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    IL3Ralpha Antibody Conjugates And Uses Thereof
    71.
    发明申请
    IL3Ralpha Antibody Conjugates And Uses Thereof 有权
    IL3Rα抗体缀合物及其用途

    公开(公告)号：US20160031994A1

    公开(公告)日：2016-02-04

    申请号：US14632178

    申请日：2015-02-26

    Applicant: Stemline Therapeutics, Inc.

    Inventor： Ivan Bergstein

    IPC: C07K16/28 ,  C12N9/10

    CPC classification number: C07K16/2866 ,  A61K39/00 ,  C07K16/18 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2317/94 ,  C07K2319/55 ,  C12N5/163 ,  C12N9/1048 ,  C12N9/1077 ,  C12N15/86 ,  C12Y204/02036

    Abstract: The present invention provides antibodies that bind to the IL-3 receptor alpha subunit alpha (Il3Rα) chain, and compositions comprising such antibodies. The present invention provides methods for inhibiting or reducing an IL3Rα-expressing cell population, the methods comprising contacting a population of IL3Rα-expressing cells (e.g., cancer cells and/or cancer stem cells) with an antibody that binds to IL3Rα. The present invention also provides antibody conjugates comprising an antibody that binds to an IL3Rα chain linked to a cytotoxic agent or anticellular agent and compositions comprising such conjugates. The present invention also provides methods for preventing, treating and/or managing a disorder associated with IL3Rα-expressing cells (e.g., a hematological cancer), the methods comprising administering to a subject in need thereof an antibody that binds to IL3Rα.

    Abstract translation: 本发明提供了结合IL-3受体α亚基α（II3Rα）链的抗体和包含此类抗体的组合物。 本发明提供了抑制或减少IL3Rα表达细胞群体的方法，所述方法包括将IL3Rα表达细胞群（例如癌细胞和/或癌干细胞）与结合IL3Rα的抗体接触。 本发明还提供了包含结合与细胞毒剂或抗细胞剂连接的IL3Rα链的抗体的抗体缀合物和包含这种缀合物的组合物。 本发明还提供了用于预防，治疗和/或控制与表达IL3Rα的细胞相关的病症（例如，血液癌症）的方法，所述方法包括向有需要的受试者施用与IL3Rα结合的抗体。

    Modified forms of Pseudomonas exotoxin A
    76.
    发明授权
    Modified forms of Pseudomonas exotoxin A 有权
    假单胞菌外毒素A的修​​饰形式

    公开(公告)号：US08932586B2

    公开(公告)日：2015-01-13

    申请号：US13604173

    申请日：2012-09-05

    Applicant: Timothy David Jones ,  Francis Joseph Carr

    Inventor： Timothy David Jones ,  Francis Joseph Carr

    IPC: C12N9/10 ,  A61K39/00 ,  A61K39/02 ,  C07K16/28 ,  C07K14/21 ,  A61K38/00

    CPC classification number: C12N9/1077 ,  A61K38/00 ,  A61K39/00 ,  A61K39/02 ,  C07K14/21 ,  C07K16/2803 ,  C07K2317/622 ,  C12Y204/02036

    Abstract: Pseudomonas exotoxin A or “PE” is a 66 kD, highly potent, cytotoxic protein secreted by the bacterium Pseudomonas aeruginosa. Various forms of PE have been coupled to other proteins, such as antibodies, to generate therapeutically useful cytotoxin conjugates that selectively target cells of a desired phenotype (such as tumor cells). In the present invention, peptides spanning the sequence of an approximately 38 kD form of Pseudomonas exotoxin A protein were analyzed for the presence of immunogenic CD4+ T cell epitopes. Six immunogenic T cell epitopes were identified. Residues were identified within each epitope for introduction of targeted amino acid substitutions to reduce or prevent immunogenic T-cell responses in PE molecules which may be administered to a heterologous host.

    Abstract translation: 假单胞菌外毒素A或“PE”是由铜绿假单胞菌分泌的66kD，高效的细胞毒性蛋白质。 已经将各种形式的PE偶联到其它蛋白质，例如抗体，以产生选择性靶向所需表型细胞（例如肿瘤细胞）的治疗上有用的细胞毒素缀合物。 在本发明中，分析跨越约38kD形式的假单胞菌外毒素A蛋白的序列的免疫原性CD4 + T细胞表位的存在。 鉴定了6种免疫原性T细胞表位。 在每个表位内鉴定出残基，用于引入靶向氨基酸取代，以减少或预防可能施用于异源宿主的PE分子中的免疫原性T细胞应答。

    Modified Forms of Pseudomonas Exotoxin A
    79.
    发明申请
    Modified Forms of Pseudomonas Exotoxin A 有权
    假单胞菌外毒素A的修​​饰形式

    公开(公告)号：US20130121983A1

    公开(公告)日：2013-05-16

    申请号：US13604173

    申请日：2012-09-05

    Applicant: Timothy David JONES ,  Francis Joseph Carr

    Inventor： Timothy David JONES ,  Francis Joseph Carr

    IPC: C12N9/10

    CPC classification number: C12N9/1077 ,  A61K38/00 ,  A61K39/00 ,  A61K39/02 ,  C07K14/21 ,  C07K16/2803 ,  C07K2317/622 ,  C12Y204/02036

    Abstract: Pseudomonas exotoxin A or “PE” is a 66 kD, highly potent, cytotoxic protein secreted by the bacterium Pseudomonas aeruginosa. Various forms of PE have been coupled to other proteins, such as antibodies, to generate therapeutically useful cytotoxin conjugates that selectively target cells of a desired phenotype (such as tumor cells). In the present invention, peptides spanning the sequence of an approximately 38 kD form of Pseudomonas exotoxin A protein were analyzed for the presence of immunogenic CD4+ T cell epitopes. Six immunogenic T cell epitopes were identified. Residues were identified within each epitope for introduction of targeted amino acid substitutions to reduce or prevent immunogenic T-cell responses in PE molecules which may be administered to a heterologous host.

    Abstract translation: 假单胞菌外毒素A或“PE”是由铜绿假单胞菌分泌的66kD，高效的细胞毒性蛋白质。 已经将各种形式的PE偶联到其它蛋白质，例如抗体，以产生选择性靶向所需表型细胞（例如肿瘤细胞）的治疗上有用的细胞毒素缀合物。 在本发明中，分析跨越约38kD形式的假单胞菌外毒素A蛋白的序列的免疫原性CD4 + T细胞表位的存在。 鉴定了6种免疫原性T细胞表位。 在每个表位内鉴定出残基，用于引入靶向氨基酸取代，以减少或预防可能施用于异源宿主的PE分子中的免疫原性T细胞应答。

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