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公开(公告)号：US06562863B2
公开(公告)日：2003-05-13
申请号：US09768473
申请日：2001-01-24
Applicant: Leo J. Romanczyk, Jr. , John F. Hammerstone, Jr. , Margaret M. Buck
Inventor： Leo J. Romanczyk, Jr. , John F. Hammerstone, Jr. , Margaret M. Buck
IPC: A01N4316
CPC classification number: A61K31/78 , A23L33/105 , A61K31/353 , A61K36/185 , C07D311/62
Abstract: Disclosed and claimed are cocoa extracts such as polyphenols or procyanidins, methods for preparing such extracts, as well as uses for them, especially as antineoplastic agents and antioxidants. Disclosed and claimed are antineoplastic compositions containing cocoa polyphenols or procyanidins and methods for treating patients employing the compositions. Additionally disclosed and claimed is a kit for treating a patient in need of treatment with an antineoplastic agent containing cocoa polyphenols or procyanidins as well as a lyophilized antineoplastic composition containing cocoa polyphenols or procyanidins. Further, disclosed and claimed is the use of the invention in antioxidant, preservative and topiosomerase-inhibiting compositions and methods.
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72.发明授权Use of (meth)acrylic acid copolymers to increase the permeability of mucous membranes 失效使用（甲基）丙烯酸共聚物来增加粘膜的渗透性公开(公告)号：US06555124B1
公开(公告)日：2003-04-29
申请号：US09230741
申请日：1999-02-01
Applicant: Karl Kolter , Thomas Subkowski , Martin Raditsch , Volker Schehlmann
Inventor： Karl Kolter , Thomas Subkowski , Martin Raditsch , Volker Schehlmann
IPC: A61K914
CPC classification number: A61K47/32 , A61K9/2027 , A61K9/2846 , A61K31/78 , A61K33/24 , A61K45/06 , A61K2300/00
Abstract: (Meth)acrylic acid copolymers are used to increase mucosal permeability, comonomers present being (meth)acrylic esters and/or other monomers capable of free-radical polymerization, and the (meth)acrylic acid:comonomer molar ratio varying from 99:1 to 1:99.
Abstract translation: （甲基）丙烯酸共聚物用于增加粘膜渗透性，作为（甲基）丙烯酸酯和/或能够进行自由基聚合的其它单体存在的共聚单体，和（甲基）丙烯酸：共聚单体的摩尔比为99:1至 1:99。
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公开(公告)号：US20020168427A1
公开(公告)日：2002-11-14
申请号：US10073357
申请日：2002-02-13
Applicant: CSIR
Inventor： Fanie Retief Van Heerden , Robert Vleggaar , Roelof Marthinus Horak , Robin Alec Learmonth , Vinesh Maharaj , Rory Desmond Whittal
IPC: A61K035/78
CPC classification number: A61K31/57 , A23L33/105 , A61K31/58 , A61K31/704 , A61K31/78 , A61K36/27 , C07H3/04 , C07H3/06 , C07H5/10 , C07H13/08 , C07J7/002 , C07J7/0025 , C07J7/0035 , C07J7/007 , C07J15/00 , C07J17/00 , C07J17/005 , C07J41/00 , Y02P20/582 , A61K2300/00
Abstract: A pharmaceutical composition contains an extract obtainable from a plant of the genus Trichocaulon or Hoodia containing an appetite suppressant agent having the formula (1). A process for obtaining the extract and a process for synthesizing compound (1) and its analogues and derivatives is also provided. The invention also extends to the use of such extracts and compound (1) and its analogues for the manufacture of medicaments having appetite suppressant activity. The invention further provides novel intermediates for the synthesis of compound (1).
