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    Peptides effective for diagnosis and detection of hepatitis C infection
    54.
    发明授权
    Peptides effective for diagnosis and detection of hepatitis C infection 失效
    有效的诊断和检测丙型肝炎感染的肽

    公开(公告)号：US5736321A

    公开(公告)日：1998-04-07

    申请号：US530550

    申请日：1995-09-19

    申请人： Barbara Helen Hosein ,  Chang Yi Wang

    发明人： Barbara Helen Hosein ,  Chang Yi Wang

    IPC分类号： G01N33/53 ,  A61K38/00 ,  C07K14/18 ,  C07K16/00 ,  C07K16/42 ,  G01N33/576

    CPC分类号： C07K14/005 ,  G01N33/5767 ,  A61K38/00 ,  C12N2770/24222 ,  Y10S436/82

    摘要： The present invention relates to novel linear and branched peptides specific for the diagnosis and prevention of hepatitis C virus (HCV) infection. More particularly, the present invention is directed to linear and branched synthetic peptides containing at least one antigenic site which is effective for detecting HCV-associated antibodies in patients using immunoassay techniques. In some cases, these peptides are also library peptides with degenerate amino acid positions. Preferred mixtures for detection of HCV antibodies are provided as well as a novel spliced peptide useful for blocking the non-specific reactivity of certain NS-3 conformational epitopes.

    摘要翻译： 本发明涉及特异于丙型肝炎病毒（HCV）感染的诊断和预防的新型线性和支链肽。 更具体地说，本发明涉及含有至少一个抗原位点的线性和支链合成肽，该抗原位点在使用免疫测定技术的患者中检测HCV相关抗体是有效的。 在某些情况下，这些肽也是具有简并氨基酸位置的文库肽。 提供了用于检测HCV抗体的优选混合物以及可用于阻断某些NS-3构象表位的非特异性反应性的新型剪接肽。

    Linear and branched peptides effective in diagnosing and detecting non-A, non-B hepatitis
    56.
    发明授权
    Linear and branched peptides effective in diagnosing and detecting non-A, non-B hepatitis 失效
    线性和支链肽有效诊断和检测非甲非乙型肝炎

    公开(公告)号：US5639594A

    公开(公告)日：1997-06-17

    申请号：US83947

    申请日：1993-06-28

    申请人： Chang Yi Wang ,  Barbara Helen Hosein

    发明人： Chang Yi Wang ,  Barbara Helen Hosein

    IPC分类号： G01N33/53 ,  A61K39/00 ,  A61K39/29 ,  A61P31/12 ,  C07K14/18 ,  C07K16/10 ,  C12N15/09 ,  C12Q1/70 ,  G01N33/576 ,  C07K17/02

    CPC分类号： C07K14/005 ,  C07K16/109 ,  A61K39/00 ,  C07K2317/34 ,  C12N2770/24222

    摘要： The present invention relates to novel linear and branched peptides specific for the diagnosis and prevention of non-A, non-B hepatitis (NANBH), as well as hepatitis C virus (HCV) infection. More particularly, the present invention is directed to linear peptides diagnostic for NS-3 of HCV as well as branched synthetic substituted and hybrid peptides containing at least one epitope which is effective in detecting NANBH-associated antibodies in patients with NANBH using immunoassay techniques. In addition, this invention provides immunoassays for the detection and diagnosis of NANBH using the subject peptides, vaccine compositions for prevention and treatment of NANBH or HCV infection as well as a method of treating or preventing NANBH and HCV infection.

