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公开(公告)号：US20180057610A1
公开(公告)日：2018-03-01
申请号：US15803543
申请日：2017-11-03
CPC分类号： C07K16/468 , A61B6/42 , A61B6/503 , A61B8/0883 , A61K9/0019 , A61K35/12 , A61K35/28 , A61K35/34 , A61K47/6901 , A61K49/0002 , A61K49/1821 , A61K49/1896 , A61K51/0421 , A61K51/1203 , A61K51/1282 , A61K2039/505 , C12N15/11
摘要： The disclosure relates to compositions comprising isolated mitochondria or combined mitochondrial agents, and methods of treating disorders using such compositions.
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82.发明申请公开(公告)号：US20170340882A1
公开(公告)日：2017-11-30
申请号：US15596555
申请日：2017-05-16
发明人： Giulio Ruffini , Oscar Ripolles Mateu , Alvaro Pascual-Leone , Michael D. Fox , Pedro Michael Cavaleiro Miranda
CPC分类号： A61N1/36025 , A61N1/0456
摘要： A system and a method for optimizing the configuration of multisite transcranial current stimulation, including providing an electric field characteristic target map on the brain's cortex, the target map including multiple cortical targets, the multiple cortical targets are localized and/or continuously varying and spatially extended, providing a weight map on the cortical surface prioritizing the important of areas in the target map for the purposes of optimization; and calculating, based on the target and weight maps, optimal currents and optimal locations for a plurality of electrodes intended for providing transcranial current stimulation to globally stimulate at once the multiple cortical targets with excitatory, inhibitory or neutral stimulation.
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公开(公告)号：US09822358B2
公开(公告)日：2017-11-21
申请号：US14517514
申请日：2014-10-17
发明人： Pier Paolo Pandolfi , Sujung Song
IPC分类号： C12N15/113 , A61K31/7115 , A61K31/712 , A61K31/7125
CPC分类号： C12N15/113 , C12N2310/113
摘要： The invention relates to the treatment and prevention of cancers, including blood-based cancers and breast cancers, by administering agents that inhibit the activity of microRNAs, including miR-22. Inhibitors can include oligonucleotides that are at least partially complementary to these miRNAs. In some embodiments, these inhibitors are chemically modified oligonucleotides, including locked nucleic acids (LNAs).
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公开(公告)号：US20170304310A1
公开(公告)日：2017-10-26
申请号：US15645683
申请日：2017-07-10
申请人： Beth Israel Deaconess Medical Center, Inc. , The United States of America, as represented by the Secretary, Department of Health and Human Serv
发明人： Kun Ping LU , Matthew Brian BOXER , Mindy Irene Emily DAVIS , Rajan PRAGANI , Min SHEN , Anton Momtchilov SIMEONOV , Shuo WEI , Xiao Zhen ZHOU
IPC分类号： A61K31/5377 , A61K31/185 , A61K31/473 , A61K31/4704 , A61K31/428 , A61K31/427 , A61K31/4245 , A61K31/405 , A61K31/404 , A61K31/4025 , A61K31/402 , A61K31/382 , A61K31/381 , A61K31/365 , A61K31/357 , A61K31/341 , A61K31/496 , A61K45/06
CPC分类号： A61K31/5377 , A61K31/185 , A61K31/341 , A61K31/357 , A61K31/365 , A61K31/381 , A61K31/382 , A61K31/402 , A61K31/4025 , A61K31/404 , A61K31/405 , A61K31/4245 , A61K31/427 , A61K31/428 , A61K31/4704 , A61K31/473 , A61K31/496 , A61K45/06 , A61K2300/00
摘要： The invention features compositions and methods for inhibiting the Pin1 protein, and the treatment of disorders characterized by elevated Pin1 levels.
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公开(公告)号：US20170298347A1
公开(公告)日：2017-10-19
申请号：US15417868
申请日：2017-01-27
IPC分类号： C12N15/11 , C12Q1/68 , C12N5/073 , C12N15/113
CPC分类号： C12N15/11 , C12N5/0603 , C12N15/1135 , C12N2310/113 , C12N2310/14 , C12N2310/531 , C12N2310/532 , C12N2320/33 , C12N2330/10 , C12N2501/00 , C12Q1/6886 , C12Q2600/158 , C12Q2600/178
摘要： Novel fusion-circular RNAs (f-circRNAs) and complements thereof are provided. Diagnostic and treatment methods using f-circRNA inhibitors are provided. Non-human animals expressing exogenous f-circRNA and complements thereof are also provided.