Abstract translation: 药物组合物含有可从含有具有式（1）的食欲抑制剂的Trichocaulon或Hoodia属的植物获得的提取物。 还提供了获得提取物的方法和化合物（1）及其类似物和衍生物的合成方法。 本发明还涉及这种提取物和化合物（1）及其类似物用于制造具有食欲抑制活性的药物的用途。 本发明还提供了用于合成化合物（1）的新型中间体。
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公开(公告)号：US20020004523A1
公开(公告)日：2002-01-10
申请号：US09768473
申请日：2001-01-24
Applicant: Mars, Incorporated
Inventor： Leo J. Romanczyk JR. , John F. Hammerstone JR. , Margaret M. Buck
IPC: A01N043/16 , A61K031/35 , C07D313/00
CPC classification number: A61K31/78 , A23L33/105 , A61K31/353 , A61K36/185 , C07D311/62
Abstract: Disclosed and claimed are cocoa extracts such as polyphenols or procyanidins, methods for preparing such extracts, as well as uses for them, especially as antineoplastic agents and antioxidants. Disclosed and claimed are antineoplastic compositions containing cocoa polyphenols or procyanidins and methods for treating patients employing the compositions. Additionally disclosed and claimed is a kit for treating a patient in need of treatment with an antineoplastic agent containing cocoa polyphenols or procyanidins as well as a lyophilized antineoplastic composition containing cocoa polyphenols or procyanidins. Further, disclosed and claimed is the use of the invention in antioxidant, preservative and topiosomerase-inhibiting compositions and methods.
Abstract translation: 披露和要求的是可可提取物如多酚或原花青素，制备这些提取物的方法，以及它们的用途，特别是抗肿瘤剂和抗氧化剂。 披露和要求的是含有可可多元酚或原花青素的抗肿瘤组合物和用于治疗使用该组合物的患者的方法。 另外公开并要求保护的是用于治疗需要用含有可可多元酚或原花青素的抗肿瘤剂治疗的患者以及含有可可多元酚或原花青素的冻干抗肿瘤组合物的试剂盒。 此外，公开并要求保护的是本发明在抗氧化剂，防腐剂和拓扑异构酶抑制组合物和方法中的用途。
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公开(公告)号：US06180094B2
公开(公告)日：2001-01-30
申请号：US09147534
申请日：1999-01-15
Applicant: Yoshiyuki Sasaki , Yutaka Ishii
Inventor： Yoshiyuki Sasaki , Yutaka Ishii
IPC: A61K31785
CPC classification number: A61K33/26 , A61K31/78 , A61K31/785 , Y10S514/814 , A61K2300/00
Abstract: A medicament which comprises as an active ingredient a weakly basic anion exchange resin chelating with ferric ions, preferably a polyamine-type or an acrylic-type resin. The medicament has excellent adsorbability and selectivity to phosphate ions and efficiently adsorb phosphate ions in vivo, and accordingly, is useful for therapeutic and/or preventive treatment of hyperphosphatemia.
Abstract translation: 作为活性成分含有与铁离子螯合的弱碱性阴离子交换树脂，优选多胺型或丙烯酸类树脂的药物。 该药物对磷酸盐离子具有优异的吸附性和选择性，并有效地吸附体内磷酸根离子，因此可用于高磷酸盐血症的治疗和/或预防性治疗。
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Patent Agency Ranking
公开(公告)号：US6017521A
公开(公告)日：2000-01-25
申请号：US951419
申请日：1997-10-16
Applicant: Joseph R. Robinson , William J. Bologna
Inventor： Joseph R. Robinson , William J. Bologna
CPC classification number: A61K47/32 , A61K31/765 , A61K31/78 , A61K9/0034 , A61K9/006 , Y10S514/967
Abstract: The present invention relates to the use of a bioadhesive aqueous composition to control the pH of the vagina to alleviate microorganism growth and feminine odor such as presented by bacterial vaginosis. The composition contemplated herein comprises water and an acidic polymer, specifically one wherein 80% of the monomers contain at least one carboxyl group [--COOH] and wherein the polymer is cross-linked so as to be water-swellable, but water-insoluble. The composition of the present invention is additionally a bioadhesive providing for a long-lasting benefit and control of vaginal pH.
