公开(公告)号：US20030224447A1

公开(公告)日：2003-12-04

申请号：US10355348

申请日：2003-01-31

Applicant: Randox Laboratories Limited

Inventor： Robert Ivan McConnell ,  Elouard Benchikh ,  Stephen Peter Fitzgerald ,  John Victor Lamont

IPC: G01N033/53 ,  C07K014/00

CPC classification number: C07K16/44 ,  A61K47/64 ,  A61K47/646 ,  G01N33/94 ,  Y10S436/815 ,  Y10S436/823 ,  Y10S530/807 ,  Y10T436/13 ,  Y10T436/17

Abstract: The invention provides haptens, immunogens comprising such haptens coupled to an antigenicity-conferring carrier material, conjugates comprising such haptens bonded to a labelling agent as well as, antibodies raised against such immunogens and capable of binding with ketamine and its primary metabolite, norketamine.

Abstract translation: 本发明提供了半抗原，包含与赋予抗原性的载体材料偶联的这种半抗原的免疫原，包含与标记试剂结合的这种半抗原的缀合物，以及针对这种免疫原而产生并能够与氯胺酮及其主要代谢物诺替胺结合的抗体。

公开(公告)号：US20030215367A1

公开(公告)日：2003-11-20

申请号：US10406224

申请日：2003-04-04

Applicant: Randox Laboratories Limited

Inventor： Stephen Peter Fitzgerald ,  John Victor Lamont ,  Robert Ivan McConnell

IPC: B01L003/00

CPC classification number: G01N35/028 ,  B01F11/0022 ,  B01L7/00 ,  G01N2035/00356 ,  G01N2035/00524 ,  Y10S435/809

Abstract: An assay device incubator comprises a housing (46) defining a region within which at least one assay device is located in use, the housing defining laterally opposed sidewalls (48, 50) of at least one bay (33) in which an assay device can be located. The housing (46) includes one or more guides (49, 51) for supporting the assay device and enabling the assay device to undergo to and fro movement therealong. A vibration system (40, 60) is coupled to the at least one tray in use for vibrating the tray to and fro along the or each guide. A heating system (70) heats the region within the housing.

Abstract translation: 测定装置培养箱包括限定其中至少一个测定装置位于使用中的区域的壳体（46），所述壳体限定至少一个隔间（33）的横向相对的侧壁（48,50），其中测定装置可以 位于。 壳体（46）包括用于支撑测定装置的一个或多个引导件（49,51），并且使测定装置能够沿着其移动。 振动系统（40,60）在使用中联接到所述至少一个托盘，用于沿着或每个引导件来回振动托盘。 加热系统（70）加热壳体内的区域。

公开(公告)号：US20030157565A1

公开(公告)日：2003-08-21

申请号：US10323850

申请日：2002-12-20

Applicant: RANDOX LABORATORIES LTD.

Inventor： John Victor Lamont ,  Robert Ivan McConnell ,  Stephen Peter Fitzgerald ,  El Ouard Benchikh ,  Andrew Philip Lowry

IPC: G01N033/53 ,  G01N033/537 ,  G01N033/543 ,  C07K016/46 ,  C07K014/00 ,  C07D489/02

CPC classification number: G01N33/9486 ,  C07D489/02

Abstract: Novel haptens, which can be conjugated to form immunogens, are of formula I, II or III 1 wherein R is a divalent alkyl, cycloalkyl or aryl group having 1 to 10 carbon atoms, and X is a functional group.

Abstract translation: 可以结合形成免疫原的新型半抗原具有式I，II或III，其中R是具有1至10个碳原子的二价烷基，环烷基或芳基，X是官能团。

公开(公告)号：US20030109051A1

公开(公告)日：2003-06-12

申请号：US10269884

申请日：2002-10-15

Applicant: RANDOX LABORATORIES LTD

Inventor： Stephen Peter Fitzgerald ,  Lynne Hamilton ,  Paul Graham Winyard

IPC: G01N033/50

CPC classification number: G01N33/84

Abstract: A spin-trapping assay for nitric oxide, in a biological system such as whole blood, uses as the spin trap a lipid-soluble nitrobenzene compound such as 2,6-dimethylnitrosobenzene.

Abstract translation: 在诸如全血的生物系统中，一氧化氮的自旋捕获测定法用作可溶性硝基苯化合物如2,6-二甲基亚硝基苯的自旋阱。

公开(公告)号：US20030008385A1

公开(公告)日：2003-01-09

申请号：US10188796

申请日：2002-07-05

Applicant: RANDOX LABORATORIES LTD

Inventor： Mark Tweedie ,  John Victor Lamont ,  Robert Ivan McConnell ,  Stephen Peter Fitzgerald

IPC: C12M001/34 ,  B05D003/00 ,  B41J029/38

CPC classification number: G01N35/00603 ,  B01J19/0046 ,  B01J2219/00351 ,  B01J2219/00527 ,  B01J2219/00529 ,  B01J2219/0054 ,  B01J2219/00545 ,  B01J2219/00547 ,  B01J2219/00585 ,  B01J2219/0059 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/00659 ,  B01J2219/00677 ,  B01J2219/00689 ,  B01J2219/00691 ,  B01J2219/00693 ,  B01L3/0268 ,  B82Y30/00 ,  C40B60/14 ,  C40B70/00 ,  G01N35/10 ,  G01N2035/1034

Abstract: A biochip deposition system and method. The system comprises a deposit mechanism for depositing organic material in spots on a substrate; and a viewing system for detecting the spots on the substrate during a deposit operation and before the spots have dried, for determining if the spots have been correctly deposited, and if not, for generating a suitable output signal. The viewing system includes an illumination device for illuminating deposited spots at a relatively low angle relative to the substrate.

