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公开(公告)号:US20240254242A1
公开(公告)日:2024-08-01
申请号:US18604851
申请日:2024-03-14
发明人: Kyung Moo YEA , Beom Yong LEE , Jong Won JEONG
CPC分类号: C07K16/2863 , A61P3/00 , A61K2039/505 , C07K2317/565 , C07K2317/622
摘要: The present invention relates to a GFRAL-antagonistic antibody having improved affinity and a use thereof, and more particularly, the present invention relates to an anti-GFRAL antibody having improved affinity, comprising a heavy chain CDR and a light chain CDR of specific sequences, or an antigen-binding fragment thereof. The anti-GFRAL antibody having improved affinity exhibits higher binding ability to a GFRAL protein than a conventional anti-GFRAL antibody, and thus is expected to be effectively used for improving or treating cancer-related anorexia or cachexia syndrome and side effects of chemotherapy anticancer drugs.
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82.
公开(公告)号:US20240226150A9
公开(公告)日:2024-07-11
申请号:US18448665
申请日:2023-08-11
申请人: THE CATHOLIC UNIVERSITY OF KOREA INDUSTRY-ACADEMIC COOPERATION FOUNDATION , SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION , Daegu Gyeongbuk Institute of Science and Technology
发明人: Kiyuk CHANG , Daehee HWANG , Min-Sik KIM , Eunmin KIM , Eun Hye PARK , Chan Woo KIM
CPC分类号: A61K35/15 , A61K39/4615 , A61K39/4621 , A61P9/04 , C07K14/4702 , C12N5/0018 , C12N5/064
摘要: The present disclosure relates to the preparation of citrullinated vimentin antigen-specific immune tolerogenic dendritic cells and a composition for preventing or treating heart failure after myocardial infarction comprising the same. According to the present disclosure, it is confirmed that immune tolerogenic dendritic cells differentiated by treating immature dendritic cells with citrullinated vimentin regulate the expression of immune-related factors and have an excellent therapeutic effect on heart failure caused by myocardial infarction.
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公开(公告)号:US20240141558A1
公开(公告)日:2024-05-02
申请号:US18410007
申请日:2024-01-11
发明人: Ju Ahn Park , Sangaraju Shanmugam
CPC分类号: D01F9/10 , D01D5/003 , D01D5/0061 , H01M8/10 , H01M2008/1095
摘要: Disclosed are porous multi-metal oxide nanotubes and a production method therefor. In one aspect, methods for producing porous multi-metal oxide nanotubes are provided comprising: (a) preparing an admixture comprising metal-acetylacetonate precursors, polyacrylonitrile (PAN) and a solvent component; and (b) producing a nanocomposite from the admixture, wherein metals of the metal-acetylacetonate precursors comprise a non-radioactive alkali metal stable isotope and a non-radioactive alkaline earth metal stable isotope. As such, porous multi-metal oxide nanotubes having a single-phase multivalence may be obtained in high yield without using harmful chemical substances. In addition, the polymer electrolyte membrane including the porous multi-metal oxide nanotubes may have maintained and improved mechanical strength, and thus may have maintained durability even during cell operation and may also have improved proton conductivity even at low humidity. The fuel cell including the polymer electrolyte membrane may have improved performance.
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公开(公告)号:US20240139474A1
公开(公告)日:2024-05-02
申请号:US18494369
申请日:2023-10-25
发明人: Hong Soo Choi , Hak Joon Lee , Jin Young Kim
CPC分类号: A61M25/0127 , A61B6/4441 , A61B6/487 , A61B34/73 , A61B2034/731
摘要: Provided is a magnetic actuation system controlling a magnetic microrobot, a magnetic actuation catheter, or a guide wire by using a magnetic field, and more particularly, a magnetic actuation system compatible with a C-arm that is applied to the C-arm, which is a mobile X-ray fluoroscopy device, in order to enable control of the microrobot or a catheter treatment in a human body by using the C-arm.
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公开(公告)号:US11971315B2
公开(公告)日:2024-04-30
申请号:US17427775
申请日:2019-07-23
发明人: June Seo Kim , Myoung Jae Lee , Hyeon Jun Lee
CPC分类号: G01L1/122 , H01F10/14 , H01F10/325 , H01F10/3254
摘要: Disclosed is a force sensor. More particularly, the force sensor includes a first permanent magnet layer; a magnetic tunnel junction disposed on the first permanent magnet layer and configured to have a preset resistance value; and a second permanent magnet layer disposed to be spaced apart from the magnetic tunnel junction, wherein the second permanent magnet layer moves in a direction of the first permanent magnet layer when pressure is applied from outside, the preset resistance value of the magnetic tunnel junction is changed when a magnetic field strength formed between the first permanent magnet layer and the second permanent magnet layer becomes a preset strength or more according to movement of the second permanent magnet layer, and the force sensor senses the pressure based on a change in the preset resistance value.