Abstract translation: 本发明涉及生物粘附性水性组合物用于控制阴道pH以减轻微生物生长和女性气味（如由细菌性阴道病引起的）的用途。 本文考虑的组合物包含水和酸性聚合物，特别是其中80％的单体含有至少一个羧基[-COOH]的聚合物，并且其中聚合物被交联以使其水溶胀，但是不溶于水。 本发明的组合物另外是生物粘附剂，其提供持久的益处并控制阴道pH。
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公开(公告)号：US5877206A
公开(公告)日：1999-03-02
申请号：US834637
申请日：1997-04-14
Applicant: Leo J. Romanczyk, Jr. , John F. Hammerstone, Jr. , Margaret M. Buck
Inventor： Leo J. Romanczyk, Jr. , John F. Hammerstone, Jr. , Margaret M. Buck
IPC: A23L1/30 , A23G1/02 , A23G1/30 , A61K31/35 , A61K31/352 , A61K31/353 , A61K31/7048 , A61K31/78 , A61K36/00 , A61K36/18 , A61K36/185 , A61P35/00 , C07D311/62 , C07D311/78 , C08K5/54 , C08K9/06 , C08L27/12 , C08L27/16
CPC classification number: A61K31/78 , A23L33/105 , A61K31/353 , A61K36/185 , C07D311/62
Abstract: Disclosed and claimed are cocoa extracts such as polyphenols or procyanidins, methods for preparing such extracts, as well as uses for them, especially as antineoplastic agents and antioxidants. Disclosed and claimed are antineoplastic compositions containing cocoa polyphenols or procyanidins and methods for treating patients employing the compositions. Additionally disclosed and claimed is a kit for treating a patient in need of treatment with an antineoplastic agent containing cocoa polyphenols or procyanidins as well as a lyophilized antineoplastic composition containing cocoa polyphenols or procyanidins. Further, disclosed and claimed is the use of the invention in antioxidant, preservative and topiosomerase-inhibiting compositions and methods.
Abstract translation: 披露和要求的是可可提取物如多酚或原花青素，制备这些提取物的方法，以及它们的用途，特别是抗肿瘤剂和抗氧化剂。 披露和要求的是含有可可多元酚或原花青素的抗肿瘤组合物和用于治疗使用该组合物的患者的方法。 另外公开并要求保护的是用于治疗需要用含有可可多元酚或原花青素的抗肿瘤剂治疗的患者以及含有可可多元酚或原花青素的冻干抗肿瘤组合物的试剂盒。 此外，公开并要求保护的是本发明在抗氧化剂，防腐剂和拓扑异构酶抑制组合物和方法中的用途。
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公开(公告)号：US5639796A
公开(公告)日：1997-06-17
申请号：US117880
申请日：1993-09-07
Applicant: Clarence C. Lee
Inventor： Clarence C. Lee
IPC: A61K9/107 , A61K9/00 , A61K31/715 , A61K31/717 , A61K31/721 , A61K31/722 , A61K31/728 , A61K31/729 , A61K31/731 , A61K31/737 , A61K31/74 , A61K31/745 , A61K31/75 , A61K31/765 , A61K31/77 , A61K31/78 , A61K31/785 , A61K38/04 , A61K38/06 , A61K38/08 , A61K38/17 , A61K38/38 , A61K38/39 , A61M5/178 , A61P13/02 , A61P15/00 , A61P43/00 , A61K91/10 , A61K47/36 , A61K47/42
CPC classification number: A61K9/0024 , A61K31/715 , A61K31/717 , A61K31/721 , A61K31/722 , A61K31/728 , A61K31/729 , A61K31/731 , A61K31/734 , A61K31/737 , A61K31/745 , A61K31/75 , A61K31/765 , A61K31/77 , A61K31/78 , A61K31/785 , A61K38/04 , A61K38/06 , A61K38/08 , A61K38/17 , A61K38/38 , A61K38/39 , Y10S514/801 , Y10S514/937 , Y10S514/95
Abstract: The present invention is an injectable medical composition useful for replacing natural lubricating fluids in the body of humans or animals. The method and composition can be used for the treatment of joints and other parts of the body wherein natural lubrication between surfaces is deficient or where additional lubrication is required. The composition comprises a hydrophilic polymer suspended in a hydrophobic carrier so that the suspension is easily injectable into the desired body part. After injection, the carrier diffuses away from the polymer and is replaced by aqueous body fluids thereby causing the polymer to absorb or adsorb water forming a viscous, lubricating fluid.
