公开(公告)号：US07303757B2

公开(公告)日：2007-12-04

申请号：US10635847

申请日：2003-08-05

Applicant: Kemal Schankereli ,  Ronald Dieck

Inventor： Kemal Schankereli ,  Ronald Dieck

IPC: A61F2/02 ,  A61F2/06 ,  A61M5/00

CPC classification number: C09J189/00 ,  A61K9/0024 ,  A61K47/42 ,  A61L24/0021 ,  A61L24/10 ,  A61L29/044 ,  A61L31/043

Abstract: Biocompatible phase invertable proteinaceous compositions and methods for making and using the same are provided. The subject phase invertable compositions are prepared by combining a proteinaceous substrate and a cross-linker. The proteinaceous substrate includes one or more proteins and an adhesion modifier, and may also include one or more of: a pasticizer, a carbohydrate, or other modification agent. In certain embodiments, the cross-linker is a heat-treated dialdehyde, e.g., heat-treated glutaraldehyde. Also provided are kits for use in preparing the subject compositions. The subject compositions, kits and systems find use in a variety of different applications.

Abstract translation: 提供了生物相容性相可逆蛋白质组合物及其制备和使用方法。 通过组合蛋白质底物和交联剂制备目标相可逆组合物。 蛋白质底物包括一种或多种蛋白质和粘合改性剂，并且还可以包括以下的一种或多种：增塑剂，碳水化合物或其它改性剂。 在某些实施方案中，交联剂是经热处理的二醛，例如经热处理的戊二醛。 还提供了用于制备主题组合物的试剂盒。 主题组合物，试剂盒和系统可用于各种不同的应用。

公开(公告)号：US20070224251A1

公开(公告)日：2007-09-27

申请号：US11385750

申请日：2006-03-22

Applicant: Masao Tanihara ,  Hisao Kinoshita ,  Takayuki Imamura ,  Chikateru Nozaki

Inventor： Masao Tanihara ,  Hisao Kinoshita ,  Takayuki Imamura ,  Chikateru Nozaki

IPC: A61K38/48 ,  A61L15/00

CPC classification number: A61K38/4833 ,  A61L15/225 ,  A61L15/32 ,  A61L24/043 ,  A61L24/10 ,  A61L2400/04

Abstract: The present invention provides a hemostatic material which is excellent in hemostatic property, biodegradability and bioabsorbability, uniformity and stability of the quality, as well as reduces a risk of contamination with a pathogenic organism derived from an animal. The hemostatic material comprises a thrombin and a synthetic polypeptide capable of forming a triple helical structure. The polypeptide may show a peak of the molecular weight in the range from 5×104 to 100×104 in the molecular weight distribution. The polypeptide may contain at least a peptide unit represented by the formula: -Pro-X-Gly- (in the formula, X represents Pro or Hyp). The thrombin may be a recombinant. In the hemostatic material, the proportion of the thrombin may be about 0.1 to 500 units (U) relative to 1 mg of the polypeptide. The hemostatic material may further comprise a binder component having biodegradability and bioabsorbability. The hemostatic material may be formed on a substrate.

Abstract translation: 本发明提供止血性，生物降解性和生物吸收性，质量的均匀性和稳定性优异的止血材料，并且降低了来自动物的病原体的污染的风险。 止血材料包含能够形成三重螺旋结构的凝血酶和合成多肽。 多肽可以在分子量分布中显示分子量在5×10 4至1​​00×10 4范围内的峰。 多肽可以至少含有由下式表示的肽单元：-Pro-X-Gly-（在该式中，X表示Pro或Hyp）。 凝血酶可以是重组体。 在止血材料中，相对于1mg多肽，凝血酶的比例可以为约0.1至500单位（U）。 止血材料还可以包含具有生物降解性和生物吸收性的粘合剂组分。 止血材料可以形成在基底上。

公开(公告)号：US20070190083A1

公开(公告)日：2007-08-16

申请号：US11404202

申请日：2006-04-14

Applicant: Jeffrey Scifert ,  William McKay

Inventor： Jeffrey Scifert ,  William McKay

IPC: A61K9/00

CPC classification number: A61L27/24 ,  A61F2/02 ,  A61K9/0019 ,  A61K9/0024 ,  A61K9/1652 ,  A61L24/0015 ,  A61L24/0036 ,  A61L24/0042 ,  A61L24/0084 ,  A61L24/02 ,  A61L24/10 ,  A61L24/102 ,  A61L27/02 ,  A61L27/46 ,  A61L27/54 ,  A61L27/56 ,  A61L27/58 ,  A61L2300/112 ,  A61L2300/252 ,  A61L2300/412 ,  A61L2300/414 ,  A61L2300/45 ,  A61L2300/604 ,  A61L2400/06 ,  A61L2430/02 ,  A61L2430/38

Abstract: Described is a medically useful article comprising a three-dimensional body including one or more implantable substances, wherein the body defines one or more reservoirs for receiving amounts of a biocompatible wetting liquid. In certain embodiments the body is disruptable upon wetting with the biocompatible liquid to form a conformable implantable material such as a putty, paste or more flowable wetted implant material. Also described are methods for manufacturing such medical materials, and methods for using such medical materials to treat patients.

