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81.发明授权公开(公告)号：US09381277B2
公开(公告)日：2016-07-05
申请号：US14245071
申请日：2014-04-04
申请人： Purac Biochem bv
发明人： Timo Lehtonen , Jukka Tuominen , Fredrik Ollila
IPC分类号： C03C3/04 , C03C3/087 , C03C3/095 , C03C3/078 , A61K8/25 , A61K33/42 , A61K33/08 , A61L31/02 , A61L27/10 , A61L27/44 , A61L27/58 , A61L31/12 , A61L31/14 , C03C3/091 , C03C3/097 , C03C4/00
CPC分类号： A61L31/026 , A61L27/10 , A61L27/446 , A61L27/58 , A61L31/127 , A61L31/128 , A61L31/148 , C03C3/078 , C03C3/091 , C03C3/097 , C03C4/0007 , C03C2201/10 , C03C2201/28 , C03C2213/02 , Y10T428/29
摘要： Biocompatible and resorbable melt derived glass compositions which include: SiO2 60-70 weight-%, Na2O 5-20 weight-%, CaO 5-25 weight-%, MgO 0-10 weight-%, P2O5 0.5-3.0 weight-%, B2O3 0-15 weight-%, Al2O3 0-5 weight-%, and which contain less than 0.05 weight-% potassium. Biocompatible and resorbable glass fibers manufactured from these glass compositions, medical devices containing fibers of the invention, the use of these compositions for the manufacture of glass fiber and the use of the fibers for the manufacture of medical devices are also disclosed.
摘要翻译： 生物相容性和可再吸收的熔融衍生玻璃组合物，其包括：SiO 2 60-70重量％，Na 2 O 5-20重量％，CaO 5-25重量％，MgO 0-10重量％，P 2 O 5 0.5-3.0重量％ B2O3 0-15重量％，Al2O3 0-5重量％，并且其含有小于0.05重量％的钾。 还公开了由这些玻璃组合物制造的生物相容性和可再吸收的玻璃纤维，含有本发明的纤维的医疗装置，这些组合物用于制造玻璃纤维的用途以及纤维用于制造医疗装置的用途。
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公开(公告)号：US09353041B2
公开(公告)日：2016-05-31
申请号：US14406556
申请日：2013-06-14
申请人： PURAC BIOCHEM BV
IPC分类号： C07C67/03
摘要： The present invention relates to a process for the transesterification of a fatty acid ester of a lower alcohol and a salt of hydroxycarboxylic acid without making use of organic solvents. The process can also be carried out without added anionic surface active agents.
摘要翻译： 本发明涉及一种低级醇的脂肪酸酯和羟基羧酸的盐的酯交换方法，而不使用有机溶剂。 该方法也可以在不加入阴离子表面活性剂的情况下进行。
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公开(公告)号：US20160075821A1
公开(公告)日：2016-03-17
申请号：US14888460
申请日：2014-04-29
申请人： PURAC BIOCHEM BV
CPC分类号： C08G63/85 , C07F7/003 , C08F4/76 , C08F2410/03 , C08G18/428 , C08G63/08 , C08G63/823
摘要： The invention relates to a method for manufacturing polylactide, comprising the steps of mixing lactide and a metal-coordination compound as polymerization catalyst to obtain a reaction mixture, polymerizing the lactide in liquid phase at a temperature of at least 150° C. to form polylactide in liquid phase and allowing the polylactide to solidify, characterized in that the polymerization catalyst comprises a metal-ligand coordination compound whereby the parent ligand answers the formula (I), whereby R represents an H atom, an aliphatic group, a halide atom or a nitro group and the metal is at least one of Zr and Hf. The invented catalysts show kinetics which is comparable to the kinetics of the known Sn-octoate catalyst.
