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71.发明申请公开(公告)号：US20190017125A1
公开(公告)日：2019-01-17
申请号：US16076886
申请日：2017-02-07
Applicant: JAPANESE FOUNDATION FOR CANCER RESEARCH
Inventor： Kengo TAKEUCHI , Kana SAKAMOTO , Ryohei KATAYAMA , Seiji SAKATA
IPC: C12Q1/6886 , A61K31/167 , A61K31/4045 , A61K31/635 , G01N33/50 , A61K31/55 , A61K31/675
Abstract: The diagnostic markers that provide novel diagnostic criteria to blastic plasmacytoid dendritic cell neoplasm (BPDCN) has been searched, and the presence of immunoblastoid cytomorphology, 8q24 rearrangement, and MYC expression were established as novel markers for subtyping BPDCN. It has been further found that the inhibitors which directly or indirectly inhibit the expression, functions, or signaling pathways of MYC, such as BET bromodomain-selective inhibitors or aurora kinase inhibitors, are effective in MYC-positive BPDCN, and HDAC inhibitors or BCL2 family protein inhibitors are effective as therapeutic drugs for BPDCN.
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公开(公告)号：US20180237518A1
公开(公告)日：2018-08-23
申请号：US15744507
申请日：2016-07-11
Applicant: JAPANESE FOUNDATION FOR CANCER RESEARCH
Inventor： Naoya Fujita , Takaya Sekiguchi , Satoshi Takagi
IPC: C07K16/28 , G01N33/574 , C07K7/06 , A61P35/00
Abstract: A novel domain of Aggrus involved in the binding to CLEC-2 was searched for, and monoclonal antibodies recognizing the domain were obtained. The newly found PLAG4 domain is important for Aggrus binding to CLEC-2. Monoclonal antibodies recognizing this region were further developed. The present invention can provide novel Aggrus-CLEC-2 binding inhibitors, platelet aggregation inhibitors, cancer metastasis inhibitors, and tumor growth inhibitors using these antibodies.
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公开(公告)号：US09815866B2
公开(公告)日：2017-11-14
申请号：US14428017
申请日：2013-09-12
Applicant: JAPANESE FOUNDATION FOR CANCER RESEARCH
Inventor： Kiyotaka Shiba , Katsutoshi Kokubun , Kanako Suga
IPC: C07K7/06 , C07K7/08 , G01N33/574 , C07K14/705 , C07K14/47 , C07K16/00 , G01N33/68
CPC classification number: C07K7/06 , C07K7/08 , C07K14/47 , C07K14/70596 , C07K16/005 , C07K2319/00 , C07K2319/60 , G01N33/574 , G01N33/6872 , G01N2333/70596
Abstract: [Problem to be Solved]An object of the present invention is to provide a novel peptide that has the high ability to bind to EpCAM, which can be easily prepared by a chemical synthesis method or a genetic engineering method.[Solution]The present inventors have improved a method for screening a phage library and thereby successfully screened for a peptide that has the higher ability to bind to EpCAM compared with publicly known peptides. The present inventors have also used an already disclosed peptide having the ability to bind to EpCAM as a lead compound to prepare diverse populations of derivatives thereof, from among which a peptide strongly binding to EpCAM has been selected. The obtained peptides exhibit at least 10 times higher ability to bind to EpCAM compared with publicly known peptides and as such, are effective for the detection or diagnosis of cancer cells.