Abstract translation: 描述了一种医学上有用的制品，其包括包含一种或多种可植入物质的三维体，其中所述主体限定用于接收生物相容性润湿液体量的一个或多个储存器。 在某些实施方案中，身体在与生物相容性液体润湿时形成适形植入材料，例如油灰，糊状物或更易流动的润湿植入材料。 还描述了制造这种医疗材料的方法，以及使用这种医疗材料来治疗患者的方法。

公开(公告)号：US07094428B2

公开(公告)日：2006-08-22

申请号：US10315918

申请日：2002-12-10

Applicant: Charles R. Spillert ,  Marcelle Khalil

Inventor： Charles R. Spillert ,  Marcelle Khalil

IPC: A61K9/14 ,  A61K33/38 ,  A61K38/36 ,  A61F2/00 ,  A61F13/00

CPC classification number: A61L26/0028 ,  A61K33/28 ,  A61K33/38 ,  A61K38/36 ,  A61K38/363 ,  A61K38/37 ,  A61K38/39 ,  A61L15/18 ,  A61L15/32 ,  A61L24/02 ,  A61L24/10 ,  A61L26/0004 ,  A61L2400/04 ,  A61K2300/00

Abstract: A hemostatic composition which comprises at least one procoagulant metal ion, such as silver (I) or mercury (II), and at least one procoagulant biopolymer, such as collagen, thrombin, prothrombin, fibrin, fibrinogen, heparinase, Factor VIIa, Factor VIII, Factor IXa, Factor Xa, Factor XII, von Willebrand Factor, a selectin, a procoagulant venom, a plasminogen activator inhibitor, glycoprotein IIb-IIIa, a protease, or plasma. The composition in the form of a paste, dough, glue, liquid, lyophilized powder or foam, may be provided, for application to a wound. A hemostatic device is also described which comprises a hemostatic composition as described above. The device may be in the form of, for example, a plug, bandage, gauze, cloth, tampon, membrane or sponge. Methods are also provided for prophylaxis or treatment of bleeding at a site by application to the site of the composition or device as described.

公开(公告)号：US20040063613A1

公开(公告)日：2004-04-01

申请号：US10675407

申请日：2003-09-30

Inventor： James Rolke ,  Luis Burzio ,  Eugene Pashkovski

IPC: A61K038/17

CPC classification number: A61L24/108 ,  A61L24/001 ,  A61L24/043 ,  A61L24/10 ,  C08L89/00

Abstract: The invention provides methods and compositions that are useful for adhering biological and/or synthetic tissues, sealing fluid and/or gaseous leaks in biological and/or synthetic tissues, and preparing implants useful for delivery of a bioactive molecule such as a drug, for bulking applications, or for tissue prostheses. The present invention also relates to bio-erodable adhesive or occluding compositions and methods of using the same.

Abstract translation: 本发明提供了可用于粘附生物和/或合成组织，密封生物和/或合成组织中的流体和/或气体泄漏的方法和组合物，以及制备用于递送生物活性分子例如药物的用于膨胀的植入物 应用或组织假体。 本发明还涉及生物可侵蚀粘合剂或闭塞组合物及其使用方法。

公开(公告)号：US20040052850A1

公开(公告)日：2004-03-18

申请号：US10243482

申请日：2002-09-13

Inventor： Kemal Schankereli

IPC: A61K031/74 ,  A61K009/14

CPC classification number: A61L24/10 ,  A61L24/0021 ,  A61L29/044 ,  A61L31/043

Abstract: A sealant useful for the control of fluid leakage in bloody and non-bloody surgical fields.

Abstract translation: 一种用于控制血液和非血腥手术领域流体泄漏的密封剂。

公开(公告)号：USRE38158E1

公开(公告)日：2003-06-24

申请号：US09185732

申请日：1998-11-04

Applicant: Thomas H. Barrows ,  Terry W. Lewis ,  Myhanh T. Truong ,  Matthew T. Scholz

Inventor： Thomas H. Barrows ,  Terry W. Lewis ,  Myhanh T. Truong ,  Matthew T. Scholz

IPC: A61K3800

CPC classification number: A61L24/043 ,  A61L24/046 ,  A61L24/10 ,  A61L24/106 ,  C09J189/00 ,  Y10S530/83 ,  C08L89/00

Abstract: This invention is related to an adhesive composition which may be used to bond or seal tissue in vivo. The adhesive composition is readily formed from a two component mixture which includes a first part of a protein, preferably a serum albumin protein, in an aqueous buffer having a pH in the range of about 8.0-11.0 and a second part of a water-compatible or water-soluble bifunctional crosslinking agent. When the two parts of the mixture are combined, the mixture is initially a liquid which cures in vivo on the surface of tissue in less than about one minute to give a strong, flexible, pliant substantive composition which bonds to the tissue and is absorbed in about four to sixty days. The adhesive composition may be used either to bond tissue, to seal tissue or to prevent tissue adhesions caused by surgery.

