Fermentation process
    60.
    发明授权

    公开(公告)号:US11136602B2

    公开(公告)日:2021-10-05

    申请号:US16462978

    申请日:2017-11-29

    申请人: PURAC BIOCHEM BV

    摘要: A fermentation product manufacturing process includes fermenting under fermentation conditions in an aqueous fermentation medium in a fermentation reactor a carbohydrate source with a microorganism capable of converting the carbohydrate into a fermentation product which is a salt or a product with a boiling point above the boiling point of water, during the process withdrawing part of the medium including biomass from the reactor in the form of a recycle stream, providing the stream including biomass to a pressure vessel wherein the pressure is such that the temperature of the stream decreases 1-8° C., as compared to the temperature of the medium in the reactor, by the evaporation of water, and recycling the cooled recycle stream to the reactor. The process makes it possible to obtain a homogeneous temperature profile of the fermentation medium with limited occurrence of hot or cool spots within the reactor which results in improved fermentation performance.