公开(公告)号：US20220104798A1

公开(公告)日：2022-04-07

申请号：US17549432

申请日：2021-12-13

Applicant: Critical Innovations, LLC

Inventor： Ross I. Donaldson ,  Timothy Fisher ,  Oliver Buchanan ,  Jon Armstrong ,  John Cambridge

IPC: A61B17/00 ,  A61L24/00 ,  A61L24/04

Abstract: Systems, methods and compositions relating to delivering synthetic polymer formulations to the body are described, which can be used by a range of medical personnel including those with minimal experience and training. Under some embodiments, the present invention relates to systems and devices for delivering polymer formulations to a body cavity (e.g. peritoneal cavity) to reduce or stop bleeding. Under some embodiments, an initial percutaneous access pathway is first formed using a delivery device with a probe and needle mechanism that automatically stops the advance of the device upon insertion into a body cavity or space, thus minimizing user error and improving patient safety. The hollow probe then allows transmission of polymer, mixed with gas and/or additional substances, from a holding chamber or canister to flow through the device and hollow probe into the patient's anatomic cavity or space of interest, stopping expansion when the device senses the appropriate pressure. Once reaching the body cavity, the polymer formulation functions to reduce and/or stop bleeding.

公开(公告)号：US20220072195A1

公开(公告)日：2022-03-10

申请号：US17525095

申请日：2021-11-12

Applicant: Baxter International Inc. ,  Baxter Healthcare SA

Inventor： Yves A. Delmotte ,  Jonathan Payssan

IPC: A61L24/04 ,  A61L24/00

Abstract: Compositions and methods for sealing tissue of a patient in a wet environment are disclosed.

公开(公告)号：US20220072194A1

公开(公告)日：2022-03-10

申请号：US17418731

申请日：2019-12-23

Applicant: 3M INNOVATIVE PROPERTIES COMPANY

Inventor： Takeshi Ito

IPC: A61L24/04 ,  C09J7/35 ,  C09J193/04 ,  C09J133/10

Abstract: Provided is a radiation sterilization resistant adhesive agent layer capable of reducing or preventing a decrease in wettability of an adhesive after radiation sterilization treatment. The adhesive can be used with a medical implement, for example medical implements that are sterilized. The adhesive agent layer includes a (meth)acrylic polymer and a wettability stabilizer, and the wettability stabilizer is at least one selected from a rosin ester resin, a terpene phenol resin, and hydrides thereof.

公开(公告)号：US20220002601A1

公开(公告)日：2022-01-06

申请号：US17292646

申请日：2019-11-08

Applicant: 3M INNOVATIVE PROPERTIES COMPANY

Inventor： Aizoh Sakurai

IPC: C09J183/04 ,  C09J7/38 ,  C08G77/12 ,  C08G77/16 ,  C08G77/20 ,  C08G77/00 ,  C08G77/08 ,  A61L24/04

Abstract: Silicone pressure-sensitive adhesives is the reaction product of a composition including a silanol end group-containing linear organopolysiloxane; a non-functional linear organopolysiloxane; and a silicate resin; wherein the dynamic viscosity of the non-functional linear organopolysiloxane at 25° C. is 100,000 mm2/sec or greater. The silicone pressure-sensitive adhesive has enhanced adhesion while minimizing skin damage and pain during removal of the adhesive.

公开(公告)号：US20220001075A1

公开(公告)日：2022-01-06

申请号：US17365795

申请日：2021-07-01

Applicant: Davol Inc.

Inventor： Keith Greenawalt ,  Christopher Bowley ,  Frederick H. Strickler, JR. ,  Andrew C. Yang ,  Rajendra R. Bhat ,  Jessica Powell ,  Michael T. Cash ,  Aaron D. Strickland ,  Esther M. Valliant

IPC: A61L24/04 ,  A61L24/00 ,  A61L24/10 ,  C08L79/08 ,  C08L89/00

Abstract: Compositions and methods related to flowable hemostats that crosslink during and/or after application to a bleeding site are generally described.

公开(公告)号：US20210379207A1

公开(公告)日：2021-12-09

申请号：US17342945

申请日：2021-06-09

Applicant: Arsenal Medical, Inc.