Abstract translation: 本发明涉及可用于在体内粘合或密封组织的粘合剂组合物。 粘合剂组合物容易地由包含蛋白质的第一部分，优选血清白蛋白的双组分混合物形成，所述第一部分混合物在pH为约8.0-11.0的水性缓冲液中，第二部分为水相容性 或水溶性双功能交联剂。 当混合物的两部分组合时，混合物最初是在小于约1分钟内在组织表面上体内固化的液体，以产生结合到组织上并被吸收的强的，柔性的，柔韧的，完整的组合物 约四六十天。 粘合剂组合物可以用于粘合组织，以密封组织或防止由手术引起的组织粘连。

公开(公告)号：US06475508B1

公开(公告)日：2002-11-05

申请号：US09658345

申请日：2000-09-07

Applicant: Daniel M. Schwartz ,  Jeffrey A. Hubbell ,  Alexander R. Irvine

Inventor： Daniel M. Schwartz ,  Jeffrey A. Hubbell ,  Alexander R. Irvine

IPC: C08L2100

CPC classification number: A61L24/10 ,  A61K31/74 ,  A61K31/77 ,  A61K41/0061 ,  A61K45/06 ,  A61L24/046 ,  A61L24/06 ,  A61L2430/16 ,  C08L71/02 ,  C08L33/00

Abstract: Described are compositions, methods, and articles of manufacture for the closure of retinal breaks with a non-toxic polymer. Transformation to a gel-like coat is achieved by photochemical reactivity, chemical reactivity, and by physicochemical response.

Abstract translation: 描述了用无毒聚合物封闭视网膜断裂的组合物，方法和制品。 通过光化学反应性，化学反应性和物理化学反应实现对凝胶状涂层的转变。

公开(公告)号：US06310036B1

公开(公告)日：2001-10-30

申请号：US09227400

申请日：1999-01-09

Applicant: David A. Browdie

Inventor： David A. Browdie

IPC: A01N3718

CPC classification number: A61L24/102 ,  A61B17/00491 ,  A61B17/0057 ,  A61K38/39 ,  A61L24/10 ,  A61K2300/00

Abstract: Disclosed is a novel tissue adhesive technology comprising a combination of ultrasonically treated proteins including collagen and albumin which form a viscous material that develops adhesive properties when chemically cross-linked. A novel new cross-linking agent with surprisingly stable properties was developed in association with the tissue adhesive described and claimed herein and is considered to be within the scope of the present invention. This new cross-linking agent is a product of reacting glutaraldehyde with amino acids or peptides and allowing the reaction to proceed to completion. This chemical cross-linker is mixed with the ultrasonically treated proteins, allowed to react for a pre-determined time, then used to seal large surface areas of vigorously bleeding tissues including, but not limited to, the liver, lungs and major vascular systems in patients with and without bleeding disorders. This same tissue adhesive has proven to work well in sealing suture sites to prevent leakage.

Abstract translation: 公开了一种新型组织粘合剂技术，其包括超声处理的蛋白质（包括胶原蛋白和白蛋白）的组合，其形成当化学交联时产生粘合性质的粘性材料。 与本文所述和要求保护的组织粘合剂相关联地开发出具有令人惊奇的稳定性质的新型交联剂，并被认为在本发明的范围内。 这种新的交联剂是使戊二醛与氨基酸或肽反应并使反应进行完成的产物。 将该化学交联剂与超声处理的蛋白质混合，允许反应预定时间，然后用于密封大量出血组织的大表面积，包括但不限于肝，肺和主要血管系统 有无出血性疾病的患者。 证明这种相同的组织粘合剂在密封缝合部位中能很好地起作用以防止泄漏。

公开(公告)号：US06183498B2

公开(公告)日：2001-02-06

申请号：US09180687

申请日：1999-09-20

Applicant: Dale P. Devore ,  Charles Putnam ,  James M. Pachence

Inventor： Dale P. Devore ,  Charles Putnam ,  James M. Pachence

IPC: A61B1704

CPC classification number: A61L24/102 ,  A61B17/00491 ,  A61B17/0057 ,  A61B2017/005 ,  A61L24/10 ,  A61L24/104 ,  A61L24/106 ,  A61L24/108

Abstract: Methods and products for rapidly sealing a fluid leak in a tissue are provided. A polymerizable protein is applied to a tissue having an opening which creates a fluid leak in the tissue, in order to seal the opening. The tissue area and opening coated with the polymerizable protein are exposed to an initiator in order to polymerize the covering in situ, and create a seal over the opening that prevents fluid leakage. The methods and products to the invention may be used, for example, to seal airholes in lung injuries and to seal anastomoses and suture lines for blood vessels.

Abstract translation: 提供了用于快速密封组织中的流体泄漏的方法和产品。 将可聚合蛋白质施加到具有在组织中产生流体泄漏的开口的组织，以便密封开口。 涂覆有可聚合蛋白质的组织区域和开口暴露于引发剂以便原位聚合覆盖物，并且在开口上形成防止流体泄漏的密封。 本发明的方法和产品可用于例如密封肺损伤中的气孔并密封吻合缝合线以用于血管。