    摘要翻译： 本发明涉及专门用于诊断和预防非甲非乙型肝炎（NANBH）以及丙型肝炎病毒（HCV）感染的新型线性和支链肽。 更具体地，本发明涉及诊断HCV的NS-3的线性肽以及含有至少一个表位的支链合成取代和杂合肽，其在使用免疫测定技术的NANBH患者中有效检测NANBH相关抗体。 此外，本发明提供了使用本发明肽，用于预防和治疗NANBH或HCV感染的疫苗组合物以及治疗或预防NANBH和HCV感染的方法来检测和诊断NANBH的免疫测定。

    Detection of both an antibody and an antigen in a single sample aliquot
    57.
    发明授权
    Detection of both an antibody and an antigen in a single sample aliquot 失效
    在单个样品等分试样中检测抗体和抗原

    公开(公告)号：US5627026A

    公开(公告)日：1997-05-06

    申请号：US364432

    申请日：1994-12-27

    申请人： Thomas P. O'Connor ,  Quentin J. Tonelli

    发明人： Thomas P. O'Connor ,  Quentin J. Tonelli

    IPC分类号： G01N33/543 ,  G01N33/569 ,  G01N33/576 ,  C12Q1/70

    CPC分类号： G01N33/56983 ,  G01N33/54306 ,  G01N33/54366 ,  G01N33/56988 ,  G01N33/576 ,  Y10S436/82

    摘要： A method for detecting the presence of antibody to FIV in a biological sample. The method includes the steps of providing a first antigen having a first epitope recognized by the antibody, the first antigen being detectable; contacting the first antigen with the sample under conditions under which the antibody can bind to the first antigen to form an immune complex; and detecting the immune complex. An ELISA test for FIV, using purified FIV antigen, is also described.

    摘要翻译： 一种检测生物样品中FIV抗体存在的方法。 该方法包括提供具有由抗体识别的第一表位的第一抗原，第一抗原可检测的步骤; 在抗体可以结合第一抗原的条件下使第一抗原与样品接触以形成免疫复合物; 并检测免疫复合物。 还描述了使用纯化的FIV抗原的FIV的ELISA测试。

    Hepatitis B virus surface proteins with reduced host carbohydrate content
    58.
    发明授权
    Hepatitis B virus surface proteins with reduced host carbohydrate content 失效
    乙型肝炎病毒表面蛋白质具有降低的宿主碳水化合物含量

    公开(公告)号：US5614384A

    公开(公告)日：1997-03-25

    申请号：US368287

    申请日：1995-01-04

    申请人： Peter J. Kniskern ,  Arpi Hagopian

    发明人： Peter J. Kniskern ,  Arpi Hagopian

    IPC分类号： A61K39/29 ,  A61P31/12 ,  C07K1/22 ,  C07K14/00 ,  C07K14/02 ,  C07K14/10 ,  C07K14/18 ,  C12N1/19 ,  C12N15/09 ,  C12N15/36 ,  C12P21/02 ,  C12R1/865 ,  G01N33/53 ,  G01N33/576

    CPC分类号： C07K14/005 ,  C12N2730/10122

    摘要： In order to produce hepatitis B virus (HBV) surface proteins in the form of particles with substantially reduced entrapped carbohydrate content, DNA encoding the HBV surface proteins was expressed in a recombinant yeast host which is deficient in its ability to glycosylate proteins. These HBV surface proteins display the antigenie sites genetically encoded by the S domain of the HBV virion envelope open reading frame and contains substantially reduced levels of entrapped carbohydrate when compared with HBsAg particles produced in "wild-type" yeast cells. These particles are useful as a vaccine for both the active and passive treatment or prevention of disease and/or infection caused by HBV or other agents serologically related to HBV.

    摘要翻译： 为了产生具有显着降低的夹带碳水化合物含量的颗粒形式的乙型肝炎病毒（HBV）表面蛋白质，编码HBV表面蛋白的DNA在重组酵母宿主中表达，其缺乏糖基化蛋白质的能力。 这些HBV表面蛋白质显示由HBV病毒粒子包膜开放阅读框架的S结构域遗传编码的抗原位点，与“野生型”酵母细胞中产生的HBsAg颗粒相比，含有显着降低的包埋碳水化合物水平。 这些颗粒可用作活性和被动治疗或预防HBV或与HBV血清学相关的其他试剂引起的疾病和/或感染的疫苗。