Inventor： Jeffrey Groom ,  Craig Wiltsey ,  Quynh Pham ,  Nikhita Mansukhani ,  Courtney Guertin ,  Lee Core ,  Upma Sharma

IPC: A61K49/04 ,  A61K47/34 ,  A61K47/02 ,  A61L24/04 ,  A61L24/02

Abstract: The present disclosure pertains to crosslinkable compositions and systems as well as methods for forming crosslinked compositions in situ, including the use of the same for embolizing vasculature including the neurovasculature within a patient, among many other uses.

公开(公告)号：US11191867B2

公开(公告)日：2021-12-07

申请号：US16726375

申请日：2019-12-24

Applicant: CASE WESTERN RESERVE UNIVERSITY

Inventor： Eben Alsberg ,  Oju Jeon

IPC: A61L24/04 ,  A61L24/00

Abstract: A bioadhesive includes a crosslinked biodegradable hydrogel that includes a plurality of oxidized, acrylated or methacrylated, natural polymer.

公开(公告)号：US20210369276A1

公开(公告)日：2021-12-02

申请号：US16885375

申请日：2020-05-28

Applicant: Ethicon, Inc.

Inventor： Duan Li Ou ,  Robert Rousseau ,  Leo B. Kriksunov ,  Julian Quintero

IPC: A61B17/08 ,  A61L24/04 ,  A61L26/00 ,  A61L24/02 ,  A61L24/00

Abstract: Novel compositions and systems for closure of wounds are disclosed. The compositions provide devices of improved flexibility and elasticity and are readily applied to wound sites or over wound closure devices. The present invention is also directed to a novel platinum catalyst for use in such compositions. The catalyst provides for rapid curing on topical surfaces such as skin and bonds to such surfaces in about 2-5 minutes.

公开(公告)号：US11160899B2

公开(公告)日：2021-11-02

申请号：US16183221

申请日：2018-11-07

Applicant: Abyrx, Inc.

Inventor： Richard L. Kronenthal ,  Aniq Darr ,  John Pacifico

IPC: A61L24/02 ,  A61L24/04 ,  A61L24/00 ,  A61L27/42 ,  A61L27/18 ,  A61L27/44 ,  A61L27/46 ,  A61L27/16 ,  C08L33/12 ,  C08L75/04

Abstract: Provided herein are bio-absorbable, settable and homogenous multi-putty bone-adhesive compositions for medical use in tissue hemostasis, surgical repair and reconstruction. Also provided are improved methods of intraoperative use of said compositions for re-approximation of adjacent bone fragments to create a restored alignment and stabilize fracture line.

公开(公告)号：US20210332179A1

公开(公告)日：2021-10-28

申请号：US17246819

申请日：2021-05-03

Applicant: Hyalex Orthopaedics, Inc.

Inventor： Lampros KOURTIS ,  David MYUNG ,  Daniel CHANG ,  Bing YU ,  Timothy SUN ,  Michael J. JAASMA ,  Vernon HARTDEGEN

IPC: C08G18/62 ,  C08G18/48 ,  C08G18/65 ,  C08G18/67 ,  C08G18/32 ,  C09J4/06 ,  C09J135/02 ,  C08L33/08 ,  C08L33/12 ,  F01D5/08 ,  F01D11/02 ,  F01D11/00 ,  A61F2/30 ,  A61K47/32 ,  A61M5/19 ,  B65D85/00 ,  C09J133/14 ,  A61L24/06 ,  A61L24/00 ,  A61L24/04 ,  C08G18/72 ,  C08G81/02

Abstract: Methods, compositions, and kits for adhering polymers and other materials to another material, and in particular to bone or bone-like structures or surfaces. A composition of matter includes a urethane dimethacrylate-methyl methacrylate copolymer with a plurality of first polymer regions based on urethane dimethacrylate and a plurality of second polymer regions based on methyl methacrylate. The method includes placing an orthopedic joint implant having an attachment surface in a joint space, applying a first non-urethane-containing precursor, a second urethane-containing precursor, and a initiator to the attachment surface; contacting the first and second precursors and the initiator with the joint surface; and copolymerizing the first and second precursors and forming an adhesive copolymer and attaching the implant to the joint.