Abstract translation: 一种生物芯片沉积系统及方法。 该系统包括用于在基板上的点沉积有机材料的沉积机构; 以及观察系统，用于在沉积操作期间和斑点干燥之前检测基板上的斑点，以确定斑点是否已被正确沉积，如果不是，则用于产生合适的输出信号。 观察系统包括用于以相对于衬底相对低的角度照射沉积点的照明装置。

公开(公告)号：US20020045287A1

公开(公告)日：2002-04-18

申请号：US09881744

申请日：2001-06-18

Applicant: RANDOX LABORATORIES LIMITED

Inventor： Harold S. Gamble ,  S.J. Neil Mitchell ,  Andrzej Prochaska ,  Stephen Peter Fitzgerald

IPC: H01L021/00

CPC classification number: B81C1/00158 ,  B41J2/16 ,  B41J2/1623 ,  B41J2/1628 ,  B41J2/1632 ,  B41J2/1639 ,  B81B2203/0315 ,  B81C2201/0115 ,  B81C2201/0146

Abstract: A method of manufacturing a diaphragm utilizing a precision grinding technique after etching a cavity in a wafer. A technique for preventing distortion of the diaphragm based on use of a sacrificial layer of porous silicon is disclosed.

Abstract translation: 在蚀刻晶片中的空腔之后利用精密研磨技术制造隔膜的方法。 公开了一种基于使用多孔硅牺牲层防止隔膜变形的技术。

公开(公告)号：US12246323B2

公开(公告)日：2025-03-11

申请号：US17602826

申请日：2020-04-09

Applicant: RANDOX LABORATORIES LTD

Inventor： Marc Wharry ,  Martin Reid ,  Peter Fitzgerald

IPC: B01L3/00 ,  B01L9/00

Abstract: An assay cartridge for use in a molecular diagnostics assay having an assay region; a first end comprising a first engagement member for engaging with a support housing; and a second end comprising a second engagement member for engaging with a support housing. The second engagement member has a clip, the clip being formed by a resilient element extending from the second end of the cartridge and a fastening element extending from said resilient element. The clip has a release element extending from the resilient element actuatable to release the clip from a caddy in use.

公开(公告)号：US12214102B2

公开(公告)日：2025-02-04

申请号：US17602853

申请日：2020-04-09

Applicant: RANDOX LABORATORIES LTD

Inventor： Catherine McCooke ,  Peter Fitzgerald

IPC: A61L2/28 ,  A61L2/10 ,  G01J1/42 ,  G01J1/44

Abstract: There is provided a sterilisation monitoring device for a molecular diagnostics analyser. The device comprises a sensor arranged in use to detect radiation; and an analysis unit connected to the sensor. The analysis unit is arranged in use to issue a signal when the radiation level incident on the sensor is lower than a threshold level.

公开(公告)号：US20240426855A1

公开(公告)日：2024-12-26

申请号：US18708031

申请日：2022-11-08

Applicant: RANDOX LABORATORIES LTD.

Inventor： Stephen Fawl ,  Colin Bell

IPC: G01N35/00 ,  B01L9/06 ,  G01N35/10

Abstract: A method of monitoring and controlling the processing of biological samples, the method comprising the steps of: receiving (101) a plurality of sample containers, each containing biological material; assigning (102) a priority to each of the sample containers; queueing (103) the sample containers for analysis based on the assigned priorities; extracting (104) a biological sample from each of the plurality of sample containers based on said sample container's position in the queue; analysing (105) each biological sample; providing (106) either a valid result or an inconclusive result for each of the biological samples based on said analysing; for each biological sample for which an inconclusive result has been provided, assigning (109) a new priority to the respective sample container and repeating the queueing, extracting, analysing, and providing steps.

公开(公告)号：US20240402176A1

公开(公告)日：2024-12-05

申请号：US18696817

申请日：2022-09-29

Applicant: RANDOX LABORATORIES LTD.

Inventor： Stephen Peter Fitzgerald ,  Mark Ruddock ,  John Lamont

IPC: G01N33/574 ,  G01N33/543

Abstract: Haematuria is a considerable burden within primary and secondary care; too many haematuria patients are referred to secondary care for invasive and expensive investigations that could be managed in primary care. The current invention has identified biomarker combinations with utility for the diagnosis of bladder cancer in males. Using gender specific biomarker algorithms in combination with clinical risks that are associated with bladder cancer, would allow clinicians to better manage haematuria patients in primary care setting.