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97 条记录 (耗时 0.033 秒)

    Modified antibodies stably produced in milk and methods of producing same
    61.
    发明申请
    Modified antibodies stably produced in milk and methods of producing same 审中-公开
    在牛奶中稳定生产的修饰抗体及其制备方法

    公开(公告)号：US20050097625A1

    公开(公告)日：2005-05-05

    申请号：US10722903

    申请日：2003-11-26

    申请人： Harry Meade ,  Eszter Birck-Wilson ,  Daniel Pollock

    发明人： Harry Meade ,  Eszter Birck-Wilson ,  Daniel Pollock

    IPC分类号： A01K67/027 ,  C07K16/04 ,  C12N15/85 ,  C12P21/00

    CPC分类号： A01K67/0275 ,  A01K2217/05 ,  A01K2227/105 ,  A01K2267/01 ,  C07K16/04 ,  C07K2317/21 ,  C07K2317/41 ,  C07K2317/52 ,  C07K2317/53 ,  C12N15/8509 ,  C12N2830/008 ,  C12N2830/85

    摘要： The invention features methods of producing an antibody in the milk of a transgenic mammal. The methods include providing a transgenic mammal whose somatic and germ cells comprise a sequence encoding an exogenous heavy chain variable region or antigen binding fragment thereof, at least one heavy chain constant region, or a fragment thereof, and a hinge region, operably linked to a promoter which directs expression in mammary epithelial cells, wherein said hinge region has been altered from the hinge region normally associated with the heavy chain constant region. The invention also features transgenic mammals, methods of producing these mammals, compositions comprising such antibodies, and nucleic acids encoding the antibodies.

    摘要翻译： 本发明的特征在于在转基因哺乳动物的乳中产生抗体的方法。 所述方法包括提供转基因哺乳动物，其体细胞和生殖细胞包含编码外源重链可变区或其抗原结合片段的序列，至少一个重链恒定区或其片段和铰链区，其可操作地连接到 其指导乳腺上皮细胞中的表达，其中所述铰链区已经从通常与重链恒定区相关联的铰链区改变。 本发明还涉及转基因哺乳动物，产生这些哺乳动物的方法，包含此类抗体的组合物和编码抗体的核酸。

    Method and apparatus for separation of milk, colostrum, and whey
    62.
    发明申请
    Method and apparatus for separation of milk, colostrum, and whey 审中-公开
    用于分离牛奶，初乳和乳清的方法和设备

    公开(公告)号：US20050053707A1

    公开(公告)日：2005-03-10

    申请号：US10482548

    申请日：2002-09-10

    申请人： Henry Kopf ,  Henry Kopf III

    发明人： Henry Kopf ,  Henry Kopf III

    IPC分类号： A23C1/00 ,  A23C9/12 ,  A23C9/142 ,  A23C9/146 ,  A23C9/20 ,  B01D61/02 ,  B01D61/12 ,  B01D61/14 ,  B01D61/16 ,  B01D61/22 ,  C07K14/47 ,  C07K16/04

    CPC分类号： B01D61/142 ,  A23C9/1422 ,  A23C9/1425 ,  B01D61/022 ,  B01D61/025 ,  B01D61/12 ,  B01D61/145 ,  B01D61/147 ,  B01D61/16 ,  B01D61/22 ,  B01D2311/04 ,  B01D2311/10 ,  B01D2311/165

    摘要： Apparatus and method for separation of milk and milk products, e.g., involving sequential separation of milk, colostrum, and whey components by cross-flow filtration. The apparatus and method in a preferred aspect employ cross-flow filtration, chromatography and fermentation to separate and fully utilize the components of milk, colostrum, and whey to generate numerous individual components, minimize waste, lower adverse environmental issues and provide enhanced economic benefits to dairy producers. A wide variety of consumer and nutraceutical products can be produced from the fractions and/or sub-fractions of milk products obtained from such separation. The invention further contemplates a methodology for selecting optimum membrane, device, and operating conditions to achieve a desired separation.

    摘要翻译： 用于分离牛奶和奶制品的装置和方法，例如通过交叉流过滤连续分离乳，初乳和乳清组分。 优选方案中的装置和方法采用交叉流过滤，色谱和发酵以分离和充分利用牛奶，初乳和乳清的组分以产生许多单独组分，最小化废物，降低不利环境问题并提供增强的经济效益 奶制品生产商。 从这种分离获得的乳制品的级分和/或亚级分可以生产各种各样的消费和营养产品。 本发明进一步考虑了用于选择最佳膜，装置和操作条件以实现期望分离的方法。

    Mammalian protein associated with uncontrolled cell division
    67.
    发明授权
    Mammalian protein associated with uncontrolled cell division 失效
    与不受控制的细胞分裂相关的哺乳动物蛋白质

    公开(公告)号：US5756676A

    公开(公告)日：1998-05-26

    申请号：US468066

    申请日：1995-06-06

    申请人： Gary R. Pasternack

    发明人： Gary R. Pasternack

    IPC分类号： A61K38/00 ,  C07K14/47 ,  C07K16/04 ,  C07K16/18 ,  C07K16/30 ,  C12Q1/68 ,  C07K14/435 ,  G01N33/574

    CPC分类号： C07K16/30 ,  C07K14/47 ,  C07K16/04 ,  C07K16/18 ,  C12Q1/68 ,  C12Q1/6886 ,  A61K38/00 ,  C12N2799/026 ,  C12Q2600/112 ,  C12Q2600/136 ,  Y10S530/828

    摘要： Three mammalian are disclosed which are useful in the diagnosis and prognosis of tumors of lymphoid and epithelial origin. The three proteins are immunologically related to each other. The level of expression of the proteins correlates with the malignant potential of lymphoid and epithelial tumors. In addition, in some cases the subcellular location of the proteins is indicative of malignant potential. Antibodies reactive with the proteins are disclosed as diagnostic tools, as are nucleic acid probes and primers for quantitating the messenger RNAs encoding the proteins. Methods for preparing and purifying the proteins are also taught.

    摘要翻译： 公开了三种哺乳动物，其可用于淋巴和上皮起源的肿瘤的诊断和预后。 三种蛋白质在免疫学上相互关联。 蛋白质的表达水平与淋巴样和上皮性肿瘤的恶性潜能相关。 此外，在一些情况下，蛋白质的亚细胞位置指示恶性潜能。 公开了与蛋白质反应的抗体作为诊断工具，核酸探针和引物用于定量编码蛋白质的信使RNA。 还教导了制备和纯化蛋白质的方法。