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    Isomaltooligosaccharides from Leuconostoc as neutraceuticals
    61.
    发明授权
    Isomaltooligosaccharides from Leuconostoc as neutraceuticals 有权
    来自明串珠菌属的异麦芽低聚糖作为中性药物

    公开(公告)号：US07291607B2

    公开(公告)日：2007-11-06

    申请号：US10848981

    申请日：2004-05-19

    申请人： Donal F. Day ,  Chang-Ho Chung

    发明人： Donal F. Day ,  Chang-Ho Chung

    IPC分类号： A61K31/702 ,  A61K31/718

    CPC分类号： A61K31/715

    摘要： Isomaltooligosaccharides (IMOs) produced by Leuconostoc mesenteroides ATCC 13146 fermentation with a sucrose:maltose ratio of 2:1 have been discovered to be effective prebiotics in mixed cultures of microbial populations, including cultures from chicken ceca. Surprisingly in mixed microbial cultures this IMO composition proved as effective as FOS. Thus, these IMOs can be used as effective prebiotics for both birds and mammals. Moreover, the IMOs were discovered to be effective non-competitive inhibitors of α-glucosidase. These IMOs also will be useful, as an α-glucosidase inhibitor, in a therapeutic application for several diseases, including obesity, diabetes mellitus, pre-diabetes, gastritis, gastric ulcer, duodenal ulcer, caries, cancer, viral disease such as hepatitis B and C, HIV, and AIDS. A diet with 5-20% IMOs was also shown to reduce the abdominal fat tissue in mammals.

    摘要翻译： 已经发现，微生物种群的混合培养物（包括来自鸡肉盲肠的培养物）中，具有蔗糖：麦芽糖比例为2:1的由明串珠菌肠球菌ATCC13146发酵产生的异麦芽低聚糖（IMO）是有效的益生元。 令人惊讶的是，在混合微生物培养物中，这种IMO组成证明与FOS一样有效。 因此，这些IMO可以用作鸟类和哺乳动物的有效益生元。 此外，IMO被发现是有效的非竞争性的α-葡萄糖苷酶抑制剂。 在多种疾病的治疗应用中，这些IMO也可用作α-葡萄糖苷酶抑制剂，包括肥胖症，糖尿病，糖尿病前期，胃炎，胃溃疡，十二指肠溃疡，龋齿，癌症，病毒性疾病如乙型肝炎 和C，艾滋病毒和艾滋病。 具有5-20％IMO的饮食也显示可以减少哺乳动物的腹部脂肪组织。

    Delivery systems for functional ingredients
    62.
    发明申请
    Delivery systems for functional ingredients 审中-公开
    功能成分的输送系统

    公开(公告)号：US20070196496A1

    公开(公告)日：2007-08-23

    申请号：US11584748

    申请日：2006-10-23

    申请人： Michael Farber ,  Jonathan Farber

    发明人： Michael Farber ,  Jonathan Farber

    IPC分类号： A61K31/718 ,  A61K9/14

    CPC分类号： A61K9/0056 ,  A61K31/718

    摘要： Oral gel delivery systems are provided that comprise an ingestible matrix within which one or more functional ingredients are substantially uniformly and completely dispersed and in which degradation of the functional ingredient(s) is minimised or eliminated. The matrix of the delivery systems comprises a carbohydrate component that comprises one or more carbohydrates that exhibit good moisture binding and low gelatinisation temperature; a sugar component comprising one or more sugars, sugar syrups and/or sugar alcohols; a hydrocolloid component, and a solvent component comprising one or more polyhydric alcohols. The delivery systems can be formulated to comprise a range of functional ingredients including various drugs and nutritional supplements.

    摘要翻译： 提供口服凝胶递送系统，其包含可摄取的基质，其中一种或多种功能成分基本上均匀和完全分散，并且功能成分的降解被最小化或消除。 递送系统的基质包括碳水化合物组分，其包含一种或多种表现出良好的水分结合和低糊化温度的碳水化合物; 糖组分，其包含一种或多种糖，糖浆和/或糖醇; 水胶体组分和包含一种或多种多元醇的溶剂组分。 递送系统可以配制成包括一系列功能成分，包括各种药物和营养补充剂。

    Bile preparations for colorectal disorders
    63.
    发明申请
    Bile preparations for colorectal disorders 审中-公开
    用于结肠直肠疾病的胆汁制剂

    公开(公告)号：US20070072828A1

    公开(公告)日：2007-03-29

    申请号：US11522162

    申请日：2006-09-15

    申请人： Seo Yoo

    发明人： Seo Yoo

    IPC分类号： A61K31/718 ,  A61K31/56

    CPC分类号： A61K31/56 ,  A61K31/718 ,  A61K45/06 ,  A61K2300/00

    摘要： The present disclosure relates to methods and compositions to ameliorate or treat at least one symptom of colorectal cancer and/or adenomatous polyposis coli (APC). For example, some embodiments of the methods and compositions may reduce recurrence of colorectal adenomas and/or extend the life of a subject having colorectal cancer and/or APC. Some embodiments of the disclosure include maintaining a the total body weight in a subject having colorectal cancer and/or APC. According to some embodiments, a method of the disclosure may include administering a bile acid composition to a subject. A bile acid composition may include, in some embodiments, an aqueous solution that is free or substantially free of precipitates or particles. A aqueous solution may include (1) a bile acid, an aqueous soluble derivative of a bile acid, a bile acid salt, and/or 7-ketolithocholic acid, (2) a carbohydrate, and (3) water. An aqueous composition may further include an alkali.