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公开(公告)号：US20170290928A1
公开(公告)日：2017-10-12
申请号：US15633349
申请日：2017-06-26
发明人： John V. Frangioni
IPC分类号： A61K49/00 , C07D209/42 , G01N33/58 , C07D209/02 , C09B23/01 , C09B23/08 , A61B6/00 , C07D255/02
CPC分类号： A61K49/0032 , A61B5/0059 , A61B6/00 , C07D209/02 , C07D209/42 , C07D255/02 , C09B23/0066 , C09B23/086 , C09B67/0025 , G01N33/582 , G01N2800/347
摘要： The present invention relates to a method for detecting renal disease and for assessing the efficacy of dialysis treatment using imaging agents having desirable in vivo properties.
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公开(公告)号：US09745631B2
公开(公告)日：2017-08-29
申请号：US14367341
申请日：2012-12-19
IPC分类号： C12Q1/25 , C12Q1/68 , A61K48/00 , A61K31/436 , A61K31/4412
CPC分类号： C12Q1/6886 , A61K31/436 , A61K31/4412 , C12Q2600/112 , C12Q2600/118 , C12Q2600/158
摘要： Methods for diagnosing and treating cancer associated with an oncogenic Kras mutation in a subject are provided.
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公开(公告)号：US09730941B2
公开(公告)日：2017-08-15
申请号：US14406401
申请日：2013-06-07
申请人： Beth Israel Deaconess Medical Center, Inc. , The United States of America, as represented by the Secretary, Department of Health and Human Services
发明人： Kun Ping Lu , Matthew Brian Boxer , Mindy Irene Emily Davis , Rajan Pragani , Min Shen , Anton Momtchilov Simeonov , Shuo Wei , Xiao Zhen Zhou
IPC分类号： A61K31/5377 , A61K31/473 , A61K45/06 , A61K31/185 , A61K31/341 , A61K31/357 , A61K31/365 , A61K31/381 , A61K31/382 , A61K31/402 , A61K31/4025 , A61K31/404 , A61K31/405 , A61K31/4245 , A61K31/427 , A61K31/428 , A61K31/4704 , A61K31/496
CPC分类号： A61K31/5377 , A61K31/185 , A61K31/341 , A61K31/357 , A61K31/365 , A61K31/381 , A61K31/382 , A61K31/402 , A61K31/4025 , A61K31/404 , A61K31/405 , A61K31/4245 , A61K31/427 , A61K31/428 , A61K31/4704 , A61K31/473 , A61K31/496 , A61K45/06 , A61K2300/00
摘要： The invention features compositions and methods for inhibiting the Pin1 protein, and the treatment of disorders characterized by elevated Pin1 levels.
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公开(公告)号：US20170226194A1
公开(公告)日：2017-08-10
申请号：US15270461
申请日：2016-09-20
IPC分类号： C07K16/12
CPC分类号： C07K16/1271 , A61K2039/505 , C07K16/12 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/73 , Y02A50/407
摘要： The present invention relates to peptides, particularly human monoclonal antibodies, that bind specifically to poly-N-acetyl glucosamine (PNAG), such as Staphylococcal PNAG, in acetylated, partially acetylated and/or fully deacetylated form. The invention further provides methods for using these peptides in the diagnosis, prophylaxis and therapy of infections by bacteria that express PNAG such as but not limited to Staphylococci and E. coli. Some antibodies of the invention enhance opsonophagocytic killing and in vivo protection against bacteria that express PNAG such as but not limited to Staphylococci and E. coli. Compositions of these peptides, including pharmaceutical compositions, are also provided, as are functionally equivalent variants of such peptides.
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90.发明申请公开(公告)号：US20170112792A1
公开(公告)日：2017-04-27
申请号：US15126714
申请日：2015-03-19
发明人： Kun Ping LU , Xiao Zhen ZHOU , Shuo WEI
IPC分类号： A61K31/203 , A61K45/06 , C12Q1/533 , C07C57/26
CPC分类号： A61K31/203 , A61K38/21 , A61K45/06 , C07C57/26 , C12Q1/533 , G01N2333/99 , G01N2500/04 , G01N2800/24 , G01N2800/307 , G01N2800/7028 , G16B35/00 , G16C20/60 , Y02A50/414 , A61K2300/00
摘要： The invention features all-trans retinoic acid (ATRA)-related compounds capable of associating with Pin1 and methods of identifying the same. The invention also provides methods of treating a condition selected from the group consisting of a proliferative disorder, an autoimmune disease, and an addiction condition characterized by elevated Pin1 marker levels, Pin1 degradation, and/or reduced Pin1 Ser71 phosphorylation in a subject by administering a retinoic acid compound. Additionally, the invention features methods of treating proliferative disorders, autoimmune diseases, and addiction conditions (e.g., diseases, disorders, and conditions characterized by elevated Pin1 marker levels) by administering a retinoic acid compound in combination with another therapeutic compound. The invention also features a co-crystal including Pin1 and a retinoic acid compound. Finally, the invention also provides methods of developing and identifying enhanced Pin1-targeted ATRA-related compounds based on the newly defined unique binding pockets in the Pin1 active site revealed from the co-crystal structure, structure-activity relationship, and structural modeling.
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