摘要翻译： 本发明涉及一种制备聚丙交酯的方法，包括以下步骤：将丙交酯和金属配位化合物作为聚合催化剂进行混合，得到反应混合物，在至少150℃的温度下使液态丙交酯聚合形成聚丙交酯 在液相中并使聚交酯固化，其特征在于聚合催化剂包含金属 - 配体配位化合物，由此母体配体应答式（I），其中R表示H原子，脂族基团，卤素原子或 硝基和金属是Zr和Hf中的至少一种。 本发明的催化剂显示出与已知的Sn-辛酸酯催化剂的动力学相当的动力学。
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公开(公告)号：US20150376107A1
公开(公告)日：2015-12-31
申请号：US14767004
申请日：2014-02-13
申请人： PURAC BIOCHEM BV
CPC分类号： C07C29/095 , C07C29/149 , C07C67/08 , C07C67/38 , C12P7/62 , C07C69/68
摘要： The invention pertains to a process for preparing methyl lactate inluding the steps of: bringing an aqueous liquid comprising lactic acid, methanol, and at least 5 wt. % of a dissolved chloride salt selected from magnesium chloride, calcium chloride, and zinc chloride to reaction conditions, thereby obtaining methyl lactate, wherein an extractant is provided to the reaction mixture before, during, and/or after formation of methyl lactate; subjecting the reaction mixture to a liquid-liquid separation step wherein an organic phase comprising methyl lactate and extractant is separated from an aqueous phase comprising dissolved chloride salt. The extractant preferably includes one or more compounds selected from C5+ ketones and C3-C10 ethers, in particular C5-C8 ketones, more in particular methyl isobutyl ketone. It has been found that the process according to the invention makes it possible to manufacture methyl lactate efficiently and in high yield.
摘要翻译： 本发明涉及一种制备乳酸甲酯的方法，包括以下步骤：使含有乳酸，甲醇和至少5wt。 将选自氯化镁，氯化钙和氯化锌的溶解氯化物盐的百分比调节至反应条件，由此得到乳酸甲酯，其中在形成甲酸乳酸酯之前，期间和/或之后向反应混合物中提供萃取剂; 使反应混合物进行液 - 液分离步骤，其中将包含乳酸甲酯和萃取剂的有机相与包含溶解的氯化物盐的水相分离。 提取剂优选包括一种或多种选自C 5+酮和C 3 -C 10醚，特别是C 5 -C 8酮，更特别是甲基异丁基酮的化合物。 已经发现，根据本发明的方法使得有效和高产率地制备乳酸甲酯成为可能。
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公开(公告)号：US20150368170A1
公开(公告)日：2015-12-24
申请号：US14767021
申请日：2014-02-13
申请人： PURAC BIOCHEM BV
CPC分类号： C07C29/095 , C07C29/149 , C07C67/08 , C07C67/38 , C12P7/62 , C07C69/68
摘要： The invention pertains to a process for preparing a succinic acid ester comprising the steps of bringing an aqueous liquid comprising succinic acid, alcohol, and at least 5 wt. % of a dissolved chloride salt selected from magnesium chloride, calcium chloride, and zinc chloride, calculated on the weight of the liquid, to reaction conditions, thereby obtaining a succinic acid ester, and recovering the succinic acid ester and an aqueous solution comprising the dissolved chloride salt. It has been found that the process according to the invention shows a high yield and has a high reaction rate. Additionally, it has been found that the process makes it possible to carry out the separation of the succinic acid ester from the aqueous reaction medium in high yield.
摘要翻译： 本发明涉及一种制备琥珀酸酯的方法，包括以下步骤：将含有琥珀酸，醇和至少5wt。 将根据液体重量计算的选自氯化镁，氯化钙和氯化锌的溶解氯化物盐的百分比转化为反应条件，从而得到琥珀酸酯，并回收琥珀酸酯和包含溶解的水溶液 氯化物盐。 已经发现，根据本发明的方法显示出高产率并具有高反应速率。 此外，已经发现，该方法可以高产率地从水性反应介质中进行琥珀酸酯的分离。
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公开(公告)号：US20150141683A1
公开(公告)日：2015-05-21
申请号：US14406556
申请日：2013-06-14
申请人： PURAC BIOCHEM BV
IPC分类号： C07C67/03
摘要： The present invention relates to a process for the transesterification of a fatty acid ester of a lower alcohol and a salt hydroxycarboxylic acid without making use of organic solvents. The process can also be carried out without added anionic surface active agents.
