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    SMART CONTRAST AGENTS FOR MRI IMAGING
    82.
    发明申请
    SMART CONTRAST AGENTS FOR MRI IMAGING 审中-公开
    用于MRI成像的SMART对比剂

    公开(公告)号：US20110243857A1

    公开(公告)日：2011-10-06

    申请号：US13140360

    申请日：2009-12-18

    申请人： Geraldine Gouhier ,  Francois Estour

    发明人： Geraldine Gouhier ,  Francois Estour

    IPC分类号： A61K49/10 ,  C07F5/00 ,  C12Q1/02 ,  C07K2/00

    CPC分类号： A61K49/189 ,  A61K49/0002 ,  A61K49/085 ,  A61K49/12 ,  B82Y5/00

    摘要： A contrast agent for MRI imaging includes: (a) one cyclodextrin, whose truncated-cone-shaped structure defines a central axis, a first and a second openings along the axis, (b) one paramagnetic element, located on the cyclodextrin axis, outside the structure and proximate to the first opening, (c) one or several coordination ligand(s) of the paramagnetic element which coordinate(s) the paramagnetic element, (d) one arm covalently bound to the cyclodextrin, proximate to the second opening, which is able to form an inclusion complex with the cyclodextrin.

    摘要翻译： 用于MRI成像的造影剂包括：（a）一个环糊精，其截头锥形结构限定中心轴线，沿轴线的第一和第二开口，（b）位于环糊精轴上的一个顺磁元件，外部 所述结构并且靠近所述第一开口，（c）顺磁元件的一个或几个配位配体，其协调顺磁元件，（d）与所述环糊精共价结合的一个臂，靠近所述第二开口， 其能够与环糊精形成包合物。

    THERANOSTIC POLYCATION BEACONS COMPRISING OLIGOETHYLENEAMINE REPEATING UNITS AND LANTHANIDE CHELATES
    83.
    发明申请
    THERANOSTIC POLYCATION BEACONS COMPRISING OLIGOETHYLENEAMINE REPEATING UNITS AND LANTHANIDE CHELATES 审中-公开
    包含二乙烯基苯胺重复单元和兰花糖酸酯的聚合物聚合物

    公开(公告)号：US20110009478A1

    公开(公告)日：2011-01-13

    申请号：US12832915

    申请日：2010-07-08

    申请人： Theresa M. REINEKE ,  Joshua M. Bryson

    发明人： Theresa M. REINEKE ,  Joshua M. Bryson

    IPC分类号： A61K48/00 ,  C12N5/02 ,  C12Q1/68 ,  C07C229/16 ,  A61P31/00 ,  A61P37/04 ,  C08G69/10

    CPC分类号： C12N15/87 ,  A61K49/0019 ,  A61K49/0054 ,  A61K49/12 ,  C07C237/10 ,  C08G69/26 ,  C12Q1/6816 ,  Y02A50/52 ,  Y02A50/55 ,  Y02A50/58 ,  C12Q2525/301 ,  C12Q2565/601

    摘要： The present invention relates to vehicles for delivering macromolecules into cells. More particularly, embodiments of the invention relate to compounds and methods for binding and compacting nucleic acids into nanoparticles for transferring the polynucleotides into cells and which can be configured to provide a mechanism for visualization of the delivery vehicles on the nm/μm scale by microscopy and on the sub-mm scale by magnetic resonance imaging. Polycations according to embodiments of the invention have been designed to contain repeated oligoethyleneamines, for binding and compacting nucleic acids into nanoparticles, and lanthanide (Ln) chelates (for example, using luminescent europium Eu3+ and paramagnetic gadolinium Gd3+). Preferred polymeric imaging beacons according to embodiments of the invention comprise repeating units of metal chelates within an oligoamine backbone, the repeating units comprising: wherein n ranges from 2 to 10,000,000; M is a metal capable of exhibiting an imaging functionality for an imaging modality; and the oligoamine backbone comprises from 1 to 8 ethlyeneamines and is chosen from diethyleneamine, triethylenediamine, tetraethylenetriamine, pentaethylenetetraamine, hexaethylenepentamine, heptaethylenehexamine, octaethyleneheptamine or nonethyleneoctaamine. Especially preferred, are structures chelated with either Eu3+ or Gd3+ for microscopy or MRI imaging, respectively. Such chelated lanthanides allow for the visualization of the delivery vehicle both on the nm/μm scale by way of microscopy and on the sub-mm scale using MRI.

    摘要翻译： 本发明涉及用于将大分子输送到细胞中的载体。 更具体地，本发明的实施方案涉及用于将核酸结合并压实成纳米颗粒的化合物和方法，用于将多核苷酸转移到细胞中，并且其可以被配置为提供通过显微镜在nm /μm规模上可视化递送载体的机制， 通过磁共振成像在sub-mm尺度上。 已经设计了根据本发明实施方案的聚阳离子包含重复的低聚亚乙基胺，用于将核酸结合并压实成纳米颗粒，以及镧系元素（Ln）螯合物（例如，使用发光铕Eu3 +和顺磁钆Gd3 +）。 根据本发明实施方案的优选的聚合成像信标包含寡胺主链内的金属螯合物的重复单元，所述重复单元包含：其中n的范围为2至10,000,000; M是能够呈现成像模态的成像功能的金属; 寡胺骨架包含1至8个乙烯胺，并选自二亚乙基胺，三亚乙基二胺，四亚乙基三胺，五亚乙基四胺，六亚乙基五胺，七亚乙基六胺，八亚乙基庚胺或壬基三胺。 特别优选的是分别与Eu3 +或Gd3 +螯合的结构用于显微镜或MRI成像。 这种螯合的镧系元素允许通过显微镜在nm /μm尺度上使用MRI在sub-mm尺度上可视化递送载体。