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公开(公告)号：US09798770B2
公开(公告)日：2017-10-24
申请号：US14652581
申请日：2013-12-06
Applicant: SONY CORPORATION , JAPANESE FOUNDATION FOR CANCER RESEARCH
Inventor： Takeshi Ohashi , Jun Yokono , Takuya Narihira
CPC classification number: G06F17/30424 , G06F17/30247 , G06F17/30265 , G06F17/30277 , G06F17/3028 , G06F19/00 , G06F19/321 , G06K9/00147 , G06K9/6215 , G06K9/6253 , G06Q50/24 , G06T7/0012 , G06T2200/24 , G06T2207/30024 , G06T2207/30096
Abstract: An information processing unit includes: a diagnostic image input section that inputs the diagnostic image; an operation information obtaining section that obtains display operation history information representing an operation history of a user who controls displaying of the diagnostic image; a query image generation section that extracts a predetermined region of the input diagnostic image to generate a query image; a diagnosed image obtaining section that supplies the generated query image and the display operation history information to a diagnosed image search unit and obtains the diagnosed image obtained as a search result by the diagnosed image search unit; and a display control section that displays the diagnostic image and the obtained diagnosed image for comparison.
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公开(公告)号：US20160166665A1
公开(公告)日：2016-06-16
申请号：US14901384
申请日：2014-06-30
Inventor： Masaki ITO , Kiyotaka SHIBA
IPC: A61K39/00
CPC classification number: A61K39/0011 , A61K2039/62 , A61K2039/64 , C07K14/4748 , C07K14/70539 , Y02A50/412
Abstract: A novel vaccine that can induce sufficiently high cell-mediated immunity is disclosed. The vaccine of the present invention contains, as an effective component, a polypeptide comprising a tandem repeat structure in which an MHC class I epitope region derived from an antigen protein and a spacer sequence are linked to each other alternately and repeatedly at least three times, or a recombinant vector which comprises a polynucleotide encoding said polypeptide and is capable of expressing said polypeptide in vivo. The spacer sequence is, for example, a sequence generated as an amino acid sequence inevitably encoded by a single base sequence which is designed such that the MHC class I epitope region derived from the antigen protein, an MHC class II epitope region derived from the antigen protein, and at least one higher-order-structure-stabilizing region are encoded by different reading frames in said single base sequence.
Abstract translation: 公开了能诱导足够高的细胞介导免疫的新型疫苗。 本发明的疫苗作为有效成分含有包含串联重复结构的多肽，其中源自抗原蛋白质的MHC I类表位区域和间隔区序列交替地和重复地相互连接至少三次， 或包含编码所述多肽并且能够在体内表达所述多肽的多核苷酸的重组载体。 间隔序列例如是作为不可避免地由单碱基序列编码的氨基酸序列产生的序列，其被设计为使得衍生自抗原蛋白的MHC I类表位区域，源自抗原的MHC II类表位区域 蛋白质，并且至少一个高级结构稳定区域由所述单碱基序列中的不同阅读框编码。
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Patent Agency Ranking
76.发明申请公开(公告)号：US20150228053A1
公开(公告)日：2015-08-13
申请号：US14424222
申请日：2013-08-23
Applicant: Sony Corporation , Japanese Foundation For Cancer Research
Inventor： Takeshi Ohashi
CPC classification number: G06T3/0006 , A61B6/5217 , A61B6/5294 , G02B21/365 , G06F19/00 , G06F19/321 , G06T5/50 , G06T11/00 , G06T2207/20212
Abstract: Provided is an information processing apparatus including an image supply unit that supplies a plurality of input images showing corresponding objects to an image processing unit and obtains a plurality of object images as an image processed result from the image processing unit, and a display control unit that synchronously displays the plurality of object images that have been obtained. The object images are regions including the corresponding objects extracted from the plurality of input images, and orientations, positions, and sizes of the corresponding objects of the plurality of object images are unified.
Abstract translation: 提供了一种信息处理设备，包括图像提供单元，其向图像处理单元提供显示相应对象的多个输入图像，并且从图像处理单元获取作为图像处理结果的多个对象图像;以及显示控制单元， 同步地显示已经获得的多个对象图像。 对象图像是包括从多个输入图像中提取的对应对象的区域，并且多个对象图像中的对应对象的取向，位置和大小是统一的。
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公开(公告)号：US12198811B2
公开(公告)日：2025-01-14
申请号：US17639062
申请日：2020-08-27
Applicant: JAPANESE FOUNDATION FOR CANCER RESEARCH , KONINKLIJKE PHILIPS N.V. , FINGGAL LINK CO., LTD.