Abstract translation: 本发明是一种可用于替代人或动物身体中的天然润滑液的可注射医用组合物。 该方法和组合物可用于处理身体的接头和其他部分，其中表面之间的天然润滑不足或需要额外的润滑。 该组合物包含悬浮在疏水载体中的亲水性聚合物，使得悬浮液容易地注入所需的身体部位。 注射后，载体从聚合物扩散，并被体内体液代替，从而使聚合物吸收或吸附形成粘性润滑流体的水。
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79.发明授权
公开(公告)号：US5554645A
公开(公告)日：1996-09-10
申请号：US317226
申请日：1994-10-03
Applicant: Leo J. Romanczyk, Jr. , John F. Hammerstone, Jr. , Margaret M. Buck
Inventor： Leo J. Romanczyk, Jr. , John F. Hammerstone, Jr. , Margaret M. Buck
IPC: A23L1/30 , A23G1/02 , A23G1/30 , A61K31/35 , A61K31/352 , A61K31/353 , A61K31/7048 , A61K31/78 , A61K36/00 , A61K36/18 , A61K36/185 , A61P35/00 , C07D311/62 , C07D311/78 , A01N43/16 , C07D313/00
CPC classification number: A61K31/78 , A23L33/105 , A61K31/353 , A61K36/185 , C07D311/62
Abstract: Disclosed and claimed are cocoa extracts such as polyphenols or procyanidins, methods for preparing such extracts, as well as uses for them, especially as antineoplastic agents and antioxidants. Disclosed and claimed are antineoplastic compositions containing cocoa polyphenols or procyanidins and methods for treating patients employing the compositions. Additionally disclosed and claimed is a kit for treating a patient in need of treatment with an antineoplastic agent containing cocoa polyphenols or procyanidins as well as a lyophilized antineoplastic composition containing cocoa polyphenols or procyanidins. Further, disclosed and claimed is the use of the invention in antioxidant, preservative and topiosomerase-inhibiting compositions and methods.
Abstract translation: 披露和要求的是可可提取物如多酚或原花青素，制备这些提取物的方法，以及它们的用途，特别是抗肿瘤剂和抗氧化剂。 披露和要求的是含有可可多元酚或原花青素的抗肿瘤组合物和用于治疗使用该组合物的患者的方法。 另外公开并要求保护的是用于治疗需要用含有可可多元酚或原花青素的抗肿瘤剂治疗的患者以及含有可可多元酚或原花青素的冻干抗肿瘤组合物的试剂盒。 此外，公开并要求保护的是本发明在抗氧化剂，防腐剂和拓扑异构酶抑制组合物和方法中的用途。
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公开(公告)号：US5554367A
公开(公告)日：1996-09-10
申请号：US334512
申请日：1994-11-04
Applicant: Yusuf Ali , Rajni Jani , George R. McCarty
Inventor： Yusuf Ali , Rajni Jani , George R. McCarty
IPC: A61K9/08 , A61K9/00 , A61K31/13 , A61K31/137 , A61K31/415 , A61K31/4168 , A61K31/4178 , A61K31/765 , A61K31/78 , A61K47/32 , A61K47/48 , A61P27/02 , A61P27/06
CPC classification number: A61K47/48184 , A61K31/137 , A61K31/4168 , A61K31/4178 , A61K31/765 , A61K31/78 , A61K9/0048 , Y10S514/913
Abstract: Compositions for controlling glaucoma and ocular hypertension are disclosed.
Abstract translation: 公开了用于控制青光眼和高眼压症的组合物。
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