    Cell-specific gene delivery vehicles
    85.
    发明授权
    Cell-specific gene delivery vehicles 失效
    细胞特异性基因递送载体

    公开(公告)号：US06962686B2

    公开(公告)日：2005-11-08

    申请号：US08541191

    申请日：1995-10-11

    申请人： Jon F. Kayyem ,  Thomas J. Meade ,  Scott E. Fraser

    发明人： Jon F. Kayyem ,  Thomas J. Meade ,  Scott E. Fraser

    IPC分类号： A61K49/12 ,  A61K51/00 ,  A61M36/14

    CPC分类号： A61K49/146 ,  A61K49/12 ,  A61K49/189 ,  B82Y5/00

    摘要： A delivery vehicle is described that is capable of being specifically bound to and taken into targeted cells, delivering numerous physiological agents, particularly paramagnetic ions for magnetic resonance imaging (MRI) of the cells. The delivery vehicle comprises a polymeric molecule having a net positive charge complexed with another polymeric molecule having a net negative charge. Cell targeting moieties and physiological agents, including contrast agents and therapeutic agents, are attached to one or both of the polymeric molecules. In one embodiment, the polymeric molecule having a net negative charge is a nucleic acid. Thus, the delivery vehicles can be used in clinical protocols in which nucleic acids for gene therapy and agents for MRI contrast are co-transported to specific cells allowing medical imaging monitoring of nucleic acid delivery.

    摘要翻译： 描述了能够特异性结合并进入靶细胞的递送载体，递送许多生理剂，特别是顺磁离子用于细胞的磁共振成像（MRI）。 递送载体包含具有与具有净负电荷的另一个聚合物分子络合的净正电荷的聚合物分子。 细胞靶向部分和生理剂，包括造影剂和治疗剂，连接到一个或两个聚合物分子。 在一个实施方案中，具有净负电荷的聚合物分子是核酸。 因此，递送载体可以用于其中用于基因治疗的核酸和用于MRI对比的药剂共同转运到特定细胞的临床方案，允许核酸递送的医学成像监测。

    Diagnostic imaging agent with backbone with modified sugar chain end
    87.
    发明授权
    Diagnostic imaging agent with backbone with modified sugar chain end 失效
    具有改性糖链末端的骨架的诊断显像剂

    公开(公告)号：US5863518A

    公开(公告)日：1999-01-26

    申请号：US544548

    申请日：1995-10-18

    申请人： Yuji Hashiguchi ,  Hideki Sugino ,  Kenji Kamimura ,  Shigemi Seri

    发明人： Yuji Hashiguchi ,  Hideki Sugino ,  Kenji Kamimura ,  Shigemi Seri

    IPC分类号： A61K47/48 ,  A61K49/08 ,  A61K49/12 ,  A61K51/00 ,  A61M36/14

    CPC分类号： A61K49/12 ,  A61K47/4823 ,  A61K49/085

    摘要： There is disclosed a diagnostic imaging agent which comprises a compound wherein at least one bifunctional ligand is chemically bonded to an amino group of amino oligosaccharide having the molecular weight of 500 to 2000 and having a reduction-treated reducing end of a sugar chain, or to an aldehyde group of a dialdehyde-oligosaccharide, at least one constituent monosaccharide of which is oxidation-cleaved, having the molecular weight of 500 to 2000 and having a reduction-treated reducing end of a sugar chain, and said ligand is coordinated with at least one metal ion selected from the group consisting of metal ions having the atomic number of 21-29, 31, 32, 37-39, 42-44, 49 and 56-83.

    摘要翻译： 公开了一种诊断成像剂，其包含其中至少一个双功能配体与分子量为500〜2000的氨基寡糖的氨基化学键合并具有还原处理的糖链的还原末端的化合物，或者 二醛低聚糖的醛基，其至少一种构成单糖被氧化分解，分子量为500〜2000，并具有还原处理的糖链还原端，所述配体至少与 一种金属离子选自原子序数为21-29,31,32,37-39,42-44,49和56-83的金属离子。

    GADOLINIUM CHELATE, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF
    88.
    发明公开
    GADOLINIUM CHELATE, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF 审中-公开

    公开(公告)号：US20240139349A1

    公开(公告)日：2024-05-02

    申请号：US18279528

    申请日：2021-11-01

    申请人： SUZHOU ZHECI PHARMACEUTICAL TECHNOLOGY CO., LTD. ,  SOUTH MEDICAL UNIVERSITY

    发明人： Zheyu SHEN ,  Yudie LU

    IPC分类号： A61K49/12

    CPC分类号： A61K49/12

    摘要： A gadolinium chelate, a preparation method therefor, and an application thereof. The gadolinium chelate is a complex formed by chelation of gadolinium ions and macromolecules. The macromolecules comprise any one of or a copolymer or mixture of two or more of carboxylic acid-containing high-molecular polymers, amino-containing high-molecular polymers, hydroxyl-containing high-molecular polymers, polyester high-molecular polymers, polyether high-molecular polymers, polyamide high-molecular polymers, proteins, polypeptides, and polysaccharides. The gadolinium ions and the macromolecules form the gadolinium chelate by means of chelation. The gadolinium chelate is a water-soluble macromolecular drug, can improve a longitudinal relaxation rate r1 and reduce a ratio of r2/r1, has good water-solubility and high stability, and meanwhile, can exhibit a good imaging effect in a short period of time and shorten an MRI time.