    摘要翻译： 本公开涉及改善或治疗结肠直肠癌和/或腺瘤性息肉病大肠杆菌（APC）的至少一种症状的方法和组合物。 例如，方法和组合物的一些实施方案可以减少结肠直肠腺瘤的复发和/或延长具有结肠直肠癌和/或APC的受试者的寿命。 本公开的一些实施方案包括在具有结肠直肠癌和/或APC的受试者中维持总体重。 根据一些实施方案，本公开的方法可以包括向受试者施用胆汁酸组合物。 在一些实施方案中，胆汁酸组合物可包括游离或基本上不含沉淀物或颗粒的水溶液。 水溶液可以包括（1）胆汁酸，胆汁酸的水溶性衍生物，胆汁酸盐和/或7-酮皮磷酸，（2）碳水化合物和（3）水。 水性组合物还可以包含碱。

    Methods for promoting the healing of cutaneous wounds and ulcers using compositions of .alpha.-D-glucans
    67.
    发明授权
    Methods for promoting the healing of cutaneous wounds and ulcers using compositions of .alpha.-D-glucans 有权
    使用α-D-葡聚糖的组合促进皮肤伤口和溃疡愈合的方法

    公开(公告)号：US6165994A

    公开(公告)日：2000-12-26

    申请号：US246994

    申请日：1999-02-08

    申请人： Karla J. Henley

    发明人： Karla J. Henley

    IPC分类号： A61K31/19 ,  A61K31/716 ,  A61K31/718 ,  A61P17/02 ,  C08B31/12 ,  C08B35/04 ,  C08B37/00 ,  A61K31/715

    CPC分类号： A61K31/716 ,  A61K31/718

    摘要： The present invention provides methods of promoting the healing of cutaneous wounds and ulcers in vertebrates by administering a composition of a branched chain polymeric .alpha.-D-glucan to the wound or ulcer. In a preferred embodiment, the branched chain polymeric .alpha.-D-glucan may be hetastarch. The cutaneous wound or ulcer may be an open wound or ulcer, and may be chronic. The compositions are useful for treating these wounds in vertebrates. The vertebrate may be a mammal such as a human, a canine, or any mammal. The composition utilized in the methods of the present invention may contain hetastarch.

    摘要翻译： 本发明提供通过向伤口或溃疡施用支链聚合物α-D-葡聚糖的组合物来促进脊椎动物皮肤伤口和溃疡愈合的方法。 在优选的实施方案中，支链聚合物α-D-葡聚糖可以是hetastarch。 皮肤伤口或溃疡可能是开放的伤口或溃疡，可能是慢性的。 组合物可用于治疗脊椎动物中的这些伤口。 脊椎动物可以是哺乳动物如人，犬或任何哺乳动物。 用于本发明方法的组合物可以含有hetastarch。

    Plasma like solution and methods of use
    68.
    发明授权
    Plasma like solution and methods of use 失效
    等离子体如溶液和使用方法

    公开(公告)号：US6080538A

    公开(公告)日：2000-06-27

    申请号：US896823

    申请日：1997-07-18

    申请人： Paul E. Segall ,  Hal Sternberg ,  Harold D. Waitz ,  Judith M. Segall

    发明人： Paul E. Segall ,  Hal Sternberg ,  Harold D. Waitz ,  Judith M. Segall

    IPC分类号： A61K33/00 ,  A01N1/02 ,  A61K9/00 ,  A61K31/00 ,  A61K31/19 ,  A61K31/718 ,  A61K33/06 ,  A61K33/10 ,  A61K33/14 ,  A61K35/14 ,  A61P7/08 ,  A61M31/00

    CPC分类号： A01N1/0221 ,  A01N1/0284 ,  A61K33/10 ,  A61K33/14 ,  A61K9/0026 ,  Y10S514/832 ,  Y10S514/833

    摘要： Aqueous solutions comprising a polysaccharide oncotic agent, a physiologically compatible buffer, a simple hexose sugar, dissolved chloride salts of calcium, sodium and magnesium, and a dissolved organic salt of sodium are disclosed. The solutions are effective substitutes for blood and may be used to preserve the biological integrity of the organs of a mammalian donor organism as shown by superior anatomical integrity of cryopreserved organs and tissues of subjects perfused with the solution. The solutions may be used for maintaining a partially or substantially completely exsanguinated subject at normal temperatures and at temperatures substantially below those normally maintained by a mammal and may be used in conjunction with hypobaric environments to maintain such partially or completed exsanguinated subjects alive without infusing blood back into the subject.

    摘要翻译： 公开了包含多糖起始剂，生理相容性缓冲液，简单己糖，钙，钠和镁的溶解氯化物盐和钠的溶解有机盐的水溶液。 该解决方案是有效的血液代用品，可用于保护哺乳动物供体生物的器官的生物完整性，如通过冷冻保存的器官和用溶液灌注的受试者的组织的优异的解剖学完整性所示。 该溶液可用于在正常温度和基本上低于通常由哺乳动物保持的温度下维持部分或基本完全放血的受试者，并且可以与低压环境结合使用以保持这种部分或完全的放血对象活着而不会将血液返回 进入主题。