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公开(公告)号：US11499152B2
公开(公告)日：2022-11-15
申请号：US16979782
申请日：2019-03-14
IPC分类号： C07H21/04 , C12N15/113 , A61K31/713
摘要： The present disclosure provides compositions and methods that inhibit the activity of microRNAs, for example miR-22.
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公开(公告)号：US20150111949A1
公开(公告)日：2015-04-23
申请号：US14517514
申请日：2014-10-17
发明人： Pier Paolo Pandolfi , Sujung Song
IPC分类号： C12N15/113
CPC分类号： C12N15/113 , C12N2310/113
摘要： The invention relates to the treatment and prevention of cancers, including blood-based cancers and breast cancers, by administering agents that inhibit the activity of microRNAs, including miR-22. Inhibitors can include oligonucleotides that are at least partially complementary to these miRNAs. In some embodiments, these inhibitors are chemically modified oligonucleotides, including locked nucleic acids (LNAs).
摘要翻译： 本发明涉及通过施用抑制微小RNA（包括miR-22）活性的药剂来治疗和预防癌症，包括血液中的癌症和乳腺癌。 抑制剂可以包括与这些miRNA至少部分互补的寡核苷酸。 在一些实施方案中，这些抑制剂是化学修饰的寡核苷酸，包括锁定的核酸（LNA）。
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公开(公告)号：US11753639B2
公开(公告)日：2023-09-12
申请号：US16979777
申请日：2019-03-14
IPC分类号： C12N15/113 , A61K31/713
CPC分类号： C12N15/113 , A61K31/713 , C12N2310/11 , C12N2310/113 , C12N2310/14 , C12N2310/141 , C12N2310/3231 , C12N2310/344 , C12N2320/50
摘要： The present disclosure provides a method of treating or preventing metabolic disorders by administering agents that inhibit the activity of microRNAs that modulate metabolism.
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4.发明申请公开(公告)号：US20180195067A1
公开(公告)日：2018-07-12
申请号：US15845573
申请日：2017-12-18
发明人： Pier Paolo Pandolfi , Assaf C. Bester , Yvonne Tay
IPC分类号： C12N15/113 , A61P35/00
CPC分类号： C12N15/113 , A61P35/00 , C12N15/1135 , C12N2310/141 , C12N2310/315 , C12N2310/321 , C12N2750/14143 , C12N2310/3521
摘要： Novel mIR-330 agents and their methods of use are provided. Methods of treating MYC-associated cancers are provided.
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公开(公告)号：US11274301B2
公开(公告)日：2022-03-15
申请号：US15727156
申请日：2017-10-06
IPC分类号： C12N15/11 , C12N15/113 , A61K45/06
摘要： The invention relates to the treatment and prevention of cancer by administering agents that inhibit the activity of microRNAs that modulate tumor suppressor genes, which can include PTEN, p53, and INPP4B, among others. Inhibitors can include oligonucleotides that are at least partially complementary to these miRNAs. In some embodiments, these inhibitors are chemically modified oligonucleotides, including locked nucleic acids (LNAs).
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公开(公告)号：US20180105813A1
公开(公告)日：2018-04-19
申请号：US15724860
申请日：2017-10-04
发明人： Pier Paolo Pandolfi , Sujung Song
IPC分类号： C12N15/113
CPC分类号： C12N15/113 , C12N2310/113
摘要： The invention relates to the treatment and prevention of cancers, including blood-based cancers and breast cancers, by administering agents that inhibit the activity of microRNAs, including miR-22. Inhibitors can include oligonucleotides that are at least partially complementary to these miRNAs. In some embodiments, these inhibitors are chemically modified oligonucleotides, including locked nucleic acids (LNAs).
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公开(公告)号：US09822358B2
公开(公告)日：2017-11-21
申请号：US14517514
申请日：2014-10-17
发明人： Pier Paolo Pandolfi , Sujung Song
IPC分类号： C12N15/113 , A61K31/7115 , A61K31/712 , A61K31/7125
CPC分类号： C12N15/113 , C12N2310/113
摘要： The invention relates to the treatment and prevention of cancers, including blood-based cancers and breast cancers, by administering agents that inhibit the activity of microRNAs, including miR-22. Inhibitors can include oligonucleotides that are at least partially complementary to these miRNAs. In some embodiments, these inhibitors are chemically modified oligonucleotides, including locked nucleic acids (LNAs).
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公开(公告)号：US20170298347A1
公开(公告)日：2017-10-19
申请号：US15417868
申请日：2017-01-27
IPC分类号： C12N15/11 , C12Q1/68 , C12N5/073 , C12N15/113
CPC分类号： C12N15/11 , C12N5/0603 , C12N15/1135 , C12N2310/113 , C12N2310/14 , C12N2310/531 , C12N2310/532 , C12N2320/33 , C12N2330/10 , C12N2501/00 , C12Q1/6886 , C12Q2600/158 , C12Q2600/178
摘要： Novel fusion-circular RNAs (f-circRNAs) and complements thereof are provided. Diagnostic and treatment methods using f-circRNA inhibitors are provided. Non-human animals expressing exogenous f-circRNA and complements thereof are also provided.
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9.发明授权公开(公告)号：US10443055B2
公开(公告)日：2019-10-15
申请号：US15845573
申请日：2017-12-18
发明人： Pier Paolo Pandolfi , Assaf C. Bester , Yvonne Tay
IPC分类号： C07H21/04 , C12N15/113 , A61P35/00
摘要： Novel mIR-330 agents and their methods of use are provided. Methods of treating MYC-associated cancers are provided.
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公开(公告)号：US20180073025A1
公开(公告)日：2018-03-15
申请号：US15727156
申请日：2017-10-06
IPC分类号： C12N15/113 , A61K45/06
CPC分类号： C12N15/113 , A61K45/06 , C12N2310/113 , C12N2310/315 , C12N2310/321 , C12N2310/3231 , C12N2320/30
摘要： The invention relates to the treatment and prevention of cancer by administering agents that inhibit the activity of microRNAs that modulate tumor suppressor genes, which can include PTEN, p53, and INPP4B, among others. Inhibitors can include oligonucleotides that are at least partially complementary to these miRNAs. In some embodiments, these inhibitors are chemically modified oliognucleotides, including locked nucleic acids (LNAs).
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