura Tandeske , Carlos George-Nascimento , Doris Coit , Angelica Medina-Selby
IPC: C07K1700
CPC classification number: C07K14/005 , C07K2319/00 , C12N2770/24222 , G01N33/5767 , G01N2333/18 , G01N2469/10 , G01N2469/20
Abstract: HCV immunoassays comprising an NS3/4a conformational epitope and a multiple epitope fusion antigen are provided, as well as immunoassay solid supports for use with the immunoassays.
Abstract translation: 提供包含NS3 / 4a构象表位和多表位融合抗原的HCV免疫测定，以及用于免疫测定的免疫测定固体支持物。
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公开(公告)号：US06632601B2
公开(公告)日：2003-10-14
申请号：US09881654
申请日：2001-06-14
Applicant: David Y. Chien , Phillip Arcangel , Laura Tandeske , Carlos George-Nascimento , Doris Coit , Angelica Medina-Selby
Inventor： David Y. Chien , Phillip Arcangel , Laura Tandeske , Carlos George-Nascimento , Doris Coit , Angelica Medina-Selby
IPC: C12Q170
CPC classification number: C07K14/005 , C07K2319/00 , C12N2770/24222 , G01N33/5767 , G01N2333/18 , G01N2469/10 , G01N2469/20
Abstract: HCV immunoassays comprising an NS3/4a conformational epitope and a multiple epitope fusion antigen are provided, as well as immunoassay solid supports for use with the immunoassays.
Abstract translation: 提供包含NS3 / 4a构象表位和多表位融合抗原的HCV免疫测定，以及用于免疫测定的免疫测定固体支持物。
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公开(公告)号：US6054264A
公开(公告)日：2000-04-25
申请号：US336553
申请日：1994-11-09
Applicant: David Y. Chien , George Kuo
Inventor： David Y. Chien , George Kuo
IPC: A61K39/29 , C07K14/18 , C12N15/09 , C12N15/40 , G01N33/576
CPC classification number: C07K14/005 , G01N33/5767 , C12N2770/24222 , Y10S436/82
Abstract: The claimed invention provides methods of detecting and typing HCV using type specific and type-cluster specific epitopes. The claimed invention also provides peptides having type specific and type-cluster specific epitopes.
Abstract translation: 所要求保护的发明提供了使用特异型和类型簇特异性表位检测和分型HCV的方法。 所要求保护的发明还提供具有类型特异性和类型簇特异性表位的肽。
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