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公开(公告)号:US20240118497A1
公开(公告)日:2024-04-11
申请号:US18273837
申请日:2022-01-26
申请人: DAEGU GYEONGBUK INSTITUTE OF SCIENCE AND TECHNOLOGY , KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY
发明人: Kyoung Sik YU , Sang Yoon HAN
CPC分类号: G02B6/3584 , G02B6/34
摘要: A multicast switch array and a multi-beam steering device using the same are provided. Accordingly, it is possible to precisely steer a large-scale multi-beam.
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公开(公告)号:US11905624B2
公开(公告)日:2024-02-20
申请号:US17341955
申请日:2021-06-08
发明人: Ju Ahn Park , Sangaraju Shanmugam
CPC分类号: D01F9/10 , D01D5/003 , D01D5/0061 , H01M8/10 , H01M2008/1095
摘要: Disclosed are porous multi-metal oxide nanotubes and a production method therefor. In one aspect, methods for producing porous multi-metal oxide nanotubes are provided comprising: (a) preparing an admixture comprising metal-acetylacetonate precursors, polyacrylonitrile (PAN) and a solvent component; and (b) producing a nanocomposite from the admixture, wherein metals of the metal-acetylacetonate precursors comprise a non-radioactive alkali metal stable isotope and a non-radioactive alkaline earth metal stable isotope. As such, porous multi-metal oxide nanotubes having a single-phase multivalence may be obtained in high yield without using harmful chemical substances. In addition, the polymer electrolyte membrane including the porous multi-metal oxide nanotubes may have maintained and improved mechanical strength, and thus may have maintained durability even during cell operation and may also have improved proton conductivity even at low humidity. The fuel cell including the polymer electrolyte membrane may have improved performance.
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公开(公告)号:US20240050113A1
公开(公告)日:2024-02-15
申请号:US18446036
申请日:2023-08-08
发明人: Hong Soo CHOI , Hak Joon LEE , Jin Young KIM
IPC分类号: A61B17/221 , A61B34/00
CPC分类号: A61B17/221 , A61B34/73 , A61B2017/00327
摘要: Provided is an aspiration catheter having a tubular shape and used to remove an embolus or a thrombus by being inserted into a blood vessel, and more particularly, a steerable and expandable aspiration catheter which may apply an effective aspiration force to an embolus or a thrombus by steering a distal tip of the catheter in a three-dimensional direction and expanding a diameter of the tip.
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公开(公告)号:US20240044025A1
公开(公告)日:2024-02-08
申请号:US18366025
申请日:2023-08-07
发明人: Jong Sung YU , Tong Hyun Kang
IPC分类号: C25B11/067 , C25B11/077
CPC分类号: C25B11/067 , C25B11/077
摘要: Provided is a catalyst for oxygen evolution reaction (OER) which has excellent catalytic performance and durability of oxygen evolution reaction (OER) by applying an oxide of divalent titanium having high electrical conductivity as a support, and more particularly, a porous catalyst for oxygen evolution reaction (OER) including a porous titanium oxide support satisfying TiO2−x (0.1≤x
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公开(公告)号:US20240039428A1
公开(公告)日:2024-02-01
申请号:US18203696
申请日:2023-05-31
发明人: Sang Hoon LEE , Min Seok KANG , Hee Jae SHIN
IPC分类号: H02N1/04
CPC分类号: H02N1/04
摘要: The present invention relates to a neuro-stimulator, and more particularly, to a rotational triboelectric nanogenerator for a neuro-stimulator providing, as a device that may directly utilize nerve stimulation triboelectricity generated by rotational energy for nerve electrical stimulation, a device that may adjust waveforms and stimulation parameters of electricity generated during frictional contact through a combination of various materials with triboelectric properties and patterns of materials and electrodes, implement various nerve stimulation parameters by adjusting an external rotational speed or a distance between friction layers, does not require complicated circuits or voltages and batteries to drive the batteries, and may be driven through relatively small volume, inexpensive materials, a simple structure, and a simple operation method.
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