摘要翻译： 本发明涉及不使用有机溶剂的低级醇和盐羟基羧酸的脂肪酸酯的酯交换反应的方法。 该方法也可以在不加入阴离子表面活性剂的情况下进行。
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公开(公告)号：US20140349355A1
公开(公告)日：2014-11-27
申请号：US14366620
申请日：2012-12-21
申请人： PURAC BIOCHEM BV
摘要： The invention pertains to method for recovering polycarboxylic acid from an aqueous mixture including the steps of: providing an aqueous mixture including polycarboxylic acid and at least 5 wt. % dissolved halide salt, based on the total weight of water and dissolved material in the aqueous mixture; extracting the polycarboxylic acid from the aqueous mixture into a first organic liquid including an organic solvent selected from the group consisting of ketones and ethers, thereby obtaining an organic polycarboxylic acid solution and an aqueous waste liquid including the halide salt; and extracting the polycarboxylic acid from the organic carboxylic acid solution into an aqueous liquid, thereby obtaining an aqueous polycarboxylic acid solution and a second organic liquid. The method according to the invention allows a combined purification and concentration step for feed solutions of polycarboxylic acids.
摘要翻译： 本发明涉及从水性混合物中回收多元羧酸的方法，包括以下步骤：提供包含多元羧酸和至少5wt。 基于水和混合物中溶解的材料的总重量，溶解的卤化物盐％ 将所述多元羧酸从所述含水混合物中提取成包含选自酮和醚的有机溶剂的第一有机液体，由此得到有机多元羧酸溶液和包含所述卤化物盐的废水; 并将多元羧酸从有机羧酸溶液中提取到水性液体中，从而得到多元羧酸水溶液和第二有机液体。 根据本发明的方法允许多元羧酸的进料溶液的组合的纯化和浓缩步骤。
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公开(公告)号：US12031171B2
公开(公告)日：2024-07-09
申请号：US16329910
申请日：2017-09-05
申请人： PURAC BIOCHEM BV
摘要： An antibacterial agent suppresses the growth of gram-positive contaminating bacteria. The antibacterial agent is selected from: a lactylate in accordance with the general formula (R—(O—CH(CH3)—CO)aO)bM; a glycerol ester in accordance with the general formula CH2OR1—CHOR2—CH2OR3; and, mixtures thereof. In the general formulae: R represents a C4-C18 acyl group, R1, R2 and R3 are each independently selected from H or a C4-C18 acyl group, the acyl group having an alkyl or alkenyl chain which may be branched or unbranched, with the proviso that at least one of R1, R2 or R3 is H and at least one of R1, R2, or R3 is an acyl group; M represents a proton (H+) or a counter-cation chosen from the group Li, Na, K, Ca, Mg, Zn, Fe(II), Cu, Mn, Ag, ammonium or substituted ammonium having one or more (C1-4)alkyl optionally substituted with one or more hydroxyl.
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公开(公告)号：US20220240528A1
公开(公告)日：2022-08-04
申请号：US17726778
申请日：2022-04-22
申请人： PURAC BIOCHEM BV
摘要： Methods to prepare a fruit ferment containing propionic acid and/or a salt thereof comprising i) obtaining a liquid fruit preparation, ii) optionally supplementing the liquid fruit preparation with water and/or with additional components to support fermentation, iii) fermenting the optionally supplemented liquid fruit preparation with a propionic acid-producing bacterial strain, iv) optionally further processing the fermentation product, to obtain the fruit ferment. Next to a propionic acid-producing bacterial strain, a lactic acid-producing bacterial strain may be used in the fermentation. And, a fruit ferment obtainable by said method.
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公开(公告)号：US11352600B2
公开(公告)日：2022-06-07
申请号：US16304959
申请日：2017-05-29
申请人： PURAC Biochem BV
摘要： The invention pertains to a method for separating biomass from solid fermentation product wherein a slurry comprising biomass and solid fermentation product is provided to the top of a biomass separator unit and an aqueous medium is provided to the bottom of a biomass separator unit, while a product stream comprising solid fermentation product is withdrawn from the bottom of the biomass separator unit and a waste stream comprising biomass is withdrawn from the top of the biomass separator unit. It has been found that the method according to the invention makes it possible to provide a solid fermentation product which comprises very low amounts of remaining biomass, while product loss can be limited.
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