公开(公告)号：US20240426855A1

公开(公告)日：2024-12-26

申请号：US18708031

申请日：2022-11-08

Applicant: RANDOX LABORATORIES LTD.

Inventor： Stephen Fawl ,  Colin Bell

IPC: G01N35/00 ,  B01L9/06 ,  G01N35/10

Abstract: A method of monitoring and controlling the processing of biological samples, the method comprising the steps of: receiving (101) a plurality of sample containers, each containing biological material; assigning (102) a priority to each of the sample containers; queueing (103) the sample containers for analysis based on the assigned priorities; extracting (104) a biological sample from each of the plurality of sample containers based on said sample container's position in the queue; analysing (105) each biological sample; providing (106) either a valid result or an inconclusive result for each of the biological samples based on said analysing; for each biological sample for which an inconclusive result has been provided, assigning (109) a new priority to the respective sample container and repeating the queueing, extracting, analysing, and providing steps.

公开(公告)号：US20240402176A1

公开(公告)日：2024-12-05

申请号：US18696817

申请日：2022-09-29

Applicant: RANDOX LABORATORIES LTD.

Inventor： Stephen Peter Fitzgerald ,  Mark Ruddock ,  John Lamont

IPC: G01N33/574 ,  G01N33/543

Abstract: Haematuria is a considerable burden within primary and secondary care; too many haematuria patients are referred to secondary care for invasive and expensive investigations that could be managed in primary care. The current invention has identified biomarker combinations with utility for the diagnosis of bladder cancer in males. Using gender specific biomarker algorithms in combination with clinical risks that are associated with bladder cancer, would allow clinicians to better manage haematuria patients in primary care setting.

公开(公告)号：US20240345092A1

公开(公告)日：2024-10-17

申请号：US18682668

申请日：2022-08-10

Applicant: RANDOX LABORATORIES LTD.

Inventor： Stephen Peter Fitzgerald ,  Mark Ruddock ,  John Lamont ,  Declan McKenna

IPC: G01N33/574

CPC classification number: G01N33/57434 ,  G01N33/57488

Abstract: Single markers lack both sensitivity and specificity to stratify risk of PCa in patients who present with elevated tPSA and abnormal DRE. The novel combination of serum markers identified in this study could be employed to help triage patients into ‘low’ and ‘high’ risk categories, allowing general practitioners (GPs) to improve management of patients in primary care settings and potentially reducing the number of referrals for unnecessary, invasive, and costly treatments.

公开(公告)号：US20220341943A1

公开(公告)日：2022-10-27

申请号：US17765383

申请日：2020-10-07

Applicant: Randox Laboratories Ltd ,  Randox Teoranta

Inventor： Ivan McConnell ,  Peter Fitzgerald ,  Ciaran Richardson ,  Kenneth Martin

IPC: G01N33/68 ,  G01N33/50 ,  G01N33/543

Abstract: Methods, devices and kits for the detection and quantification of XBP1s and XBP1u are described.

公开(公告)号：US11467163B2

公开(公告)日：2022-10-11

申请号：US16065646

申请日：2016-12-23

Applicant: Randox Laboratories Ltd. ,  Randox Teoranta

Inventor： Ivan McConnell ,  Peter Fitzgerald ,  John Lamont ,  Ciaran Richardson

IPC: G01N33/574

Abstract: The present invention describes methods of determining the glycosylation signature and determining the level of a protein in a sample obtained from a patient.
The present invention also describes use of a patient protein glycosylation profile to identify the presence or absence of a disease in subjects.

公开(公告)号：US11383216B2

公开(公告)日：2022-07-12

申请号：US16424330

申请日：2019-05-28

Applicant: Randox Laboratories Ltd. ,  Randox Teoranta

Inventor： Peter Fitzgerald ,  John Lamont ,  Ivan McConnell ,  Elouard Benchikh ,  Deepesh Upadhyay ,  Ciaran Richardson

IPC: B01J19/00 ,  C09D11/102 ,  C09D11/03 ,  G01N33/543 ,  C12M1/00

Abstract: A substrate comprising a coating of a masking material, and a plurality of discrete reaction zones onto which one or more binding agents are intended to be attached, wherein said zones are uncoated areas on the substrate.

公开(公告)号：US20220160921A1

公开(公告)日：2022-05-26

申请号：US17602853

申请日：2020-04-09

Applicant: RANDOX LABORATORIES LTD

Inventor： Catherine McCooke ,  Peter Fitzgerald

IPC: A61L2/28 ,  A61L2/10 ,  G01J1/42

Abstract: There is provided a sterilisation monitoring device for a molecular diagnostics analyser. The device comprises a sensor arranged in use to detect radiation; and an analysis unit connected to the sensor. The analysis unit is arranged in use to issue a signal when the radiation level incident on the sensor is lower than a threshold level.

公开(公告)号：US20220152244A1

公开(公告)日：2022-05-19

申请号：US17602831

申请日：2020-04-09

Applicant: RANDOX LABORATORIES LTD

Inventor： Peter Fitzgerald ,  David Sloan ,  Martin Reid ,  Stuart Jackson

IPC: A61L2/10 ,  G01N35/00

Abstract: There is provided a sterilisation assembly for a molecular diagnostic assay analyse. The assembly comprising: an enclosure having a passage therethrough, the passage being arranged in use to allow an assay sample set to pass through the enclosure, the enclosure defining a barrier adapted in use to restrict fluid communication across the enclosure to communication through the passage; and a decontaminator located within the passage, the decontaminator is arranged in use to sterilise contamination in the passage.

公开(公告)号：US10815192B2

公开(公告)日：2020-10-27

申请号：US15903361

申请日：2018-02-23

Applicant: Randox Laboratories Ltd.

Inventor： Ivan McConnell ,  Peter Fitzgerald ,  Elouard Benchikh ,  Philip Lowry

IPC: C07C233/79 ,  C07K16/18 ,  G01N33/94 ,  G01N33/53 ,  C07K16/44 ,  C07K16/16

Abstract: Antibodies, immunoassay methods and kits for the detection and determination of 3,4,-dichloro-N-[2-(dimethylamino)cyclohexyl]-N-methylbenzamide and 3,4,-dichloro-N-[2-(methylamino)cyclohexyl]-N-methylbenzamide, as well as the precursory immunogens, are described.

公开(公告)号：US10168331B2

公开(公告)日：2019-01-01

申请号：US15304473

申请日：2015-04-02

Applicant: Randox Laboratories Ltd.

Inventor： Mark Ruddock ,  Cherith Reid ,  John Lamont ,  Stephen Fitzgerald ,  Ricardo De Matos Simoes ,  Kathleen Williamson

IPC: G01N33/574 ,  G01N33/68 ,  G01N33/543 ,  G01N33/577

Abstract: The present invention provides a method and a solid state device for identifying the presence of urothelial cancer in a patient comprising assigning the subject to a sub-population according to smoking habits, measuring the level of each biomarker of a panel of biomarkers in one or more samples obtained from the subject; and correlating the measured levels of the panel of biomarkers with the likelihood of the subject having urothelial cancer such that the subject can be classified as having urothelial cancer or as being a control.