Inventor： Naoko Tsuyama , Kengo Takeuchi , Sayuri Nakamura , Masayuki Hayashi , Takuya Sato
Abstract: A laboratory information system (LIS) is linked with a whole slide image (WSI) management system to build a pathology image management system that can efficiently manage and utilize a digitized pathology image. A scan notification notifying that an image of a glass slide is scanned by a scanner is delivered to the LIS from the WSI management system to form a WSI link in the LIS, so that the LIS is linked with the WSI management system. By linking two systems with each other can eliminate the problem of mixing up specimens, for example, and hence, a pathologist can easily grasp the status of a pathology sample for which the pathologist is responsible.
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公开(公告)号：US20240393349A1
公开(公告)日：2024-11-28
申请号：US18690047
申请日：2022-09-08
Inventor： Kohei YUYAMA , Yukifusa IGETA , Koji UEDA
IPC: G01N33/68
Abstract: Provided are a method of simply detecting Alzheimer's disease (AD) and a method of simply stratifying AD pathological phases, and a reagent that can be used for the methods, based on the fact that measurement of a protein contained in extracellular vesicles enables detection of Alzheimer's disease and stratification of AD pathological phases.
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79.发明公开公开(公告)号：US20240285587A1
公开(公告)日：2024-08-29
申请号：US18572244
申请日：2022-06-24
Applicant: JAPANESE FOUNDATION FOR CANCER RESEARCH
Inventor： Satoshi Takagi , Ryohei Katayama
IPC: A61K31/4192 , A61K31/192 , A61K31/195 , A61K31/40 , A61K31/42 , A61P35/00 , G01N33/50
CPC classification number: A61K31/4192 , A61K31/192 , A61K31/195 , A61K31/40 , A61K31/42 , A61P35/00 , G01N33/5023 , G01N2333/726
Abstract: It has been revealed that lysophosphatidic acid (LPA) functions as a mediator that augments invasive ability in osteosarcoma. Furthermore, it has been found that LPAR1, which is a receptor for LPA, is highly expressed in osteosarcoma and glioma, and the LPA-LPAR1 interaction is involved in the metastasis and proliferation of osteosarcoma and glioma. Examinations carried out on the basis of these findings have found that LPAR1 antagonists can serve as therapeutic agents for suppressing the metastasis and proliferation of osteosarcoma and glioma.
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公开(公告)号：US12055538B2
公开(公告)日：2024-08-06
申请号：US17144776
申请日：2021-01-08
Applicant: JAPANESE FOUNDATION FOR CANCER RESEARCH
Inventor： Kengo Takeuchi , Seiji Sakata , Yuki Togashi , Naoya Fujita , Ryohei Katayama
IPC: C07H21/04 , A61K31/519 , A61K38/00 , A61P35/00 , C07K14/82 , C12N9/12 , C12N9/88 , C12N15/113 , C12N15/62 , G01N33/50 , G01N33/574 , C12Q1/6853 , C12Q1/686 , C12Q1/6886
CPC classification number: G01N33/5011 , A61K31/519 , A61K38/005 , A61P35/00 , C07K14/82 , C12N9/12 , C12N9/88 , C12N15/113 , C12N15/62 , C12Y207/11025 , C12Y402/01047 , G01N33/57446 , C12Q1/6853 , C12Q1/686 , C12Q1/6886
Abstract: It is intended to reveal a polynucleotide serving as a novel causative gene of a cancer and, on the basis of this finding, to provide a method for detecting the polynucleotide or a polypeptide encoded thereby, a kit and a primer set for the detection, a method for screening for a substance that inhibits the polypeptide, and a pharmaceutical composition for the treatment of a cancer, containing the inhibiting substance. The detection method of the present invention detects a BRAF fusion protein or a fusion gene encoding the fusion protein, or a PXN or GMDS fusion protein or a fusion gene encoding the fusion protein in a digestive organ-derived sample obtained from a subject.
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